TWAS
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Models
Genes
Traits
[Hub]/) :
Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
←
→
chr3:128,334,272-129,714,372
Best TWAS P=5.18e-09 · Best GWAS P=3.16e-09 conditioned to 0.00491
128.4M
128.6M
128.8M
129M
129.2M
129.4M
129.6M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
H1FX
0.02
0.00
blup
36
0.00
5.1e-01
-5.9
5.8
5.2e-09
-0.65
0.01
0.60
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
H1FX
0.02
0.02
lasso
5
0.03
6.5e-07
3.6
5.8
8.3e-09
-0.62
0.09
0.88
FALSE
1
YFS
Blood
H1FX
0.02
0.01
lasso
3
0.01
1.4e-03
-5.2
5.3
8.7e-08
-0.84
0.04
0.75
FALSE