Hub : Traits :

High blood pressure (siblings)

52 significantly associated models · 11 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	11181327	12600396	1	1	2.0e-10	5.9e-12	0.0084	85	CLCN6
2	10	63870456	65606229	2	1	1.6e-09	6.5e-07	0.9060	100	NRBF2
3	15	90730363	92135418	1	1	7.2e-10	3.0e-09	0.2950	97	FES
4	16	30347731	31833122	7	1	3.5e-08	4.7e-08	0.1830	94	KAT8

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	4.52	1	0	0.0	0.00	1.00000	FES
Bipolar Disorder or Schizophrenia	7.88	2	1	2.2	0.00	1.00000	CLCN6 FES
Neuroticism (Nagel 2018)	3.35	2	0	0.0	0.00	1.00000	FES KAT8
Schizophrenia (2018)	7.52	1	1	2.2	0.00	1.00000	FES
Worry (Nagel 2018)	3.89	1	0	0.0	0.00	1.00000	KAT8
Alzheimer’s Disease (in mother)	3.04	1	0	0.0	0.00	1.00000	KAT8
Alzheimer’s Disease (including proxy)	4.46	1	0	0.0	0.00	1.00000	KAT8
Breast Cancer	3.45	1	0	0.0	0.00	1.00000	FES
HDL Cholesterol	3.50	1	0	0.0	0.00	1.00000	NRBF2
Schizophrenia (2014)	7.01	1	1	2.2	0.00	1.00000	FES
Triglycerides	7.48	2	0	0.0	0.00	1.00000	KAT8 NRBF2
Blood Eosinophil Count	1.41	2	0	0.0	0.00	1.00000	CLCN6 KAT8
Blood Platelet Count	13.14	2	1	2.2	0.00	1.00000	CLCN6 NRBF2
Blood Red Count	2.83	3	2	4.4	0.00	1.00000	CLCN6 FES KAT8
Blood White Count	3.69	2	2	4.4	0.00	1.00000	FES NRBF2
Heel T-Score	1.40	2	1	2.2	0.00	1.00000	KAT8 NRBF2
BMI	6.29	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Height	0.44	1	1	2.2	0.00	1.00000	FES
Systolic Blood Pressure	39.71	3	3	6.7	0.00	1.00000	CLCN6 FES NRBF2
Smoking Status	4.51	2	0	0.0	0.00	1.00000	FES KAT8
Allergy or Eczema	5.01	3	0	0.0	0.00	1.00000	CLCN6 FES NRBF2
Cardiovascular Disease	30.98	4	4	8.9	1.00	0.00027	CLCN6 FES KAT8 NRBF2
Respiratory disease	2.57	1	0	0.0	0.00	1.00000	FES
Lung FEV1/FVC ratio	4.53	1	1	2.2	0.00	1.00000	NRBF2
Lung FVC	3.58	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Neuroticism	2.48	1	0	0.0	0.00	1.00000	KAT8
Hair Pigment	0.45	1	1	2.2	0.00	1.00000	FES
Tanning	1.30	1	1	2.2	0.00	1.00000	NRBF2
Hand grip strength (left)	3.24	2	0	0.0	0.00	1.00000	FES KAT8
Number of treatments/medications taken	4.69	1	0	0.0	0.00	1.00000	FES
Sensitivity / hurt feelings	4.72	1	1	2.2	0.00	1.00000	FES
Systolic blood pressure, automated reading	34.46	4	3	6.7	0.99	0.00752	CLCN6 FES KAT8 NRBF2
Angina	8.93	1	1	2.2	0.00	1.00000	FES
Impedance of leg (right)	3.41	2	2	4.4	0.00	1.00000	FES KAT8
Leg fat-free mass (left)	3.91	2	1	2.2	0.00	1.00000	FES KAT8
Trunk fat percentage	5.05	2	1	2.2	0.00	1.00000	CLCN6 KAT8
Townsend deprivation index at recruitment	2.72	1	0	0.0	0.00	1.00000	KAT8
High blood pressure	32.60	4	4	8.9	0.99	0.00589	CLCN6 FES KAT8 NRBF2
Hayfever, allergic rhinitis or eczema	4.48	1	0	0.0	0.00	1.00000	FES
Multivitamins +/- minerals	3.71	1	0	0.0	0.00	1.00000	NRBF2
Supplements: Glucosamine	6.12	1	1	2.2	0.00	1.00000	NRBF2
Medication: Atenolol	12.59	2	1	2.2	0.00	1.00000	CLCN6 FES
Sitting height	0.48	1	0	0.0	0.00	1.00000	FES
High blood pressure (mother)	23.62	3	1	2.2	0.00	1.00000	CLCN6 FES NRBF2
Body mass index (BMI)	7.87	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Impedance of leg (left)	3.37	2	2	4.4	0.00	1.00000	FES KAT8
Leg predicted mass (left)	3.90	2	1	2.2	0.00	1.00000	FES KAT8
Trunk fat mass	5.64	2	1	2.2	0.00	1.00000	CLCN6 KAT8
Waist circumference	8.32	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Number of incorrect matches in round	8.67	2	1	2.2	0.00	1.00000	FES KAT8
Past tobacco smoking	3.04	1	0	0.0	0.00	1.00000	KAT8
Alcohol usually taken with meals	4.11	1	0	0.0	0.00	1.00000	FES
Nervous feelings	3.10	1	0	0.0	0.00	1.00000	KAT8
Had other major operations	6.17	1	0	0.0	0.00	1.00000	NRBF2
Forced vital capacity (FVC)	2.39	1	1	2.2	0.00	1.00000	KAT8
Financial difficulties in last 2 years	3.22	1	0	0.0	0.00	1.00000	KAT8
Heart attack	6.32	1	1	2.2	0.00	1.00000	FES
Allergy	4.36	1	0	0.0	0.00	1.00000	FES
Medication: Ramipril	7.48	1	0	0.0	0.00	1.00000	FES
Medication: Simvastatin	9.50	3	1	2.2	0.00	1.00000	CLCN6 FES KAT8
Illnesses of siblings	16.93	4	2	4.4	-0.99	0.00565	CLCN6 FES KAT8 NRBF2
Weight	6.39	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Impedance of arm (right)	3.21	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Arm fat percentage (right)	6.26	2	1	2.2	0.00	1.00000	CLCN6 KAT8
Trunk fat-free mass	2.57	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Hip circumference	9.72	3	2	4.4	0.00	1.00000	CLCN6 KAT8 NRBF2
Father's age at death	7.78	1	1	2.2	0.00	1.00000	FES
Worrier / anxious feelings	2.26	1	0	0.0	0.00	1.00000	KAT8
Number of live births	3.76	1	0	0.0	0.00	1.00000	FES
Forced expiratory volume in 1-second (FEV1)	3.78	2	0	0.0	0.00	1.00000	KAT8 NRBF2
Asthma	2.38	1	0	0.0	0.00	1.00000	FES
Medication: Cholesterol lowering	11.13	3	1	2.2	0.00	1.00000	CLCN6 FES KAT8
Illnesses of mother	10.80	1	1	2.2	0.00	1.00000	FES
Forced expiratory volume in 1-second (FEV1), Best measure	5.04	2	2	4.4	0.00	1.00000	KAT8 NRBF2
Pulse wave Arterial Stiffness index	7.05	1	0	0.0	0.00	1.00000	FES
Impedance of arm (left)	3.11	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Arm fat mass (right)	7.21	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Trunk predicted mass	2.53	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Breastfed as a baby	3.97	1	0	0.0	0.00	1.00000	FES
Tense / 'highly strung'	3.63	1	0	0.0	0.00	1.00000	KAT8
Hair/balding pattern: Pattern 4	1.58	1	0	0.0	0.00	1.00000	FES
Birth weight of first child	14.32	2	2	4.4	0.00	1.00000	CLCN6 FES
Headache pain in last month	3.87	1	0	0.0	0.00	1.00000	FES
Medication for cholesterol, blood pressure or diabetes	20.50	2	2	4.4	0.00	1.00000	CLCN6 FES
Gout (self-reported)	3.64	1	0	0.0	0.00	1.00000	NRBF2
Medication: Amlodipine	13.70	2	2	4.4	0.00	1.00000	CLCN6 FES
Birth weight	7.31	2	1	2.2	0.00	1.00000	CLCN6 FES
Forced vital capacity (FVC), Best measure	2.99	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Body fat percentage	5.89	2	1	2.2	0.00	1.00000	CLCN6 KAT8
Leg fat percentage (right)	6.56	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Arm fat-free mass (right)	3.81	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Comparative body size at age 10	3.35	1	0	0.0	0.00	1.00000	KAT8
Number of full brothers	2.96	1	0	0.0	0.00	1.00000	KAT8
Pulse wave peak to peak time	7.07	1	0	0.0	0.00	1.00000	FES
Qualifications: College or University degree	1.27	1	0	0.0	0.00	1.00000	KAT8
Medication: Blood pressure	22.31	2	2	4.4	0.00	1.00000	CLCN6 FES
Angina (self-reported)	9.20	1	1	2.2	0.00	1.00000	FES
Mean time to correctly identify matches	2.20	1	0	0.0	0.00	1.00000	FES
Heart disease (mother)	2.83	1	0	0.0	0.00	1.00000	FES
Whole body fat mass	6.36	2	1	2.2	0.00	1.00000	CLCN6 KAT8
Leg fat mass (right)	7.36	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Arm predicted mass (right)	3.95	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Alcohol intake frequency.	2.74	1	0	0.0	0.00	1.00000	KAT8
Comparative height size at age 10	1.11	1	0	0.0	0.00	1.00000	FES
Number of full sisters	5.47	1	0	0.0	0.00	1.00000	NRBF2
Overall health rating	5.02	1	1	2.2	0.00	1.00000	KAT8
Medication: Aspirin	9.51	1	1	2.2	0.00	1.00000	FES
Knee pain experienced in last month	3.13	1	0	0.0	0.00	1.00000	KAT8
Hypertension (Self-reported)	32.64	4	4	8.9	0.99	0.00574	CLCN6 FES KAT8 NRBF2
Illnesses of father: Heart disease	11.76	1	1	2.2	0.00	1.00000	FES
Whole body fat-free mass	3.19	2	1	2.2	0.00	1.00000	FES KAT8
Leg fat-free mass (right)	3.58	2	1	2.2	0.00	1.00000	FES KAT8
Arm fat percentage (left)	6.03	1	1	2.2	0.00	1.00000	KAT8
Handedness (chirality/laterality): Left-handed	3.28	1	0	0.0	0.00	1.00000	FES
Medication for cholesterol	11.24	4	0	0.0	-0.99	0.00670	CLCN6 FES KAT8 NRBF2
Mineral and other dietary supplements	5.83	2	0	0.0	0.00	1.00000	FES NRBF2
Asthma (self-reported)	2.31	1	0	0.0	0.00	1.00000	FES
Medication: Aspirin	9.97	1	1	2.2	0.00	1.00000	FES
Illnesses of father: None of the above (group 1)	12.26	1	1	2.2	0.00	1.00000	FES
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.03	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Whole body water mass	3.21	2	1	2.2	0.00	1.00000	FES KAT8
Leg predicted mass (right)	3.63	2	1	2.2	0.00	1.00000	FES KAT8
Arm fat mass (left)	7.15	1	1	2.2	0.00	1.00000	KAT8
Number of self-reported non-cancer illnesses	6.91	1	1	2.2	0.00	1.00000	CLCN6
Medication: Blood pressure	22.22	4	2	4.4	0.99	0.01474	CLCN6 FES KAT8 NRBF2
High cholesterol (Self-reported)	7.64	3	0	0.0	0.00	1.00000	CLCN6 FES KAT8
Medication: Bendroflumethiazide	12.67	4	1	2.2	0.99	0.00503	CLCN6 FES KAT8 NRBF2
Medication: Lisinopril	8.99	2	0	0.0	0.00	1.00000	FES NRBF2
Illnesses of father: High blood pressure	18.14	2	1	2.2	0.00	1.00000	CLCN6 FES
Ever smoked	3.52	1	0	0.0	0.00	1.00000	FES
Basal metabolic rate	4.03	3	1	2.2	0.00	1.00000	FES KAT8 NRBF2
Leg fat percentage (left)	6.64	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Arm fat-free mass (left)	4.30	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Risk taking	2.96	1	0	0.0	0.00	1.00000	FES
Fractured/broken bones in last 5 years	4.05	1	0	0.0	0.00	1.00000	KAT8
Age started oral contraceptive pill	2.60	1	0	0.0	0.00	1.00000	FES
Diastolic blood pressure, automated reading	31.55	4	4	8.9	0.99	0.00714	CLCN6 FES KAT8 NRBF2
Vascular/heart problems diagnosed by doctor	34.59	4	4	8.9	-0.99	0.00997	CLCN6 FES KAT8 NRBF2
Cholesterol lowering medication	5.93	1	0	0.0	0.00	1.00000	KAT8
Pain experienced in last month	3.09	1	0	0.0	0.00	1.00000	KAT8
Heart attack/myocardial infarction (self-reported)	6.23	1	1	2.2	0.00	1.00000	FES
Heart disease (siblings)	7.30	1	0	0.0	0.00	1.00000	FES
Impedance of whole body	3.19	2	1	2.2	0.00	1.00000	KAT8 NRBF2
Leg fat mass (left)	7.24	3	1	2.2	0.00	1.00000	CLCN6 KAT8 NRBF2
Arm predicted mass (left)	4.44	2	1	2.2	0.00	1.00000	KAT8 NRBF2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.5
GTEx	Adipose Visceral Omentum	2	0.098	1.4
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	1	0.034	1.5
GTEx	Artery Coronary	1	0.085	1.6
GTEx	Artery Tibial	1	0.027	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.5
GTEx	Brain Cerebellum	1	0.050	1.5
GTEx	Brain Cortex	1	0.097	1.7
GTEx	Brain Frontal Cortex BA9	1	0.108	1.6
GTEx	Brain Hippocampus	0	0.000	1.7
GTEx	Brain Hypothalamus	0	0.000	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.6
GTEx	Brain Putamen basal ganglia	0	0.000	1.6
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	2	0.048	1.5
GTEx	Colon Sigmoid	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Atrial Appendage	1	0.063	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Liver	1	0.139	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Muscle Skeletal	0	0.000	1.5
GTEx	Nerve Tibial	0	0.000	1.5
GTEx	Ovary	1	0.110	1.6
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.5
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.4
GTEx	Stomach	0	0.000	1.6
GTEx	Testis	0	0.000	1.5
GTEx	Thyroid	1	0.025	1.5
GTEx	Uterus	0	0.000	1.6
GTEx	Vagina	0	0.000	1.5
GTEx	Whole Blood	2	0.100	1.5
METSIM	Adipose	1	0.022	1.4
NTR	Blood	1	0.042	1.4
ROSMAP	Brain Pre-frontal Cortex	3	0.068	1.5
YFS	Blood	2	0.043	1.4
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3