Best TWAS P=1.65e-08 · Best GWAS P=1e-10 conditioned to 0.00726
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | SLMAP | 0.06 | 0.05 | lasso | 4 | 0.05 | 0.00052 | 6.1 | 5.7 | 1.6e-08 | 0.63 | 0.04 | 0.93 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | DNAH12 | 0.04 | 0.00 | blup | 448 | 0.02 | 0.00103 | 2.6 | 5.2 | 2.0e-07 | 0.26 | 0.18 | 0.08 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLMAP | 0.01 | 0.01 | blup | 86 | 0.01 | 0.00911 | 5.9 | 5.3 | 1.1e-07 | 0.62 | 0.04 | 0.75 | FALSE |
| 4 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HESX1 | 0.08 | 0.05 | blup | 29 | 0.04 | 0.01120 | 4.5 | 5.2 | 2.1e-07 | 0.16 | 0.02 | 0.11 | TRUE |