Hub : Traits :

High blood pressure (siblings)

52 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 11181327 12600396 1 1 2.0e-10 5.9e-12 0.0084 85 CLCN6
2 10 63870456 65606229 2 1 1.6e-09 6.5e-07 0.9060 100 NRBF2
3 15 90730363 92135418 1 1 7.2e-10 3.0e-09 0.2950 97 FES
4 16 30347731 31833122 7 1 3.5e-08 4.7e-08 0.1830 94 KAT8

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 4.52 1 0 0.0 0.00 1.00000 FES
Bipolar Disorder or Schizophrenia 7.88 2 1 2.2 0.00 1.00000 CLCN6 FES
Neuroticism (Nagel 2018) 3.35 2 0 0.0 0.00 1.00000 FES KAT8
Schizophrenia (2018) 7.52 1 1 2.2 0.00 1.00000 FES
Worry (Nagel 2018) 3.89 1 0 0.0 0.00 1.00000 KAT8
Alzheimer’s Disease (in mother) 3.04 1 0 0.0 0.00 1.00000 KAT8
Alzheimer’s Disease (including proxy) 4.46 1 0 0.0 0.00 1.00000 KAT8
Breast Cancer 3.45 1 0 0.0 0.00 1.00000 FES
HDL Cholesterol 3.50 1 0 0.0 0.00 1.00000 NRBF2
Schizophrenia (2014) 7.01 1 1 2.2 0.00 1.00000 FES
Triglycerides 7.48 2 0 0.0 0.00 1.00000 KAT8 NRBF2
Blood Eosinophil Count 1.41 2 0 0.0 0.00 1.00000 CLCN6 KAT8
Blood Platelet Count 13.14 2 1 2.2 0.00 1.00000 CLCN6 NRBF2
Blood Red Count 2.83 3 2 4.4 0.00 1.00000 CLCN6 FES KAT8
Blood White Count 3.69 2 2 4.4 0.00 1.00000 FES NRBF2
Heel T-Score 1.40 2 1 2.2 0.00 1.00000 KAT8 NRBF2
BMI 6.29 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Height 0.44 1 1 2.2 0.00 1.00000 FES
Systolic Blood Pressure 39.71 3 3 6.7 0.00 1.00000 CLCN6 FES NRBF2
Smoking Status 4.51 2 0 0.0 0.00 1.00000 FES KAT8
Allergy or Eczema 5.01 3 0 0.0 0.00 1.00000 CLCN6 FES NRBF2
Cardiovascular Disease 30.98 4 4 8.9 1.00 0.00027 CLCN6 FES KAT8 NRBF2
Respiratory disease 2.57 1 0 0.0 0.00 1.00000 FES
Lung FEV1/FVC ratio 4.53 1 1 2.2 0.00 1.00000 NRBF2
Lung FVC 3.58 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Neuroticism 2.48 1 0 0.0 0.00 1.00000 KAT8
Hair Pigment 0.45 1 1 2.2 0.00 1.00000 FES
Tanning 1.30 1 1 2.2 0.00 1.00000 NRBF2
Hand grip strength (left) 3.24 2 0 0.0 0.00 1.00000 FES KAT8
Number of treatments/medications taken 4.69 1 0 0.0 0.00 1.00000 FES
Sensitivity / hurt feelings 4.72 1 1 2.2 0.00 1.00000 FES
Systolic blood pressure, automated reading 34.46 4 3 6.7 0.99 0.00752 CLCN6 FES KAT8 NRBF2
Angina 8.93 1 1 2.2 0.00 1.00000 FES
Impedance of leg (right) 3.41 2 2 4.4 0.00 1.00000 FES KAT8
Leg fat-free mass (left) 3.91 2 1 2.2 0.00 1.00000 FES KAT8
Trunk fat percentage 5.05 2 1 2.2 0.00 1.00000 CLCN6 KAT8
Townsend deprivation index at recruitment 2.72 1 0 0.0 0.00 1.00000 KAT8
High blood pressure 32.60 4 4 8.9 0.99 0.00589 CLCN6 FES KAT8 NRBF2
Hayfever, allergic rhinitis or eczema 4.48 1 0 0.0 0.00 1.00000 FES
Multivitamins +/- minerals 3.71 1 0 0.0 0.00 1.00000 NRBF2
Supplements: Glucosamine 6.12 1 1 2.2 0.00 1.00000 NRBF2
Medication: Atenolol 12.59 2 1 2.2 0.00 1.00000 CLCN6 FES
Sitting height 0.48 1 0 0.0 0.00 1.00000 FES
High blood pressure (mother) 23.62 3 1 2.2 0.00 1.00000 CLCN6 FES NRBF2
Body mass index (BMI) 7.87 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Impedance of leg (left) 3.37 2 2 4.4 0.00 1.00000 FES KAT8
Leg predicted mass (left) 3.90 2 1 2.2 0.00 1.00000 FES KAT8
Trunk fat mass 5.64 2 1 2.2 0.00 1.00000 CLCN6 KAT8
Waist circumference 8.32 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Number of incorrect matches in round 8.67 2 1 2.2 0.00 1.00000 FES KAT8
Past tobacco smoking 3.04 1 0 0.0 0.00 1.00000 KAT8
Alcohol usually taken with meals 4.11 1 0 0.0 0.00 1.00000 FES
Nervous feelings 3.10 1 0 0.0 0.00 1.00000 KAT8
Had other major operations 6.17 1 0 0.0 0.00 1.00000 NRBF2
Forced vital capacity (FVC) 2.39 1 1 2.2 0.00 1.00000 KAT8
Financial difficulties in last 2 years 3.22 1 0 0.0 0.00 1.00000 KAT8
Heart attack 6.32 1 1 2.2 0.00 1.00000 FES
Allergy 4.36 1 0 0.0 0.00 1.00000 FES
Medication: Ramipril 7.48 1 0 0.0 0.00 1.00000 FES
Medication: Simvastatin 9.50 3 1 2.2 0.00 1.00000 CLCN6 FES KAT8
Illnesses of siblings 16.93 4 2 4.4 -0.99 0.00565 CLCN6 FES KAT8 NRBF2
Weight 6.39 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Impedance of arm (right) 3.21 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Arm fat percentage (right) 6.26 2 1 2.2 0.00 1.00000 CLCN6 KAT8
Trunk fat-free mass 2.57 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Hip circumference 9.72 3 2 4.4 0.00 1.00000 CLCN6 KAT8 NRBF2
Father's age at death 7.78 1 1 2.2 0.00 1.00000 FES
Worrier / anxious feelings 2.26 1 0 0.0 0.00 1.00000 KAT8
Number of live births 3.76 1 0 0.0 0.00 1.00000 FES
Forced expiratory volume in 1-second (FEV1) 3.78 2 0 0.0 0.00 1.00000 KAT8 NRBF2
Asthma 2.38 1 0 0.0 0.00 1.00000 FES
Medication: Cholesterol lowering 11.13 3 1 2.2 0.00 1.00000 CLCN6 FES KAT8
Illnesses of mother 10.80 1 1 2.2 0.00 1.00000 FES
Forced expiratory volume in 1-second (FEV1), Best measure 5.04 2 2 4.4 0.00 1.00000 KAT8 NRBF2
Pulse wave Arterial Stiffness index 7.05 1 0 0.0 0.00 1.00000 FES
Impedance of arm (left) 3.11 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Arm fat mass (right) 7.21 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Trunk predicted mass 2.53 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Breastfed as a baby 3.97 1 0 0.0 0.00 1.00000 FES
Tense / 'highly strung' 3.63 1 0 0.0 0.00 1.00000 KAT8
Hair/balding pattern: Pattern 4 1.58 1 0 0.0 0.00 1.00000 FES
Birth weight of first child 14.32 2 2 4.4 0.00 1.00000 CLCN6 FES
Headache pain in last month 3.87 1 0 0.0 0.00 1.00000 FES
Medication for cholesterol, blood pressure or diabetes 20.50 2 2 4.4 0.00 1.00000 CLCN6 FES
Gout (self-reported) 3.64 1 0 0.0 0.00 1.00000 NRBF2
Medication: Amlodipine 13.70 2 2 4.4 0.00 1.00000 CLCN6 FES
Birth weight 7.31 2 1 2.2 0.00 1.00000 CLCN6 FES
Forced vital capacity (FVC), Best measure 2.99 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Body fat percentage 5.89 2 1 2.2 0.00 1.00000 CLCN6 KAT8
Leg fat percentage (right) 6.56 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Arm fat-free mass (right) 3.81 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Comparative body size at age 10 3.35 1 0 0.0 0.00 1.00000 KAT8
Number of full brothers 2.96 1 0 0.0 0.00 1.00000 KAT8
Pulse wave peak to peak time 7.07 1 0 0.0 0.00 1.00000 FES
Qualifications: College or University degree 1.27 1 0 0.0 0.00 1.00000 KAT8
Medication: Blood pressure 22.31 2 2 4.4 0.00 1.00000 CLCN6 FES
Angina (self-reported) 9.20 1 1 2.2 0.00 1.00000 FES
Mean time to correctly identify matches 2.20 1 0 0.0 0.00 1.00000 FES
Heart disease (mother) 2.83 1 0 0.0 0.00 1.00000 FES
Whole body fat mass 6.36 2 1 2.2 0.00 1.00000 CLCN6 KAT8
Leg fat mass (right) 7.36 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Arm predicted mass (right) 3.95 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Alcohol intake frequency. 2.74 1 0 0.0 0.00 1.00000 KAT8
Comparative height size at age 10 1.11 1 0 0.0 0.00 1.00000 FES
Number of full sisters 5.47 1 0 0.0 0.00 1.00000 NRBF2
Overall health rating 5.02 1 1 2.2 0.00 1.00000 KAT8
Medication: Aspirin 9.51 1 1 2.2 0.00 1.00000 FES
Knee pain experienced in last month 3.13 1 0 0.0 0.00 1.00000 KAT8
Hypertension (Self-reported) 32.64 4 4 8.9 0.99 0.00574 CLCN6 FES KAT8 NRBF2
Illnesses of father: Heart disease 11.76 1 1 2.2 0.00 1.00000 FES
Whole body fat-free mass 3.19 2 1 2.2 0.00 1.00000 FES KAT8
Leg fat-free mass (right) 3.58 2 1 2.2 0.00 1.00000 FES KAT8
Arm fat percentage (left) 6.03 1 1 2.2 0.00 1.00000 KAT8
Handedness (chirality/laterality): Left-handed 3.28 1 0 0.0 0.00 1.00000 FES
Medication for cholesterol 11.24 4 0 0.0 -0.99 0.00670 CLCN6 FES KAT8 NRBF2
Mineral and other dietary supplements 5.83 2 0 0.0 0.00 1.00000 FES NRBF2
Asthma (self-reported) 2.31 1 0 0.0 0.00 1.00000 FES
Medication: Aspirin 9.97 1 1 2.2 0.00 1.00000 FES
Illnesses of father: None of the above (group 1) 12.26 1 1 2.2 0.00 1.00000 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.03 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Whole body water mass 3.21 2 1 2.2 0.00 1.00000 FES KAT8
Leg predicted mass (right) 3.63 2 1 2.2 0.00 1.00000 FES KAT8
Arm fat mass (left) 7.15 1 1 2.2 0.00 1.00000 KAT8
Number of self-reported non-cancer illnesses 6.91 1 1 2.2 0.00 1.00000 CLCN6
Medication: Blood pressure 22.22 4 2 4.4 0.99 0.01474 CLCN6 FES KAT8 NRBF2
High cholesterol (Self-reported) 7.64 3 0 0.0 0.00 1.00000 CLCN6 FES KAT8
Medication: Bendroflumethiazide 12.67 4 1 2.2 0.99 0.00503 CLCN6 FES KAT8 NRBF2
Medication: Lisinopril 8.99 2 0 0.0 0.00 1.00000 FES NRBF2
Illnesses of father: High blood pressure 18.14 2 1 2.2 0.00 1.00000 CLCN6 FES
Ever smoked 3.52 1 0 0.0 0.00 1.00000 FES
Basal metabolic rate 4.03 3 1 2.2 0.00 1.00000 FES KAT8 NRBF2
Leg fat percentage (left) 6.64 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Arm fat-free mass (left) 4.30 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Risk taking 2.96 1 0 0.0 0.00 1.00000 FES
Fractured/broken bones in last 5 years 4.05 1 0 0.0 0.00 1.00000 KAT8
Age started oral contraceptive pill 2.60 1 0 0.0 0.00 1.00000 FES
Diastolic blood pressure, automated reading 31.55 4 4 8.9 0.99 0.00714 CLCN6 FES KAT8 NRBF2
Vascular/heart problems diagnosed by doctor 34.59 4 4 8.9 -0.99 0.00997 CLCN6 FES KAT8 NRBF2
Cholesterol lowering medication 5.93 1 0 0.0 0.00 1.00000 KAT8
Pain experienced in last month 3.09 1 0 0.0 0.00 1.00000 KAT8
Heart attack/myocardial infarction (self-reported) 6.23 1 1 2.2 0.00 1.00000 FES
Heart disease (siblings) 7.30 1 0 0.0 0.00 1.00000 FES
Impedance of whole body 3.19 2 1 2.2 0.00 1.00000 KAT8 NRBF2
Leg fat mass (left) 7.24 3 1 2.2 0.00 1.00000 CLCN6 KAT8 NRBF2
Arm predicted mass (left) 4.44 2 1 2.2 0.00 1.00000 KAT8 NRBF2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.5
GTEx Adipose Visceral Omentum 2 0.098 1.4
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 1 0.034 1.5
GTEx Artery Coronary 1 0.085 1.6
GTEx Artery Tibial 1 0.027 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.6
GTEx Brain Cerebellar Hemisphere 1 0.067 1.5
GTEx Brain Cerebellum 1 0.050 1.5
GTEx Brain Cortex 1 0.097 1.7
GTEx Brain Frontal Cortex BA9 1 0.108 1.6
GTEx Brain Hippocampus 0 0.000 1.7
GTEx Brain Hypothalamus 0 0.000 1.6
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.6
GTEx Brain Putamen basal ganglia 0 0.000 1.6
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.5
GTEx Breast Mammary Tissue (Female) 0 0.000 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 2 0.048 1.5
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.5
GTEx Esophagus Mucosa 0 0.000 1.5
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 1 0.063 1.5
GTEx Heart Left Ventricle 0 0.000 1.5
GTEx Liver 1 0.139 1.5
GTEx Lung 1 0.035 1.5
GTEx Muscle Skeletal 0 0.000 1.5
GTEx Nerve Tibial 0 0.000 1.5
GTEx Ovary 1 0.110 1.6
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.5
GTEx Skin Sun Exposed Lower leg 2 0.055 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.6
GTEx Testis 0 0.000 1.5
GTEx Thyroid 1 0.025 1.5
GTEx Uterus 0 0.000 1.6
GTEx Vagina 0 0.000 1.5
GTEx Whole Blood 2 0.100 1.5
METSIM Adipose 1 0.022 1.4
NTR Blood 1 0.042 1.4
ROSMAP Brain Pre-frontal Cortex 3 0.068 1.5
YFS Blood 2 0.043 1.4
CommonMind Brain Pre-frontal Cortex 1 0.019 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.049 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 3 0.102 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.126 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.4
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3