Best TWAS P=2.35e-08 · Best GWAS P=1.23e-10 conditioned to 0.00025
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | DLG5 | 0.22 | 0.14 | lasso | 6 | 0.11 | 8.5e-05 | -4.8 | -5.6 | 2.6e-08 | -0.04 | 0.02 | 0.96 | TRUE |
2 | GTEx | Brain Cortex | C10orf11 | 0.32 | 0.15 | lasso | 8 | 0.21 | 1.4e-06 | 5.2 | -5.6 | 2.3e-08 | 0.77 | 0.37 | 0.58 | TRUE |
3 | GTEx | Muscle Skeletal | C10orf11 | 0.11 | 0.13 | lasso | 3 | 0.12 | 5.1e-12 | 5.2 | -5.5 | 3.2e-08 | 0.73 | 0.80 | 0.20 | FALSE |
4 | GTEx | Ovary | RP13-39P12.3 | 0.42 | 0.29 | lasso | 5 | 0.33 | 7.5e-09 | -4.9 | -5.2 | 2.4e-07 | -0.01 | 0.02 | 0.97 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | C10orf11 | 0.20 | 0.23 | lasso | 4 | 0.23 | 1.1e-29 | 5.2 | -5.5 | 3.4e-08 | 0.69 | 0.80 | 0.20 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | DLG5 | 0.08 | 0.03 | blup | 116 | 0.06 | 2.1e-04 | 4.3 | -5.2 | 2.2e-07 | -0.07 | 0.05 | 0.90 | FALSE |