Best TWAS P=5.25e-12 · Best GWAS P=4.23e-13 conditioned to 0.00428
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RHEBL1 | 0.03 | 0.01 | blup | 315 | 0.02 | 4.4e-03 | 7.10 | 5.5 | 3.6e-08 | 0.64 | 0.01 | 0.94 | FALSE |
2 | GTEx | Adipose Subcutaneous | LMBR1L | 0.12 | 0.09 | lasso | 6 | 0.08 | 1.9e-07 | 4.38 | -5.3 | 1.3e-07 | -0.54 | 0.75 | 0.23 | FALSE |
3 | GTEx | Artery Aorta | CCDC65 | 0.19 | 0.08 | enet | 7 | 0.11 | 1.9e-06 | 4.11 | 6.7 | 2.0e-11 | 0.82 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | CCDC65 | 0.14 | 0.08 | enet | 39 | 0.11 | 7.9e-09 | 7.25 | 6.9 | 5.2e-12 | 0.80 | 0.01 | 0.99 | TRUE |
5 | GTEx | Esophagus Mucosa | LMBR1L | 0.07 | 0.03 | lasso | 5 | 0.04 | 1.8e-03 | 5.58 | -6.3 | 2.5e-10 | -0.72 | 0.02 | 0.96 | FALSE |
6 | GTEx | Lung | LMBR1L | 0.05 | 0.02 | lasso | 2 | 0.00 | 1.5e-01 | 5.58 | -5.7 | 1.2e-08 | -0.61 | 0.12 | 0.33 | FALSE |
7 | GTEx | Lung | RP11-302B13.5 | 0.08 | 0.03 | lasso | 5 | 0.03 | 4.5e-03 | -5.05 | -5.3 | 1.2e-07 | -0.39 | 0.79 | 0.01 | FALSE |
8 | GTEx | Muscle Skeletal | RP11-386G11.5 | 0.09 | 0.07 | enet | 17 | 0.08 | 7.4e-08 | 6.06 | -5.7 | 1.2e-08 | -0.78 | 0.13 | 0.87 | FALSE |
9 | GTEx | Nerve Tibial | LMBR1L | 0.08 | 0.04 | lasso | 4 | 0.06 | 3.1e-05 | 6.15 | -6.0 | 2.2e-09 | -0.65 | 0.48 | 0.42 | FALSE |
10 | GTEx | Ovary | CCDC65 | 0.38 | 0.03 | lasso | 10 | 0.15 | 2.0e-04 | -0.89 | 5.4 | 7.1e-08 | 0.63 | 0.06 | 0.73 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | CCDC65 | 0.12 | 0.09 | enet | 10 | 0.08 | 2.6e-07 | -4.51 | 5.2 | 2.5e-07 | 0.57 | 0.89 | 0.11 | FALSE |
12 | GTEx | Testis | PRKAG1 | 0.17 | 0.11 | lasso | 5 | 0.09 | 1.2e-04 | 5.58 | -6.0 | 2.6e-09 | -0.69 | 0.11 | 0.86 | FALSE |