Best TWAS P=2.3e-12 · Best GWAS P=2.27e-16 conditioned to 1.15e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | C10orf11 | 0.35 | 0.27 | lasso | 4 | 0.25 | 9.8e-08 | 6.4 | -6.5 | 9.4e-11 | 0.69 | 0.73 | 0.21 | FALSE |
| 2 | GTEx | Brain Cortex | C10orf11 | 0.32 | 0.15 | lasso | 8 | 0.21 | 1.4e-06 | 6.5 | -7.0 | 2.3e-12 | 0.77 | 0.36 | 0.58 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | C10orf11 | 0.33 | 0.18 | enet | 11 | 0.19 | 9.3e-06 | 6.4 | -6.4 | 2.2e-10 | 0.70 | 0.52 | 0.30 | FALSE |
| 4 | GTEx | Muscle Skeletal | C10orf11 | 0.11 | 0.13 | lasso | 3 | 0.12 | 5.1e-12 | 6.5 | -6.9 | 4.3e-12 | 0.73 | 1.00 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | C10orf11 | 0.20 | 0.23 | lasso | 4 | 0.23 | 1.1e-29 | 6.5 | -6.6 | 3.6e-11 | 0.69 | 1.00 | 0.00 | FALSE |