Best TWAS P=8.76e-12 · Best GWAS P=6.67e-11 conditioned to 0.476
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 6.3 | -6.4 | 1.7e-10 | -0.97 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -5.6 | -5.1 | 2.7e-07 | -0.52 | 0.13 | 0.80 | FALSE |
3 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -5.6 | -6.5 | 6.2e-11 | -0.81 | 0.03 | 0.96 | FALSE |
4 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -5.5 | -5.5 | 5.0e-08 | -0.52 | 0.55 | 0.26 | FALSE |
5 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 6.4 | 5.7 | 9.0e-09 | 0.95 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 6.3 | -6.8 | 1.4e-11 | -0.93 | 0.01 | 0.93 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -5.6 | -5.6 | 2.6e-08 | -0.56 | 0.02 | 0.16 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 6.3 | -6.8 | 8.8e-12 | -0.91 | 0.01 | 0.96 | TRUE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 6.5 | -6.7 | 2.5e-11 | -0.97 | 0.01 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf64 | 0.07 | 0.03 | enet | 14 | 0.03 | 3.3e-04 | -5.5 | 5.6 | 1.9e-08 | 0.59 | 0.02 | 0.60 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -5.5 | -5.6 | 2.3e-08 | -0.71 | 0.09 | 0.56 | FALSE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -5.6 | 6.4 | 1.7e-10 | 0.74 | 0.02 | 0.73 | FALSE |