Best TWAS P=2.17e-10 · Best GWAS P=5.17e-10 conditioned to 0.0659
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PCCB | 0.09 | 0.19 | lasso | 7 | 0.18 | 1.2e-21 | -6.1 | -6.0 | 2.5e-09 | 0.95 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Coronary | RP11-85F14.5 | 0.15 | 0.01 | lasso | 4 | 0.00 | 2.3e-01 | -6.2 | -6.1 | 9.1e-10 | 0.97 | 0.03 | 0.83 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | PCCB | 0.11 | 0.01 | enet | 12 | 0.01 | 2.1e-01 | -5.8 | -5.7 | 1.5e-08 | 0.80 | 0.04 | 0.52 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PCCB | 0.10 | 0.09 | lasso | 3 | 0.07 | 5.0e-06 | -5.8 | -5.6 | 2.1e-08 | 0.87 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Colon Transverse | PCCB | 0.07 | 0.06 | lasso | 3 | 0.04 | 7.7e-03 | -5.9 | -5.7 | 1.4e-08 | 0.91 | 0.04 | 0.90 | FALSE |
| 6 | GTEx | Esophagus Mucosa | PCCB | 0.10 | 0.12 | lasso | 3 | 0.11 | 4.8e-08 | -6.2 | -5.9 | 4.0e-09 | 0.93 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Heart Left Ventricle | PCCB | 0.08 | 0.05 | enet | 7 | 0.01 | 7.2e-02 | -5.4 | -5.6 | 2.7e-08 | 0.90 | 0.04 | 0.95 | FALSE |
| 8 | GTEx | Lung | PCCB | 0.07 | 0.04 | lasso | 3 | 0.03 | 4.2e-03 | -5.7 | -5.8 | 5.0e-09 | 0.86 | 0.04 | 0.89 | FALSE |
| 9 | GTEx | Muscle Skeletal | PCCB | 0.09 | 0.09 | enet | 13 | 0.11 | 1.2e-10 | -6.1 | -5.5 | 4.1e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Testis | PCCB | 0.26 | 0.22 | lasso | 10 | 0.22 | 4.7e-10 | -6.2 | -6.0 | 1.6e-09 | 0.93 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Thyroid | PCCB | 0.10 | 0.09 | lasso | 6 | 0.09 | 1.3e-07 | -6.0 | -5.5 | 3.2e-08 | 0.83 | 0.03 | 0.97 | FALSE |
| 12 | METSIM | Adipose | PCCB | 0.07 | 0.06 | lasso | 12 | 0.06 | 4.1e-09 | -6.1 | -5.4 | 6.3e-08 | 0.88 | 0.02 | 0.98 | FALSE |
| 13 | YFS | Blood | PCCB | 0.13 | 0.20 | lasso | 9 | 0.20 | 1.3e-64 | -6.2 | -6.1 | 9.9e-10 | 0.95 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PCCB | 0.05 | 0.03 | blup | 53 | 0.03 | 1.2e-03 | -6.2 | -5.6 | 2.4e-08 | 0.92 | 0.01 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | PCCB | 0.11 | 0.03 | blup | 54 | 0.04 | 2.3e-03 | -6.2 | -6.2 | 5.3e-10 | 0.95 | 0.01 | 0.76 | FALSE |
| 16 | The Cancer Genome Atlas | Esophageal Carcinoma | PCCB | 0.15 | 0.03 | blup | 54 | 0.05 | 9.6e-03 | -5.4 | -6.1 | 1.2e-09 | 0.92 | 0.01 | 0.68 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | PCCB | 0.10 | 0.03 | blup | 53 | 0.02 | 5.8e-02 | -5.4 | -6.0 | 1.9e-09 | 0.93 | 0.01 | 0.72 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MSL2 | 0.07 | 0.02 | enet | 6 | 0.03 | 1.7e-04 | -6.0 | -5.7 | 9.8e-09 | 0.84 | 0.00 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCCB | 0.12 | 0.05 | enet | 7 | 0.09 | 9.7e-11 | -6.0 | -6.1 | 1.4e-09 | 0.84 | 0.01 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STAG1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.1e-03 | 5.6 | -6.3 | 2.2e-10 | 0.81 | 0.04 | 0.89 | TRUE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PCCB | 0.05 | 0.05 | blup | 54 | 0.05 | 3.5e-06 | -6.2 | -5.8 | 8.8e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PCCB | 0.07 | 0.06 | blup | 53 | 0.06 | 2.1e-04 | -5.8 | -5.4 | 7.8e-08 | 0.90 | 0.01 | 0.97 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCCB | 0.06 | 0.05 | lasso | 2 | 0.03 | 1.2e-04 | -6.2 | -5.9 | 4.7e-09 | 0.93 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCCB | 0.11 | 0.10 | lasso | 3 | 0.10 | 1.3e-11 | -6.2 | -6.0 | 2.0e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 25 | The Cancer Genome Atlas | Lung Adenocarcinoma | STAG1 | 0.02 | 0.02 | enet | 6 | 0.02 | 3.5e-03 | -6.2 | -6.1 | 8.9e-10 | 0.99 | 0.02 | 0.89 | FALSE |
| 26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MSL2 | 0.04 | 0.02 | blup | 35 | 0.01 | 1.9e-02 | -6.0 | -5.8 | 5.3e-09 | 0.84 | 0.00 | 0.94 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PCCB | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.4e-11 | -5.4 | -5.5 | 3.7e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | STAG1 | 0.05 | 0.00 | blup | 151 | 0.01 | 2.9e-02 | -6.1 | -6.2 | 6.0e-10 | 0.92 | 0.03 | 0.96 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MSL2 | 0.09 | 0.01 | blup | 35 | 0.02 | 8.1e-03 | 4.7 | -5.8 | 6.9e-09 | 0.85 | 0.00 | 0.90 | FALSE |
| 30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PCCB | 0.12 | 0.07 | enet | 3 | 0.06 | 1.0e-04 | -6.0 | -6.0 | 2.4e-09 | 0.90 | 0.01 | 0.98 | FALSE |
| 31 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PCCB | 0.12 | 0.02 | lasso | 5 | 0.02 | 6.7e-02 | -6.2 | -5.9 | 4.8e-09 | 0.97 | 0.01 | 0.82 | FALSE |
| 32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCCB | 0.06 | 0.02 | lasso | 2 | 0.03 | 2.3e-04 | 4.4 | -5.5 | 4.6e-08 | 0.85 | 0.02 | 0.95 | FALSE |
| 33 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCCB | 0.14 | 0.10 | enet | 6 | 0.10 | 1.0e-06 | -6.2 | -6.2 | 5.1e-10 | 0.96 | 0.00 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Soft Tissue Sarcoma | STAG1 | 0.06 | 0.06 | lasso | 1 | 0.04 | 2.0e-03 | -6.1 | -6.1 | 1.2e-09 | 0.93 | 0.02 | 0.81 | FALSE |
| 35 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PCCB | 0.07 | 0.04 | lasso | 1 | 0.02 | 1.1e-02 | -6.2 | -6.2 | 6.6e-10 | 0.95 | 0.01 | 0.97 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | PCCB | 0.06 | 0.03 | enet | 8 | 0.03 | 2.3e-04 | -6.2 | -5.9 | 4.0e-09 | 0.98 | 0.01 | 0.99 | FALSE |