Best TWAS P=4.23e-09 · Best GWAS P=8.66e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | KREMEN1 | 0.38 | 0.26 | lasso | 3 | 0.22 | 1.7e-08 | 5.7 | 5.6 | 1.8e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Heart Left Ventricle | KREMEN1 | 0.47 | 0.32 | lasso | 6 | 0.34 | 5.0e-19 | 5.5 | 5.9 | 4.2e-09 | 0.96 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Ovary | KREMEN1 | 0.28 | 0.18 | enet | 5 | 0.19 | 1.7e-05 | 5.5 | 5.7 | 1.4e-08 | 0.87 | 0.02 | 0.90 | FALSE |
| 4 | GTEx | Pancreas | KREMEN1 | 0.33 | 0.24 | lasso | 7 | 0.23 | 4.2e-10 | 5.8 | 5.6 | 2.0e-08 | 0.99 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Thyroid | KREMEN1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.3e-06 | 5.7 | 5.8 | 8.7e-09 | 1.00 | 0.01 | 0.99 | FALSE |
| 6 | METSIM | Adipose | KREMEN1 | 0.12 | 0.12 | lasso | 8 | 0.11 | 1.7e-16 | 5.3 | 5.1 | 2.7e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KREMEN1 | 0.13 | 0.10 | lasso | 5 | 0.11 | 3.3e-12 | 5.5 | 5.6 | 2.1e-08 | 0.93 | 0.02 | 0.98 | FALSE |