[Hub]/) : Traits : Neuroticism score : ← →

chr14:74,424,938-76,089,054

Best TWAS P=5.42e-14 · Best GWAS P=4.18e-12 conditioned to 0.232

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DLST 0.09 0.11 lasso 2 0.11 4.0e-13 -6.4 6.6 4.2e-11 -0.66 0.08 0.92 FALSE
2 CommonMind Brain Pre-frontal Cortex RPS6KL1 0.04 0.02 lasso 5 0.02 4.8e-04 4.4 -5.3 1.1e-07 0.67 0.18 0.49 FALSE
3 GTEx Adipose Subcutaneous YLPM1 0.10 0.03 lasso 6 0.02 7.9e-03 -6.3 6.6 3.0e-11 -0.77 0.08 0.48 FALSE
4 GTEx Adrenal Gland RPS6KL1 0.21 0.13 enet 25 0.15 4.4e-06 4.8 5.2 2.1e-07 -0.46 0.36 0.55 FALSE
5 GTEx Muscle Skeletal DLST 0.28 0.26 enet 23 0.26 2.1e-25 -6.7 -6.8 1.2e-11 0.93 0.02 0.98 TRUE
6 GTEx Skin Not Sun Exposed Suprapubic RPS6KL1 0.08 0.08 enet 11 0.07 1.5e-04 6.3 7.0 2.4e-12 -0.72 0.08 0.91 FALSE
7 GTEx Testis AREL1 0.20 0.14 enet 34 0.13 2.1e-06 6.3 7.5 5.4e-14 -0.57 0.14 0.86 TRUE
8 The Cancer Genome Atlas Breast Invasive Carcinoma RPS6KL1 0.03 0.02 lasso 3 0.02 8.5e-06 6.3 6.2 6.2e-10 -0.58 0.12 0.88 FALSE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS6KL1 0.04 0.04 lasso 3 0.03 1.8e-04 6.3 6.0 1.8e-09 -0.59 0.11 0.82 TRUE
10 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPS6KL1 0.09 0.10 blup 49 0.11 5.1e-07 -4.3 5.5 4.7e-08 -0.77 0.64 0.33 FALSE
11 The Cancer Genome Atlas Lung Adenocarcinoma RPS6KL1 0.03 0.01 blup 49 0.02 2.3e-03 5.0 5.7 9.0e-09 -0.73 0.04 0.33 FALSE