[Hub]/) : Traits : Neuroticism score :

chr3:48,702,606-51,234,774

Best TWAS P=4.47e-09 · Best GWAS P=4.6e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous HYAL1 0.09 0.06 lasso 1 0.05 4.3e-05 5.3 5.3 8.8e-08 0.90 0.01 0.98 FALSE
2 GTEx Brain Caudate basal ganglia RBM6 0.20 0.14 enet 16 0.11 5.5e-04 -3.9 -5.5 3.2e-08 -0.29 0.66 0.11 FALSE
3 GTEx Brain Cerebellum RNF123 0.36 0.31 enet 43 0.36 2.4e-11 4.2 5.1 3.1e-07 0.11 0.53 0.43 FALSE
4 GTEx Brain Frontal Cortex BA9 GPX1 0.16 0.06 lasso 6 0.15 7.9e-05 3.8 5.6 2.2e-08 0.01 0.05 0.40 TRUE
5 GTEx Cells Transformed fibroblasts SEMA3B-AS1 0.15 0.01 enet 3 0.00 3.9e-01 5.0 5.4 6.8e-08 0.89 0.03 0.91 FALSE
6 GTEx Esophagus Gastroesophageal Junction HYAL1 0.30 0.13 lasso 9 0.10 2.1e-04 5.3 5.4 6.2e-08 0.91 0.02 0.96 FALSE
7 GTEx Esophagus Mucosa CYB561D2 0.07 0.02 lasso 4 0.02 3.1e-02 5.6 -5.3 1.0e-07 -0.92 0.03 0.89 FALSE
8 GTEx Esophagus Muscularis RASSF1 0.10 0.00 lasso 7 0.01 8.7e-02 4.9 5.4 7.7e-08 0.82 0.06 0.66 FALSE
9 GTEx Esophagus Muscularis HYAL1 0.11 0.08 lasso 5 0.05 3.3e-04 5.3 5.6 2.4e-08 0.92 0.01 0.99 FALSE
10 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 -3.6 5.2 1.8e-07 0.01 0.04 0.38 FALSE
11 GTEx Muscle Skeletal HYAL1 0.08 0.08 lasso 3 0.06 7.6e-07 5.8 5.8 6.3e-09 0.94 0.01 0.99 FALSE
12 GTEx Muscle Skeletal CYB561D2 0.13 0.06 enet 14 0.07 1.4e-07 4.7 -5.2 2.4e-07 -0.86 0.06 0.93 FALSE
13 GTEx Nerve Tibial HYAL1 0.08 0.06 enet 14 0.05 3.6e-04 3.6 5.8 8.8e-09 0.61 0.06 0.84 FALSE
14 GTEx Nerve Tibial U73166.2 0.07 0.03 lasso 3 0.03 2.8e-03 5.8 -5.9 4.5e-09 -0.96 0.01 0.98 TRUE
15 GTEx Skin Sun Exposed Lower leg HYAL1 0.08 0.04 lasso 4 0.04 3.4e-04 5.9 -5.4 8.4e-08 -0.97 0.01 0.98 FALSE
16 GTEx Thyroid U73166.2 0.05 0.02 enet 6 0.01 5.9e-02 5.8 -5.8 5.0e-09 -0.98 0.01 0.97 FALSE
17 METSIM Adipose CYB561D2 0.09 0.08 lasso 5 0.07 3.8e-10 5.2 -5.2 2.1e-07 -0.89 0.02 0.98 FALSE
18 ROSMAP Brain Pre-frontal Cortex CACNA2D2 0.05 0.02 lasso 3 0.02 3.6e-03 5.8 -5.8 7.4e-09 -0.94 0.01 0.98 FALSE
19 ROSMAP Brain Pre-frontal Cortex SEMA3B 0.05 0.03 lasso 6 0.02 8.3e-04 5.2 5.4 6.2e-08 0.91 0.01 0.99 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma HYAL1 0.10 0.06 lasso 3 0.05 1.2e-06 5.8 5.4 8.8e-08 0.93 0.00 1.00 FALSE
21 The Cancer Genome Atlas Prostate Adenocarcinoma CYB561D2 0.08 0.07 lasso 2 0.09 1.7e-09 4.7 -5.5 4.8e-08 -0.92 0.02 0.98 FALSE