Best TWAS P=1.12e-15 · Best GWAS P=1.77e-13 conditioned to 0.000368
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAM19 | 0.09 | 0.08 | lasso | 6 | 0.05 | 5.6e-05 | -7.2 | -7.2 | 6.7e-13 | -0.53 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | ADAM19 | 0.11 | 0.10 | lasso | 1 | 0.06 | 3.6e-04 | -7.2 | -7.2 | 5.9e-13 | -0.52 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | ADAM19 | 0.08 | 0.03 | lasso | 1 | -0.01 | 7.7e-01 | 5.7 | -5.7 | 1.0e-08 | -0.39 | 0.05 | 0.21 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | ADAM19 | 0.11 | 0.14 | lasso | 6 | 0.10 | 5.1e-04 | -7.2 | -7.0 | 2.0e-12 | -0.51 | 0.01 | 0.88 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | ADAM19 | 0.16 | 0.02 | enet | 17 | 0.06 | 3.0e-05 | 3.7 | -6.8 | 1.1e-11 | -0.40 | 0.09 | 0.90 | FALSE |
| 6 | GTEx | Colon Sigmoid | CYFIP2 | 0.24 | 0.26 | lasso | 5 | 0.24 | 6.2e-09 | -5.5 | -5.6 | 2.5e-08 | -0.26 | 0.98 | 0.01 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ADAM19 | 0.14 | 0.03 | enet | 19 | 0.09 | 2.4e-06 | 2.7 | -6.2 | 5.7e-10 | -0.28 | 0.08 | 0.86 | FALSE |
| 8 | GTEx | Muscle Skeletal | ADAM19 | 0.06 | 0.02 | lasso | 4 | 0.01 | 1.5e-02 | -7.2 | -7.8 | 9.5e-15 | -0.47 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Nerve Tibial | ADAM19 | 0.34 | 0.16 | enet | 45 | 0.30 | 1.2e-21 | -4.6 | -5.6 | 2.3e-08 | -0.38 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Ovary | ADAM19 | 0.32 | 0.11 | lasso | 9 | 0.08 | 6.5e-03 | -4.0 | -5.9 | 4.5e-09 | -0.37 | 0.06 | 0.66 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | ADAM19 | 0.10 | 0.01 | lasso | 4 | 0.08 | 5.2e-05 | -4.8 | -6.9 | 4.0e-12 | -0.40 | 0.02 | 0.97 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | ADAM19 | 0.07 | 0.04 | lasso | 6 | 0.06 | 1.2e-05 | -5.9 | -7.7 | 1.2e-14 | -0.45 | 0.02 | 0.97 | FALSE |
| 13 | GTEx | Testis | ADAM19 | 0.16 | 0.00 | enet | 17 | -0.01 | 6.7e-01 | -4.5 | -7.2 | 7.9e-13 | -0.44 | 0.03 | 0.86 | FALSE |
| 14 | GTEx | Whole Blood | ADAM19 | 0.12 | 0.07 | enet | 20 | 0.07 | 9.8e-07 | -4.6 | -5.5 | 5.2e-08 | -0.41 | 0.92 | 0.08 | FALSE |
| 15 | METSIM | Adipose | ADAM19 | 0.08 | 0.07 | lasso | 9 | 0.07 | 2.5e-10 | -7.2 | -7.2 | 5.6e-13 | -0.52 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAM19 | 0.08 | 0.02 | blup | 159 | 0.03 | 5.3e-04 | -5.9 | -8.0 | 1.1e-15 | -0.55 | 0.04 | 0.78 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADAM19 | 0.09 | 0.03 | lasso | 4 | 0.05 | 2.4e-06 | -7.2 | -7.5 | 4.4e-14 | -0.54 | 0.01 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADAM19 | 0.05 | 0.01 | blup | 159 | 0.03 | 9.5e-04 | 3.8 | -7.2 | 5.8e-13 | -0.44 | 0.06 | 0.19 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | ADAM19 | 0.07 | 0.00 | blup | 159 | 0.02 | 2.0e-03 | 2.6 | -7.0 | 2.5e-12 | -0.49 | 0.15 | 0.17 | FALSE |