Best TWAS P=4.98e-19 · Best GWAS P=6.49e-15 conditioned to 0.72
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CTPS1 | 0.10 | 0.00 | enet | 8 | 0.00 | 4.6e-01 | 4.85 | 5.2 | 2.1e-07 | 0.50 | 0.10 | 0.12 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | CTPS1 | 0.12 | -0.01 | lasso | 4 | -0.01 | 7.5e-01 | 4.80 | 5.3 | 1.2e-07 | 0.42 | 0.04 | 0.07 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | CTPS1 | 0.26 | 0.11 | lasso | 6 | 0.08 | 1.6e-03 | 5.98 | 5.6 | 2.2e-08 | 0.79 | 0.22 | 0.27 | FALSE |
| 4 | GTEx | Lung | CTPS1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.4e-04 | 5.72 | 5.9 | 3.1e-09 | 0.69 | 0.20 | 0.65 | FALSE |
| 5 | GTEx | Nerve Tibial | SCMH1 | 0.16 | 0.03 | enet | 24 | 0.07 | 1.6e-05 | 7.75 | -7.8 | 5.4e-15 | -0.77 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCMH1 | 0.04 | 0.01 | enet | 7 | 0.02 | 2.5e-03 | -0.59 | -5.9 | 3.2e-09 | -0.29 | 0.05 | 0.20 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCMH1 | 0.03 | 0.03 | lasso | 2 | 0.02 | 6.2e-03 | 7.34 | -7.3 | 2.2e-13 | -0.63 | 0.08 | 0.58 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SCMH1 | 0.07 | 0.08 | blup | 97 | 0.07 | 2.5e-07 | 7.79 | -8.9 | 5.0e-19 | -0.89 | 0.01 | 0.99 | TRUE |