Best TWAS P=9.54e-10 · Best GWAS P=7.27e-10 conditioned to 0.0537
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DRAM1 | 0.12 | 0.01 | lasso | 3 | 0.00 | 3.5e-01 | -4.6 | 5.9 | 4.1e-09 | 0.16 | 0.05 | 0.04 | FALSE |
| 2 | GTEx | Artery Aorta | DRAM1 | 0.20 | 0.03 | lasso | 9 | 0.03 | 6.3e-03 | -4.1 | 5.5 | 3.0e-08 | 0.20 | 0.69 | 0.08 | FALSE |
| 3 | METSIM | Adipose | DRAM1 | 0.12 | 0.03 | enet | 24 | 0.08 | 1.1e-12 | 4.4 | 6.1 | 9.5e-10 | 0.13 | 0.98 | 0.02 | TRUE |
| 4 | YFS | Blood | DRAM1 | 0.33 | 0.13 | enet | 101 | 0.19 | 1.6e-58 | 4.5 | 5.9 | 4.5e-09 | 0.12 | 0.97 | 0.02 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC53 | 0.07 | 0.07 | blup | 55 | 0.06 | 1.3e-04 | 5.2 | -5.5 | 5.0e-08 | -0.75 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C12orf48 | 0.09 | 0.08 | lasso | 4 | 0.07 | 3.5e-04 | 5.2 | 5.4 | 6.4e-08 | 0.84 | 0.06 | 0.74 | FALSE |