TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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chr3:56,629,678-58,613,378
Best TWAS P=1.65e-08 · Best GWAS P=1e-10 conditioned to 0.00726
57M
57.5M
58M
58.5M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
SLMAP
0.06
0.05
lasso
4
0.05
0.00052
6.1
5.7
1.6e-08
0.63
0.04
0.93
TRUE
4
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
HESX1
0.08
0.05
blup
29
0.04
0.01120
4.5
5.2
2.1e-07
0.16
0.02
0.11
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
SLMAP
0.01
0.01
blup
86
0.01
0.00911
5.9
5.3
1.1e-07
0.62
0.04
0.75
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
DNAH12
0.04
0.00
blup
448
0.02
0.00103
2.6
5.2
2.0e-07
0.26
0.18
0.08
FALSE