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chr3:48,702,606-51,234,774

Best TWAS P=4.47e-09 · Best GWAS P=4.6e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HYAL1	0.09	0.06	lasso	1	0.05	4.3e-05	5.3	5.3	8.8e-08	0.90	0.01	0.98	FALSE
2	GTEx	Brain Caudate basal ganglia	RBM6	0.20	0.14	enet	16	0.11	5.5e-04	-3.9	-5.5	3.2e-08	-0.29	0.66	0.11	FALSE
3	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	4.2	5.1	3.1e-07	0.11	0.53	0.43	FALSE
4	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	3.8	5.6	2.2e-08	0.01	0.05	0.40	TRUE
5	GTEx	Cells Transformed fibroblasts	SEMA3B-AS1	0.15	0.01	enet	3	0.00	3.9e-01	5.0	5.4	6.8e-08	0.89	0.03	0.91	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	HYAL1	0.30	0.13	lasso	9	0.10	2.1e-04	5.3	5.4	6.2e-08	0.91	0.02	0.96	FALSE
7	GTEx	Esophagus Mucosa	CYB561D2	0.07	0.02	lasso	4	0.02	3.1e-02	5.6	-5.3	1.0e-07	-0.92	0.03	0.89	FALSE
8	GTEx	Esophagus Muscularis	RASSF1	0.10	0.00	lasso	7	0.01	8.7e-02	4.9	5.4	7.7e-08	0.82	0.06	0.66	FALSE
9	GTEx	Esophagus Muscularis	HYAL1	0.11	0.08	lasso	5	0.05	3.3e-04	5.3	5.6	2.4e-08	0.92	0.01	0.99	FALSE
10	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	-3.6	5.2	1.8e-07	0.01	0.04	0.38	FALSE
11	GTEx	Muscle Skeletal	HYAL1	0.08	0.08	lasso	3	0.06	7.6e-07	5.8	5.8	6.3e-09	0.94	0.01	0.99	FALSE
12	GTEx	Muscle Skeletal	CYB561D2	0.13	0.06	enet	14	0.07	1.4e-07	4.7	-5.2	2.4e-07	-0.86	0.06	0.93	FALSE
13	GTEx	Nerve Tibial	HYAL1	0.08	0.06	enet	14	0.05	3.6e-04	3.6	5.8	8.8e-09	0.61	0.06	0.84	FALSE
14	GTEx	Nerve Tibial	U73166.2	0.07	0.03	lasso	3	0.03	2.8e-03	5.8	-5.9	4.5e-09	-0.96	0.01	0.98	TRUE
15	GTEx	Skin Sun Exposed Lower leg	HYAL1	0.08	0.04	lasso	4	0.04	3.4e-04	5.9	-5.4	8.4e-08	-0.97	0.01	0.98	FALSE
16	GTEx	Thyroid	U73166.2	0.05	0.02	enet	6	0.01	5.9e-02	5.8	-5.8	5.0e-09	-0.98	0.01	0.97	FALSE
17	METSIM	Adipose	CYB561D2	0.09	0.08	lasso	5	0.07	3.8e-10	5.2	-5.2	2.1e-07	-0.89	0.02	0.98	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	CACNA2D2	0.05	0.02	lasso	3	0.02	3.6e-03	5.8	-5.8	7.4e-09	-0.94	0.01	0.98	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	SEMA3B	0.05	0.03	lasso	6	0.02	8.3e-04	5.2	5.4	6.2e-08	0.91	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	HYAL1	0.10	0.06	lasso	3	0.05	1.2e-06	5.8	5.4	8.8e-08	0.93	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYB561D2	0.08	0.07	lasso	2	0.09	1.7e-09	4.7	-5.5	4.8e-08	-0.92	0.02	0.98	FALSE