TWAS
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Models
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Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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→
chr5:176,040,488-177,260,129
Best TWAS P=7.18e-09 · Best GWAS P=5.54e-09 conditioned to 0.0319
176M
176.2M
176.4M
176.6M
176.8M
177M
177.2M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Heart Atrial Appendage
MXD3
0.33
0.15
enet
24
0.16
1.5e-07
2.2
5.8
7.2e-09
0.29
0.80
0.02
TRUE
1
CommonMind
Brain Pre-frontal Cortex
RAB24
0.14
0.06
enet
14
0.09
4.2e-11
4.9
5.5
3.7e-08
0.71
0.10
0.90
TRUE
5
The Cancer Genome Atlas
Colon Adenocarcinoma
RAB24
0.08
0.04
enet
7
0.06
3.4e-04
-3.9
5.7
1.3e-08
0.54
0.01
0.27
FALSE
4
GTEx
Nerve Tibial
RAB24
0.27
0.08
enet
32
0.17
6.3e-12
3.6
5.6
2.1e-08
0.47
0.12
0.86
FALSE
2
GTEx
Artery Tibial
RAB24
0.18
0.09
lasso
3
0.07
2.3e-06
4.9
5.3
1.2e-07
0.77
0.05
0.95
FALSE