Hub : Genes

TULP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1650 0.0380 2.7e-11 0.080 0.115 0.117 0.119 0.115 6.0e-10 7.1e-14 4.4e-14 2.9e-14 7.7e-14
2 GTEx Adipose Visceral Omentum 0.1530 0.0650 8.7e-03 -0.004 NA 0.000 NA -0.002 5.6e-01 NA 3.1e-01 NA 4.2e-01
3 GTEx Brain Cerebellar Hemisphere 0.4370 0.0880 3.1e-07 0.370 NA 0.247 NA 0.324 1.9e-10 NA 5.2e-07 NA 4.3e-09
4 GTEx Brain Cerebellum 0.4610 0.0850 1.1e-07 0.316 NA 0.201 NA 0.278 4.7e-10 NA 1.4e-06 NA 7.6e-09
5 GTEx Esophagus Mucosa 0.3780 0.0750 3.7e-09 0.275 NA 0.290 NA 0.265 1.4e-18 NA 1.2e-19 NA 6.9e-18
6 GTEx Muscle Skeletal 0.0757 0.0307 1.2e-03 0.010 NA 0.024 NA 0.013 3.5e-02 NA 1.9e-03 NA 1.6e-02
7 GTEx Stomach 0.2510 0.0620 6.5e-07 0.180 NA 0.144 NA 0.165 5.2e-09 NA 2.3e-07 NA 2.7e-08
8 GTEx Thyroid 0.0950 0.0340 1.3e-03 0.025 NA 0.011 NA 0.033 4.9e-03 NA 4.5e-02 NA 1.4e-03
9 ROSMAP Brain Pre-frontal Cortex 0.0691 0.0262 1.2e-03 0.018 0.017 0.025 0.017 0.029 1.7e-03 2.8e-03 2.8e-04 2.7e-03 1.2e-04
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0879 0.0436 4.5e-04 0.046 0.041 0.037 NA 0.039 6.6e-06 2.0e-05 5.2e-05 NA 3.2e-05
11 TCGA Brain Lower Grade Glioma 0.0320 0.0175 4.9e-03 0.028 0.015 0.009 NA 0.016 3.2e-04 7.4e-03 3.2e-02 NA 5.1e-03
12 TCGA Prostate Adenocarcinoma 0.0569 0.0317 7.0e-03 0.014 0.007 0.016 NA 0.009 1.1e-02 5.7e-02 8.1e-03 NA 3.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.4 0.7 2.9 0.5 -0.3 1.2 0.9 -1.7 -0.0 -1.0 0.2 0.9 0.7 -0.8 0.2
Bipolar Disorder or Schizophrenia 0.2 0.4 1.3 0.0 -0.9 0.6 0.5 -1.0 -0.2 -1.1 0.8 -0.3 -0.3 -0.3 -0.3
Depressed Affect (Nagel 2018) 0.3 0.6 2.0 1.2 0.0 0.1 -0.4 0.8 -0.2 0.3 -0.4 -0.5 -1.4 -0.2 -1.4
Depression (Nagel 2018) 1.1 1.6 5.7 0.9 -0.3 1.1 0.6 -0.8 -1.4 -0.1 0.7 -2.0 -1.4 -1.2 -2.4
Intelligence (Savage-Jansen 2018) 1.5 4.5 19.4 2.1 -0.5 -0.7 -0.6 0.8 -1.1 -0.6 -2.1 3.5 4.4 1.4 2.9
Neuroticism (Nagel 2018) 0.4 0.9 3.8 2.0 0.3 0.1 -0.2 0.9 -0.9 -0.9 -1.3 0.4 -0.3 -0.0 -1.5
Schizophrenia (2018) 0.2 0.4 1.1 -0.5 -1.0 -0.2 -0.1 0.2 -0.2 -0.7 0.9 -1.1 -0.9 0.3 -0.5
Schizophrenia vs Biploar Disorder 1.6 2.1 5.9 1.3 0.4 -2.0 -2.4 2.0 -0.3 1.2 -1.8 0.2 -0.7 1.9 -0.7
Worry (Nagel 2018) 0.1 0.3 0.7 0.5 0.5 0.8 0.4 0.1 0.8 0.1 -0.5 0.7 -0.4 -0.5 0.1
Alzheimer’s Disease (in mother) 0.7 0.9 2.2 -1.2 0.3 -1.5 -0.9 0.3 -0.6 0.9 0.2 -1.4 0.7 1.3 0.6
Alzheimer’s Disease (in father) 1.4 1.6 2.8 1.4 1.7 -1.1 -1.5 1.5 -1.3 -0.0 -1.4 0.8 -0.1 1.1 -1.7
Alzheimer’s Disease (including proxy) 1.1 1.6 5.0 0.5 1.0 -2.1 -1.8 1.5 -1.5 0.7 -0.7 -0.2 0.9 2.2 -0.3
Crohns Disease (2017) 0.7 1.5 3.5 0.6 -0.5 -1.4 -0.7 0.6 -1.5 -1.9 -1.8 -0.1 1.7 1.4 -0.7
Irritable Bowel Disease (IBD) 0.5 1.3 3.5 0.3 0.5 -1.7 -1.3 1.1 -0.6 -1.0 -1.9 -0.7 0.6 1.5 -1.1
Ulcerative Colitis (UC) 0.5 1.0 2.6 0.0 1.2 -1.5 -1.6 1.3 0.4 0.3 -1.3 -0.7 -0.0 1.4 -0.3
Major Depression (MDD) 0.5 0.6 2.4 1.2 0.3 -0.4 0.1 -0.1 -0.9 -1.2 -0.7 0.5 1.6 0.6 0.2
Reaction Time 1.6 3.1 7.6 1.6 0.7 -2.1 -1.9 2.2 -1.0 -1.4 -2.1 2.8 0.9 2.0 -1.2
Verbal and Numeric Reasoning (VNR) 1.9 4.6 18.7 2.5 -0.1 -0.5 -0.4 0.5 -0.4 -1.1 -2.2 3.8 4.3 1.2 2.8
Breast Cancer 0.5 1.1 8.1 -0.6 0.8 0.9 0.8 -0.5 0.4 1.1 -0.2 0.9 0.9 -0.3 2.9
Ovarian Cancer 0.3 0.4 1.6 0.4 1.2 -0.1 0.3 1.3 -0.4 -0.5 -0.6 0.9 0.2 -0.1 -0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.8 4.0 8.9 -2.6 -0.8 3.0 2.5 -2.9 1.6 0.3 2.1 -0.6 -1.0 -2.5 1.4
Bipolar Disorder (2011) 2.7 2.7 7.6 0.1 -0.9 1.8 2.2 -1.7 -2.0 -2.8 1.0 -0.8 0.1 -1.9 -1.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.9 0.9 -0.0 -0.1 0.2 0.9 -0.5 -0.7 0.1 -0.7 0.8 0.2 -0.6
Coronary Artery Disease (CAD) 1.1 1.3 2.8 -0.7 -1.6 -1.5 -1.6 0.1 0.1 0.5 1.7 0.3 -1.1 1.4 -1.2
Crohns Disease (2012) 1.1 1.8 4.6 0.4 -0.9 -2.0 -1.6 0.4 -1.5 -0.7 -1.8 0.0 1.8 2.2 -0.1
Mean Putamen Volume 0.8 0.9 3.2 -0.2 -1.8 -0.6 -0.6 0.3 0.5 1.2 -0.4 1.4 0.4 0.7 1.4
Fasting Glucose 1.1 1.3 5.0 -0.8 0.1 -0.1 -0.5 0.0 2.2 2.0 1.1 0.5 0.0 0.6 2.0
HbA1C 0.6 0.6 4.6 0.3 -2.1 0.2 -0.1 -0.6 0.8 0.6 0.4 1.0 0.1 0.0 0.4
HDL Cholesterol 0.2 0.4 3.4 -0.5 -0.4 -0.2 0.7 0.3 0.2 -1.8 0.1 0.2 -0.0 -0.1 0.4
LDL Cholesterol 0.3 0.5 1.7 1.0 -0.4 0.0 0.2 -0.6 -1.2 -1.1 -0.5 -0.2 0.0 -0.2 -1.3
Lupus 0.4 0.6 1.6 0.7 -1.1 -0.8 -0.9 -0.5 -0.8 -0.4 0.1 0.4 0.6 0.8 -1.3
Neuroticism (2016) 0.2 0.3 1.4 0.4 0.3 -0.0 -0.4 -0.2 -0.5 1.2 -0.3 -0.5 -0.7 0.2 -0.9
Primary Biliary Cirrhosis 1.4 2.0 4.5 1.3 -1.0 -2.0 -1.5 1.6 -0.6 -1.6 -0.8 0.8 2.1 1.8 -0.7
Rheumatoid Arthritis 0.4 0.5 3.2 0.6 0.4 -0.5 -0.5 0.6 -0.8 -0.2 -0.7 -0.6 -0.3 0.4 -1.8
Schizophrenia (2014) 0.3 0.8 2.0 -0.5 -1.0 0.7 0.8 -0.8 0.2 -0.6 1.4 -1.1 -1.4 -0.6 -0.4
Triglycerides 0.8 1.3 4.4 0.5 -1.1 -0.0 -0.1 1.1 -1.4 1.2 1.0 -2.1 -1.4 -0.1 -1.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.5 -1.6 -0.3 -0.4 0.3 0.6 -0.5 0.7 1.2 -1.0 0.6 0.7 0.4
Ulcerative Colitis 0.5 0.7 1.9 -0.1 1.4 -0.5 -1.3 0.1 1.1 1.2 -1.1 -0.0 -0.4 0.8 0.2
Blood Eosinophil Count 0.2 1.6 3.8 0.7 0.8 -1.7 -1.4 1.7 -0.5 -0.4 -1.8 0.0 2.0 1.6 -0.2
Blood Platelet Count 0.7 8.0 36.1 3.8 -0.2 -0.9 0.3 0.0 -2.0 -3.3 -3.9 3.3 6.0 0.9 1.6
Blood Red Count 0.8 7.5 12.8 3.6 1.6 -2.7 -1.9 3.0 -2.4 -3.6 -3.5 2.8 2.7 2.9 -1.1
Blood White Count 2.4 18.1 35.3 5.1 2.4 -4.5 -2.6 4.3 -5.1 -4.6 -5.9 2.1 5.8 4.1 -1.6
Heel T-Score 1.9 15.3 32.1 5.2 2.9 -4.3 -4.7 1.4 -3.7 -1.4 -4.3 4.1 5.7 4.9 -0.7
BMI 0.3 1.6 5.2 -0.6 0.3 -1.5 -1.9 1.5 0.8 2.3 0.3 -0.6 0.3 1.6 0.9
Height 3.1 59.2 179.6 -10.9 0.6 7.3 6.1 -3.8 6.6 6.3 9.4 -8.1 -13.4 -8.3 -0.6
Waist Hip Ratio (WHR) 0.8 3.4 9.0 -2.0 -0.4 2.4 1.8 -1.4 1.1 1.7 1.7 -1.9 -3.0 -2.4 1.0
Systolic Blood Pressure 1.1 5.5 11.5 2.0 -0.4 -3.4 -2.9 2.3 -0.8 -0.9 -2.7 2.8 3.1 3.3 0.8
Smoking Status 2.5 6.0 11.8 -1.6 1.4 3.4 2.8 -2.4 1.7 1.2 3.1 -2.7 -3.0 -3.4 0.6
Allergy or Eczema 0.7 1.8 10.6 0.3 1.8 -0.0 0.4 1.1 -1.1 -1.6 -3.2 0.6 1.5 -0.1 -0.1
Cardiovascular Disease 0.1 0.4 1.1 0.7 0.1 -1.0 -0.7 1.0 0.7 -0.3 -0.1 -0.3 0.7 0.6 -0.5
Hypothyroidism (self reported) 1.6 3.7 7.6 2.8 -1.1 -2.6 -2.5 2.3 -1.8 -0.2 -1.6 1.6 1.3 2.6 -0.9
Respiratory disease 1.6 3.5 9.4 1.7 0.5 -2.6 -2.1 1.6 -1.5 -1.1 -3.1 0.7 2.4 2.3 -0.9
Type 2 Diabetes (T2D) (2018) 0.7 1.2 2.8 -0.1 1.0 -1.5 -1.4 1.2 0.3 1.5 -0.3 -0.3 0.6 1.5 1.7
Lung FEV1/FVC ratio 0.3 1.5 5.1 -0.4 1.1 -1.3 -1.3 0.8 0.3 0.3 2.2 -1.8 0.3 1.1 -1.6
Lung FVC 5.3 27.1 50.9 -5.6 -2.0 7.1 6.5 -5.7 3.9 2.0 5.3 -5.0 -6.2 -7.1 1.5
Neuroticism 0.2 0.5 1.3 1.1 0.8 1.2 0.7 -0.6 -0.0 -0.3 -0.6 0.3 -0.3 -1.0 -0.4
Chronotype (morning person) 0.3 0.6 2.0 1.2 -0.3 0.7 0.6 -0.7 0.3 -0.8 0.4 0.7 1.4 -0.8 0.4
Hair Pigment 1.2 34.1 225.0 5.3 2.4 -1.5 -0.2 4.6 -7.2 -5.5 -15.0 2.4 6.0 1.5 -0.6
Tanning 0.1 1.5 4.5 0.9 0.2 1.3 2.0 -1.2 -0.4 -2.1 1.4 -0.4 0.3 -1.5 -1.1
Hand grip strength (left) 2.2 5.8 11.6 -3.0 -1.1 3.0 2.8 -2.6 2.9 0.8 2.2 -1.4 -2.9 -3.4 0.2
Number of treatments/medications taken 0.5 1.0 5.2 0.1 2.3 -0.7 -0.7 1.2 0.2 0.4 -0.3 -1.2 1.2 0.6 0.4
Average weekly spirits intake 2.9 3.6 7.5 2.0 1.2 -2.7 -2.0 2.1 -1.3 -1.2 -2.1 1.9 1.8 2.7 0.2
Sensitivity / hurt feelings 1.5 2.6 9.5 2.4 -0.6 -1.1 -0.6 1.2 -3.1 -2.0 -1.4 -0.2 1.2 1.1 -1.9
Frequency of depressed mood in last 2 weeks 1.0 1.4 4.6 0.7 -0.7 1.2 0.5 -0.3 -0.8 0.2 1.2 -1.9 -1.5 -1.3 -2.1
Hearing difficulty/problems: Yes 2.5 3.8 6.7 -0.5 -1.0 2.6 2.2 -2.2 2.1 2.1 2.5 -0.5 -1.2 -2.3 2.5
Relative age of first facial hair 0.5 1.0 4.3 -1.0 1.4 1.0 0.1 -0.3 1.0 1.4 0.8 -0.1 -2.1 -0.7 -0.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.8 0.7 -0.2 -0.4 -1.2 0.8 -0.8 1.4 -0.5 -0.8 -0.3 0.5 -0.9
Ever used hormone-replacement therapy (HRT) 3.0 3.9 8.5 1.7 1.0 -2.2 -2.5 1.5 -0.2 0.5 -2.5 2.5 2.9 2.5 1.3
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.3 0.1 0.7 0.2 -0.4 0.4 0.8 0.5 -0.5 0.3 -0.8 0.0
Systolic blood pressure, automated reading 1.3 3.6 6.7 2.1 0.8 -2.5 -2.3 1.6 -0.7 -0.4 -2.6 1.8 2.6 2.6 1.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 5.0 -0.7 1.5 0.4 0.5 -0.0 1.7 0.6 0.8 1.2 0.7 -0.3 2.2
Angina 1.4 1.8 5.5 -2.3 -0.8 0.1 -0.4 -0.4 1.5 2.1 1.6 -1.8 -1.6 -0.4 -0.2
Medication for hormone replacement therapy 0.8 0.9 4.6 -0.2 0.2 0.7 0.8 -0.9 1.0 0.5 -0.3 1.3 0.7 -0.4 2.2
Vitamin and mineral supplements 0.6 0.8 2.2 -0.5 -0.8 0.8 0.9 -1.1 -0.2 -0.9 0.6 -0.4 -1.5 -0.8 -1.3
Supplements: Zinc 0.9 0.9 6.9 -0.2 2.6 -0.3 -0.3 0.1 -0.0 0.1 -1.2 -0.9 1.2 0.3 0.4
Medication: Co-codamol 1.0 1.2 7.8 -0.6 -0.6 0.3 0.5 0.1 -0.7 0.1 0.4 -2.8 -1.4 -0.6 -1.4
Medication: Metformin 0.5 0.6 3.6 -0.4 0.8 -0.2 -0.2 0.0 -0.0 1.3 -0.2 -0.4 1.1 0.3 1.9
Diabetes (father) 1.2 1.5 3.7 -1.0 -0.4 1.0 0.4 -1.0 1.4 1.9 1.9 -0.5 -1.8 -1.0 1.2
Diabetes (mother) 2.0 2.6 8.7 -2.0 0.5 1.3 0.7 -1.0 2.1 1.5 2.3 -0.9 -3.0 -1.3 0.1
Severe depression (siblings) 1.2 1.3 7.4 -0.6 -2.7 1.2 1.0 -1.0 -0.0 0.5 1.2 -0.8 -0.8 -1.3 -0.5
Pack years adult smoking proportion 4.0 6.1 13.4 -2.7 -0.4 3.3 3.6 -2.0 1.6 -0.4 3.4 -1.9 -2.5 -3.7 -0.3
Impedance of leg (right) 0.4 2.1 4.4 2.1 -0.4 -1.8 -1.9 1.4 -0.1 -0.3 -1.4 2.1 1.2 2.0 -0.0
Leg fat-free mass (left) 1.5 7.8 20.5 -4.1 0.1 2.6 2.2 -1.3 2.1 2.6 3.5 -3.3 -4.5 -3.0 -0.0
Trunk fat percentage 0.7 2.9 10.9 -1.9 0.6 -1.2 -1.9 1.7 2.4 3.3 0.8 0.3 -1.3 1.2 1.7
Hand grip strength (right) 3.3 8.9 20.1 -3.9 -0.5 3.2 2.7 -2.5 3.5 2.1 3.0 -3.1 -4.5 -3.6 0.0
Townsend deprivation index at recruitment 1.2 1.7 3.6 -1.4 0.6 1.4 0.9 -0.6 1.8 1.4 1.9 -0.8 -1.7 -1.6 0.1
Current tobacco smoking 3.7 6.0 13.1 -2.2 0.2 3.3 3.4 -3.2 0.7 0.4 2.7 -2.6 -2.5 -3.6 0.4
Average weekly fortified wine intake 0.4 0.5 3.0 0.2 0.2 -0.0 -0.4 -0.8 0.9 0.0 -0.5 1.7 -0.1 0.2 0.6
Maternal smoking around birth 1.2 1.8 6.9 -0.4 0.2 1.7 1.1 -0.7 2.6 0.3 0.9 2.1 -0.3 -1.3 1.5
Fed-up feelings 0.8 1.4 4.3 1.8 0.9 -1.1 -1.4 2.1 -0.3 -0.1 -1.2 1.1 1.0 1.3 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 -0.1 -1.2 1.0 0.6 -1.1 -0.2 0.4 1.1 -0.8 -1.2 -0.9 -0.5
Relative age voice broke 0.6 0.9 4.0 -0.4 0.5 -0.5 -1.2 0.5 1.2 2.0 0.5 -0.5 -1.3 0.6 -0.1
Taking other prescription medications 0.4 0.5 2.9 0.5 1.7 -0.3 -0.5 0.7 0.4 0.1 -0.6 -0.9 -0.1 0.1 -1.2
Age when periods started (menarche) 0.1 0.3 0.9 0.7 0.2 0.3 0.7 -0.0 -0.8 -1.0 0.6 -0.4 0.7 -0.3 -0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 3.9 -0.2 2.0 0.1 0.0 -0.1 -0.3 0.6 -0.5 -0.4 0.1 -0.2 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 9.4 1.9 1.4 -2.5 -3.1 1.3 -0.5 1.3 -1.8 1.6 1.4 2.6 -0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.4 -1.4 1.1 0.4 0.5 0.4 1.5 -0.1 0.8 -0.4 -0.7 -0.6 0.2
Qualifications: CSEs or equivalent 0.4 0.5 1.6 0.5 -1.3 -0.4 -0.6 0.3 -0.2 0.3 0.7 -1.0 -0.6 0.2 -1.1
Serious illness, injury or assault to yourself 0.7 0.9 2.9 -0.1 -0.1 -0.7 -1.2 0.3 0.9 1.4 -0.3 -0.7 -1.7 0.4 -1.3
High blood pressure 0.2 0.5 3.7 0.9 0.1 -0.1 -0.0 -0.1 -0.1 -0.0 -0.6 -0.3 1.9 0.1 1.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 4.3 -0.2 1.4 0.4 0.4 1.0 -0.6 -0.5 -2.1 0.0 0.9 -0.2 0.3
Multivitamins +/- minerals 0.4 0.5 1.3 0.6 0.6 -0.6 -0.7 1.1 -0.3 0.7 -0.2 0.4 1.1 0.8 0.6
Stomach or abdominal pain in last month 0.5 0.6 3.0 0.6 1.1 -0.4 -0.6 0.9 -0.5 -0.3 -0.8 -0.0 -0.4 0.1 -1.7
Supplements: Glucosamine 0.3 0.4 1.9 0.1 -0.4 0.6 0.3 -1.1 0.4 0.4 -0.2 0.5 1.4 -0.2 0.9
Diverticular disease/diverticulitis (self-reported) 2.7 3.2 13.9 3.7 2.9 -0.5 -1.1 0.8 -1.7 0.0 -2.5 1.7 1.0 0.7 -0.8
Medication: Atenolol 1.1 1.4 5.8 -1.5 0.7 0.7 0.6 -0.2 1.1 1.5 1.2 -2.4 -0.8 -1.0 0.9
Medication: Levothyroxine sodium 1.9 3.2 7.2 2.3 -0.2 -2.4 -2.3 2.7 -1.5 -0.4 -1.3 1.5 0.5 2.5 -1.2
Sitting height 2.9 20.4 59.0 -5.8 -0.2 4.6 4.1 -2.3 3.2 3.3 5.7 -5.3 -7.7 -5.2 -0.3
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 -0.0 -0.8 -0.5 -0.2 0.8 -0.5 -0.1 0.2 0.2 -0.1 0.4 0.4
High blood pressure (mother) 1.1 1.5 4.7 -0.3 2.2 -1.6 -2.0 0.6 -0.0 1.6 0.4 0.1 -0.7 1.7 -0.6
Body mass index (BMI) 0.4 1.5 4.2 -0.7 0.4 -1.8 -2.0 1.6 0.5 2.0 -0.0 -0.1 0.4 1.8 0.6
Impedance of leg (left) 0.4 1.7 4.3 1.4 -0.0 -1.9 -2.1 1.7 0.2 0.1 -0.9 1.5 0.6 2.0 -0.2
Leg predicted mass (left) 1.5 8.0 20.3 -4.2 -0.0 2.7 2.3 -1.4 2.1 2.5 3.5 -3.3 -4.5 -3.1 -0.1
Trunk fat mass 0.8 3.3 12.5 -2.8 0.7 -0.4 -1.0 1.1 2.5 3.5 1.7 -0.8 -2.3 0.2 1.4
Waist circumference 0.5 1.7 8.4 -1.7 0.5 -0.3 -1.1 0.3 1.4 2.9 1.1 -1.0 -1.6 0.2 0.8
Number of incorrect matches in round 5.1 8.4 22.8 -3.9 0.7 1.8 1.5 -2.1 0.9 2.6 4.8 -4.7 -4.1 -2.1 -1.2
Past tobacco smoking 0.6 1.1 3.1 0.4 0.0 -1.5 -1.8 0.2 -0.9 0.5 -1.7 0.7 0.9 1.4 -1.0
Alcohol usually taken with meals 1.8 2.9 9.5 1.8 0.2 -1.1 -0.9 -0.2 -1.5 -1.4 -2.3 3.1 2.7 1.5 0.7
Nervous feelings 0.1 0.3 0.8 0.4 0.1 0.6 0.5 0.1 0.6 -0.2 -0.7 0.9 -0.1 -0.3 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 5.5 0.9 0.2 -0.8 -1.0 1.4 -1.7 -0.2 -0.8 -1.8 -0.2 0.6 -2.3
Hearing difficulty/problems with background noise 1.3 2.1 5.2 -0.4 -1.1 1.6 1.0 -1.5 2.3 1.8 1.8 0.2 -1.0 -1.3 1.8
Hair/balding pattern: Pattern 2 0.8 1.0 5.2 0.1 -0.7 0.5 0.2 -0.0 0.9 0.5 -0.4 2.1 0.3 -0.1 2.3
Had menopause 0.8 0.9 2.9 0.9 1.2 -0.5 -1.1 0.3 0.3 1.4 -1.7 0.3 1.0 0.8 0.9
Had other major operations 0.8 1.0 5.4 -0.6 -0.1 1.2 0.8 -2.3 0.6 -0.3 0.1 1.1 1.0 -1.1 0.2
Forced vital capacity (FVC) 6.5 25.0 57.6 -5.3 -1.8 6.5 5.4 -5.0 3.9 2.4 5.5 -4.5 -7.6 -6.7 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 2.7 6.1 15.1 2.7 0.3 -3.5 -3.9 1.9 -1.1 0.6 -2.6 2.8 2.3 3.7 -0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 2.5 0.8 -0.3 0.9 0.6 -1.3 0.0 -0.8 -0.7 1.6 0.4 -0.8 0.2
Qualifications: None of the above 0.3 0.6 2.2 -0.1 -0.8 -0.3 -0.2 1.5 0.9 -0.0 0.2 -1.1 -1.0 -0.1 -1.1
Financial difficulties in last 2 years 0.5 0.7 3.8 0.6 0.4 -0.5 -0.6 0.7 -0.5 -0.0 0.7 -0.5 -1.2 0.1 -2.0
Mouth/teeth dental problems 3.4 5.2 16.0 2.8 1.4 -2.2 -2.0 1.0 -4.0 -1.6 -3.3 1.2 2.2 2.2 -1.4
Heart attack 1.3 1.7 6.8 -2.6 0.5 -0.3 -0.5 -0.3 2.1 1.4 1.1 -1.8 -1.3 -0.3 -0.2
Allergy 0.3 0.8 4.5 0.4 -1.7 0.3 0.3 -0.4 0.2 0.4 2.1 0.3 -0.9 -0.1 0.1
Pain all over the body in last month 2.4 2.6 9.3 -1.9 -0.9 0.0 0.3 0.7 1.0 2.0 3.1 -2.4 -2.5 -0.3 -0.3
Diabetes (self-reported) 0.4 0.6 3.0 -0.4 0.8 -0.3 -0.5 -0.2 0.4 1.7 0.4 -0.8 -0.1 0.4 1.4
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.4 -1.6 0.6 1.1 1.4 0.0 1.6 -0.6 -0.4 -0.4 -0.6 -1.4 0.3
Medication: Ramipril 0.6 0.8 2.2 -1.1 -0.0 -0.3 -0.8 -0.1 1.5 1.5 1.1 -0.0 0.2 0.5 1.4
Medication: Simvastatin 0.9 1.4 3.1 -1.6 1.7 0.3 0.3 0.2 1.7 1.1 0.5 -1.7 -1.8 -0.7 -0.0
Fluid intelligence score 0.9 1.8 7.4 1.5 -0.8 -0.1 0.0 -0.1 0.0 -1.1 -1.1 2.7 2.6 0.4 1.5
Illnesses of siblings 0.6 0.9 3.8 -0.3 -0.0 1.1 0.9 -0.8 -0.1 0.1 -0.1 -0.4 -1.9 -1.2 -1.6
Neuroticism score 0.3 0.6 2.9 1.7 -0.7 0.4 -0.1 0.3 -0.0 -0.5 -1.2 1.2 0.5 -0.1 0.1
Weight 0.8 4.0 10.9 -3.2 0.4 0.5 -0.0 0.3 1.9 3.2 2.5 -2.3 -3.3 -0.8 0.3
Impedance of arm (right) 0.2 0.8 4.2 0.7 -0.5 0.9 1.0 -0.0 0.6 -0.6 0.1 2.1 -0.5 -0.8 1.0
Arm fat percentage (right) 0.3 1.3 3.8 -1.0 0.1 -1.3 -1.6 1.5 0.9 1.9 0.3 0.6 0.1 1.3 1.2
Trunk fat-free mass 1.5 8.4 21.8 -4.2 0.2 2.5 2.3 -1.4 1.6 2.2 3.5 -4.2 -4.7 -3.0 -0.9
Hip circumference 0.4 1.7 8.5 -1.4 -0.1 -0.9 -1.6 0.6 1.2 2.9 1.2 -0.2 -1.4 0.8 0.5
Time employed in main current job 0.4 0.5 2.4 -0.3 -0.1 0.4 1.0 -0.4 -0.6 -0.3 0.3 1.6 -0.7 -0.2 1.0
Alcohol intake versus 10 years previously 0.4 0.6 2.6 -0.9 1.1 0.6 -0.0 0.1 0.9 1.6 0.1 -0.4 -0.5 -0.6 0.7
Father’s age at death 1.4 1.9 6.1 -1.4 -0.4 2.0 1.8 -2.5 0.4 0.2 1.1 -0.3 -0.1 -1.6 1.6
Worrier / anxious feelings 0.5 0.9 3.6 1.5 0.3 -0.5 -0.6 1.6 -0.1 -0.4 -1.9 0.9 0.0 0.5 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 8.1 1.4 1.8 -0.7 -1.0 0.8 -0.6 -0.2 -0.9 -0.4 -1.5 0.3 -2.8
Falls in the last year 0.7 0.9 2.2 -0.4 0.2 1.1 1.2 -0.2 1.3 -0.3 1.5 -1.3 -0.3 -1.3 -0.5
Hair/balding pattern: Pattern 3 0.6 0.8 2.9 -1.2 0.1 0.2 0.4 -1.4 0.7 0.8 1.5 -1.7 0.1 -0.5 0.3
Number of live births 0.2 0.3 1.3 1.1 0.2 -0.4 -0.5 0.7 -1.0 0.4 -0.1 -0.3 0.3 0.2 -0.4
Forced expiratory volume in 1-second (FEV1) 5.2 17.7 40.3 -4.6 -1.4 5.1 4.4 -3.9 3.1 1.6 5.2 -4.5 -6.3 -5.3 -1.3
Pulse rate 0.2 0.4 1.3 -0.4 -0.0 0.2 0.1 0.1 -1.1 -0.4 -0.3 -0.9 -1.1 -0.3 -0.9
Happiness 0.7 0.8 2.0 -0.7 0.0 -0.5 -1.3 1.4 0.7 1.4 0.6 -0.3 -1.0 0.6 -1.0
Noisy workplace 0.4 0.5 1.8 -0.1 1.1 -0.5 0.0 0.9 -0.2 -1.3 -0.7 -0.7 0.4 0.3 -0.7
Qualifications: A levels/AS levels or equivalent 1.1 2.4 6.5 -1.0 -0.0 2.3 1.8 -2.5 0.5 1.2 1.1 0.5 -0.6 -1.7 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.1 0.3 -0.6 -0.8 -0.3 1.0 -1.0 -1.0 -0.6 0.9 0.2 0.6 -0.1
Mouth/teeth dental problems: Dentures 1.7 2.9 9.3 -2.3 0.8 1.2 0.8 -0.9 3.1 2.2 2.1 -1.1 -1.6 -1.3 1.3
Asthma 1.1 2.1 5.9 0.9 1.5 -1.6 -1.5 0.4 -1.2 -0.6 -2.4 1.0 2.4 1.6 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.0 -0.1 1.0 0.3 0.2 -0.4 0.3 0.6 0.4 1.4 0.3 -0.1 1.1
Medication: Cholesterol lowering 0.4 0.6 2.1 -1.4 0.7 -0.0 0.1 0.3 0.9 0.5 0.6 -1.3 -1.1 -0.3 -0.4
Depression (self-reported) 0.7 0.8 2.1 1.2 1.5 -0.9 -1.4 0.4 0.3 0.1 -0.9 0.7 0.2 1.0 -1.1
Medication: Lansoprazole 0.5 0.5 1.4 0.6 0.9 0.8 1.2 -0.0 -0.4 -0.8 -0.0 0.0 1.1 -0.7 0.9
Prospective memory result 0.6 0.8 2.2 -1.1 0.7 0.8 1.1 -0.2 0.5 -0.2 1.5 -1.1 -1.1 -0.9 0.2
Lung cancer (father) 1.2 1.5 5.0 1.9 1.3 -0.8 -0.6 1.0 -1.3 -0.7 -1.1 0.3 2.2 1.0 0.8
Illnesses of mother 1.0 1.3 3.8 1.9 -1.2 0.0 0.2 0.1 -0.4 -2.0 -1.8 1.4 0.6 -0.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 4.6 14.7 31.1 -3.6 -1.9 4.8 4.2 -4.1 2.4 0.9 5.0 -3.6 -5.6 -4.9 -1.2
Pulse wave Arterial Stiffness index 0.9 1.1 5.0 -1.0 1.2 1.0 1.1 -0.1 0.8 -0.2 -0.9 0.6 0.9 -0.7 2.2
Impedance of arm (left) 0.3 1.2 3.8 -0.1 -0.3 1.1 1.1 -0.6 1.5 0.1 0.6 1.9 -0.8 -1.0 1.8
Arm fat mass (right) 0.5 2.1 8.1 -2.4 0.2 -0.6 -1.0 1.1 1.6 2.9 1.4 -1.0 -1.5 0.5 0.9
Trunk predicted mass 1.5 8.3 22.5 -4.2 0.2 2.5 2.2 -1.4 1.6 2.2 3.4 -4.1 -4.7 -3.0 -0.9
Standing height 2.1 20.9 66.7 -5.7 0.0 4.8 4.2 -2.3 3.5 3.2 5.7 -4.7 -8.2 -5.4 -0.7
Length of working week for main job 0.7 0.8 4.9 -0.1 0.6 -0.9 -0.7 2.2 -0.4 -0.2 -1.5 -0.1 0.1 0.7 -0.1
Exposure to tobacco smoke at home 0.4 0.5 1.7 -0.2 1.1 0.6 0.3 0.4 0.6 0.9 1.3 -0.5 -0.5 -0.5 0.1
Breastfed as a baby 0.5 0.7 2.2 -0.5 1.2 0.2 -0.1 -1.0 0.5 0.9 0.8 1.0 -0.3 0.2 1.5
Tense / ‘highly strung’ 0.4 0.6 1.8 -0.4 -1.1 1.2 1.4 -0.0 0.3 -0.6 0.2 -1.1 -0.1 -1.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 5.0 1.9 -0.6 0.1 0.8 0.0 0.0 -2.2 -0.8 0.9 1.3 -0.0 -0.0
Hair/balding pattern: Pattern 4 0.5 1.1 2.8 0.4 1.7 -0.7 -0.4 1.7 -1.7 -0.7 -0.8 -1.2 0.4 0.5 -1.0
Birth weight of first child 0.8 1.5 3.4 -1.5 0.6 1.3 1.4 -1.8 1.2 -0.1 1.1 -0.6 -1.8 -1.5 -0.5
Peak expiratory flow (PEF) 3.5 8.2 23.6 -4.2 -2.3 1.9 2.1 -1.2 2.2 1.3 4.9 -3.7 -4.0 -2.3 -1.0
Pulse wave reflection index 0.8 1.0 5.5 -0.3 0.8 -0.2 0.3 0.6 1.0 -0.8 -1.1 0.6 2.3 0.3 1.4
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.3 0.0 2.1 1.4 0.8 -1.4 -0.4 -0.8 -0.3 -0.6 -0.4 -1.6 -1.5
Loud music exposure frequency 1.8 2.0 4.8 1.3 -0.9 1.5 1.3 -1.3 -0.5 -2.1 -1.4 -0.9 0.3 -1.7 -2.2
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 2.1 0.0 -0.6 1.4 1.1 -1.4 -0.7 0.6 1.1 0.2 0.3 -0.9 1.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.3 0.3 -0.1 -1.7 -1.8 1.8 1.0 1.0 -0.6 1.5 -0.8 1.5 0.1
Blood clot in the leg (DVT) 2.9 3.7 9.5 -2.4 1.5 1.8 1.4 -2.1 1.6 0.8 2.0 -3.1 -1.8 -2.1 -1.3
Medication: Paracetamol 0.5 0.9 2.5 1.3 0.4 -0.6 -0.1 1.6 -0.6 -1.2 -0.9 0.7 1.5 0.7 0.0
Headache pain in last month 0.2 0.4 2.5 -0.5 0.4 0.7 0.2 0.1 1.6 0.6 0.2 0.3 -0.1 -0.7 0.0
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.2 0.4 0.4 0.2 -0.4 -0.2 -0.1 0.1 0.1 0.0 -0.1 -0.2
Glaucoma (self-reported) 1.4 1.7 5.5 2.1 0.6 -0.4 -0.2 0.8 -1.1 -1.8 -2.4 1.0 1.9 0.3 0.0
Gout (self-reported) 1.0 1.3 2.9 1.6 -0.4 -1.7 -1.4 1.5 -0.7 -0.4 -1.6 0.8 -0.1 1.4 -0.8
Hypothyroidism/myxoedema (self-reported) 2.4 4.7 9.9 3.1 -0.1 -2.7 -2.4 2.5 -2.0 -0.8 -2.1 2.5 1.8 2.8 -0.5
Medication: Amlodipine 0.8 1.2 3.3 0.6 -1.8 0.8 1.2 -1.8 0.7 -1.3 1.0 -0.2 0.4 -1.1 -0.8
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.3 0.7 0.8 -1.1 -1.1 -0.1 -0.8 -0.7 -1.0 -0.1 1.0 0.9 -0.9
Birth weight 3.3 7.2 19.9 -2.5 0.2 3.1 2.9 -1.3 -0.4 -0.5 2.2 -3.9 -4.5 -3.6 -2.7
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.5 1.4 0.8 -0.2 0.2 1.0 -1.1 -2.1 -1.0 1.6 1.9 0.3 -1.1
High blood pressure (siblings) 0.7 1.0 4.7 -0.4 -0.6 -0.6 -0.1 0.8 -0.2 -0.3 0.7 0.5 2.0 0.8 2.2
Forced vital capacity (FVC), Best measure 5.7 20.7 47.7 -4.4 -1.9 5.9 5.3 -5.0 2.8 1.3 5.1 -4.0 -6.9 -6.2 -0.8
Body fat percentage 0.7 2.6 8.5 -1.3 0.6 -1.7 -2.3 1.9 1.7 2.9 0.4 0.5 -0.3 1.7 1.6
Leg fat percentage (right) 1.0 3.5 9.9 0.1 0.4 -2.7 -3.1 2.3 0.7 2.5 -0.5 1.0 1.2 2.9 1.3
Arm fat-free mass (right) 1.2 5.9 16.8 -3.8 0.8 1.0 0.6 -0.2 1.7 2.9 2.6 -4.1 -4.1 -1.6 -0.8
Exposure to tobacco smoke outside home 0.7 1.0 2.8 -1.2 0.7 0.4 0.6 1.7 1.3 0.5 0.5 -1.4 -1.3 -0.8 0.2
Comparative body size at age 10 0.5 1.5 4.4 1.1 -2.1 -0.9 -0.9 -0.2 -2.0 -0.2 0.5 -1.0 -0.5 0.7 -2.0
Number of full brothers 1.1 1.4 6.2 -1.0 -0.9 0.9 0.5 -0.7 1.7 1.2 2.5 -0.1 -1.2 -0.9 0.5
Worry too long after embarrassment 0.2 0.3 1.4 0.9 -0.6 0.0 0.0 0.4 -0.1 -0.8 -1.2 0.3 0.6 0.1 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.7 1.6 -0.5 -1.0 -0.9 0.8 -0.4 -0.1 -1.1 0.9 0.8 1.2 0.8
Wheeze or whistling in the chest in last year 0.3 0.6 2.7 -0.9 1.6 0.7 0.3 -0.7 0.2 0.0 -0.5 -1.2 0.2 -0.9 -0.3
Number of children fathered 0.3 0.3 1.2 0.3 -0.5 -0.7 -0.8 -0.4 1.1 0.6 -0.2 0.0 0.4 0.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 2.3 0.1 -0.4 0.1 0.5 -0.9 -1.5 -0.8 0.0 -0.5 0.3 0.1 -0.5
Age at first live birth 0.9 1.7 8.6 -0.3 -0.8 2.0 1.4 -2.9 -0.4 -0.8 0.2 0.7 -0.5 -1.8 -0.3
Pulse wave peak to peak time 1.0 1.2 5.7 0.6 -1.3 -0.7 -0.8 0.0 -0.7 0.3 1.2 -1.0 -1.5 0.4 -2.4
Health satisfaction 1.3 1.6 5.2 1.3 0.2 -1.6 -1.7 1.4 -1.0 -0.5 -1.2 1.0 -0.6 1.2 -2.3
Shortness of breath walking on level ground 0.6 0.7 3.0 0.9 0.7 -0.5 -0.7 0.5 -1.0 -0.6 -1.4 -0.1 0.4 0.3 -1.7
Qualifications: College or University degree 0.4 1.4 9.4 0.5 -0.6 0.3 0.0 0.1 0.2 0.4 -1.1 3.1 0.8 0.3 2.2
Eye problems/disorders: None of the above 1.8 2.1 6.9 -1.5 -1.8 0.1 -0.7 -1.0 1.3 1.7 1.0 -1.4 -2.6 -0.2 -1.8
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.9 -1.0 -1.3 1.9 1.9 -1.5 0.2 0.1 1.7 -0.8 -1.4 -2.0 0.1
Emphysema/chronic bronchitis 1.4 1.6 3.7 -1.7 0.2 1.4 1.2 -1.8 0.8 0.6 1.2 -0.9 -1.9 -1.5 -0.6
Medication for pain relief, constipation, heartburn 0.6 1.0 3.3 0.6 -1.8 -0.1 0.1 -1.3 -1.7 -1.1 -0.0 -0.1 -0.2 0.0 -1.4
Neck or shoulder pain in last month 0.8 1.1 2.4 0.8 1.1 -1.5 -1.5 1.0 -0.2 -0.4 -1.4 0.3 1.0 1.3 -1.1
Medication: Blood pressure 0.2 0.4 2.5 -0.3 -0.7 -0.1 -0.3 -0.2 0.4 1.1 0.1 0.6 0.3 0.1 1.6
Angina (self-reported) 1.6 2.1 6.6 -2.6 -0.7 0.3 -0.2 -0.7 1.7 2.1 1.7 -2.0 -1.7 -0.6 -0.4
Migraine (self-reported) 0.4 0.5 3.1 -0.2 -0.3 0.2 -0.1 0.1 0.9 1.7 -0.2 0.1 -0.1 -0.2 1.3
Medication: Ibuprofen 0.4 0.5 1.9 -0.3 0.5 -0.3 -0.4 0.2 0.1 0.8 0.3 1.4 0.6 0.6 1.4
Medication: Allopurinol 0.1 0.1 0.7 0.4 -0.3 -0.2 -0.0 0.4 -0.0 0.1 -0.9 -0.3 -0.2 0.1 0.3
Medication: Omeprazole 1.0 1.2 3.6 1.4 0.4 -1.1 -0.5 1.6 -0.8 -1.7 -0.5 -0.0 1.9 1.2 -0.2
Medication: Seretide 50 evohaler 0.3 0.4 0.9 -0.2 1.0 0.6 1.0 -0.6 0.5 -0.7 -0.0 -0.7 0.1 -0.8 -0.2
Mean time to correctly identify matches 1.2 2.3 5.3 1.3 1.3 -1.7 -1.3 1.9 -0.6 -0.9 -2.0 2.3 1.5 1.8 0.0
Heart disease (mother) 0.6 0.7 2.4 0.5 -1.1 0.2 -0.6 -1.3 -0.0 1.5 0.5 0.1 1.2 0.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.8 0.6 0.4 -1.0 -1.1 1.0 -0.7 0.1 -0.1 -1.3 1.0 1.2 -1.1
Whole body fat mass 0.7 3.1 12.2 -2.6 0.5 -0.6 -1.2 1.1 2.2 3.5 1.7 -0.9 -2.1 0.5 1.3
Leg fat mass (right) 0.5 1.8 8.1 -1.5 0.7 -1.1 -1.6 1.4 1.3 2.8 1.0 -0.4 -1.0 1.0 1.0
Arm predicted mass (right) 1.2 6.1 17.1 -3.9 0.7 1.2 0.8 -0.4 1.8 2.9 2.7 -4.1 -4.1 -1.7 -0.7
Pulse rate, automated reading 0.4 1.3 4.6 0.5 2.1 0.2 0.4 1.1 -1.6 -1.5 -0.5 -1.6 0.4 -0.3 -1.0
Alcohol intake frequency. 0.4 0.9 2.5 -0.8 1.3 0.7 0.5 0.3 0.4 1.3 0.7 -1.6 -1.2 -0.9 -0.1
Comparative height size at age 10 2.1 11.6 34.3 -4.3 -0.8 3.2 2.9 -1.4 3.7 2.9 4.3 -3.2 -5.9 -3.6 0.8
Number of full sisters 0.6 0.7 1.8 -0.9 0.7 -0.8 -1.0 0.0 1.3 1.0 0.8 0.8 -0.5 0.9 0.5
Suffer from ‘nerves’ 0.5 0.8 1.6 0.1 0.4 1.2 0.4 -0.9 1.3 1.2 0.5 0.7 -1.1 -0.8 1.0
Overall health rating 0.4 0.8 2.3 0.1 0.9 -0.3 -0.7 0.4 0.9 1.2 0.9 -0.7 -1.5 -0.2 -1.3
Chest pain or discomfort 1.3 1.8 2.9 -1.4 -0.6 1.5 1.2 -1.7 1.6 1.2 1.7 -1.4 -1.3 -1.6 0.2
Had major operations 2.2 2.6 6.6 -0.4 -1.9 1.9 2.1 -2.6 0.1 -1.1 1.4 -0.7 -1.7 -2.0 -1.4
Age at last live birth 1.0 1.4 6.4 0.5 -0.7 1.6 1.4 -2.5 -0.7 -1.0 0.4 1.0 -0.4 -1.5 -0.4
Family relationship satisfaction 0.5 0.6 2.9 -0.9 -0.8 0.7 0.6 -0.0 0.1 0.6 1.7 0.5 -0.2 -0.4 1.2
Leg pain on walking 0.2 0.2 1.1 0.1 1.1 0.5 -0.1 -0.0 0.4 0.8 0.2 0.3 -0.5 -0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 6.6 -0.9 2.6 0.9 0.7 -0.3 -0.4 0.1 0.5 -1.8 -0.6 -1.0 -0.8
Commuting to job workplace: Car/motor vehicle 3.7 4.3 8.0 2.1 1.1 -2.8 -1.9 2.3 -2.1 -2.4 -1.4 0.8 1.7 2.6 -2.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.6 -0.1 0.3 0.8 -0.5 -0.1 -0.6 0.1 -0.4 0.6 -0.4 0.5
Medication: Aspirin 0.5 0.6 2.8 -1.2 0.9 0.2 0.1 -0.2 1.7 0.7 -0.0 -0.9 -0.8 -0.4 0.5
Supplements: Vitamin C 1.6 1.9 8.6 -0.3 0.9 -1.2 -0.9 2.2 0.0 -0.1 -2.9 0.9 1.7 1.1 1.2
Knee pain experienced in last month 0.8 1.2 3.9 1.2 1.1 -1.2 -1.8 0.4 -0.9 -0.3 -0.7 0.0 0.4 1.2 -2.0
Hypertension (Self-reported) 0.2 0.5 3.6 0.6 0.4 -0.1 0.0 -0.0 0.5 0.1 -0.5 -0.4 1.9 0.0 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 5.1 2.3 1.7 -0.0 0.3 0.0 -1.6 -1.9 -1.1 0.9 1.2 0.2 -0.4
Illnesses of father: Heart disease 0.6 0.8 3.6 -0.0 0.2 -0.4 -0.2 0.1 0.4 -0.4 -1.9 1.3 1.7 0.5 0.9
Illnesses of siblings: Diabetes 0.4 0.5 1.5 -0.5 0.9 0.1 -0.3 -0.3 1.2 1.2 1.2 -0.4 -0.4 0.0 0.7
Smoking status: Previous 0.2 0.4 1.4 0.8 0.1 0.3 0.6 0.5 0.4 -1.2 0.4 0.8 0.3 -0.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.9 -0.5 -1.1 1.4 1.5 -1.0 0.3 0.4 1.3 -1.4 -2.2 -1.7 -1.2
Whole body fat-free mass 1.5 8.4 22.7 -4.3 0.2 2.4 2.1 -1.3 1.9 2.5 3.5 -4.0 -4.8 -3.0 -0.7
Leg fat-free mass (right) 1.6 8.5 22.8 -4.4 0.1 2.7 2.3 -1.3 2.1 2.6 3.6 -3.5 -4.8 -3.1 -0.2
Arm fat percentage (left) 0.5 1.9 6.7 -1.4 0.5 -1.2 -1.7 1.3 1.4 2.6 0.5 0.6 -0.0 1.3 1.8
Average weekly red wine intake 1.3 1.8 8.5 0.8 -0.7 -0.0 0.4 -1.2 -0.6 -1.4 -0.6 2.9 2.4 0.5 1.5
Handedness (chirality/laterality): Left-handed 0.5 0.5 1.1 0.7 0.4 1.1 1.1 -0.9 -0.3 -0.6 -0.3 0.4 0.7 -0.9 0.9
Mood swings 0.1 0.2 1.0 1.0 -0.1 0.4 -0.1 0.4 0.6 0.6 0.6 -0.2 -0.1 -0.2 -0.0
Loneliness, isolation 1.1 1.5 6.0 -0.9 -2.4 0.4 0.3 0.1 0.0 0.4 1.6 -1.8 -1.9 -0.6 -1.1
Long-standing illness, disability or infirmity 0.5 0.8 3.1 0.6 1.5 -1.2 -0.9 1.8 -0.8 0.4 -0.1 -0.4 -0.2 1.0 0.3
Ever had bowel cancer screening 0.9 1.0 2.5 -0.5 0.7 0.8 1.3 0.2 -1.6 -1.4 -0.6 -1.3 -0.6 -1.2 -1.0
Diabetes diagnosed by doctor 0.5 0.8 2.8 -0.2 1.2 -1.0 -1.0 0.4 0.2 1.7 -0.2 -0.4 0.0 1.0 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.3 0.7 1.2 0.5 1.0 -0.0 -1.1 -1.5 0.2 -0.0 0.3 -0.6 -0.8
Friendships satisfaction 2.0 2.5 5.4 -2.0 -1.1 1.8 1.6 -0.8 1.0 0.4 2.3 -1.3 -2.3 -2.0 -0.8
Qualifications: nursing, teaching 0.3 0.5 1.0 -0.0 0.2 0.9 0.6 -0.9 -0.6 0.7 1.0 -0.4 -0.8 -0.6 0.7
Commuting to job workplace: Walk 4.5 4.8 11.1 -2.1 -0.4 3.3 3.2 -2.0 1.9 0.9 1.6 0.7 -1.6 -3.1 2.9
Eye problems/disorders: Cataract 1.1 1.2 3.0 1.3 1.4 -0.7 0.5 1.7 -1.4 -1.7 -0.7 -0.1 1.3 0.5 0.4
Mouth/teeth dental problems: Mouth ulcers 3.5 5.6 14.6 -2.2 -1.1 3.8 3.5 -2.6 1.5 0.2 2.6 -1.9 -0.7 -3.5 1.2
Medication for cholesterol 0.2 0.3 2.3 0.1 -1.5 0.1 -0.0 0.4 -1.0 -0.2 0.1 0.3 -0.3 0.0 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 4.7 -2.1 -0.3 0.4 0.2 -0.1 1.7 2.1 1.9 -1.0 -2.2 -0.4 1.1
Back pain experienced in last month 0.3 0.5 1.9 0.9 0.7 -0.1 -0.9 -0.3 -0.1 1.4 -0.3 -1.1 -0.2 0.3 -0.4
Mineral and other dietary supplements 0.9 1.2 5.2 -1.8 0.0 0.6 0.7 -0.0 0.5 -0.0 1.3 -1.0 -2.3 -0.8 -1.1
Breast cancer (self-reported) 1.1 1.3 4.5 -0.5 2.1 -1.0 -1.2 1.3 0.1 1.6 -0.6 0.3 0.0 1.2 1.6
Asthma (self-reported) 0.9 1.8 5.1 0.7 1.4 -1.6 -1.3 0.5 -1.4 -0.7 -2.3 0.7 2.1 1.5 0.1
Osteoporosis (self-reported) 1.4 1.7 5.0 -0.0 1.7 1.2 1.6 -0.6 -1.5 -1.4 -0.9 -0.8 2.2 -0.9 1.2
Osteoarthritis (self-reported) 0.2 0.3 0.9 -0.3 -0.5 -0.0 -0.3 -0.1 1.0 0.9 0.8 -0.3 -0.4 -0.1 -0.2
Medication: Aspirin 0.5 0.6 2.5 -1.1 0.8 -0.1 -0.3 -0.3 1.6 0.9 -0.3 -1.0 -0.7 -0.0 0.7
Medication: Gliclazide 0.3 0.4 2.2 0.3 0.6 0.3 0.3 -0.3 -1.5 0.8 -0.2 -0.6 0.3 -0.2 0.8
Illnesses of father: None of the above (group 1) 0.6 0.7 2.2 1.1 1.5 -1.0 -0.7 1.1 -1.2 -0.3 -0.2 -0.2 0.3 0.9 -0.6
Smoking status: Current 5.0 8.0 16.7 -2.6 0.1 3.8 3.8 -3.5 1.1 0.9 3.3 -3.0 -3.0 -4.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 2.2 -0.6 -0.6 0.5 0.6 -0.2 0.9 -0.4 0.4 -1.5 -0.9 -0.7 -0.8
Whole body water mass 1.4 7.8 21.3 -4.3 0.3 2.4 2.0 -1.2 1.9 2.4 3.3 -3.9 -4.6 -2.9 -0.6
Leg predicted mass (right) 1.7 8.8 23.2 -4.5 0.1 2.8 2.4 -1.4 2.2 2.6 3.7 -3.5 -4.8 -3.2 -0.1
Arm fat mass (left) 0.6 2.3 9.2 -2.5 0.6 -0.5 -1.0 0.9 1.9 3.0 1.3 -0.9 -1.5 0.3 1.1
Number of self-reported non-cancer illnesses 0.9 1.6 4.3 0.4 2.1 -1.7 -1.8 1.3 -0.2 0.7 -1.9 -0.6 0.7 1.5 -0.2
Average weekly champagne plus white wine intake 1.2 1.7 6.3 1.3 0.4 -1.1 -1.8 0.3 -0.5 0.5 -1.0 2.5 1.6 1.6 1.1
Miserableness 0.5 0.9 3.9 2.0 -1.2 0.8 0.5 -0.1 0.0 -1.2 -1.0 0.9 0.3 -0.8 -0.5
Guilty feelings 2.1 3.2 9.0 3.0 -0.3 -2.1 -1.6 1.8 -1.7 -1.6 -2.1 1.1 0.8 1.9 -1.7
Wears glasses or contact lenses 0.2 0.2 0.6 0.6 -0.1 0.0 0.3 0.1 -0.7 -0.6 -0.3 0.3 0.8 0.4 0.6
Ever taken oral contraceptive pill 0.8 0.8 2.9 0.4 -1.3 -1.3 -1.1 0.3 0.7 -0.3 0.2 1.7 0.4 1.3 -0.1
Hearing aid user 0.9 1.1 3.6 0.4 0.5 1.3 1.4 -1.9 0.5 0.0 0.7 -1.1 0.9 -1.4 0.8
Mother’s age at death 0.1 0.1 0.5 0.1 0.1 0.1 -0.0 -0.4 -0.1 0.3 0.4 -0.7 -0.1 0.1 0.0
Financial situation satisfaction 0.6 0.8 2.3 -0.6 -0.0 -0.7 -1.1 1.1 1.0 0.8 0.5 -0.9 -1.0 0.5 -1.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.1 -0.6 -0.5 -0.2 -0.1 1.4 1.1 0.6 -0.9 -0.5 -0.3 0.2 0.6
Commuting to job workplace: Public transport 1.6 1.9 4.4 -1.0 0.3 1.9 0.8 -2.1 1.7 1.7 0.5 -0.2 -1.8 -1.8 0.4
Eye problems/disorders: Glaucoma 0.8 0.9 3.2 1.6 0.8 -0.2 -0.2 0.6 -0.7 -1.0 -1.6 0.6 1.8 0.1 0.3
Medication: Blood pressure 0.2 0.3 2.0 -0.0 0.7 -0.5 -0.6 0.2 0.5 0.7 0.1 -1.4 0.3 0.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.4 0.4 0.4 0.2 -0.0 0.6 0.1 0.3 -0.2 -0.7 -0.4 -0.4 -0.4
Supplements: Fish oil (including cod liver oil) 1.5 2.0 5.3 1.8 0.4 -1.6 -1.9 1.2 -0.2 0.3 -2.3 1.4 1.8 1.6 -0.2
High cholesterol (Self-reported) 0.3 0.6 2.5 -0.1 1.6 0.5 1.1 0.4 0.6 -1.0 -0.4 -0.5 -0.9 -0.6 -0.2
Medication: Bendroflumethiazide 1.5 2.4 7.1 -2.0 -0.3 1.7 1.6 -2.0 0.3 0.7 2.7 -1.9 -0.2 -1.7 0.5
Medication: Paracetamol 0.6 1.0 3.9 0.9 0.3 -0.8 -0.4 1.6 -0.5 -0.8 -1.2 0.3 2.0 0.8 0.4
Medication: Lisinopril 0.4 0.5 3.3 0.5 -1.8 0.4 0.3 -1.1 -0.3 -0.2 -0.0 0.2 0.5 -0.3 -0.2
Medication: Atorvastatin 0.3 0.3 1.4 0.4 0.7 -0.1 -0.1 0.3 -0.3 -0.8 -0.9 -0.1 0.3 0.0 -1.2
Illnesses of father: High blood pressure 0.6 0.7 1.7 -0.3 -0.7 0.9 0.5 -1.2 0.8 1.0 1.3 -0.8 0.0 -0.6 1.1
Alcohol drinker status: Never 0.5 0.5 2.2 0.5 0.5 0.1 0.6 0.8 -0.5 -1.5 -1.1 0.1 1.1 -0.2 -0.3
Ever smoked 0.8 1.4 4.2 -0.4 0.2 1.7 2.0 -0.3 0.4 -0.1 1.8 -1.0 -1.2 -1.8 0.9
Basal metabolic rate 1.3 7.1 20.2 -4.1 0.2 1.9 1.5 -0.9 1.9 2.8 3.3 -3.6 -4.5 -2.4 -0.5
Leg fat percentage (left) 1.0 3.5 10.2 -0.2 0.6 -2.8 -3.2 2.4 0.6 2.5 -0.3 0.7 1.0 2.9 1.1
Arm fat-free mass (left) 1.1 5.5 15.1 -3.8 0.7 1.1 0.8 -0.2 1.7 2.6 2.4 -3.9 -3.9 -1.6 -0.9
Number of operations (self-reported) 3.0 4.4 14.1 -1.5 -0.1 3.0 2.4 -3.8 1.9 0.7 2.2 0.0 -1.9 -2.9 0.5
Average weekly beer plus cider intake 3.4 4.9 12.0 -3.5 -0.5 2.0 1.4 -0.0 2.7 2.1 2.7 -2.3 -3.3 -2.2 0.7
Irritability 1.2 2.0 6.3 0.1 -1.2 2.5 1.5 -2.1 0.5 0.6 -0.4 1.4 -0.3 -1.9 1.6
Risk taking 1.0 1.4 4.1 -0.8 1.2 1.3 2.0 0.4 0.2 -0.3 0.7 -1.8 -1.6 -1.6 -0.2
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 -0.7 0.7 -0.1 0.5 -0.6 0.3 -0.2 0.3 -0.7 0.6 -0.0 0.7
Fractured/broken bones in last 5 years 0.7 0.9 2.1 -0.8 -1.5 0.9 1.2 -0.9 0.5 -0.4 1.4 -1.2 0.5 -1.0 -0.0
Age started oral contraceptive pill 0.3 0.4 1.5 0.2 1.2 -0.4 -0.5 -0.3 -0.1 -0.1 -0.6 0.8 0.9 0.6 0.2
Diastolic blood pressure, automated reading 1.6 5.1 12.7 1.6 1.3 -3.3 -2.9 3.3 -1.0 0.4 -1.9 1.7 1.8 3.6 1.7
Ever depressed for a whole week 0.2 0.3 0.7 -0.0 0.4 0.7 0.1 -0.4 0.8 0.7 -0.0 0.3 -0.4 -0.6 0.7
Unable to work because of sickness or disability 0.5 0.7 4.3 -0.5 -2.1 -0.5 -0.3 1.4 0.5 0.8 0.3 -0.4 -0.5 0.3 0.3
Commuting to job workplace: Cycle 1.0 1.2 2.8 -0.1 -1.1 1.6 1.7 -1.3 1.1 -0.1 0.6 0.7 0.3 -1.4 1.3
Myopia 0.6 0.9 1.8 0.8 -0.5 -1.1 -1.3 0.1 -1.1 0.5 -1.2 -0.5 0.7 1.2 -1.1
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.1 0.0 0.1 0.3 0.3 -0.3 -0.6 -0.8 -0.0 0.6 -0.9 -0.2 -1.0
Cholesterol lowering medication 0.3 0.4 1.7 -0.1 1.3 -0.8 -0.6 0.0 1.1 0.2 -0.4 0.6 -0.1 0.6 0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 4.6 1.8 0.6 -1.0 -0.6 1.8 -1.4 -1.5 -0.9 0.7 2.1 1.2 -0.1
Pain experienced in last month 0.8 1.3 3.8 -1.3 -1.9 0.8 1.3 -0.9 0.4 -0.3 1.3 1.2 0.1 -0.6 1.8
Supplements: Calcium 0.9 1.0 6.4 -0.5 2.5 -0.6 -0.6 1.6 -0.0 1.0 -0.5 -0.6 -0.2 0.6 0.7
Basal cell carcinoma (self-reported) 0.4 0.5 3.2 0.1 -1.8 0.1 -0.2 -1.0 -0.7 0.6 0.4 -0.5 0.1 -0.1 -0.3
Heart attack/myocardial infarction (self-reported) 1.4 1.8 7.3 -2.7 0.6 -0.2 -0.4 -0.3 2.1 1.5 1.3 -1.8 -1.3 -0.3 0.0
Deep venous thrombosis (DVT) (self-reported) 2.3 3.0 7.7 -2.2 1.1 1.7 1.4 -1.7 1.4 0.2 1.7 -2.8 -1.6 -2.0 -1.6
Heart disease (siblings) 0.7 0.9 2.6 1.1 -0.3 -1.1 -0.7 0.7 0.1 -0.8 -0.6 1.6 1.5 1.0 0.7
Alcohol drinker status: Previous 0.3 0.4 1.5 0.1 0.5 0.1 0.4 0.8 0.4 -0.2 1.0 -1.2 -0.8 -0.3 -0.5
Pack years of smoking 3.5 5.1 11.2 -2.6 -0.1 3.1 3.3 -1.9 1.8 -0.4 3.1 -1.3 -2.1 -3.4 0.2
Impedance of whole body 0.1 0.7 4.3 0.9 -0.2 -0.5 -0.6 0.7 0.8 0.0 -0.5 2.1 -0.1 0.6 0.8
Leg fat mass (left) 0.5 1.9 7.5 -1.5 0.7 -1.3 -1.6 1.7 1.1 2.7 0.9 -0.5 -0.9 1.2 0.9
Arm predicted mass (left) 1.0 5.0 14.5 -3.5 0.6 1.0 0.7 -0.2 1.4 2.4 2.4 -3.8 -3.8 -1.5 -1.2