[Hub]/) : Traits : Neuroticism score :

chr3:135,273,949-137,261,517

Best TWAS P=2.17e-10 · Best GWAS P=5.17e-10 conditioned to 0.0659

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PCCB 0.09 0.19 lasso 7 0.18 1.2e-21 -6.1 -6.0 2.5e-09 0.95 0.02 0.98 FALSE
2 GTEx Artery Coronary RP11-85F14.5 0.15 0.01 lasso 4 0.00 2.3e-01 -6.2 -6.1 9.1e-10 0.97 0.03 0.83 FALSE
3 GTEx Brain Caudate basal ganglia PCCB 0.11 0.01 enet 12 0.01 2.1e-01 -5.8 -5.7 1.5e-08 0.80 0.04 0.52 FALSE
4 GTEx Cells Transformed fibroblasts PCCB 0.10 0.09 lasso 3 0.07 5.0e-06 -5.8 -5.6 2.1e-08 0.87 0.04 0.96 FALSE
5 GTEx Colon Transverse PCCB 0.07 0.06 lasso 3 0.04 7.7e-03 -5.9 -5.7 1.4e-08 0.91 0.04 0.90 FALSE
6 GTEx Esophagus Mucosa PCCB 0.10 0.12 lasso 3 0.11 4.8e-08 -6.2 -5.9 4.0e-09 0.93 0.02 0.98 FALSE
7 GTEx Heart Left Ventricle PCCB 0.08 0.05 enet 7 0.01 7.2e-02 -5.4 -5.6 2.7e-08 0.90 0.04 0.95 FALSE
8 GTEx Lung PCCB 0.07 0.04 lasso 3 0.03 4.2e-03 -5.7 -5.8 5.0e-09 0.86 0.04 0.89 FALSE
9 GTEx Muscle Skeletal PCCB 0.09 0.09 enet 13 0.11 1.2e-10 -6.1 -5.5 4.1e-08 0.92 0.02 0.98 FALSE
10 GTEx Testis PCCB 0.26 0.22 lasso 10 0.22 4.7e-10 -6.2 -6.0 1.6e-09 0.93 0.02 0.98 FALSE
11 GTEx Thyroid PCCB 0.10 0.09 lasso 6 0.09 1.3e-07 -6.0 -5.5 3.2e-08 0.83 0.03 0.97 FALSE
12 METSIM Adipose PCCB 0.07 0.06 lasso 12 0.06 4.1e-09 -6.1 -5.4 6.3e-08 0.88 0.02 0.98 FALSE
13 YFS Blood PCCB 0.13 0.20 lasso 9 0.20 1.3e-64 -6.2 -6.1 9.9e-10 0.95 0.01 0.99 FALSE
14 The Cancer Genome Atlas Bladder Urothelial Carcinoma PCCB 0.05 0.03 blup 53 0.03 1.2e-03 -6.2 -5.6 2.4e-08 0.92 0.01 0.95 FALSE
15 The Cancer Genome Atlas Colon Adenocarcinoma PCCB 0.11 0.03 blup 54 0.04 2.3e-03 -6.2 -6.2 5.3e-10 0.95 0.01 0.76 FALSE
16 The Cancer Genome Atlas Esophageal Carcinoma PCCB 0.15 0.03 blup 54 0.05 9.6e-03 -5.4 -6.1 1.2e-09 0.92 0.01 0.68 FALSE
17 The Cancer Genome Atlas Glioblastoma Multiforme PCCB 0.10 0.03 blup 53 0.02 5.8e-02 -5.4 -6.0 1.9e-09 0.93 0.01 0.72 FALSE
18 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MSL2 0.07 0.02 enet 6 0.03 1.7e-04 -6.0 -5.7 9.8e-09 0.84 0.00 0.97 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PCCB 0.12 0.05 enet 7 0.09 9.7e-11 -6.0 -6.1 1.4e-09 0.84 0.01 0.99 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma STAG1 0.04 0.02 lasso 3 0.02 4.1e-03 5.6 -6.3 2.2e-10 0.81 0.04 0.89 TRUE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCCB 0.05 0.05 blup 54 0.05 3.5e-06 -6.2 -5.8 8.8e-09 0.90 0.01 0.99 FALSE
22 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PCCB 0.07 0.06 blup 53 0.06 2.1e-04 -5.8 -5.4 7.8e-08 0.90 0.01 0.97 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma PCCB 0.06 0.05 lasso 2 0.03 1.2e-04 -6.2 -5.9 4.7e-09 0.93 0.01 0.99 FALSE
24 The Cancer Genome Atlas Lung Adenocarcinoma PCCB 0.11 0.10 lasso 3 0.10 1.3e-11 -6.2 -6.0 2.0e-09 0.95 0.01 0.99 FALSE
25 The Cancer Genome Atlas Lung Adenocarcinoma STAG1 0.02 0.02 enet 6 0.02 3.5e-03 -6.2 -6.1 8.9e-10 0.99 0.02 0.89 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MSL2 0.04 0.02 blup 35 0.01 1.9e-02 -6.0 -5.8 5.3e-09 0.84 0.00 0.94 FALSE
27 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PCCB 0.13 0.10 lasso 4 0.10 2.4e-11 -5.4 -5.5 3.7e-08 0.92 0.02 0.98 FALSE
28 The Cancer Genome Atlas Lung Squamous Cell Carcinoma STAG1 0.05 0.00 blup 151 0.01 2.9e-02 -6.1 -6.2 6.0e-10 0.92 0.03 0.96 FALSE
29 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MSL2 0.09 0.01 blup 35 0.02 8.1e-03 4.7 -5.8 6.9e-09 0.85 0.00 0.90 FALSE
30 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PCCB 0.12 0.07 enet 3 0.06 1.0e-04 -6.0 -6.0 2.4e-09 0.90 0.01 0.98 FALSE
31 The Cancer Genome Atlas Pancreatic Adenocarcinoma PCCB 0.12 0.02 lasso 5 0.02 6.7e-02 -6.2 -5.9 4.8e-09 0.97 0.01 0.82 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma PCCB 0.06 0.02 lasso 2 0.03 2.3e-04 4.4 -5.5 4.6e-08 0.85 0.02 0.95 FALSE
33 The Cancer Genome Atlas Soft Tissue Sarcoma PCCB 0.14 0.10 enet 6 0.10 1.0e-06 -6.2 -6.2 5.1e-10 0.96 0.00 0.99 FALSE
34 The Cancer Genome Atlas Soft Tissue Sarcoma STAG1 0.06 0.06 lasso 1 0.04 2.0e-03 -6.1 -6.1 1.2e-09 0.93 0.02 0.81 FALSE
35 The Cancer Genome Atlas Stomach Adenocarcinoma PCCB 0.07 0.04 lasso 1 0.02 1.1e-02 -6.2 -6.2 6.6e-10 0.95 0.01 0.97 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma PCCB 0.06 0.03 enet 8 0.03 2.3e-04 -6.2 -5.9 4.0e-09 0.98 0.01 0.99 FALSE