TWAS
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Usage
Models
Genes
Traits
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Traits
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Forced vital capacity (FVC), Best measure
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chr6:158,041,511-159,632,250
Best TWAS P=4.77e-12 · Best GWAS P=6.83e-10 conditioned to 0.00105
158M
158.2M
158.4M
158.6M
158.8M
159M
159.2M
159.4M
159.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
TULP4
0.09
0.05
blup
148
0.04
2.0e-05
5.8
-6.9
4.8e-12
-0.48
0.02
0.97
TRUE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
TULP4
0.03
0.03
lasso
3
0.02
5.1e-03
6.1
-6.2
6.6e-10
-0.99
0.01
0.94
FALSE
1
GTEx
Brain Cerebellar Hemisphere
TULP4
0.44
0.37
lasso
12
0.32
4.3e-09
6.2
5.9
3.5e-09
0.98
0.02
0.98
FALSE
2
GTEx
Brain Cerebellum
TULP4
0.46
0.32
lasso
15
0.28
7.6e-09
5.2
5.3
1.4e-07
0.91
0.19
0.81
FALSE