Best TWAS P=2e-10 · Best GWAS P=5.86e-12 conditioned to 0.0084
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | CLCN6 | 0.08 | 0.02 | enet | 17 | 0.05 | 1.6e-04 | -6.7 | -5.9 | 3.5e-09 | 0.76 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | CLCN6 | 0.12 | 0.03 | lasso | 3 | 0.04 | 3.3e-03 | -3.0 | -5.5 | 2.9e-08 | 0.83 | 0.01 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CLCN6 | 0.06 | 0.06 | blup | 104 | 0.06 | 5.0e-12 | -4.2 | -5.5 | 3.6e-08 | 0.76 | 0.24 | 0.76 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | CLCN6 | 0.14 | 0.05 | blup | 104 | 0.09 | 1.2e-05 | -6.7 | -5.4 | 7.0e-08 | 0.81 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CLCN6 | 0.06 | 0.04 | blup | 104 | 0.04 | 5.2e-06 | -6.7 | -6.4 | 2.0e-10 | 0.91 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CLCN6 | 0.10 | 0.07 | blup | 104 | 0.07 | 3.9e-08 | -5.6 | -5.6 | 1.7e-08 | 0.59 | 0.19 | 0.80 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CLCN6 | 0.07 | 0.04 | blup | 104 | 0.05 | 2.4e-04 | -6.7 | -6.0 | 1.5e-09 | 0.93 | 0.01 | 0.98 | FALSE |