TWAS
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Traits
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Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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→
chr12:93,165,619-94,589,220
Best TWAS P=4.67e-09 · Best GWAS P=4.26e-16 conditioned to 1.13e-09
93.2M
93.4M
93.6M
93.8M
94M
94.2M
94.4M
94.6M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue (Male)
MRPL42
0.21
-0.01
lasso
2
-0.01
0.6
5.7
-5.9
4.7e-09
-0.47
0.05
0.06
TRUE