Hub : Traits :

Neuroticism score

887 significantly associated models · 143 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	20373107	22200998	2	1	2.6e-08	2.5e-08	1.2e-01	92	EIF4G3
2	1	171053153	172474017	1	1	2.9e-10	3.7e-09	3.7e-03	76	METTL13
3	2	147993969	149475737	2	1	2.2e-12	1.2e-12	1.1e-02	87	ORC4L
4	3	16154636	17814553	1	1	5.1e-08	4.8e-09	1.0e+00	100	PLCL2
5	3	35439546	36079910	1	1	2.0e-08	2.0e-10	2.3e-03	77	ARPP21
6	3	48702606	51234774	10	2	4.5e-09	4.6e-09	1.0e+00	100	GPX1 U73166.2
7	3	135273949	137261517	4	1	2.2e-10	5.2e-10	6.6e-02	91	STAG1
8	5	87104604	88677293	1	1	2.2e-07	6.7e-08	6.1e-03	74	LINC00461
9	5	106500969	108412472	1	1	9.3e-09	1.8e-10	5.3e-05	60	FBXL17
10	6	100712304	101576316	1	1	2.1e-07	2.3e-07	1.4e-01	92	ASCC3
11	7	11553163	12967449	1	1	1.4e-09	2.4e-09	4.6e-01	98	TMEM106B
12	7	125383444	127590914	1	1	2.6e-07	6.0e-11	7.5e-06	53	GRM8
13	7	154388677	155777228	1	1	8.2e-08	4.6e-08	1.0e+00	100	AC144652.1
14	8	8092025	13120332	38	2	2.6e-25	2.3e-20	3.7e-03	90	AF131215.9 RP11-981G7.6
15	9	95502571	96913764	2	1	2.3e-09	2.9e-09	1.0e-05	45	RP11-165J3.6
16	9	97520168	98975128	1	1	4.5e-08	7.5e-10	4.6e-03	79	PTCH1
17	9	119768572	121177842	1	1	2.7e-08	1.4e-08	9.4e-03	79	TLR4
18	11	12611333	14105497	1	1	6.8e-10	3.3e-09	2.5e-01	96	ARNTL
19	11	31573646	32085420	1	1	2.3e-08	3.9e-11	2.7e-05	60	PAX6
20	11	46033104	48559571	10	1	8.5e-13	2.0e-10	5.5e-02	91	MADD
21	11	56742853	58178587	3	1	7.7e-12	7.6e-11	1.0e+00	100	ZDHHC5
22	11	112135760	113969669	5	6	8.1e-16	7.1e-16	1.0e+00	100	ANKK1 DRD2 NCAM1 TTC12
23	12	108763672	110704487	3	1	3.8e-09	9.7e-10	6.5e-02	91	KCTD10
24	13	66643767	68053176	1	1	4.6e-10	3.5e-08	6.0e-06	33	PCDH9
25	14	69027866	70518587	2	1	8.0e-08	1.9e-08	4.7e-02	88	DCAF5
26	14	74424938	76089054	4	3	5.4e-14	4.2e-12	2.3e-01	97	AREL1 DLST RPS6KL1
27	15	77207277	78806023	1	1	2.6e-07	7.1e-10	4.4e-05	56	LINGO1
28	16	30347731	31758245	6	1	1.7e-08	2.6e-08	3.3e-01	97	RP11-196G11.2
29	16	88030355	89448663	2	1	6.3e-09	5.0e-08	3.3e-03	71	SNAI3-AS1
30	17	1805677	3287175	1	1	1.9e-07	1.8e-09	8.2e-05	57	PAFAH1B1
31	17	42607368	45796313	20	1	1.1e-21	5.6e-20	1.6e-01	98	WNT3
32	17	78843139	79380547	1	1	1.9e-09	2.6e-09	1.3e-01	93	AATK
33	18	30921425	31568499	1	1	1.2e-07	3.1e-07	4.6e-03	69	ASXL3
34	18	34124783	35844220	1	2	5.2e-08	8.2e-17	2.0e-06	68	CELF4
35	18	52209411	54028036	1	1	2.1e-09	2.6e-10	1.0e-04	62	TCF4
36	20	32594714	34109427	2	1	2.4e-07	5.4e-07	2.0e-01	93	NCOA6
37	20	44501458	44999958	1	1	1.3e-07	7.2e-07	2.1e-02	78	CD40
38	22	39219932	42614362	6	2	8.9e-09	2.0e-09	3.9e-01	98	ATF4 L3MBTL2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	1.64	1	0	0.0	0.00	1.0e+00	L3MBTL2
Depressed Affect (Nagel 2018)	12.86	38	23	51.1	0.99	3.7e-31	AATK AC144652.1 ANKK1 AREL1 ARNTL ARPP21 ASCC3 ASXL3 CD40 CELF4 DCAF5 DLST DRD2 GPX1 GRM8 KCTD10 L3MBTL2 LINC00461 LINGO1 MADD METTL13 NCAM1 ORC4L PAFAH1B1 PCDH9 PLCL2 PTCH1 RP11-165J3.6 RP11-196G11.2 RPS6KL1 SNAI3-AS1 STAG1 TCF4 TLR4 TMEM106B TTC12 WNT3 ZDHHC5
Depression (Nagel 2018)	7.92	14	5	11.1	0.98	7.0e-10	AATK ANKK1 CELF4 DCAF5 MADD NCAM1 PCDH9 RP11-165J3.6 STAG1 TMEM106B TTC12 U73166.2 WNT3 ZDHHC5
Intelligence (Savage-Jansen 2018)	2.80	10	5	11.1	-0.36	3.1e-01	AATK ATF4 GPX1 LINC00461 METTL13 NCAM1 PLCL2 STAG1 WNT3 ZDHHC5
Neuroticism (Nagel 2018)	16.85	44	38	84.4	0.99	2.8e-43	AATK AC144652.1 ANKK1 AREL1 ARNTL ARPP21 ASCC3 ASXL3 CD40 CELF4 DCAF5 DLST DRD2 EIF4G3 FBXL17 GPX1 GRM8 KCTD10 L3MBTL2 LINC00461 LINGO1 MADD METTL13 NCAM1 NCOA6 ORC4L PAFAH1B1 PAX6 PCDH9 PLCL2 PTCH1 RP11-165J3.6 RP11-196G11.2 RP11-981G7.6 RPS6KL1 SNAI3-AS1 STAG1 TCF4 TLR4 TMEM106B TTC12 U73166.2 WNT3 ZDHHC5
Schizophrenia (2018)	2.02	3	0	0.0	0.00	1.0e+00	L3MBTL2 STAG1 ZDHHC5
Schizophrenia vs Biploar Disorder	2.01	1	0	0.0	0.00	1.0e+00	ARNTL
Worry (Nagel 2018)	11.23	32	17	37.8	0.99	8.3e-25	AATK ANKK1 AREL1 ARNTL ARPP21 ASXL3 CELF4 DLST DRD2 EIF4G3 FBXL17 KCTD10 L3MBTL2 MADD METTL13 NCAM1 NCOA6 ORC4L PAX6 PLCL2 PTCH1 RP11-165J3.6 RP11-196G11.2 RP11-981G7.6 RPS6KL1 SNAI3-AS1 STAG1 TMEM106B TTC12 U73166.2 WNT3 ZDHHC5
Alzheimer’s Disease (including proxy)	1.77	1	0	0.0	0.00	1.0e+00	MADD
Crohns Disease (2017)	1.32	2	1	2.2	0.00	1.0e+00	CD40 GPX1
Irritable Bowel Disease (IBD)	1.45	2	1	2.2	0.00	1.0e+00	CD40 GPX1
Ulcerative Colitis (UC)	1.23	1	1	2.2	0.00	1.0e+00	GPX1
Major Depression (MDD)	5.07	4	0	0.0	1.00	1.1e-03	GPX1 TCF4 TMEM106B ZDHHC5
Verbal and Numeric Reasoning (VNR)	2.64	6	2	4.4	-0.33	5.2e-01	ATF4 GPX1 LINC00461 METTL13 NCAM1 STAG1
Breast Cancer	1.14	1	1	2.2	0.00	1.0e+00	WNT3
Ovarian Cancer	1.39	1	1	2.2	0.00	1.0e+00	WNT3
Prostate Cancer	1.52	1	0	0.0	0.00	1.0e+00	GPX1
Age at First Birth	1.85	1	1	2.2	0.00	1.0e+00	GPX1
Body Mass Index (BMI) (2010)	1.82	1	0	0.0	0.00	1.0e+00	MADD
Mean Putamen Volume	1.49	1	0	0.0	0.00	1.0e+00	WNT3
Fasting Glucose	1.72	1	1	2.2	0.00	1.0e+00	MADD
HDL Cholesterol	1.55	1	1	2.2	0.00	1.0e+00	KCTD10
Lupus	1.07	1	0	0.0	0.00	1.0e+00	AF131215.9
Neuroticism (2016)	9.41	14	2	4.4	0.99	6.8e-12	AF131215.9 AREL1 CELF4 DRD2 GPX1 L3MBTL2 LINC00461 MADD PAX6 PCDH9 TCF4 TLR4 U73166.2 WNT3
Primary Biliary Cirrhosis	1.46	2	0	0.0	0.00	1.0e+00	PLCL2 WNT3
Rheumatoid Arthritis	1.24	1	0	0.0	0.00	1.0e+00	CD40
Schizophrenia (2014)	2.38	2	0	0.0	0.00	1.0e+00	DRD2 ZDHHC5
Triglycerides	1.36	1	0	0.0	0.00	1.0e+00	NCOA6
Ulcerative Colitis	1.46	1	1	2.2	0.00	1.0e+00	GPX1
Blood Eosinophil Count	1.26	7	3	6.7	-0.09	8.5e-01	EIF4G3 GPX1 KCTD10 L3MBTL2 ORC4L PLCL2 WNT3
Blood Platelet Count	0.96	10	8	17.8	-0.03	9.3e-01	AC144652.1 AREL1 DLST LINC00461 MADD METTL13 RPS6KL1 SNAI3-AS1 U73166.2 ZDHHC5
Blood Red Count	2.31	11	7	15.6	0.37	2.7e-01	ARNTL DCAF5 DRD2 EIF4G3 LINC00461 METTL13 NCOA6 RP11-196G11.2 SNAI3-AS1 WNT3 ZDHHC5
Blood White Count	0.88	6	3	6.7	-0.04	9.4e-01	AATK GPX1 MADD PTCH1 SNAI3-AS1 WNT3
Heel T-Score	0.89	7	3	6.7	-0.01	9.8e-01	AREL1 DLST L3MBTL2 MADD RPS6KL1 WNT3 ZDHHC5
BMI	2.62	10	7	15.6	0.10	7.9e-01	ANKK1 ARNTL ARPP21 ASCC3 GPX1 LINC00461 MADD RP11-196G11.2 TLR4 TTC12
Height	1.45	18	15	33.3	-0.44	7.1e-02	AATK AREL1 EIF4G3 GPX1 MADD METTL13 NCOA6 ORC4L PAFAH1B1 PTCH1 RP11-165J3.6 RPS6KL1 SNAI3-AS1 STAG1 TCF4 TMEM106B U73166.2 WNT3
Waist Hip Ratio (WHR)	1.68	6	3	6.7	0.43	3.4e-01	EIF4G3 GPX1 STAG1 TTC12 U73166.2 WNT3
Systolic Blood Pressure	2.06	8	6	13.3	0.66	7.7e-02	AREL1 ARNTL GPX1 MADD ORC4L PAFAH1B1 RPS6KL1 ZDHHC5
Smoking Status	2.26	4	1	2.2	0.40	6.0e-01	AATK ASCC3 GPX1 WNT3
Allergy or Eczema	1.19	2	1	2.2	0.00	1.0e+00	L3MBTL2 PLCL2
Cardiovascular Disease	1.80	5	1	2.2	0.17	7.9e-01	ANKK1 ARNTL EIF4G3 RP11-196G11.2 TTC12
Respiratory disease	1.43	1	0	0.0	0.00	1.0e+00	SNAI3-AS1
Lung FEV1/FVC ratio	1.64	5	4	8.9	-0.86	6.1e-02	AREL1 DLST PTCH1 RPS6KL1 ZDHHC5
Lung FVC	2.69	8	5	11.1	-0.34	4.1e-01	GPX1 NCOA6 PTCH1 RP11-196G11.2 SNAI3-AS1 TCF4 U73166.2 WNT3
Neuroticism	16.83	44	40	88.9	1.00	8.6e-48	AATK AC144652.1 ANKK1 AREL1 ARNTL ARPP21 ASCC3 ASXL3 ATF4 CD40 CELF4 DCAF5 DLST DRD2 EIF4G3 FBXL17 GPX1 GRM8 KCTD10 L3MBTL2 LINC00461 LINGO1 MADD METTL13 NCAM1 NCOA6 ORC4L PAFAH1B1 PAX6 PCDH9 PLCL2 PTCH1 RP11-165J3.6 RP11-196G11.2 RPS6KL1 SNAI3-AS1 STAG1 TCF4 TLR4 TMEM106B TTC12 U73166.2 WNT3 ZDHHC5
Chronotype (morning person)	2.19	2	2	4.4	0.00	1.0e+00	EIF4G3 U73166.2
Hair Pigment	3.25	4	3	6.7	0.32	6.8e-01	L3MBTL2 NCOA6 SNAI3-AS1 WNT3
Tanning	6.03	3	2	4.4	0.00	1.0e+00	AREL1 NCOA6 SNAI3-AS1
Hand grip strength (left)	2.60	7	4	8.9	-0.02	9.7e-01	AREL1 ARPP21 LINGO1 MADD RPS6KL1 TCF4 WNT3
Number of treatments/medications taken	3.65	4	3	6.7	1.00	1.7e-03	AREL1 DLST GPX1 RPS6KL1
Sensitivity / hurt feelings	9.16	17	8	17.8	0.97	6.0e-11	AF131215.9 ANKK1 CELF4 DCAF5 DRD2 GRM8 KCTD10 METTL13 NCAM1 ORC4L PLCL2 PTCH1 RP11-165J3.6 STAG1 TTC12 WNT3 ZDHHC5
Frequency of depressed mood in last 2 weeks	7.89	13	2	4.4	0.97	5.9e-08	AATK AF131215.9 CELF4 DRD2 MADD NCAM1 PCDH9 RP11-165J3.6 STAG1 TMEM106B U73166.2 WNT3 ZDHHC5
Hearing difficulty/problems: Yes	1.73	2	0	0.0	0.00	1.0e+00	FBXL17 KCTD10
Relative age of first facial hair	2.02	1	1	2.2	0.00	1.0e+00	WNT3
Other serious medical condition/disability diagnosed by doctor	2.87	2	0	0.0	0.99	5.4e-03	ANKK1 TTC12
Systolic blood pressure, automated reading	2.18	8	2	4.4	0.08	8.6e-01	AF131215.9 AREL1 ARNTL GPX1 MADD PAFAH1B1 RPS6KL1 ZDHHC5
Pack years adult smoking proportion	2.40	2	0	0.0	0.00	1.0e+00	CELF4 GPX1
Impedance of leg (right)	2.25	11	6	13.3	0.50	1.2e-01	AF131215.9 AREL1 GPX1 LINC00461 MADD NCOA6 PTCH1 RPS6KL1 SNAI3-AS1 STAG1 U73166.2
Leg fat-free mass (left)	1.48	6	4	8.9	-0.16	7.6e-01	AF131215.9 ASCC3 LINC00461 NCOA6 PTCH1 SNAI3-AS1
Trunk fat percentage	2.63	13	5	11.1	-0.17	5.8e-01	ANKK1 AREL1 ARNTL ARPP21 GPX1 L3MBTL2 LINC00461 MADD RP11-196G11.2 RPS6KL1 TTC12 WNT3 ZDHHC5
Hand grip strength (right)	1.87	4	2	4.4	0.12	8.8e-01	ARPP21 LINGO1 MADD WNT3
Current tobacco smoking	2.62	3	1	2.2	0.00	1.0e+00	AATK CELF4 L3MBTL2
Fed-up feelings	9.59	22	9	20.0	0.98	1.8e-15	AC144652.1 AF131215.9 AREL1 ARNTL CD40 CELF4 DCAF5 DLST DRD2 GPX1 LINC00461 LINGO1 MADD NCAM1 ORC4L PAFAH1B1 PCDH9 RPS6KL1 STAG1 TLR4 WNT3 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks	7.09	10	1	2.2	0.99	1.6e-07	ANKK1 CELF4 DCAF5 DRD2 EIF4G3 PCDH9 STAG1 TTC12 U73166.2 ZDHHC5
Relative age voice broke	1.89	1	1	2.2	0.00	1.0e+00	WNT3
Taking other prescription medications	3.87	4	2	4.4	1.00	1.2e-03	AREL1 DLST GPX1 RPS6KL1
Age when periods started (menarche)	2.25	4	4	8.9	0.62	3.8e-01	ARNTL ASCC3 GPX1 MADD
Heel bone mineral density (BMD) T-score, automated (left)	1.64	2	2	4.4	0.00	1.0e+00	AF131215.9 L3MBTL2
Qualifications: CSEs or equivalent	1.51	1	0	0.0	0.00	1.0e+00	WNT3
High blood pressure	1.82	4	2	4.4	-0.20	8.0e-01	AF131215.9 ARNTL EIF4G3 MADD
Stomach or abdominal pain in last month	2.81	1	0	0.0	0.00	1.0e+00	STAG1
Medication: Levothyroxine sodium	1.03	1	0	0.0	0.00	1.0e+00	AF131215.9
Sitting height	2.03	7	6	13.3	-0.34	4.5e-01	AATK MADD NCOA6 PTCH1 SNAI3-AS1 WNT3 ZDHHC5
Body mass index (BMI)	2.77	9	7	15.6	-0.17	6.6e-01	AF131215.9 ARNTL ARPP21 ASCC3 GPX1 LINC00461 MADD RP11-196G11.2 STAG1
Impedance of leg (left)	2.29	11	5	11.1	0.46	1.6e-01	AF131215.9 AREL1 ASCC3 GPX1 LINC00461 MADD NCOA6 RPS6KL1 SNAI3-AS1 U73166.2 WNT3
Leg predicted mass (left)	1.49	6	4	8.9	-0.16	7.6e-01	AF131215.9 ASCC3 LINC00461 NCOA6 PTCH1 SNAI3-AS1
Trunk fat mass	2.26	9	4	8.9	-0.25	5.2e-01	ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12 WNT3
Waist circumference	2.12	7	4	8.9	-0.06	8.9e-01	ANKK1 ARNTL ARPP21 LINC00461 MADD RP11-196G11.2 TTC12
Number of incorrect matches in round	1.67	1	0	0.0	0.00	1.0e+00	EIF4G3
Alcohol usually taken with meals	2.97	2	1	2.2	0.00	1.0e+00	CELF4 ZDHHC5
Nervous feelings	8.74	19	7	15.6	0.99	1.9e-16	AF131215.9 ANKK1 AREL1 ARNTL ASXL3 CELF4 DLST EIF4G3 KCTD10 L3MBTL2 MADD NCOA6 ORC4L RP11-196G11.2 RPS6KL1 STAG1 TTC12 U73166.2 WNT3
Frequency of tenseness / restlessness in last 2 weeks	7.38	11	3	6.7	0.99	9.2e-09	AATK ANKK1 CELF4 DRD2 GPX1 KCTD10 RP11-165J3.6 STAG1 TMEM106B TTC12 WNT3
Hearing difficulty/problems with background noise	2.93	3	0	0.0	0.00	1.0e+00	KCTD10 PAFAH1B1 WNT3
Hair/balding pattern: Pattern 2	1.45	1	1	2.2	0.00	1.0e+00	WNT3
Forced vital capacity (FVC)	2.60	5	5	11.1	-0.29	6.3e-01	GPX1 PTCH1 RP11-196G11.2 SNAI3-AS1 WNT3
Heel bone mineral density (BMD) T-score, automated (right)	1.75	2	1	2.2	0.00	1.0e+00	AF131215.9 L3MBTL2
Ever unenthusiastic/disinterested for a whole week	2.99	1	0	0.0	0.00	1.0e+00	WNT3
Qualifications: None of the above	2.15	2	1	2.2	0.00	1.0e+00	CELF4 GPX1
Financial difficulties in last 2 years	2.32	1	0	0.0	0.00	1.0e+00	DRD2
Mouth/teeth dental problems	2.20	2	0	0.0	0.00	1.0e+00	KCTD10 WNT3
Allergy	1.39	2	0	0.0	0.00	1.0e+00	KCTD10 L3MBTL2
Fluid intelligence score	2.36	2	1	2.2	0.00	1.0e+00	METTL13 STAG1
Weight	1.69	9	5	11.1	-0.11	7.8e-01	AF131215.9 ANKK1 ARPP21 ASCC3 GPX1 LINC00461 MADD NCOA6 RP11-196G11.2
Impedance of arm (right)	2.37	10	7	15.6	0.04	9.2e-01	AF131215.9 ASCC3 GPX1 L3MBTL2 NCOA6 STAG1 TMEM106B U73166.2 WNT3 ZDHHC5
Arm fat percentage (right)	2.90	10	7	15.6	-0.12	7.2e-01	AF131215.9 ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12 ZDHHC5
Trunk fat-free mass	1.33	5	2	4.4	-0.31	6.1e-01	AF131215.9 ASCC3 NCOA6 PTCH1 RPS6KL1
Hip circumference	2.01	6	5	11.1	-0.05	9.2e-01	AF131215.9 GPX1 LINC00461 MADD PTCH1 RP11-196G11.2
Time employed in main current job	1.71	1	1	2.2	0.00	1.0e+00	WNT3
Father's age at death	1.78	1	0	0.0	0.00	1.0e+00	GPX1
Worrier / anxious feelings	10.11	22	9	20.0	0.99	5.4e-18	AF131215.9 AREL1 ARNTL ARPP21 DLST KCTD10 L3MBTL2 LINGO1 METTL13 ORC4L PAX6 PTCH1 RP11-165J3.6 RP11-196G11.2 RP11-981G7.6 RPS6KL1 STAG1 TCF4 TLR4 U73166.2 WNT3 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks	7.09	13	4	8.9	0.98	1.0e-09	AATK AC144652.1 DCAF5 GPX1 KCTD10 L3MBTL2 ORC4L PAFAH1B1 RP11-165J3.6 SNAI3-AS1 STAG1 TTC12 ZDHHC5
Hair/balding pattern: Pattern 3	2.05	1	1	2.2	0.00	1.0e+00	WNT3
Number of live births	0.94	1	0	0.0	0.00	1.0e+00	WNT3
Forced expiratory volume in 1-second (FEV1)	2.52	5	5	11.1	-0.39	5.1e-01	GPX1 PTCH1 RP11-196G11.2 SNAI3-AS1 WNT3
Qualifications: A levels/AS levels or equivalent	2.38	3	1	2.2	0.00	1.0e+00	GPX1 LINC00461 METTL13
Mouth/teeth dental problems: Dentures	2.11	2	0	0.0	0.00	1.0e+00	GPX1 STAG1
Depression (self-reported)	3.38	1	0	0.0	0.00	1.0e+00	TMEM106B
Forced expiratory volume in 1-second (FEV1), Best measure	2.41	5	4	8.9	-0.40	5.0e-01	GPX1 PTCH1 RP11-196G11.2 SNAI3-AS1 WNT3
Impedance of arm (left)	2.30	9	7	15.6	0.04	9.2e-01	AF131215.9 ASCC3 GPX1 L3MBTL2 NCOA6 STAG1 U73166.2 WNT3 ZDHHC5
Arm fat mass (right)	2.55	9	7	15.6	-0.14	6.9e-01	AF131215.9 ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12
Trunk predicted mass	1.35	5	3	6.7	-0.31	6.2e-01	AF131215.9 ASCC3 NCOA6 PTCH1 RPS6KL1
Standing height	1.51	13	11	24.4	-0.48	9.6e-02	AATK EIF4G3 GPX1 MADD METTL13 NCOA6 PTCH1 RP11-165J3.6 RPS6KL1 SNAI3-AS1 STAG1 TMEM106B WNT3
Tense / 'highly strung'	8.12	15	4	8.9	0.99	2.3e-11	AATK AC144652.1 AF131215.9 ANKK1 AREL1 ASCC3 DRD2 L3MBTL2 NCOA6 ORC4L RP11-165J3.6 RP11-196G11.2 TMEM106B TTC12 U73166.2
Seen doctor (GP) for nerves, anxiety, tension or depression	6.46	9	3	6.7	0.98	5.5e-06	ANKK1 AREL1 ASCC3 ASXL3 CELF4 DRD2 TCF4 TMEM106B TTC12
Hair/balding pattern: Pattern 4	2.95	1	1	2.2	0.00	1.0e+00	WNT3
Birth weight of first child	1.53	1	0	0.0	0.00	1.0e+00	PAFAH1B1
Peak expiratory flow (PEF)	1.59	2	1	2.2	0.00	1.0e+00	AF131215.9 WNT3
Qualifications: O levels/GCSEs or equivalent	1.85	2	1	2.2	0.00	1.0e+00	GPX1 PLCL2
Blood clot in the leg (DVT)	1.32	1	0	0.0	0.00	1.0e+00	NCOA6
Medication: Paracetamol	2.83	3	2	4.4	0.00	1.0e+00	GPX1 KCTD10 WNT3
Headache pain in last month	3.01	3	1	2.2	0.00	1.0e+00	TLR4 WNT3 ZDHHC5
Hypothyroidism/myxoedema (self-reported)	1.14	1	1	2.2	0.00	1.0e+00	AF131215.9
Birth weight	1.11	1	1	2.2	0.00	1.0e+00	PTCH1
Forced vital capacity (FVC), Best measure	2.56	5	5	11.1	-0.31	6.1e-01	GPX1 PTCH1 RP11-196G11.2 SNAI3-AS1 WNT3
Body fat percentage	2.84	12	6	13.3	-0.12	6.8e-01	ANKK1 AREL1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1 TTC12 WNT3 ZDHHC5
Leg fat percentage (right)	3.13	11	6	13.3	0.08	8.0e-01	ANKK1 AREL1 ARNTL ARPP21 DCAF5 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1 TTC12
Arm fat-free mass (right)	1.41	6	3	6.7	-0.03	9.6e-01	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1
Comparative body size at age 10	2.71	5	4	8.9	-0.95	1.5e-02	AF131215.9 MADD RP11-165J3.6 RP11-196G11.2 U73166.2
Number of full brothers	1.98	1	0	0.0	0.00	1.0e+00	WNT3
Worry too long after embarrassment	9.73	17	9	20.0	0.97	2.0e-11	AF131215.9 ANKK1 ARNTL ARPP21 ATF4 DRD2 EIF4G3 FBXL17 KCTD10 LINC00461 NCAM1 NCOA6 RP11-981G7.6 STAG1 TTC12 WNT3 ZDHHC5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.84	2	0	0.0	0.00	1.0e+00	L3MBTL2 TMEM106B
Wheeze or whistling in the chest in last year	3.02	2	0	0.0	0.00	1.0e+00	GPX1 SNAI3-AS1
Age at first live birth	2.41	3	1	2.2	0.00	1.0e+00	AF131215.9 CELF4 GPX1
Health satisfaction	3.31	3	0	0.0	0.00	1.0e+00	ANKK1 DRD2 PCDH9
Qualifications: College or University degree	2.83	6	5	11.1	-0.23	6.2e-01	CELF4 DCAF5 GPX1 LINC00461 WNT3 ZDHHC5
Medication for pain relief, constipation, heartburn	2.80	6	1	2.2	-0.98	4.3e-04	AREL1 GPX1 PCDH9 RP11-165J3.6 RPS6KL1 WNT3
Neck or shoulder pain in last month	2.35	2	1	2.2	0.00	1.0e+00	ASXL3 GPX1
Whole body fat mass	2.42	9	4	8.9	-0.07	8.4e-01	AF131215.9 ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12
Leg fat mass (right)	2.71	10	6	13.3	0.03	9.2e-01	AF131215.9 ANKK1 ARNTL ARPP21 ASCC3 GPX1 LINC00461 MADD RP11-196G11.2 TTC12
Arm predicted mass (right)	1.38	6	2	4.4	-0.04	9.4e-01	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1
Pulse rate, automated reading	1.43	3	0	0.0	0.00	1.0e+00	LINC00461 ORC4L ZDHHC5
Alcohol intake frequency.	2.94	5	3	6.7	0.21	7.4e-01	DRD2 MADD TCF4 WNT3 ZDHHC5
Comparative height size at age 10	1.59	11	6	13.3	-0.47	1.5e-01	ANKK1 DLST GPX1 KCTD10 METTL13 NCOA6 PTCH1 RPS6KL1 STAG1 TCF4 WNT3
Suffer from 'nerves'	7.69	11	3	6.7	0.97	1.2e-06	AATK AF131215.9 ANKK1 AREL1 DLST EIF4G3 MADD RP11-981G7.6 RPS6KL1 TTC12 WNT3
Overall health rating	5.01	7	4	8.9	0.98	4.7e-06	AATK ANKK1 DCAF5 GPX1 NCAM1 RP11-165J3.6 TTC12
Chest pain or discomfort	2.56	2	0	0.0	0.00	1.0e+00	AC144652.1 ASXL3
Age at last live birth	2.05	1	1	2.2	0.00	1.0e+00	GPX1
Leg pain on walking	1.87	1	0	0.0	0.00	1.0e+00	WNT3
Supplements: Vitamin C	1.29	1	0	0.0	0.00	1.0e+00	WNT3
Hypertension (Self-reported)	1.77	4	1	2.2	-0.21	7.9e-01	AF131215.9 ARNTL EIF4G3 MADD
Illnesses of father: Heart disease	1.12	1	0	0.0	0.00	1.0e+00	WNT3
Forced expiratory volume in 1-second (FEV1), predicted	1.35	2	0	0.0	0.00	1.0e+00	NCOA6 PTCH1
Whole body fat-free mass	1.36	5	3	6.7	-0.10	8.7e-01	AF131215.9 ASCC3 LINC00461 NCOA6 PTCH1
Leg fat-free mass (right)	1.52	5	4	8.9	-0.40	5.0e-01	AF131215.9 LINC00461 NCOA6 PTCH1 SNAI3-AS1
Arm fat percentage (left)	2.86	9	6	13.3	-0.41	2.8e-01	AF131215.9 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12 ZDHHC5
Average weekly red wine intake	2.14	1	0	0.0	0.00	1.0e+00	ZDHHC5
Handedness (chirality/laterality): Left-handed	1.88	1	1	2.2	0.00	1.0e+00	WNT3
Mood swings	11.50	23	11	24.4	0.98	4.8e-16	AF131215.9 ANKK1 AREL1 ASCC3 ASXL3 CD40 CELF4 DLST DRD2 GPX1 L3MBTL2 MADD METTL13 NCAM1 PLCL2 RP11-165J3.6 SNAI3-AS1 STAG1 TCF4 TLR4 TMEM106B TTC12 WNT3
Loneliness, isolation	6.88	7	2	4.4	0.98	1.6e-04	GPX1 MADD ORC4L PCDH9 STAG1 TMEM106B WNT3
Long-standing illness, disability or infirmity	2.67	1	0	0.0	0.00	1.0e+00	ANKK1
Mouth/teeth dental problems: Mouth ulcers	1.40	1	1	2.2	0.00	1.0e+00	WNT3
Smoking status: Current	2.38	1	1	2.2	0.00	1.0e+00	AATK
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.83	2	2	4.4	0.00	1.0e+00	RP11-196G11.2 WNT3
Whole body water mass	1.36	6	3	6.7	-0.03	9.6e-01	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1
Leg predicted mass (right)	1.52	5	4	8.9	-0.40	5.0e-01	AF131215.9 LINC00461 NCOA6 PTCH1 SNAI3-AS1
Arm fat mass (left)	2.50	9	7	15.6	-0.20	6.0e-01	AF131215.9 ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12
Number of self-reported non-cancer illnesses	3.42	4	0	0.0	0.08	9.2e-01	AREL1 ARNTL EIF4G3 TMEM106B
Average weekly champagne plus white wine intake	1.50	1	0	0.0	0.00	1.0e+00	WNT3
Miserableness	11.04	25	12	26.7	0.98	8.8e-18	AF131215.9 ANKK1 ARNTL ARPP21 ASCC3 CD40 CELF4 DRD2 GPX1 KCTD10 LINGO1 MADD METTL13 NCAM1 ORC4L PAFAH1B1 PCDH9 RP11-165J3.6 RP11-981G7.6 SNAI3-AS1 STAG1 TCF4 TMEM106B TTC12 WNT3
Guilty feelings	10.33	20	10	22.2	0.98	6.0e-16	AATK AF131215.9 ANKK1 AREL1 ARNTL ARPP21 ATF4 CD40 DLST DRD2 LINGO1 MADD METTL13 NCAM1 PAFAH1B1 PTCH1 RPS6KL1 TTC12 WNT3 ZDHHC5
Financial situation satisfaction	2.94	1	1	2.2	0.00	1.0e+00	GPX1
Medication: Blood pressure	1.79	1	0	0.0	0.00	1.0e+00	AF131215.9
High cholesterol (Self-reported)	1.54	1	0	0.0	0.00	1.0e+00	RP11-196G11.2
Medication: Bendroflumethiazide	2.04	2	1	2.2	0.00	1.0e+00	AF131215.9 SNAI3-AS1
Medication: Paracetamol	2.61	2	1	2.2	0.00	1.0e+00	GPX1 WNT3
Illnesses of father: High blood pressure	1.43	1	0	0.0	0.00	1.0e+00	MADD
Ever smoked	1.92	1	0	0.0	0.00	1.0e+00	AATK
Basal metabolic rate	1.39	6	4	8.9	0.00	1.0e+00	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1
Leg fat percentage (left)	3.17	12	6	13.3	0.01	9.8e-01	AF131215.9 ANKK1 AREL1 ARNTL ARPP21 DCAF5 GPX1 LINC00461 MADD RP11-196G11.2 RPS6KL1 TTC12
Arm fat-free mass (left)	1.43	6	4	8.9	0.01	9.8e-01	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1
Number of operations (self-reported)	2.25	1	0	0.0	0.00	1.0e+00	GPX1
Average weekly beer plus cider intake	2.45	2	0	0.0	0.00	1.0e+00	AF131215.9 CELF4
Irritability	9.29	19	6	13.3	0.98	1.0e-12	AF131215.9 AREL1 CELF4 DRD2 FBXL17 GPX1 KCTD10 L3MBTL2 LINC00461 NCOA6 ORC4L PAFAH1B1 PAX6 RP11-196G11.2 RP11-981G7.6 SNAI3-AS1 TCF4 TMEM106B WNT3
Ever had prostate specific antigen (PSA) test	1.11	1	0	0.0	0.00	1.0e+00	PAFAH1B1
Fractured/broken bones in last 5 years	1.11	1	0	0.0	0.00	1.0e+00	WNT3
Diastolic blood pressure, automated reading	1.77	6	3	6.7	0.04	9.4e-01	AF131215.9 ARNTL GPX1 LINC00461 MADD PAFAH1B1
Vascular/heart problems diagnosed by doctor	1.75	4	1	2.2	0.18	8.2e-01	AF131215.9 ARNTL EIF4G3 MADD
Cholesterol lowering medication	1.50	1	0	0.0	0.00	1.0e+00	RP11-196G11.2
Pain experienced in last month	3.13	2	1	2.2	0.00	1.0e+00	GPX1 KCTD10
Basal cell carcinoma (self-reported)	1.49	1	1	2.2	0.00	1.0e+00	NCOA6
Deep venous thrombosis (DVT) (self-reported)	1.31	1	0	0.0	0.00	1.0e+00	NCOA6
Alcohol drinker status: Previous	1.67	1	0	0.0	0.00	1.0e+00	ATF4
Pack years of smoking	2.34	2	0	0.0	0.00	1.0e+00	CELF4 GPX1
Impedance of whole body	2.32	10	8	17.8	0.10	7.9e-01	AF131215.9 AREL1 ASCC3 GPX1 L3MBTL2 LINC00461 NCOA6 STAG1 U73166.2 WNT3
Leg fat mass (left)	2.70	9	6	13.3	-0.10	7.8e-01	AF131215.9 ANKK1 ARNTL ARPP21 GPX1 LINC00461 MADD RP11-196G11.2 TTC12
Arm predicted mass (left)	1.49	6	5	11.1	-0.01	9.9e-01	AF131215.9 ASCC3 GPX1 LINC00461 NCOA6 PTCH1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	17	0.49	2.0
GTEx	Adipose Visceral Omentum	11	0.54	2.2
GTEx	Adrenal Gland	11	0.75	2.2
GTEx	Artery Aorta	19	0.64	2.2
GTEx	Artery Coronary	14	1.18	2.6
GTEx	Artery Tibial	15	0.40	2.0
GTEx	Brain Caudate basal ganglia	10	1.09	2.4
GTEx	Brain Cerebellar Hemisphere	11	0.74	2.3
GTEx	Brain Cerebellum	13	0.66	2.2
GTEx	Brain Cortex	11	1.06	2.6
GTEx	Brain Frontal Cortex BA9	8	0.87	2.5
GTEx	Brain Hippocampus	4	0.76	2.5
GTEx	Brain Hypothalamus	5	0.85	2.4
GTEx	Brain Nucleus accumbens basal ganglia	7	0.81	2.3
GTEx	Brain Putamen basal ganglia	6	0.96	2.4
GTEx	Breast Mammary Tissue	14	0.71	2.2
GTEx	Breast Mammary Tissue (Male)	10	0.84	2.3
GTEx	Breast Mammary Tissue (Female)	14	0.85	2.2
GTEx	Cells EBV-transformed lymphocytes	13	0.91	2.5
GTEx	Cells Transformed fibroblasts	19	0.45	2.0
GTEx	Colon Sigmoid	10	0.68	2.3
GTEx	Colon Transverse	18	0.87	2.3
GTEx	Esophagus Gastroesophageal Junction	14	0.97	2.5
GTEx	Esophagus Mucosa	21	0.63	2.1
GTEx	Esophagus Muscularis	21	0.65	2.3
GTEx	Heart Atrial Appendage	13	0.82	2.4
GTEx	Heart Left Ventricle	13	0.85	2.4
GTEx	Liver	7	0.98	2.3
GTEx	Lung	21	0.73	2.2
GTEx	Muscle Skeletal	20	0.69	2.1
GTEx	Nerve Tibial	19	0.44	2.1
GTEx	Ovary	10	1.10	2.5
GTEx	Pancreas	14	0.86	2.3
GTEx	Pituitary	10	0.90	2.3
GTEx	Prostate	6	0.72	2.4
GTEx	Skin Not Sun Exposed Suprapubic	17	0.69	2.3
GTEx	Skin Sun Exposed Lower leg	23	0.63	2.3
GTEx	Small Intestine Terminal Ileum	6	1.30	2.8
GTEx	Spleen	13	0.92	2.4
GTEx	Stomach	12	0.83	2.4
GTEx	Testis	25	0.79	2.2
GTEx	Thyroid	23	0.58	2.1
GTEx	Uterus	11	1.94	2.9
GTEx	Vagina	7	1.10	2.6
GTEx	Whole Blood	11	0.55	2.1
METSIM	Adipose	9	0.20	1.8
NTR	Blood	10	0.42	2.0
ROSMAP	Brain Pre-frontal Cortex	28	0.64	2.2
YFS	Blood	10	0.22	1.8
CommonMind	Brain Pre-frontal Cortex	16	0.30	1.9
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	10	0.60	2.0
The Cancer Genome Atlas	Breast Invasive Carcinoma	16	0.36	1.9
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.36	1.9
The Cancer Genome Atlas	Colon Adenocarcinoma	7	0.34	2.0
The Cancer Genome Atlas	Esophageal Carcinoma	7	1.02	2.5
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.49	2.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	17	0.62	2.0
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	15	0.37	1.9
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	13	0.63	2.0
The Cancer Genome Atlas	Brain Lower Grade Glioma	13	0.30	1.8
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	6	0.54	1.9
The Cancer Genome Atlas	Lung Adenocarcinoma	14	0.48	2.0
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	10	0.40	2.0
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	9	0.57	1.9
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	6	0.36	2.0
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	9	0.68	2.0
The Cancer Genome Atlas	Prostate Adenocarcinoma	18	0.39	1.9
The Cancer Genome Atlas	Rectum Adenocarcinoma	2	0.29	1.9
The Cancer Genome Atlas	Soft Tissue Sarcoma	6	0.56	2.0
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.19	1.8
The Cancer Genome Atlas	Stomach Adenocarcinoma	8	0.48	2.0
The Cancer Genome Atlas	Testicular Germ Cell Tumors	6	0.47	2.0
The Cancer Genome Atlas	Thyroid Carcinoma	13	0.25	1.8
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.39	1.9