[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr12:55,633,142-57,684,978

Best TWAS P=1.07e-11 · Best GWAS P=1.21e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
58	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	-6.2	-6.8	1.1e-11	0.77	0.01	0.76	TRUE
42	GTEx	Thyroid	RP11-977G19.11	0.16	0.11	enet	20	0.13	3.5e-10	5.1	-6.4	2.1e-10	0.41	0.89	0.11	TRUE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	COQ10A	0.06	0.02	blup	27	0.02	5.7e-03	5.1	-5.5	2.9e-08	0.32	0.01	0.57	TRUE
30	GTEx	Nerve Tibial	CNPY2	0.07	0.00	enet	21	0.00	3.2e-01	-5.7	5.5	3.4e-08	-0.53	0.06	0.44	TRUE
13	GTEx	Cells Transformed fibroblasts	PAN2	0.09	0.07	lasso	4	0.05	1.7e-04	5.1	5.4	7.4e-08	-0.21	0.81	0.10	TRUE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	PAN2	0.08	0.04	blup	31	0.03	4.4e-02	5.1	5.3	9.3e-08	-0.22	0.01	0.56	TRUE
33	GTEx	Pituitary	RP11-977G19.11	0.47	0.40	lasso	14	0.40	4.5e-11	5.1	-5.3	1.3e-07	0.21	0.88	0.11	TRUE
26	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	-6.2	6.3	3.7e-10	-0.96	0.02	0.98	FALSE
24	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	-6.2	6.3	3.9e-10	-0.96	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	-5.5	-6.2	5.0e-10	0.93	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	-6.3	-6.2	5.9e-10	0.93	0.01	0.97	FALSE
25	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	-5.3	6.1	9.3e-10	-0.79	0.27	0.66	FALSE
20	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	-5.5	6.1	9.8e-10	-0.84	0.07	0.80	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	-5.5	-5.8	5.0e-09	0.89	0.32	0.68	FALSE
32	GTEx	Pituitary	IL23A	0.27	0.11	lasso	9	0.12	8.0e-04	5.1	5.8	5.4e-09	-0.34	0.16	0.32	FALSE
40	GTEx	Testis	RPS26	0.11	-0.01	enet	29	0.00	2.5e-01	-2.3	-5.8	6.0e-09	0.50	0.04	0.46	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	-5.5	-5.8	6.3e-09	0.89	0.30	0.70	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	-5.5	-5.7	9.5e-09	0.88	0.01	0.97	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	-5.5	-5.7	9.9e-09	0.88	0.23	0.77	FALSE
7	GTEx	Brain Caudate basal ganglia	RP11-977G19.11	0.31	0.25	lasso	5	0.28	1.2e-08	5.1	-5.7	1.1e-08	0.26	0.80	0.12	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	-5.5	-5.7	1.1e-08	0.89	0.32	0.68	FALSE
70	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	-5.5	-5.7	1.1e-08	0.88	0.34	0.66	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	-5.5	-5.7	1.4e-08	0.87	0.36	0.64	FALSE
23	GTEx	Lung	RP11-977G19.11	0.07	0.03	lasso	11	0.04	5.1e-04	5.1	-5.6	1.7e-08	0.25	0.73	0.09	FALSE
39	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	-5.3	5.6	1.7e-08	-0.86	0.11	0.89	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	-5.5	-5.6	1.7e-08	0.86	0.30	0.70	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	-5.5	-5.6	2.0e-08	0.88	0.41	0.59	FALSE
71	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	-5.5	-5.6	2.1e-08	0.86	0.02	0.96	FALSE
21	GTEx	Liver	DGKA	0.33	0.03	lasso	15	0.13	1.4e-04	5.1	5.6	2.4e-08	-0.20	0.09	0.06	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	-5.5	-5.6	2.6e-08	0.85	0.05	0.59	FALSE
64	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	-5.4	-5.5	3.3e-08	0.84	0.44	0.56	FALSE
6	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	-5.5	-5.5	3.5e-08	0.84	0.07	0.74	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	-5.5	-5.5	3.5e-08	0.84	0.38	0.62	FALSE
36	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	-5.3	5.5	4.2e-08	-0.84	0.73	0.27	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	-5.5	-5.5	4.4e-08	0.90	0.34	0.66	FALSE
9	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	-5.3	5.5	4.8e-08	-0.81	0.04	0.60	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	-5.5	-5.4	5.2e-08	0.86	0.47	0.53	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	-5.5	-5.4	5.7e-08	0.85	0.44	0.56	FALSE
43	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	-5.4	-5.4	7.2e-08	0.82	0.05	0.93	FALSE
11	GTEx	Brain Hypothalamus	RP11-977G19.11	0.32	0.20	lasso	6	0.23	4.4e-06	5.1	-5.4	7.4e-08	0.25	0.71	0.10	FALSE
10	GTEx	Brain Cortex	RP11-977G19.11	0.38	0.16	lasso	9	0.12	3.8e-04	5.1	-5.4	8.3e-08	0.20	0.20	0.07	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	-5.4	5.4	8.5e-08	-0.85	0.13	0.86	FALSE
15	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	-5.3	5.3	9.4e-08	-0.83	0.11	0.88	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	-5.3	5.3	1.0e-07	-0.81	0.14	0.84	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	-4.8	-5.3	1.1e-07	0.85	0.37	0.63	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	-4.8	-5.3	1.1e-07	0.86	0.69	0.31	FALSE
41	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	-5.3	5.3	1.2e-07	-0.81	0.74	0.26	FALSE
19	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	-5.3	5.3	1.3e-07	-0.79	0.69	0.31	FALSE
46	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	-5.4	5.3	1.3e-07	-0.79	0.67	0.33	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	-4.8	-5.3	1.3e-07	0.84	0.70	0.30	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	STAT2	0.02	0.02	blup	21	0.01	9.6e-03	5.1	5.3	1.5e-07	-0.20	0.01	0.84	FALSE
4	GTEx	Adipose Subcutaneous	RP11-977G19.11	0.12	0.10	lasso	7	0.09	7.5e-08	5.1	-5.2	1.7e-07	0.23	0.89	0.11	FALSE
44	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	-4.8	-5.2	1.8e-07	0.84	0.64	0.36	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	NABP2	0.12	0.12	lasso	4	0.13	2.7e-16	5.1	5.2	1.8e-07	-0.21	0.86	0.14	FALSE
63	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	-4.8	-5.2	1.8e-07	0.82	0.66	0.34	FALSE
38	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	-5.3	5.2	1.9e-07	-0.80	0.52	0.42	FALSE
12	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	-5.3	-5.2	2.0e-07	0.79	0.05	0.22	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CNPY2	0.06	0.05	lasso	8	0.05	2.3e-06	5.1	-5.2	2.1e-07	0.21	0.89	0.11	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBMS2	0.09	0.04	blup	332	0.02	1.3e-03	-2.9	5.2	2.3e-07	-0.36	0.62	0.10	FALSE
22	GTEx	Liver	STAT2	0.32	0.17	lasso	13	0.14	9.9e-05	5.1	5.2	2.3e-07	-0.20	0.75	0.10	FALSE
31	GTEx	Pancreas	IL23A	0.23	0.01	lasso	13	0.04	1.1e-02	5.1	5.2	2.3e-07	-0.20	0.89	0.11	FALSE
8	GTEx	Brain Cerebellum	RP11-977G19.11	0.17	0.19	lasso	14	0.18	5.4e-06	5.1	-5.2	2.4e-07	0.20	0.60	0.10	FALSE
27	GTEx	Nerve Tibial	IL23A	0.06	0.08	lasso	10	0.07	1.6e-05	5.1	5.2	2.4e-07	-0.21	0.79	0.10	FALSE
28	GTEx	Nerve Tibial	STAT2	0.08	0.05	lasso	3	0.03	5.0e-03	5.1	-5.1	2.7e-07	0.21	0.35	0.09	FALSE
37	GTEx	Skin Sun Exposed Lower leg	CNPY2	0.10	0.08	lasso	5	0.08	5.9e-07	5.1	5.1	2.7e-07	-0.20	0.86	0.11	FALSE
5	GTEx	Adrenal Gland	RP11-977G19.11	0.19	0.16	lasso	15	0.09	3.9e-04	5.1	-5.1	2.8e-07	0.20	0.77	0.11	FALSE
14	GTEx	Cells Transformed fibroblasts	RP11-977G19.11	0.11	0.07	enet	22	0.05	9.5e-05	5.1	-5.1	2.9e-07	0.21	0.88	0.11	FALSE
16	GTEx	Colon Transverse	RP11-977G19.11	0.18	0.05	lasso	2	0.00	1.9e-01	5.1	-5.1	3.0e-07	0.20	0.13	0.06	FALSE
29	GTEx	Nerve Tibial	RP11-977G19.11	0.15	0.18	enet	23	0.20	7.7e-14	5.1	-5.1	3.0e-07	0.21	0.90	0.10	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	RP11-977G19.11	0.18	0.14	lasso	13	0.07	2.0e-03	5.1	-5.1	3.1e-07	0.19	0.60	0.09	FALSE
34	GTEx	Pituitary	CNPY2	0.32	0.19	lasso	11	0.12	6.8e-04	5.1	5.1	3.1e-07	-0.19	0.28	0.11	FALSE