TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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chr1:178,129,899-179,534,540
Best TWAS P=7.36e-09 · Best GWAS P=1.26e-10 conditioned to 0.00484
178.2M
178.4M
178.6M
178.8M
179M
179.2M
179.4M
179.6M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Aorta
ANGPTL1
0.14
0.08
lasso
3
0.07
7.4e-05
6.3
5.8
7.4e-09
0.90
0.01
0.97
TRUE
2
The Cancer Genome Atlas
Lung Adenocarcinoma
ANGPTL1
0.07
0.04
blup
42
0.05
2.3e-06
-3.5
5.5
3.8e-08
0.74
0.05
0.92
FALSE