Hub : Genes

KREMEN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0360	1.7e-06	0.061	0.082	0.072	0.083	0.069	6.0e-08	3.3e-10	3.9e-09	2.8e-10	8.7e-09
2	GTEx	Adipose Subcutaneous	0.1900	0.0490	8.2e-08	0.126	NA	0.130	NA	0.122	1.7e-10	NA	9.2e-11	NA	3.7e-10
3	GTEx	Adrenal Gland	0.3847	0.0811	4.2e-06	0.258	NA	0.170	NA	0.222	8.8e-10	NA	1.1e-06	NA	1.7e-08
4	GTEx	Breast Mammary Tissue	0.1360	0.0490	4.5e-04	0.061	NA	0.102	NA	0.084	4.6e-04	NA	6.9e-06	NA	4.4e-05
5	GTEx	Breast Mammary Tissue (Male)	0.0815	0.0705	1.6e-01	-0.012	NA	-0.007	NA	-0.013	7.8e-01	NA	4.9e-01	NA	8.8e-01
6	GTEx	Heart Left Ventricle	0.4676	0.0695	4.8e-15	0.323	NA	0.338	NA	0.343	8.6e-18	NA	1.0e-18	NA	5.0e-19
7	GTEx	Ovary	0.2760	0.1040	4.0e-03	0.182	NA	0.193	NA	0.154	3.0e-05	NA	1.7e-05	NA	1.3e-04
8	GTEx	Pancreas	0.3350	0.0800	3.0e-06	0.242	NA	0.178	NA	0.230	1.3e-10	NA	5.7e-08	NA	4.3e-10
9	GTEx	Thyroid	0.0950	0.0340	7.4e-04	0.087	NA	0.070	NA	0.079	3.3e-07	NA	4.5e-06	NA	1.3e-06
10	METSIM	Adipose	0.1228	0.0282	1.2e-11	0.120	0.078	0.112	0.105	0.113	1.7e-17	1.0e-11	2.2e-16	2.3e-15	1.7e-16
11	NTR	Blood	0.0471	0.0124	1.8e-08	0.038	0.034	0.038	0.035	0.039	3.0e-12	4.6e-11	2.7e-12	1.7e-11	1.4e-12
12	YFS	Blood	0.1018	0.0197	0.0e+00	0.099	0.086	0.105	0.103	0.104	1.5e-30	1.2e-26	1.2e-32	8.5e-32	4.8e-32
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.1304	0.0464	2.4e-10	0.095	0.088	0.092	NA	0.109	7.1e-11	4.5e-10	1.5e-10	NA	3.3e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.9	1.4	4.5	0.9	0.6	1.3	2.1	1.9	1.1	0.6	1.1	1.1	1.2	-1.1	-1.0	0.7
Bipolar Disorder or Schizophrenia	1.2	3.0	5.6	1.5	1.3	1.7	2.3	1.6	1.8	1.3	1.6	1.7	1.5	-2.4	-2.0	1.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.5	-0.2	0.4	0.3	-0.3	-0.7	0.2	0.1	0.1	0.3	0.1	0.5	-0.3	0.0
Depression (Nagel 2018)	3.0	4.5	8.1	-0.2	-1.8	-2.1	-2.2	-2.1	-2.4	-2.5	-2.8	-2.5	-2.5	0.1	-0.1	-2.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	-0.8	-0.4	0.2	-0.4	-0.4	0.6	1.0	0.6	0.5	0.8	0.4	0.5	0.8
Neuroticism (Nagel 2018)	0.3	0.7	2.0	-0.5	-0.5	-0.7	-0.8	-1.0	-0.8	-1.2	-1.1	-0.8	-0.9	0.1	-0.2	-1.4
Schizophrenia (2018)	0.8	1.7	4.6	1.3	1.3	1.2	1.2	0.6	1.4	1.3	1.1	1.3	1.0	-2.1	-1.7	1.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.6	-0.2	-0.3	-0.9	-1.5	-1.9	-0.9	-0.9	-0.9	-0.7	-0.6	1.4	0.9	-0.8
Worry (Nagel 2018)	0.4	0.8	3.9	0.6	0.5	0.1	-0.1	-0.2	-0.2	-0.8	-0.5	-0.2	-0.5	-2.0	-1.7	-1.1
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	-0.5	1.0	0.4	0.6	0.2	0.5	-0.1	0.8	0.6	0.7	0.1	0.4	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.1	-0.3	-0.3	-0.2	-0.2	-0.2	0.0	0.1	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	1.9	0.6	0.9	1.1	1.0	0.5	1.0	0.5	1.3	1.2	1.4	-0.7	-0.5	0.7
Crohns Disease (2017)	0.2	0.5	1.3	1.1	-0.6	0.8	-0.4	-1.1	0.5	-0.0	0.5	0.8	0.7	-0.3	-1.0	-0.2
Irritable Bowel Disease (IBD)	0.4	1.0	5.2	2.3	-1.2	0.3	-0.8	-1.6	-0.5	-1.0	-0.1	0.2	-0.0	-0.1	-0.9	-1.1
Ulcerative Colitis (UC)	0.7	1.3	6.0	2.4	-1.4	-0.2	-1.0	-1.9	-1.0	-1.1	-0.4	-0.3	-0.5	0.2	-0.4	-1.2
Major Depression (MDD)	1.1	1.3	3.2	1.0	0.3	1.5	0.9	0.6	1.3	0.7	1.2	1.3	1.2	-1.4	-1.8	0.8
Reaction Time	3.0	5.6	9.0	2.8	1.6	2.4	2.3	2.4	2.5	2.2	2.4	2.3	2.2	-3.0	-2.3	2.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.5	-0.7	0.2	-0.4	-0.6	0.5	0.6	0.4	0.5	0.8	0.7	0.6	0.5
Breast Cancer	0.7	1.6	3.7	-0.0	0.7	1.1	0.6	1.1	1.0	1.8	1.1	1.2	1.6	-1.9	-1.4	1.5
Ovarian Cancer	1.1	1.4	2.6	-0.9	-1.5	-1.4	-0.9	-0.2	-1.1	-1.4	-1.3	-1.5	-1.6	0.2	0.9	-1.4
Prostate Cancer	2.5	3.5	5.7	0.4	-2.0	-2.1	-1.6	-1.6	-2.2	-2.4	-2.4	-2.3	-2.0	0.7	0.7	-2.4
Age at First Birth	0.3	0.4	1.6	1.2	-0.4	-0.0	-0.6	-1.2	-0.5	-0.4	-0.0	-0.3	0.1	-0.9	-0.9	-0.4
Bipolar Disorder (2011)	0.4	0.4	2.1	-0.3	-1.4	-0.6	-0.5	-0.4	-0.5	-0.3	-0.6	-0.5	-0.7	0.2	0.3	-0.5
Body Mass Index (BMI) (2010)	0.1	0.2	1.0	1.0	-0.1	0.1	0.4	0.1	-0.1	-0.6	0.0	0.0	0.3	0.7	0.4	-0.3
Coronary Artery Disease (CAD)	3.6	4.3	8.0	-1.1	-1.9	-2.0	-2.6	-2.8	-2.3	-1.8	-2.1	-2.0	-2.1	2.1	1.6	-2.2
Crohns Disease (2012)	0.4	0.6	3.3	1.0	-1.0	0.3	-1.2	-1.8	-0.1	-0.6	0.1	0.3	0.2	0.3	-0.4	-0.3
Mean Putamen Volume	0.2	0.2	0.5	-0.7	-0.1	0.4	0.4	0.4	0.3	-0.2	0.4	0.5	0.4	0.6	0.6	0.3
Fasting Glucose	0.5	0.6	2.7	0.3	0.7	0.5	1.6	1.4	0.4	-0.0	0.8	0.6	0.8	0.7	0.4	0.4
HbA1C	0.3	0.3	1.7	-0.1	-0.5	-0.1	-0.2	-0.8	-0.7	-1.3	-0.3	-0.3	-0.0	-0.3	-0.3	-1.0
HDL Cholesterol	1.8	3.0	5.2	-0.5	1.9	1.5	2.1	2.1	2.0	2.2	1.8	1.7	1.7	-1.0	-0.8	2.3
LDL Cholesterol	0.2	0.3	0.9	0.8	-0.3	0.4	-0.3	-0.7	-0.1	-0.3	0.1	0.0	0.1	-0.9	-0.9	-0.3
Lupus	0.4	0.6	1.7	1.0	-1.0	-0.4	-0.7	-1.3	-0.9	-1.0	-0.6	-0.5	0.2	0.6	0.0	-0.7
Neuroticism (2016)	0.1	0.2	0.5	-0.2	0.5	-0.6	0.2	0.3	-0.2	-0.7	-0.6	-0.7	-0.1	-0.2	-0.4	-0.6
Primary Biliary Cirrhosis	0.1	0.2	1.6	0.0	0.6	-0.1	0.2	-0.1	-0.3	-0.4	-0.1	-0.0	0.2	1.2	-0.2	-0.4
Rheumatoid Arthritis	0.6	0.8	1.8	0.8	0.6	1.1	0.4	0.0	0.9	1.0	1.2	1.2	1.3	-0.8	-0.7	0.9
Schizophrenia (2014)	0.9	1.9	4.6	1.3	1.7	1.3	1.5	0.7	1.5	1.1	1.1	1.3	1.1	-2.1	-1.6	1.1
Triglycerides	0.7	1.1	2.8	0.5	-0.7	-0.8	-1.0	-1.4	-1.3	-1.7	-1.0	-0.9	-0.7	0.6	0.2	-1.5
Type 2 Diabetes (T2D) (2012)	3.8	4.4	7.5	-1.5	-2.7	-2.2	-1.4	-1.1	-2.3	-2.3	-2.2	-2.1	-2.5	1.9	2.0	-2.5
Ulcerative Colitis	1.1	1.6	3.2	1.8	-1.4	-0.6	-1.3	-1.7	-1.4	-1.6	-1.0	-1.0	-1.0	-0.2	-0.7	-1.6
Blood Eosinophil Count	1.0	7.4	12.2	0.6	2.4	2.7	2.6	3.2	3.3	3.1	2.5	2.5	2.1	-3.5	-2.7	2.9
Blood Platelet Count	1.1	13.0	49.8	2.7	3.5	3.3	3.2	3.0	3.5	2.5	2.9	2.8	2.7	-7.1	-4.4	2.6
Blood Red Count	0.1	1.4	4.0	2.0	-1.0	0.2	-1.4	-1.4	-0.3	-1.4	-0.6	-0.2	-0.6	-1.4	-1.6	-1.4
Blood White Count	1.6	12.0	30.9	3.4	1.9	3.5	3.6	3.4	3.4	3.2	3.1	3.0	2.6	-5.6	-4.2	2.9
Heel T-Score	46.8	372.3	533.6	13.4	20.1	22.4	18.2	13.1	21.9	21.0	22.1	23.1	22.0	-12.1	-14.7	21.5
BMI	0.1	0.7	3.4	-0.1	-1.3	-0.6	-0.7	-0.9	-0.6	-0.4	-0.7	-0.5	-0.7	1.8	1.1	-0.6
Height	0.8	15.1	25.7	0.3	3.0	4.1	4.4	3.2	4.5	5.0	5.1	4.8	4.5	0.6	-0.5	5.0
Waist Hip Ratio (WHR)	2.9	13.1	31.0	0.9	-5.6	-3.1	-3.5	-2.6	-3.7	-5.1	-4.5	-3.9	-3.4	-0.3	-0.3	-4.7
Systolic Blood Pressure	1.4	6.9	11.8	-0.9	-2.8	-2.6	-2.2	-3.0	-3.1	-3.4	-3.2	-3.0	-2.8	0.8	0.2	-3.4
Smoking Status	0.3	0.6	2.7	-1.2	0.1	-0.4	0.9	0.8	-0.2	-0.3	-0.3	-0.2	-0.3	1.7	1.4	-0.2
Allergy or Eczema	2.8	7.3	15.2	1.9	2.4	3.1	2.7	1.9	2.9	1.7	2.6	2.7	2.5	-3.9	-3.8	1.7
Cardiovascular Disease	5.9	19.5	29.6	-2.2	-4.4	-4.3	-4.6	-5.0	-5.1	-5.0	-4.9	-4.7	-4.7	3.4	1.9	-5.4
Hypothyroidism (self reported)	1.9	4.3	8.0	-0.1	2.6	2.3	2.8	2.8	2.2	1.4	2.3	2.3	2.4	-0.7	-1.0	1.8
Respiratory disease	0.1	0.1	0.7	0.0	-0.1	0.1	-0.0	-0.4	-0.0	-0.8	-0.1	0.0	0.1	-0.0	0.4	-0.8
Type 2 Diabetes (T2D) (2018)	3.1	5.8	9.1	-1.8	-2.4	-2.5	-1.7	-1.9	-3.0	-2.9	-2.2	-2.5	-2.1	2.7	2.7	-2.5
Lung FEV1/FVC ratio	0.3	1.4	4.5	-0.1	1.7	1.6	-0.5	-1.4	0.6	0.5	0.9	1.4	1.2	-0.1	-2.1	0.7
Lung FVC	0.7	3.7	5.7	1.7	1.8	1.8	2.3	2.1	2.3	2.4	1.8	1.9	1.8	-1.0	-1.3	2.4
Neuroticism	0.4	0.8	2.4	0.0	-0.4	-0.6	-0.9	-1.0	-0.8	-1.1	-1.1	-0.8	-1.0	-0.5	-1.0	-1.5
Chronotype (morning person)	0.1	0.2	0.7	0.2	-0.4	-0.1	0.2	0.5	0.6	0.6	0.2	0.2	-0.1	-0.4	0.8	0.4
Hair Pigment	0.4	10.5	19.3	-0.5	-4.2	-3.4	-3.3	-2.2	-3.1	-3.7	-4.4	-3.8	-3.5	-2.3	-0.5	-4.2
Tanning	0.0	0.2	0.4	0.1	0.2	0.4	0.2	0.3	0.5	0.3	0.6	0.4	0.5	0.6	0.2	0.5
Hand grip strength (left)	0.4	1.1	3.4	1.2	-1.1	-0.5	-1.0	-1.8	-1.2	-1.5	-0.7	-0.7	-0.2	1.2	0.1	-0.8
Number of treatments/medications taken	0.6	1.0	2.5	-1.0	-0.3	-0.7	-0.8	-1.6	-0.8	-1.5	-0.9	-0.8	-1.0	1.0	0.0	-1.4
Average weekly spirits intake	0.6	0.8	1.6	-0.1	-1.2	-1.3	-0.6	-0.5	-0.9	-0.7	-1.0	-1.1	-0.8	0.7	1.1	-0.7
Sensitivity / hurt feelings	0.9	1.6	3.4	-0.9	-1.2	-1.4	-0.6	-0.6	-1.4	-1.7	-1.6	-1.5	-1.4	0.4	0.6	-1.9
Frequency of depressed mood in last 2 weeks	2.6	3.7	6.1	-0.2	-2.1	-2.0	-2.1	-2.0	-2.1	-2.3	-2.4	-2.3	-2.2	0.3	0.1	-2.5
Hearing difficulty/problems: Yes	0.6	0.9	3.0	1.6	0.7	0.7	0.6	0.6	0.8	0.8	0.7	0.4	0.1	-1.3	-1.7	0.8
Relative age of first facial hair	0.4	0.8	2.7	0.8	1.6	0.7	1.0	0.8	0.7	0.3	0.7	0.6	0.5	-0.9	-1.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.1	0.2	-0.7	-0.8	-1.1	-1.3	-1.3	-1.2	-1.2	-1.0	-1.2	0.5	-0.0	-1.4
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.8	-2.2	-0.7	-1.6	-0.9	-0.6	-1.1	-1.2	-1.4	-1.4	-1.5	2.1	2.1	-1.1
Ever had hysterectomy (womb removed)	0.8	0.9	3.7	0.0	-0.4	-0.5	-1.1	-1.9	-1.0	-1.4	-0.5	-0.5	-0.4	1.3	0.8	-1.1
Systolic blood pressure, automated reading	1.1	3.2	6.9	-0.1	-1.6	-1.9	-1.1	-1.3	-2.2	-2.6	-2.1	-2.2	-1.9	0.9	0.6	-2.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.1	-0.2	-0.4	-0.6	0.2	-0.3	-1.1	-1.5	-0.8	-0.7	-0.6	0.7	0.6	-1.4
Angina	0.5	0.7	1.5	1.0	0.7	1.2	0.1	-1.0	0.6	0.0	1.0	1.0	0.9	-0.4	-1.2	0.3
Medication for hormone replacement therapy	0.4	0.4	0.8	0.0	-0.5	-0.6	-0.8	-0.9	-0.4	-0.5	-0.8	-0.7	-0.8	-0.7	-0.6	-0.7
Vitamin and mineral supplements	0.1	0.1	0.8	0.4	-0.0	-0.0	0.4	0.9	-0.2	-0.4	0.0	-0.2	0.1	0.3	0.0	-0.4
Supplements: Zinc	0.3	0.4	1.1	-0.2	0.3	0.6	0.5	0.8	0.7	0.6	0.6	0.6	0.7	-0.5	-0.2	1.0
Medication: Co-codamol	1.7	2.0	3.2	-1.4	-0.8	-1.6	-1.5	-1.1	-1.4	-1.3	-1.5	-1.6	-1.8	1.4	1.5	-1.3
Medication: Metformin	4.6	6.6	10.4	-1.2	-2.5	-2.5	-1.9	-2.2	-3.2	-3.1	-2.3	-2.5	-2.4	3.0	2.9	-2.7
Diabetes (father)	1.5	1.8	2.9	-0.7	-1.7	-1.5	-1.3	-0.9	-1.5	-1.1	-1.4	-1.5	-1.3	1.3	1.6	-1.2
Diabetes (mother)	0.9	1.1	2.3	-0.1	-1.1	-1.1	-0.6	-0.5	-1.4	-1.5	-0.8	-1.1	-0.5	1.3	1.4	-1.3
Severe depression (siblings)	0.4	0.4	1.3	-0.8	1.1	0.0	0.5	0.9	0.5	0.6	0.6	0.3	0.2	0.4	0.9	0.6
Pack years adult smoking proportion	0.3	0.4	1.5	0.2	-0.8	-0.4	-0.6	-1.2	-0.7	-0.9	-0.2	-0.4	-0.1	0.8	0.3	-0.7
Impedance of leg (right)	0.5	2.2	9.3	-1.0	3.0	1.3	1.8	1.4	1.3	0.7	1.6	1.4	1.7	-0.2	-0.1	1.5
Leg fat-free mass (left)	0.1	0.5	1.8	1.0	-1.1	0.7	0.2	0.0	0.7	1.3	0.7	0.7	0.4	0.5	-0.3	0.7
Trunk fat percentage	1.0	4.1	7.3	-0.6	2.1	1.9	2.3	1.7	2.4	2.6	2.4	2.3	2.0	0.7	0.6	2.7
Hand grip strength (right)	0.7	2.0	4.7	0.9	-2.2	-1.1	-1.4	-1.9	-1.6	-1.8	-1.4	-1.3	-0.9	0.8	0.3	-1.4
Townsend deprivation index at recruitment	0.3	0.5	1.7	0.7	-0.1	-0.6	-0.1	-0.2	-0.9	-1.3	-0.8	-0.8	-0.6	0.0	-0.2	-1.0
Current tobacco smoking	0.7	1.2	2.5	-1.5	-0.6	-1.2	-0.0	-0.0	-1.1	-1.0	-1.1	-1.0	-1.1	1.6	1.5	-1.1
Average weekly fortified wine intake	0.2	0.2	1.2	-0.0	0.2	-0.4	0.2	0.9	0.0	0.3	-0.3	-0.4	-0.2	-1.1	-0.3	-0.1
Maternal smoking around birth	0.9	1.2	2.0	-1.4	0.7	-1.3	0.1	0.3	-1.1	-1.1	-1.4	-1.4	-1.4	1.2	1.2	-1.0
Fed-up feelings	0.7	1.2	2.6	-0.5	-0.7	-1.0	-1.5	-1.6	-1.0	-1.1	-1.1	-1.1	-1.0	1.1	0.2	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.4	0.7	-1.0	-1.3	-1.3	-1.0	-1.7	-1.9	-2.1	-1.9	-1.7	-1.0	-1.2	-2.1
Relative age voice broke	0.8	1.2	3.3	0.1	1.6	0.9	1.6	1.8	1.0	0.7	1.1	0.9	1.0	-0.7	-1.0	1.0
Taking other prescription medications	0.1	0.1	0.5	0.2	0.7	0.3	0.3	-0.5	0.1	-0.3	-0.0	0.1	-0.1	0.1	-0.5	-0.2
Age when periods started (menarche)	1.5	3.7	5.7	2.0	1.6	2.0	1.0	0.7	2.1	2.3	2.0	1.8	2.0	-2.0	-2.4	2.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.7	0.9	0.4	0.9	0.2	0.4	0.1	0.3	0.3	0.3	-1.0	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (left)	30.2	68.4	97.8	6.3	8.5	9.7	7.8	5.2	9.2	8.7	9.6	9.9	9.8	-4.8	-6.5	9.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	6.4	0.1	-1.5	-1.4	-1.7	-1.6	-2.1	-2.5	-1.8	-1.8	-1.3	0.8	0.3	-2.4
Qualifications: CSEs or equivalent	0.7	1.0	3.5	0.7	-0.6	-0.6	-0.5	-0.9	-1.1	-1.9	-0.7	-0.8	-0.2	1.4	0.4	-1.4
Serious illness, injury or assault to yourself	0.1	0.1	0.4	-0.1	0.1	0.1	-0.2	-0.7	-0.2	-0.6	-0.3	-0.1	-0.0	-0.2	-0.5	-0.5
High blood pressure	7.3	20.4	32.1	-2.9	-4.2	-4.7	-4.1	-4.3	-5.3	-5.3	-5.1	-4.9	-5.0	3.3	2.6	-5.7
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.2	0.7	0.8	1.5	1.3	1.0	1.5	0.6	1.2	1.2	1.1	-2.1	-1.8	0.6
Multivitamins +/- minerals	0.2	0.2	1.3	-0.8	0.1	0.0	-0.8	-1.1	0.1	0.5	-0.2	0.1	-0.2	-0.3	-0.5	0.3
Stomach or abdominal pain in last month	0.2	0.2	1.0	0.5	0.2	-0.1	0.5	0.8	-0.3	-1.0	-0.2	-0.3	-0.3	0.1	-0.3	-0.6
Supplements: Glucosamine	0.2	0.3	1.2	-1.1	0.5	0.2	0.0	-0.7	-0.0	-0.2	0.3	0.4	0.5	0.9	0.7	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.5	-0.5	-0.7	-0.6	-0.6	-0.8	-0.6	-0.3	-0.6	-0.4	-0.7	1.6	0.8	-0.5
Medication: Atenolol	0.5	0.6	1.5	0.4	-0.3	-0.4	-0.7	-1.2	-1.0	-1.2	-0.7	-0.7	-1.0	0.5	-0.3	-1.1
Medication: Levothyroxine sodium	1.1	1.8	3.0	0.2	1.7	1.7	1.6	1.4	1.5	0.8	1.4	1.5	1.6	-1.0	-1.5	0.9
Sitting height	2.2	15.6	28.8	1.8	2.7	4.4	3.6	3.2	4.8	5.4	4.7	4.5	4.3	-2.0	-2.5	5.2
Chronic bronchitis/emphysema (father)	2.0	2.3	4.8	1.3	2.1	1.6	1.7	1.3	1.5	0.8	2.0	1.7	2.2	-0.3	-0.6	1.4
High blood pressure (mother)	1.7	2.3	3.8	-0.3	-1.3	-1.6	-1.3	-1.3	-2.0	-1.9	-1.7	-1.6	-1.7	1.6	1.1	-1.9
Body mass index (BMI)	0.2	1.0	2.3	-0.3	-1.4	-0.9	-1.2	-1.3	-0.7	-0.4	-0.9	-0.8	-1.1	1.5	1.2	-0.7
Impedance of leg (left)	0.4	2.0	8.1	-1.1	2.8	1.0	1.9	1.7	1.2	0.5	1.3	1.1	1.4	-0.2	0.2	1.3
Leg predicted mass (left)	0.1	0.5	1.7	0.9	-1.1	0.6	0.2	0.1	0.6	1.3	0.6	0.6	0.3	0.6	-0.2	0.7
Trunk fat mass	0.6	2.5	5.2	-0.2	1.1	1.5	1.7	1.2	2.0	2.3	2.0	1.9	1.5	0.8	0.4	2.2
Waist circumference	0.4	1.3	3.3	-0.1	-1.8	-0.7	-1.1	-1.5	-0.9	-1.3	-0.9	-0.8	-0.9	1.7	1.0	-1.2
Number of incorrect matches in round	0.9	1.4	3.5	-0.4	-0.5	-1.2	-0.5	-0.4	-1.5	-1.9	-1.2	-1.2	-1.3	1.2	1.3	-1.7
Past tobacco smoking	0.3	0.5	2.6	1.1	0.0	0.5	0.3	0.7	0.3	0.4	0.2	0.2	0.4	-1.6	-1.2	0.3
Alcohol usually taken with meals	0.0	0.1	0.2	-0.5	-0.2	0.2	-0.1	0.3	0.1	0.4	0.1	0.3	0.3	0.1	0.2	0.1
Nervous feelings	0.4	0.8	3.8	0.7	0.4	-0.0	0.6	0.7	-0.3	-0.9	-0.5	-0.4	-0.4	-2.0	-1.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.5	-1.2	-0.9	-1.8	-0.9	-1.1	-1.7	-2.1	-1.8	-1.8	-1.3	1.1	1.2	-1.9
Hearing difficulty/problems with background noise	0.4	0.6	2.4	0.1	0.2	-0.7	-0.2	0.1	-0.8	-0.8	-0.8	-1.0	-1.5	-0.5	-0.3	-1.2
Hair/balding pattern: Pattern 2	4.1	5.2	9.2	-1.7	-2.1	-2.5	-2.3	-1.6	-2.5	-2.2	-2.0	-2.2	-1.8	3.0	3.0	-2.0
Had menopause	0.3	0.4	1.2	-0.2	0.2	0.1	0.4	0.7	0.7	1.0	0.4	0.5	0.4	0.6	1.1	0.9
Had other major operations	0.2	0.2	0.8	-0.3	0.5	-0.1	-0.2	-0.1	0.1	0.3	-0.5	-0.2	-0.8	-0.9	-0.8	-0.4
Forced vital capacity (FVC)	2.2	8.6	12.7	1.9	2.9	3.0	3.6	3.2	3.2	3.2	3.0	2.9	3.0	-1.7	-2.6	3.3
Heel bone mineral density (BMD) T-score, automated (right)	29.6	67.9	97.0	5.6	8.4	9.6	7.9	5.6	9.3	8.8	9.6	9.9	9.7	-5.1	-6.2	9.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.6	-0.9	0.5	-0.1	0.9	1.3	0.3	-0.1	0.0	-0.0	0.0	0.6	0.5	-0.2
Qualifications: None of the above	0.0	0.1	0.4	-0.6	0.6	0.1	0.3	0.4	0.2	0.2	0.1	0.0	-0.5	-0.0	0.1	0.3
Financial difficulties in last 2 years	4.1	5.5	11.7	-1.1	-2.5	-2.5	-1.6	-1.2	-2.9	-3.4	-2.7	-2.9	-2.3	1.2	1.2	-3.2
Mouth/teeth dental problems	0.1	0.2	0.9	-0.6	-0.0	0.2	0.1	0.5	0.3	0.7	0.2	0.2	0.4	-0.9	-0.5	0.4
Heart attack	0.1	0.2	0.6	-0.6	-0.8	-0.2	-0.4	-0.4	-0.1	-0.1	-0.2	-0.1	-0.5	-0.0	0.4	-0.3
Allergy	0.2	0.5	1.7	-0.6	-0.0	-0.9	-0.6	-0.3	-0.7	0.4	-0.6	-0.7	-0.5	1.3	1.1	0.3
Pain all over the body in last month	1.1	1.1	1.9	-0.5	-0.0	-1.4	-0.7	-0.5	-1.3	-1.2	-1.2	-1.3	-1.3	1.3	1.2	-1.0
Diabetes (self-reported)	4.4	6.8	10.2	-1.4	-2.1	-2.5	-2.3	-2.7	-3.1	-3.2	-2.3	-2.5	-2.4	3.1	2.8	-2.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.3	0.4	1.0	1.5	1.4	1.1	1.8	1.3	1.6	1.5	1.7	-1.2	-1.0	1.7
Medication: Ramipril	2.4	3.1	7.3	-1.5	-1.6	-1.4	-1.6	-2.6	-1.7	-1.7	-1.3	-1.2	-1.3	2.7	2.0	-1.5
Medication: Simvastatin	2.4	3.5	5.2	-1.1	-1.4	-1.9	-1.8	-1.8	-2.2	-2.1	-2.1	-1.9	-2.2	1.8	1.5	-2.3
Fluid intelligence score	0.5	1.1	3.8	0.1	0.2	1.3	0.3	-0.1	1.1	0.8	1.7	1.5	1.9	-0.2	-0.4	1.1
Illnesses of siblings	1.5	2.2	3.1	1.2	1.1	1.5	1.0	1.4	1.6	1.7	1.5	1.4	1.5	-1.5	-1.7	1.8
Neuroticism score	0.5	1.1	3.1	-0.1	-0.5	-1.1	-0.8	-0.8	-1.1	-1.4	-1.4	-1.3	-1.3	-0.3	-0.4	-1.7
Weight	0.1	0.6	2.2	0.1	-0.4	0.7	0.4	0.1	1.0	1.5	0.9	0.9	0.5	1.1	0.5	1.1
Impedance of arm (right)	5.9	27.7	45.8	0.7	6.8	5.5	5.7	4.7	5.8	5.7	6.1	5.9	5.6	-3.3	-2.8	6.3
Arm fat percentage (right)	0.6	2.2	4.5	-0.2	1.3	1.5	1.3	0.8	1.9	2.1	1.9	1.9	1.4	0.3	0.3	2.1
Trunk fat-free mass	0.2	1.4	7.5	0.9	-2.7	-0.6	-1.5	-1.6	-0.9	-0.5	-0.9	-0.8	-0.9	0.9	-0.1	-1.1
Hip circumference	0.6	2.7	4.8	-0.6	1.9	1.7	1.6	0.8	1.9	2.2	2.2	2.0	1.7	1.0	0.2	2.1
Time employed in main current job	1.2	1.4	5.9	0.7	1.3	0.6	1.8	2.4	1.2	1.3	1.0	0.7	0.4	-0.5	0.4	1.3
Alcohol intake versus 10 years previously	0.5	0.8	1.8	-0.1	0.5	0.8	1.2	0.7	1.3	1.2	0.9	1.0	1.1	-0.3	0.0	1.4
Father’s age at death	0.9	1.1	3.0	0.7	0.3	1.3	0.9	0.9	1.0	1.1	0.9	1.1	1.0	-1.5	-1.7	0.8
Worrier / anxious feelings	0.5	1.0	2.7	0.8	0.8	-0.4	-0.1	0.2	-0.7	-1.3	-1.1	-0.9	-0.9	-1.4	-1.6	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.8	-1.4	-1.3	-1.7	-1.2	-0.7	-1.6	-1.6	-1.9	-1.9	-2.0	0.5	0.8	-1.8
Falls in the last year	0.2	0.3	1.3	-0.6	-0.7	-0.0	-0.5	-0.7	-0.2	-0.5	0.3	0.0	0.2	1.1	0.2	-0.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.5	-0.8	0.8	0.6	1.3	0.1	0.1	-0.2	1.1	0.8	1.1	1.6	0.8	0.4
Number of live births	1.0	1.4	2.5	-1.1	0.1	-1.2	-1.3	-1.0	-1.4	-1.6	-1.3	-1.3	-1.2	0.7	0.7	-1.5
Forced expiratory volume in 1-second (FEV1)	2.5	8.3	10.6	1.6	3.3	3.1	3.0	2.6	3.1	3.1	2.9	2.9	2.9	-1.9	-3.1	3.3
Pulse rate	2.2	3.7	6.2	-1.8	-1.8	-2.2	-0.9	-0.7	-2.2	-2.4	-2.2	-2.2	-1.9	1.5	1.9	-2.5
Happiness	0.6	0.8	3.5	1.1	0.4	0.8	0.3	0.0	0.8	0.9	0.3	0.6	0.8	-1.4	-1.9	0.4
Noisy workplace	0.1	0.1	0.5	0.5	0.0	0.4	0.2	0.1	0.4	0.2	0.4	0.2	0.2	-0.7	-0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.2	0.6	-0.4	1.3	0.8	0.7	1.1	1.5	1.2	1.2	1.4	-1.4	-1.4	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	-0.8	-0.7	-0.7	-0.4	0.0	-0.7	-0.9	-0.9	-0.9	-1.1	-0.1	0.0	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	2.1	1.4	-0.5	1.0	0.2	-0.4	0.8	0.3	0.9	1.0	0.7	0.8	0.0	0.8
Asthma	0.2	0.3	1.1	-0.3	-0.3	-0.5	-0.2	-0.1	-0.3	-1.1	-0.6	-0.5	-0.4	0.4	0.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	7.7	0.2	2.0	1.7	2.5	2.8	2.0	1.9	2.0	1.8	1.8	-0.9	-1.1	1.8
Medication: Cholesterol lowering	0.6	1.0	3.9	-0.2	-1.1	-0.3	-1.5	-2.0	-1.0	-1.3	-0.5	-0.6	-0.7	0.8	0.0	-1.1
Depression (self-reported)	0.2	0.2	0.5	-0.2	-0.1	-0.3	0.6	0.7	-0.2	-0.7	-0.4	-0.4	-0.2	0.1	-0.4	-0.6
Medication: Lansoprazole	0.3	0.3	1.4	-1.2	-0.0	-0.3	-0.2	-0.4	-0.4	-0.2	-0.3	-0.3	-0.8	0.7	0.7	-0.4
Prospective memory result	0.5	0.6	3.2	-0.3	0.3	-0.3	0.1	0.3	-0.2	0.6	-0.8	-0.6	-1.1	-1.8	-1.1	-0.2
Lung cancer (father)	0.8	0.9	2.9	-0.5	-1.0	-0.7	-1.2	-1.7	-0.9	-1.0	-0.8	-0.8	-1.0	0.6	0.3	-1.0
Illnesses of mother	0.1	0.2	0.4	-0.0	0.4	0.4	0.2	0.0	0.5	0.6	0.6	0.5	0.4	-0.2	-0.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	8.6	1.3	2.9	2.5	2.5	2.2	2.6	2.7	2.5	2.4	2.6	-1.3	-2.5	2.9
Pulse wave Arterial Stiffness index	0.2	0.3	2.2	-0.5	0.4	-0.5	0.4	1.5	0.1	0.4	-0.4	-0.4	-0.3	0.1	0.3	0.1
Impedance of arm (left)	4.5	20.9	35.1	0.0	5.9	4.7	5.4	4.6	4.9	4.8	5.3	5.0	4.9	-2.6	-2.2	5.4
Arm fat mass (right)	0.2	0.8	2.2	0.0	0.2	0.8	0.7	0.3	1.2	1.5	1.1	1.1	0.7	0.8	0.5	1.3
Trunk predicted mass	0.2	1.4	7.4	0.9	-2.7	-0.5	-1.5	-1.6	-0.9	-0.5	-0.8	-0.7	-0.8	0.9	-0.1	-1.1
Standing height	0.8	7.6	13.6	0.5	1.8	3.0	3.1	2.7	3.1	3.7	3.4	3.2	3.1	-0.6	-1.1	3.6
Length of working week for main job	0.9	0.9	2.0	1.3	0.1	1.2	0.9	0.5	0.8	0.9	1.0	1.0	1.0	-1.1	-1.4	0.7
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.4	0.1	0.3	-0.2	-0.6	0.2	0.4	0.2	0.3	0.3	0.1	-0.1	0.1
Breastfed as a baby	0.4	0.5	1.6	0.1	-1.0	-1.0	-0.6	0.4	-0.6	-0.2	-0.9	-1.0	-1.2	-0.2	0.6	-0.5
Tense / ‘highly strung’	0.3	0.5	3.6	0.3	0.8	0.0	0.6	0.6	-0.0	-0.1	-0.3	-0.2	-0.5	-1.9	-1.2	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.1	-0.1	-0.1	-0.0	-0.4	-0.3	-0.9	-0.3	-0.2	-0.1	0.7	0.1	-0.5
Hair/balding pattern: Pattern 4	1.4	3.5	12.1	-2.6	2.1	0.0	3.4	3.5	0.9	1.4	0.8	0.5	0.4	1.0	2.1	1.1
Birth weight of first child	0.1	0.2	0.8	0.0	-0.9	-0.3	-0.4	-0.7	-0.5	-0.4	-0.3	-0.3	-0.5	0.1	0.6	-0.5
Peak expiratory flow (PEF)	0.2	0.4	1.5	-1.2	-0.2	-0.6	-0.7	-0.6	-0.5	-0.1	-0.6	-0.5	-0.6	1.0	0.5	-0.3
Pulse wave reflection index	0.6	0.7	1.8	0.2	-1.3	-1.0	-0.8	0.0	-0.9	-0.8	-1.1	-1.2	-0.8	0.5	0.5	-0.7
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.0	-0.1	-1.4	-1.3	-1.8	-2.0	-1.6	-1.8	-1.1	-1.3	-1.3	2.0	1.1	-1.6
Loud music exposure frequency	0.5	0.5	1.6	-0.2	1.3	0.7	1.1	0.9	0.8	0.6	0.6	0.7	0.3	-0.2	-0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.1	0.4	0.3	0.0	-0.7	-0.1	-0.2	0.5	0.3	0.6	0.1	-0.6	-0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.6	0.1	1.0	0.1	1.0	1.3	0.2	-0.2	-0.0	-0.1	-0.2	-0.4	-0.6	-0.1
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.9	-0.9	0.4	-0.4	-0.4	-0.0	-0.2	0.0	0.2	0.0	-0.9	-1.0	-0.3
Medication: Paracetamol	1.9	3.1	8.1	1.2	1.8	1.7	2.5	2.8	1.8	1.4	1.2	1.5	1.3	-1.5	-1.9	1.4
Headache pain in last month	1.3	2.2	4.1	0.8	1.5	2.0	1.7	0.8	1.7	0.8	1.6	1.7	1.5	-1.4	-2.0	0.7
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	8.5	0.5	2.2	1.4	2.5	2.9	1.9	2.0	1.8	1.6	1.7	-0.6	-0.2	2.3
Glaucoma (self-reported)	3.5	4.1	7.1	0.3	-1.9	-2.0	-2.3	-2.1	-2.4	-2.3	-2.5	-2.3	-2.5	0.7	0.5	-2.7
Gout (self-reported)	0.4	0.5	1.6	0.2	0.1	0.9	0.1	-0.3	0.8	1.2	0.7	0.8	0.3	-1.0	-0.7	0.7
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	8.6	-0.2	2.6	1.9	2.7	2.9	2.1	1.6	1.9	1.9	1.9	-0.9	-1.1	1.6
Medication: Amlodipine	1.1	1.5	2.7	-1.1	-1.4	-1.3	-0.6	-0.7	-1.4	-1.5	-1.5	-1.3	-1.3	0.9	0.8	-1.7
Medication: Ventolin 100micrograms inhaler	2.0	2.5	4.9	1.6	1.1	1.7	1.8	1.7	1.8	1.2	1.4	1.6	1.7	-2.2	-1.4	1.2
Birth weight	10.7	23.3	34.5	3.0	3.9	5.6	4.2	3.5	5.9	5.7	5.6	5.8	5.1	-3.3	-4.0	5.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.5	0.5	-0.0	0.2	0.2	-0.0	-0.3	-0.2	-0.1	-0.2	-0.3	-0.5	-0.4
High blood pressure (siblings)	0.4	0.5	1.1	-0.3	-0.8	-0.6	-0.3	-0.9	-0.8	-1.0	-0.8	-0.7	-0.7	0.6	0.2	-1.1
Forced vital capacity (FVC), Best measure	2.2	8.1	12.1	1.7	2.7	2.8	3.3	3.3	3.1	3.2	3.0	2.7	2.9	-1.8	-2.4	3.5
Body fat percentage	0.6	2.2	4.1	-0.5	1.5	1.3	1.6	1.1	1.8	2.0	1.8	1.7	1.4	0.8	0.6	2.0
Leg fat percentage (right)	0.1	0.3	2.0	-0.7	0.1	-0.2	-0.3	-0.5	0.2	0.3	0.0	0.0	-0.4	1.4	1.2	0.2
Arm fat-free mass (right)	0.7	3.4	11.8	0.3	-3.4	-1.7	-1.9	-1.6	-1.7	-1.3	-1.9	-1.8	-1.7	2.0	1.0	-2.0
Exposure to tobacco smoke outside home	1.1	1.5	3.8	1.6	1.9	1.2	1.5	0.8	1.1	0.8	1.2	1.2	1.1	-0.8	-0.6	1.2
Comparative body size at age 10	0.4	1.1	2.7	1.7	0.1	1.0	1.6	1.3	1.0	1.1	0.8	1.0	0.9	-0.4	-0.4	0.9
Number of full brothers	2.6	3.3	5.1	-0.3	-1.8	-1.8	-2.0	-1.8	-2.3	-2.1	-2.0	-2.1	-2.1	1.2	0.9	-2.1
Worry too long after embarrassment	0.4	0.7	1.4	-0.8	-0.9	-1.1	-0.5	-0.3	-0.8	-0.8	-1.1	-1.2	-1.0	-0.1	0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.7	0.6	-0.0	0.5	-0.2	-0.6	0.0	-0.3	0.4	0.4	0.5	-0.2	-0.8	-0.0
Wheeze or whistling in the chest in last year	0.3	0.5	2.5	-0.3	-0.9	-0.2	-0.4	-0.6	-0.5	-1.6	-0.4	-0.4	-0.2	0.7	0.4	-1.1
Number of children fathered	0.6	0.7	2.9	0.3	-0.4	-0.7	-1.2	-1.7	-0.9	-0.7	-0.8	-0.8	-0.7	0.1	-0.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.3	-0.9	-0.6	-1.0	-0.3	0.0	-0.6	-0.3	-0.9	-0.7	-0.8	0.7	1.1	-0.8
Age at first live birth	0.2	0.3	2.0	1.4	-0.7	0.3	-0.2	-0.4	-0.1	-0.1	0.5	0.3	0.5	-0.2	-0.2	0.0
Pulse wave peak to peak time	0.3	0.4	1.4	0.6	-0.1	0.8	-0.0	-1.2	0.3	0.0	0.8	0.8	0.7	-0.2	-0.5	0.3
Health satisfaction	0.4	0.5	1.8	0.3	1.3	0.7	0.7	-0.1	0.8	0.6	0.7	0.7	0.6	-0.0	-0.5	0.7
Shortness of breath walking on level ground	0.2	0.2	1.3	0.3	0.3	0.4	-0.1	-1.1	0.2	-0.0	0.6	0.5	0.3	0.6	0.3	0.5
Qualifications: College or University degree	0.4	1.3	3.8	1.9	-0.6	0.9	0.4	0.7	1.2	1.6	0.9	0.9	0.8	-1.6	-1.0	1.3
Eye problems/disorders: None of the above	2.1	2.4	5.9	1.0	1.2	1.4	0.5	0.8	2.1	2.4	1.5	1.6	1.2	-1.7	-1.1	2.4
Mouth/teeth dental problems: Loose teeth	1.9	2.3	3.6	0.1	-1.7	-1.8	-1.7	-1.6	-1.7	-1.4	-1.9	-1.8	-1.7	-0.0	1.0	-1.7
Emphysema/chronic bronchitis	0.6	0.7	2.4	0.3	-0.7	0.0	-0.6	-1.3	-0.7	-1.5	-0.1	-0.1	0.1	1.4	0.0	-1.2
Medication for pain relief, constipation, heartburn	0.1	0.2	1.0	-0.1	-0.1	0.3	-0.6	-1.0	0.1	0.5	0.3	0.4	0.5	-0.6	0.1	0.4
Neck or shoulder pain in last month	0.7	0.9	4.0	1.0	0.6	0.9	0.7	0.6	0.9	1.0	0.5	0.6	0.1	-2.0	-1.6	0.4
Medication: Blood pressure	2.9	5.0	10.8	-0.9	-2.7	-2.0	-2.8	-3.3	-2.3	-2.4	-2.3	-2.1	-2.1	1.1	0.7	-2.7
Angina (self-reported)	0.4	0.5	1.5	0.8	0.5	0.9	-0.1	-1.2	0.4	-0.1	0.8	0.7	0.7	-0.1	-1.0	0.0
Migraine (self-reported)	0.6	0.8	1.5	0.7	1.2	1.1	1.2	0.6	1.0	0.6	0.7	1.1	0.9	-0.1	-1.0	0.6
Medication: Ibuprofen	1.6	1.9	4.4	-0.1	1.3	1.2	2.0	2.1	1.5	1.3	1.6	1.4	1.5	-0.3	-0.5	1.3
Medication: Allopurinol	0.6	0.9	2.4	-0.8	-0.9	-0.8	-1.4	-1.2	-0.7	-0.2	-1.0	-0.9	-1.6	-0.3	-0.0	-0.9
Medication: Omeprazole	2.0	2.4	4.6	-1.9	-0.5	-1.5	-1.4	-1.6	-1.5	-1.7	-1.4	-1.4	-1.3	2.1	1.7	-1.6
Medication: Seretide 50 evohaler	0.2	0.2	1.5	-0.2	0.0	-0.1	0.3	0.6	-0.2	-0.4	-0.2	-0.2	-0.1	-1.2	-0.4	-0.5
Mean time to correctly identify matches	1.0	2.0	3.1	1.8	0.8	1.4	1.5	1.6	1.6	1.4	1.5	1.5	1.2	-1.4	-0.9	1.5
Heart disease (mother)	0.2	0.2	0.6	-0.7	0.5	0.4	-0.1	-0.0	0.5	0.7	0.1	0.4	0.2	-0.5	-0.7	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.0	-0.9	-0.7	-1.3	-1.4	-1.5	-1.3	-1.2	-1.7	-1.3	-1.7	1.4	1.1	-1.6
Whole body fat mass	0.3	1.1	2.7	0.0	0.5	1.0	1.1	0.6	1.4	1.6	1.3	1.3	0.9	0.8	0.5	1.5
Leg fat mass (right)	0.1	0.3	2.1	-0.3	-0.5	-0.1	-0.3	-0.5	0.2	0.6	0.1	0.1	-0.3	1.5	1.1	0.3
Arm predicted mass (right)	0.7	3.4	11.9	0.2	-3.5	-1.7	-1.9	-1.7	-1.8	-1.3	-1.9	-1.8	-1.7	2.0	1.1	-1.9
Pulse rate, automated reading	0.7	2.4	4.4	0.0	-1.6	-1.6	-1.4	-1.3	-1.9	-2.1	-1.7	-1.7	-1.2	1.1	1.0	-2.1
Alcohol intake frequency.	0.6	1.4	2.7	1.0	1.6	1.4	1.6	1.2	1.2	0.6	1.2	1.3	1.3	-0.3	-1.1	0.9
Comparative height size at age 10	0.2	1.3	2.4	-1.5	0.3	0.6	1.2	1.5	1.2	1.5	1.1	0.9	0.6	1.0	1.0	1.4
Number of full sisters	0.4	0.5	2.6	-0.4	1.6	0.5	0.6	0.5	0.7	1.2	0.6	0.6	0.1	-0.0	-0.0	0.7
Suffer from ‘nerves’	0.2	0.3	1.9	-0.3	0.0	0.3	0.5	0.5	0.5	0.4	0.2	0.2	0.0	-1.4	-0.9	0.3
Overall health rating	0.5	1.0	1.8	-1.1	-0.5	-0.9	-0.6	-0.8	-1.2	-1.3	-1.1	-1.2	-1.1	1.1	0.3	-1.2
Chest pain or discomfort	0.4	0.5	1.6	0.8	-0.4	0.5	-0.5	-1.0	-0.4	-1.2	0.3	0.1	0.1	-0.6	-1.2	-0.8
Had major operations	0.2	0.2	0.9	0.0	-1.0	0.2	-0.4	-0.9	-0.2	-0.5	-0.1	0.1	0.0	-0.3	-0.4	-0.5
Age at last live birth	0.2	0.3	1.2	1.1	-0.6	-0.1	-0.8	-0.6	-0.6	-0.3	-0.1	-0.3	-0.1	-0.7	-0.4	-0.5
Family relationship satisfaction	3.1	3.8	5.0	-0.6	-2.1	-2.1	-2.0	-2.1	-2.2	-2.1	-2.1	-2.1	-1.8	1.6	1.5	-2.2
Leg pain on walking	1.8	2.2	6.0	0.4	1.0	1.5	0.9	0.6	2.0	2.4	1.6	1.7	1.2	-0.9	-0.6	2.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.8	-0.7	-0.7	-1.0	-1.1	-1.1	-1.3	-1.2	-1.2	-1.1	-0.8	0.9	0.6	-1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.5	-0.4	0.0	0.2	-0.3	-0.5	-0.0	-0.2	0.4	0.2	0.3	1.2	0.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.8	0.2	0.6	0.3	0.4	0.5	0.9	1.2	0.8	0.8	0.5	0.8	1.2	1.3
Medication: Aspirin	2.4	3.1	4.5	-0.4	-1.8	-1.7	-1.7	-1.8	-2.0	-2.0	-1.7	-1.7	-2.0	1.9	1.4	-2.1
Supplements: Vitamin C	3.1	3.7	6.7	0.3	2.1	1.9	1.9	1.4	2.2	2.3	2.2	2.2	2.0	-1.5	-0.8	2.6
Knee pain experienced in last month	0.4	0.6	1.1	0.6	1.1	0.7	0.7	0.2	0.8	0.9	0.7	0.8	0.6	-0.9	-0.7	0.6
Hypertension (Self-reported)	6.9	19.3	29.3	-2.7	-4.2	-4.4	-4.3	-4.8	-5.1	-5.1	-4.8	-4.7	-4.8	3.4	2.4	-5.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.5	-0.3	-0.4	-0.8	-1.4	-1.4	-1.1	-1.2	-1.1	-1.0	-1.4	0.5	0.1	-1.6
Illnesses of father: Heart disease	0.1	0.2	0.6	0.2	0.2	0.4	0.1	-0.1	0.3	0.2	0.7	0.5	0.6	0.8	0.5	0.4
Illnesses of siblings: Diabetes	2.0	2.5	4.3	-0.7	-1.6	-1.7	-1.6	-1.1	-1.6	-1.3	-1.6	-1.6	-1.7	1.9	2.1	-1.6
Smoking status: Previous	0.1	0.2	1.0	-0.4	0.1	0.2	0.0	-0.3	0.2	0.1	0.4	0.3	0.2	1.0	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.3	0.7	0.8	1.7	1.3	1.1	1.7	2.1	1.8	1.7	1.7	-1.3	-1.1	1.8
Whole body fat-free mass	0.1	0.8	5.2	0.9	-2.3	-0.3	-1.0	-1.0	-0.4	0.1	-0.5	-0.4	-0.5	0.9	-0.1	-0.6
Leg fat-free mass (right)	0.1	0.4	1.7	0.9	-1.3	0.4	0.2	0.2	0.5	1.2	0.5	0.5	0.2	0.6	-0.1	0.6
Arm fat percentage (left)	0.3	1.3	2.8	-0.4	0.7	1.1	1.1	0.7	1.4	1.7	1.5	1.4	1.1	0.5	0.5	1.6
Average weekly red wine intake	0.2	0.2	1.4	0.7	-1.2	0.3	-0.5	-0.5	0.0	0.2	0.3	0.3	0.4	0.2	-0.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	3.0	1.7	0.5	0.6	0.3	-0.6	0.2	0.1	0.4	0.5	0.3	-0.8	-0.9	-0.2
Mood swings	0.8	1.4	2.7	-1.3	-1.5	-1.2	-1.3	-1.1	-0.9	-1.1	-1.0	-1.0	-0.8	1.7	1.2	-1.0
Loneliness, isolation	0.1	0.2	0.5	0.4	-0.6	-0.2	-0.3	-0.3	-0.3	-0.6	-0.5	-0.4	-0.2	0.2	-0.3	-0.7
Long-standing illness, disability or infirmity	0.8	1.3	3.4	-0.1	-1.0	-0.8	-1.1	-1.9	-1.1	-1.7	-0.9	-0.9	-0.8	1.4	0.5	-1.3
Ever had bowel cancer screening	0.2	0.2	0.9	0.2	-0.3	-0.0	-0.5	-0.4	0.2	0.7	-0.2	0.1	-0.6	-1.0	-0.3	0.1
Diabetes diagnosed by doctor	5.4	8.8	12.3	-2.0	-2.8	-2.9	-2.5	-2.7	-3.4	-3.4	-2.6	-2.9	-2.8	3.5	3.4	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	5.1	-1.1	-1.4	-2.0	-1.9	-1.7	-2.2	-2.3	-2.0	-2.1	-1.7	1.2	1.1	-2.1
Friendships satisfaction	0.2	0.3	0.6	0.0	0.2	-0.5	-0.6	-0.4	-0.5	-0.4	-0.8	-0.7	-0.7	-0.3	-0.2	-0.8
Qualifications: nursing, teaching	0.2	0.3	1.4	1.2	-0.3	0.2	-0.4	-0.9	0.2	0.3	-0.1	0.2	0.3	-0.8	-0.8	0.0
Commuting to job workplace: Walk	0.7	0.8	4.7	0.2	-0.4	-0.1	0.7	1.7	0.1	0.1	-0.3	-0.5	-0.3	-2.2	-1.2	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.2	0.0	-0.1	0.6	0.6	-0.4	-0.7	-0.2	-0.3	-0.3	0.2	-0.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	-1.2	1.4	-0.2	0.8	1.3	0.1	0.3	-0.4	-0.2	-0.4	-1.0	-0.2	-0.3
Medication for cholesterol	5.2	7.9	13.4	1.9	2.0	2.9	2.6	2.8	3.3	3.5	3.2	3.0	3.2	-1.9	-1.6	3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.5	-1.0	0.7	-0.7	0.3	0.9	0.0	0.1	-0.1	-0.3	-0.1	1.4	1.6	0.5
Back pain experienced in last month	0.9	1.4	2.6	1.0	1.5	1.6	0.6	-0.1	1.1	0.8	1.5	1.6	1.5	-0.4	-1.4	0.9
Mineral and other dietary supplements	0.2	0.3	1.3	0.6	0.6	0.4	0.7	1.1	0.4	0.4	0.3	0.2	0.1	-0.3	-0.3	0.2
Breast cancer (self-reported)	0.5	0.5	1.1	0.1	1.1	0.7	0.2	-0.5	1.0	1.1	0.9	0.9	0.6	0.2	-0.3	0.9
Asthma (self-reported)	0.2	0.5	1.5	-0.7	-0.1	-0.6	-0.2	-0.1	-0.4	-1.1	-0.6	-0.5	-0.4	0.7	1.2	-1.0
Osteoporosis (self-reported)	0.5	0.6	1.7	-0.4	0.2	-0.6	-0.1	0.4	-1.0	-1.3	-0.9	-1.0	-1.1	-0.3	-0.5	-1.2
Osteoarthritis (self-reported)	0.1	0.2	0.7	-0.5	0.3	0.0	0.4	0.3	0.4	0.2	0.2	0.2	-0.2	0.6	0.8	0.4
Medication: Aspirin	2.0	2.6	3.5	-0.5	-1.8	-1.5	-1.6	-1.7	-1.8	-1.8	-1.5	-1.5	-1.8	1.8	1.1	-1.9
Medication: Gliclazide	6.7	7.6	10.2	-1.7	-3.1	-2.9	-2.9	-2.3	-3.1	-2.8	-2.4	-2.8	-2.6	3.0	3.2	-2.4
Illnesses of father: None of the above (group 1)	0.3	0.3	1.1	-0.7	-0.2	-0.6	-0.7	-0.2	-0.3	0.1	-0.7	-0.7	-0.9	-1.1	-0.0	0.0
Smoking status: Current	0.5	0.8	2.1	-1.4	-0.4	-0.9	0.2	0.4	-0.8	-0.6	-0.8	-0.8	-0.8	1.4	1.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.2	0.9	2.2	1.3	2.3	2.2	1.6	1.3	1.5	1.4	1.8	-0.4	-1.0	1.8
Whole body water mass	0.1	0.8	5.2	0.9	-2.3	-0.3	-1.0	-1.1	-0.4	0.1	-0.5	-0.4	-0.6	0.9	-0.0	-0.6
Leg predicted mass (right)	0.1	0.4	1.6	0.9	-1.3	0.4	0.2	0.2	0.5	1.2	0.5	0.4	0.2	0.5	-0.2	0.6
Arm fat mass (left)	0.2	0.7	2.0	-0.1	0.1	0.8	0.7	0.4	1.1	1.4	1.1	1.0	0.8	0.7	0.4	1.2
Number of self-reported non-cancer illnesses	2.9	5.0	9.0	-1.8	-1.8	-2.2	-1.9	-2.1	-2.4	-2.8	-2.6	-2.4	-2.5	1.5	1.3	-3.0
Average weekly champagne plus white wine intake	0.2	0.2	1.4	-1.0	-0.0	-0.1	0.4	1.2	-0.2	0.1	-0.1	-0.2	-0.1	-0.6	-0.2	-0.1
Miserableness	0.2	0.3	1.6	-0.0	1.3	0.3	0.7	0.3	0.6	0.5	0.5	0.3	0.3	0.4	-0.1	0.5
Guilty feelings	2.0	3.1	6.4	-0.6	-2.1	-2.0	-1.5	-0.9	-1.7	-1.7	-2.3	-2.2	-2.5	-0.2	0.4	-2.4
Wears glasses or contact lenses	0.7	0.8	1.7	-0.4	0.6	1.0	0.7	0.6	1.2	1.3	1.1	1.2	0.8	-0.3	-0.1	1.0
Ever taken oral contraceptive pill	1.7	1.9	5.2	-1.6	-1.3	-1.1	-1.3	-1.6	-1.3	-1.7	-0.4	-0.8	-0.4	2.0	2.3	-0.8
Hearing aid user	0.9	1.1	1.7	0.4	0.8	1.2	0.9	0.8	1.1	0.9	1.2	1.1	1.2	-1.3	-1.0	1.1
Mother’s age at death	1.3	1.6	3.3	0.6	1.4	1.3	1.0	1.2	1.3	1.4	1.1	1.2	1.0	-1.8	-1.6	1.0
Financial situation satisfaction	1.0	1.3	3.4	1.0	-0.9	-0.7	-0.6	-1.6	-1.4	-1.9	-1.0	-0.9	-0.1	1.2	0.2	-1.4
Tinnitus: Yes, now most or all of the time	4.2	5.0	8.0	1.0	2.4	2.5	2.1	1.5	2.5	2.3	2.8	2.7	2.7	-0.9	-1.4	2.7
Commuting to job workplace: Public transport	1.0	1.3	3.8	1.9	0.4	1.3	0.8	0.3	1.1	1.2	1.2	1.4	1.0	-1.2	-0.5	1.0
Eye problems/disorders: Glaucoma	4.6	5.5	10.4	0.3	-1.9	-2.2	-2.5	-2.6	-2.8	-2.8	-2.8	-2.4	-2.7	1.2	1.0	-3.2
Medication: Blood pressure	4.0	7.5	12.3	-2.3	-1.7	-2.8	-2.0	-2.4	-3.3	-3.5	-2.9	-2.9	-3.2	2.4	1.9	-3.5
Pain type(s) experienced in last month: Hip pain	4.7	5.9	8.7	-2.8	-1.6	-2.8	-2.4	-1.5	-2.3	-2.0	-2.5	-2.6	-2.8	2.7	3.0	-2.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	-0.9	0.1	0.1	0.4	-0.0	0.4	0.5	0.2	0.3	0.3	-0.3	0.2	0.5
High cholesterol (Self-reported)	0.9	1.7	2.8	-1.1	-0.9	-1.1	-1.7	-1.6	-1.4	-1.3	-1.3	-1.2	-1.6	1.1	1.0	-1.5
Medication: Bendroflumethiazide	4.6	7.0	10.9	-2.2	-2.4	-2.8	-1.8	-2.1	-3.3	-3.3	-2.7	-2.8	-2.4	2.7	2.3	-3.0
Medication: Paracetamol	2.4	3.7	10.3	0.1	2.3	1.7	2.8	3.2	2.1	1.9	1.4	1.7	1.3	-1.4	-1.6	1.7
Medication: Lisinopril	2.1	2.7	7.3	0.1	-1.9	-1.0	-1.8	-2.7	-1.9	-2.3	-1.4	-1.1	-1.0	1.4	0.4	-2.2
Medication: Atorvastatin	0.1	0.1	0.6	-0.4	0.1	0.1	-0.5	0.0	0.3	0.2	0.1	0.0	-0.6	-0.8	-0.3	0.1
Illnesses of father: High blood pressure	1.3	1.6	4.1	-0.8	-1.1	-1.0	-0.9	-1.4	-1.5	-2.0	-1.2	-1.1	-1.1	1.2	0.5	-2.0
Alcohol drinker status: Never	0.4	0.4	2.3	1.5	-0.5	0.5	-0.6	-0.9	0.1	-0.4	0.2	0.2	0.1	-0.4	-1.0	-0.3
Ever smoked	0.4	0.7	2.3	-1.5	-0.1	-0.7	-0.8	-1.2	-0.6	-0.7	-0.4	-0.5	-0.6	1.1	0.9	-0.7
Basal metabolic rate	0.1	0.4	3.3	0.7	-1.8	-0.1	-0.5	-0.6	-0.1	0.4	-0.1	-0.1	-0.3	1.0	0.1	-0.2
Leg fat percentage (left)	0.1	0.4	1.8	-0.8	-0.0	-0.4	-0.1	-0.1	0.1	0.2	-0.1	-0.1	-0.6	1.3	1.3	0.1
Arm fat-free mass (left)	0.3	1.3	5.6	0.4	-2.4	-0.8	-1.3	-1.3	-0.8	-0.4	-0.9	-0.8	-0.9	1.5	0.6	-1.0
Number of operations (self-reported)	0.7	1.0	2.9	-0.2	-0.3	-0.3	-1.2	-1.7	-0.8	-0.8	-1.0	-0.7	-0.8	-1.2	-1.1	-1.4
Average weekly beer plus cider intake	1.5	2.2	4.2	-0.8	-1.0	-1.8	-1.1	-0.8	-1.8	-2.0	-1.4	-1.8	-1.5	1.4	1.6	-1.6
Irritability	0.6	1.1	1.8	0.0	-0.8	-0.9	-1.2	-1.4	-1.1	-1.4	-1.0	-1.0	-0.9	1.1	0.8	-1.2
Risk taking	0.6	0.8	1.8	-1.3	-0.4	-0.7	-1.1	-1.4	-0.9	-0.7	-0.6	-0.5	-0.6	1.1	0.9	-1.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.3	0.2	-0.4	0.6	-0.3	0.3	0.7	1.0	0.4	0.5	-0.0	-1.5	-0.9	0.6
Fractured/broken bones in last 5 years	1.7	2.2	6.4	-0.5	-1.0	-1.3	-1.2	-1.3	-1.7	-2.5	-1.3	-1.5	-1.4	1.6	0.8	-2.0
Age started oral contraceptive pill	2.0	2.5	4.7	0.8	1.4	1.5	1.9	2.2	1.8	1.7	1.7	1.6	1.7	-1.2	-1.0	1.7
Diastolic blood pressure, automated reading	1.6	5.0	9.2	-0.7	-2.3	-2.5	-1.8	-1.5	-2.6	-3.0	-2.6	-2.7	-2.4	1.8	1.3	-2.7
Ever depressed for a whole week	0.4	0.5	1.6	-0.6	0.0	-0.6	0.6	1.3	-0.4	-0.7	-0.7	-0.7	-0.7	0.7	0.7	-0.7
Unable to work because of sickness or disability	0.7	0.9	2.9	-0.7	-1.1	-0.9	-0.2	-0.1	-1.2	-1.7	-0.8	-1.0	-0.6	1.1	0.8	-1.0
Commuting to job workplace: Cycle	0.2	0.3	1.9	0.5	-1.4	-0.4	-0.3	0.5	0.1	0.2	-0.3	-0.3	-0.4	-0.5	0.2	0.0
Myopia	0.4	0.5	3.0	-1.7	-0.1	-0.8	-0.1	0.4	-0.1	0.4	-0.7	-0.5	-1.0	0.3	1.0	-0.2
Vascular/heart problems diagnosed by doctor	5.9	16.2	25.0	2.8	3.9	4.1	3.6	3.9	4.7	4.7	4.4	4.3	4.4	-3.3	-2.5	5.0
Cholesterol lowering medication	1.1	1.6	4.1	-1.2	-0.4	-1.5	-0.8	-0.2	-1.3	-1.0	-1.6	-1.4	-2.0	0.7	1.4	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	3.7	-1.8	-0.7	-1.6	-1.5	-1.5	-1.5	-1.5	-1.6	-1.5	-1.6	1.9	1.8	-1.7
Pain experienced in last month	1.6	2.6	7.2	-0.8	-2.7	-1.8	-1.9	-1.0	-1.7	-1.3	-1.6	-1.7	-1.4	1.5	1.9	-1.1
Supplements: Calcium	0.3	0.4	1.4	0.8	1.2	0.3	0.3	0.5	-0.0	-0.0	-0.1	0.0	-0.3	-1.1	-1.0	-0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	0.0	-0.4	-0.2	0.7	0.7	-0.3	-0.5	-0.3	-0.2	0.0	0.6	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.5	-0.7	0.1	-0.2	-0.2	0.1	0.2	0.0	0.1	-0.4	-0.3	0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.8	-0.7	0.6	-0.1	0.0	0.2	-0.0	0.3	0.5	0.3	-0.7	-0.8	0.0
Heart disease (siblings)	0.3	0.4	1.4	-0.2	-0.2	-0.3	-0.0	-0.2	-0.7	-1.1	-0.3	-0.4	-0.4	1.2	0.4	-0.8
Alcohol drinker status: Previous	0.9	1.0	4.1	-0.0	2.0	1.0	1.0	0.7	0.9	0.8	1.2	1.1	1.0	0.7	-0.0	1.2
Pack years of smoking	0.2	0.3	1.0	0.1	-0.5	-0.4	-0.4	-1.0	-0.6	-0.8	-0.1	-0.4	-0.1	0.9	0.6	-0.6
Impedance of whole body	2.7	13.8	28.7	-0.5	5.4	3.6	4.5	3.9	4.0	3.6	4.1	3.9	4.0	-1.7	-1.2	4.4
Leg fat mass (left)	0.1	0.3	1.9	-0.4	-0.5	-0.2	-0.0	-0.2	0.3	0.6	0.1	0.1	-0.3	1.4	1.2	0.4
Arm predicted mass (left)	0.3	1.7	6.6	0.5	-2.6	-1.0	-1.5	-1.5	-1.1	-0.7	-1.2	-1.1	-1.2	1.6	0.6	-1.3