TWAS
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Models
Genes
Traits
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Traits
:
Forced vital capacity (FVC), Best measure
:
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chr10:80,443,273-81,901,722
Best TWAS P=2.59e-11 · Best GWAS P=1.12e-07 conditioned to 0.0859
80.4M
80.6M
80.8M
81M
81.2M
81.4M
81.6M
81.8M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
ZCCHC24
0.12
0.01
lasso
6
0.03
0.0034
4.8
6.7
2.6e-11
0.43
0.04
0.80
TRUE
2
GTEx
Heart Atrial Appendage
ZCCHC24
0.19
0.01
lasso
5
0.02
0.0350
4.7
5.2
1.9e-07
0.18
0.05
0.64
TRUE
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
ZCCHC24
0.06
0.00
blup
89
0.01
0.0621
3.4
5.6
1.9e-08
0.17
0.01
0.14
FALSE