Best TWAS P=4.47e-08 · Best GWAS P=7.46e-10 conditioned to 0.00462
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 6.0 | 5.5 | 4.5e-08 | 0.91 | 0.01 | 0.94 | TRUE |
| 2 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -2.3 | 5.3 | 1.3e-07 | 0.64 | 0.04 | 0.79 | FALSE |
| 3 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 5.5 | 5.3 | 9.5e-08 | 0.95 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PTCH1 | 0.04 | 0.00 | blup | 56 | 0.02 | 1.6e-03 | 5.5 | 5.2 | 2.0e-07 | 0.72 | 0.02 | 0.38 | FALSE |