Best TWAS P=3.18e-12 · Best GWAS P=2.06e-11 conditioned to 0.0652
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ALDH2 | 0.05 | 0.11 | blup | 223 | 0.10 | 1.8e-12 | -5.0 | 5.5 | 4.4e-08 | -0.85 | 0.98 | 0.02 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | ATXN2 | 0.02 | 0.03 | enet | 8 | 0.02 | 4.8e-04 | -4.9 | 5.8 | 6.2e-09 | -0.83 | 0.08 | 0.89 | FALSE |
3 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | -5.1 | 5.6 | 2.3e-08 | -0.64 | 0.16 | 0.58 | FALSE |
4 | GTEx | Adipose Subcutaneous | MAPKAPK5-AS1 | 0.08 | 0.01 | enet | 26 | 0.03 | 2.1e-03 | -6.3 | -5.9 | 3.3e-09 | 0.92 | 0.24 | 0.76 | FALSE |
5 | GTEx | Adipose Subcutaneous | AC003029.1 | 0.08 | 0.07 | enet | 30 | 0.05 | 1.2e-04 | -5.1 | -5.9 | 3.2e-09 | 0.88 | 0.62 | 0.38 | FALSE |
6 | GTEx | Artery Aorta | AC003029.1 | 0.07 | 0.01 | lasso | 7 | 0.01 | 5.4e-02 | -6.6 | -6.1 | 9.2e-10 | 0.91 | 0.07 | 0.74 | FALSE |
7 | GTEx | Artery Tibial | ALDH2 | 0.08 | 0.09 | lasso | 2 | 0.07 | 2.7e-06 | -5.1 | 5.3 | 1.1e-07 | -0.79 | 0.86 | 0.11 | FALSE |
8 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | 6.2 | 6.5 | 1.0e-10 | -0.58 | 0.06 | 0.69 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | NAA25 | 0.11 | 0.02 | enet | 10 | 0.00 | 2.5e-01 | -3.4 | -5.7 | 1.3e-08 | 0.71 | 0.08 | 0.44 | FALSE |
10 | GTEx | Brain Cerebellum | NAA25 | 0.12 | -0.01 | lasso | 12 | 0.00 | 3.0e-01 | -3.2 | -5.5 | 2.9e-08 | 0.73 | 0.10 | 0.27 | FALSE |
11 | GTEx | Colon Transverse | MAPKAPK5-AS1 | 0.16 | 0.09 | lasso | 13 | 0.06 | 7.1e-04 | -5.0 | -5.2 | 2.4e-07 | 0.80 | 0.80 | 0.03 | FALSE |
12 | GTEx | Colon Transverse | AC003029.1 | 0.15 | 0.09 | lasso | 12 | 0.07 | 2.1e-04 | -5.1 | -5.2 | 2.5e-07 | 0.80 | 0.80 | 0.03 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | AC003029.1 | 0.06 | 0.03 | lasso | 3 | 0.04 | 1.9e-02 | -5.0 | -5.2 | 1.6e-07 | 0.80 | 0.06 | 0.62 | FALSE |
14 | GTEx | Esophagus Mucosa | ALDH2 | 0.05 | 0.06 | lasso | 6 | 0.07 | 1.7e-05 | -5.1 | 5.4 | 5.3e-08 | -0.83 | 0.45 | 0.53 | FALSE |
15 | GTEx | Esophagus Muscularis | HECTD4 | 0.06 | 0.03 | lasso | 4 | 0.02 | 1.8e-02 | -5.1 | 5.8 | 7.2e-09 | -0.82 | 0.12 | 0.80 | FALSE |
16 | GTEx | Lung | ALDH2 | 0.07 | 0.01 | lasso | 10 | 0.02 | 5.9e-03 | -5.5 | 5.1 | 3.0e-07 | -0.81 | 0.25 | 0.36 | FALSE |
17 | GTEx | Nerve Tibial | HECTD4 | 0.05 | 0.01 | enet | 6 | 0.01 | 3.6e-02 | -6.3 | 6.3 | 2.2e-10 | -0.68 | 0.03 | 0.92 | FALSE |
18 | GTEx | Nerve Tibial | AC003029.1 | 0.04 | 0.00 | lasso | 23 | 0.00 | 4.2e-01 | -3.5 | -5.1 | 2.8e-07 | 0.81 | 0.12 | 0.34 | FALSE |
19 | GTEx | Pituitary | RP3-462E2.5 | 0.15 | 0.12 | lasso | 3 | 0.14 | 2.3e-04 | -5.1 | 5.9 | 3.4e-09 | -0.91 | 0.13 | 0.45 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | ALDH2 | 0.13 | 0.18 | lasso | 9 | 0.16 | 5.0e-09 | -5.0 | 5.4 | 6.5e-08 | -0.83 | 0.85 | 0.15 | FALSE |
21 | GTEx | Skin Not Sun Exposed Suprapubic | MAPKAPK5-AS1 | 0.04 | 0.00 | enet | 30 | 0.00 | 7.0e-01 | -5.1 | -5.4 | 5.5e-08 | 0.81 | 0.17 | 0.30 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | -5.0 | 6.6 | 4.3e-11 | -0.82 | 0.55 | 0.45 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | AC003029.1 | 0.09 | 0.10 | lasso | 2 | 0.10 | 8.8e-09 | -5.2 | -5.2 | 1.9e-07 | 0.81 | 0.99 | 0.01 | FALSE |
24 | GTEx | Stomach | TMEM116 | 0.13 | 0.03 | lasso | 7 | 0.03 | 1.6e-02 | -3.2 | -5.5 | 4.9e-08 | 0.77 | 0.05 | 0.33 | FALSE |
25 | GTEx | Testis | BRAP | 0.06 | 0.03 | enet | 13 | 0.01 | 8.7e-02 | -5.1 | -5.5 | 4.3e-08 | 0.82 | 0.25 | 0.47 | FALSE |
26 | GTEx | Thyroid | BRAP | 0.07 | 0.02 | lasso | 7 | 0.03 | 1.1e-03 | -6.3 | -6.5 | 8.9e-11 | 0.86 | 0.19 | 0.70 | FALSE |
27 | GTEx | Thyroid | ALDH2 | 0.06 | 0.04 | lasso | 4 | 0.05 | 9.7e-05 | -6.6 | 5.7 | 1.4e-08 | -0.93 | 0.09 | 0.90 | FALSE |
28 | GTEx | Thyroid | AC003029.1 | 0.04 | 0.05 | lasso | 3 | 0.04 | 8.3e-04 | -5.0 | -5.2 | 2.5e-07 | 0.80 | 0.44 | 0.48 | FALSE |
29 | YFS | Blood | SH2B3 | 0.05 | 0.01 | enet | 22 | 0.02 | 3.3e-07 | -6.3 | 7.0 | 3.2e-12 | -0.80 | 0.04 | 0.96 | TRUE |
30 | The Cancer Genome Atlas | Colon Adenocarcinoma | ALDH2 | 0.07 | 0.03 | lasso | 4 | 0.06 | 3.9e-04 | -3.5 | 5.4 | 6.4e-08 | -0.69 | 0.04 | 0.72 | FALSE |
31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ACAD10 | 0.02 | 0.02 | lasso | 3 | 0.01 | 7.0e-03 | -5.5 | -5.6 | 2.2e-08 | 0.65 | 0.02 | 0.75 | FALSE |
32 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP29 | 0.11 | 0.03 | blup | 25 | 0.05 | 5.0e-03 | -5.3 | -6.1 | 8.1e-10 | 0.79 | 0.02 | 0.56 | FALSE |