TWAS
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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→
chr8:11,527,910-12,966,739
Best TWAS P=1.31e-07 · Best GWAS P=5.85e-07 conditioned to 0.0762
11.6M
11.8M
12M
12.2M
12.4M
12.6M
12.8M
13M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
FAM66A
0.23
0.26
enet
29
0.3
4.7e-39
-3.2
-5.3
1.3e-07
-0.71
0.1
0.77
TRUE