Best TWAS P=8.78e-11 · Best GWAS P=3.08e-08 conditioned to 0.0132
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Esophagus Mucosa | DARS | 0.12 | 0.05 | lasso | 4 | 0.04 | 9.0e-04 | 5.1 | 5.3 | 1.3e-07 | -0.49 | 0.06 | 0.86 | FALSE |
2 | GTEx | Esophagus Muscularis | DARS | 0.12 | 0.11 | lasso | 3 | 0.09 | 3.5e-06 | 5.1 | 5.2 | 2.3e-07 | -0.48 | 0.06 | 0.94 | FALSE |
3 | GTEx | Lung | DARS | 0.07 | 0.05 | lasso | 4 | 0.05 | 5.8e-05 | 5.0 | 5.1 | 2.9e-07 | -0.48 | 0.06 | 0.93 | FALSE |
4 | GTEx | Nerve Tibial | DARS | 0.13 | 0.06 | lasso | 5 | 0.05 | 3.2e-04 | 5.1 | 5.1 | 2.9e-07 | -0.49 | 0.06 | 0.92 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | DARS | 0.15 | 0.11 | enet | 4 | 0.10 | 3.0e-06 | 5.0 | 5.2 | 1.5e-07 | -0.48 | 0.06 | 0.94 | FALSE |
6 | GTEx | Thyroid | DARS | 0.20 | 0.13 | lasso | 3 | 0.15 | 1.3e-11 | 5.1 | 5.3 | 1.3e-07 | -0.50 | 0.07 | 0.92 | FALSE |
7 | METSIM | Adipose | DARS | 0.09 | 0.07 | blup | 311 | 0.09 | 4.6e-13 | 5.3 | 5.2 | 1.6e-07 | -0.38 | 0.04 | 0.96 | FALSE |
8 | NTR | Blood | MCM6 | 0.02 | 0.02 | lasso | 2 | 0.03 | 1.2e-08 | 4.2 | 5.2 | 2.4e-07 | -0.55 | 0.07 | 0.93 | FALSE |
9 | YFS | Blood | DARS | 0.17 | 0.19 | enet | 36 | 0.19 | 8.2e-60 | 5.3 | 6.5 | 8.8e-11 | -0.53 | 0.03 | 0.97 | TRUE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LCT | 0.02 | 0.02 | enet | 3 | 0.03 | 7.6e-07 | 4.6 | -5.1 | 3.1e-07 | 0.55 | 0.04 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DARS | 0.08 | 0.10 | lasso | 4 | 0.09 | 8.8e-05 | 5.1 | 5.2 | 2.6e-07 | -0.49 | 0.02 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DARS | 0.04 | 0.02 | blup | 40 | 0.01 | 2.1e-02 | 5.0 | 5.9 | 4.0e-09 | -0.52 | 0.02 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DARS | 0.04 | 0.04 | blup | 40 | 0.04 | 1.6e-03 | 5.0 | 5.3 | 9.7e-08 | -0.53 | 0.02 | 0.92 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | DARS | 0.22 | 0.15 | enet | 13 | 0.19 | 4.1e-18 | 5.0 | 5.3 | 1.2e-07 | -0.39 | 0.03 | 0.97 | FALSE |