Best TWAS P=1.37e-10 · Best GWAS P=3.61e-10 conditioned to 0.206
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SND1 | 0.08 | 0.07 | lasso | 4 | 0.07 | 2.2e-08 | -5.4 | 5.7 | 1.0e-08 | -0.85 | 0.05 | 0.95 | FALSE |
2 | GTEx | Adipose Subcutaneous | SND1 | 0.19 | 0.15 | enet | 22 | 0.14 | 9.8e-12 | -5.8 | 6.0 | 2.6e-09 | -0.83 | 0.04 | 0.96 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SND1 | 0.17 | 0.15 | lasso | 3 | 0.14 | 6.0e-08 | -5.8 | 6.3 | 3.4e-10 | -0.87 | 0.03 | 0.96 | FALSE |
4 | GTEx | Artery Aorta | SND1 | 0.09 | 0.10 | lasso | 3 | 0.08 | 2.2e-05 | -5.9 | 6.4 | 1.4e-10 | -0.88 | 0.03 | 0.96 | TRUE |
5 | GTEx | Artery Coronary | SND1 | 0.20 | 0.26 | lasso | 1 | 0.25 | 6.1e-09 | -5.9 | 5.9 | 3.7e-09 | -0.91 | 0.03 | 0.97 | FALSE |
6 | GTEx | Artery Tibial | SND1 | 0.20 | 0.23 | lasso | 5 | 0.24 | 4.9e-19 | -5.8 | 5.8 | 5.3e-09 | -0.87 | 0.04 | 0.96 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SND1 | 0.24 | 0.21 | lasso | 7 | 0.20 | 4.9e-15 | -5.9 | 5.8 | 6.6e-09 | -0.87 | 0.04 | 0.96 | FALSE |
8 | GTEx | Colon Sigmoid | SND1 | 0.25 | 0.18 | lasso | 4 | 0.16 | 2.0e-06 | -5.8 | 6.0 | 1.4e-09 | -0.84 | 0.04 | 0.96 | FALSE |
9 | GTEx | Muscle Skeletal | SND1 | 0.05 | 0.05 | lasso | 3 | 0.04 | 1.0e-04 | -5.8 | 6.0 | 1.8e-09 | -0.90 | 0.03 | 0.96 | FALSE |
10 | GTEx | Nerve Tibial | SND1 | 0.23 | 0.20 | lasso | 5 | 0.19 | 3.0e-13 | -5.8 | 5.9 | 4.4e-09 | -0.85 | 0.05 | 0.95 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | SND1 | 0.10 | 0.08 | lasso | 4 | 0.06 | 1.2e-05 | -5.1 | 5.3 | 9.5e-08 | -0.67 | 0.15 | 0.84 | FALSE |
12 | METSIM | Adipose | SND1 | 0.06 | 0.03 | blup | 602 | 0.04 | 1.5e-06 | -6.3 | 6.0 | 2.5e-09 | -0.74 | 0.02 | 0.98 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | SND1 | 0.06 | 0.02 | lasso | 7 | 0.02 | 2.4e-03 | -5.9 | 5.5 | 2.8e-08 | -0.89 | 0.03 | 0.97 | FALSE |
14 | YFS | Blood | SND1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 7.8e-08 | -5.8 | 5.8 | 6.9e-09 | -0.88 | 0.05 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SND1 | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-09 | -5.9 | 6.1 | 1.2e-09 | -0.87 | 0.04 | 0.96 | FALSE |