TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced vital capacity (FVC), Best measure
:
←
→
chr12:101,575,652-103,101,412
Best TWAS P=9.54e-10 · Best GWAS P=7.27e-10 conditioned to 0.0537
101.6M
101.8M
102M
102.2M
102.4M
102.6M
102.8M
103M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
METSIM
Adipose
DRAM1
0.12
0.03
enet
24
0.08
1.1e-12
4.4
6.1
9.5e-10
0.13
0.98
0.02
TRUE
5
The Cancer Genome Atlas
Colon Adenocarcinoma
CCDC53
0.07
0.07
blup
55
0.06
1.3e-04
5.2
-5.5
5.0e-08
-0.75
0.02
0.98
TRUE
1
GTEx
Adipose Subcutaneous
DRAM1
0.12
0.01
lasso
3
0.00
3.5e-01
-4.6
5.9
4.1e-09
0.16
0.05
0.04
FALSE
4
YFS
Blood
DRAM1
0.33
0.13
enet
101
0.19
1.6e-58
4.5
5.9
4.5e-09
0.12
0.97
0.02
FALSE
2
GTEx
Artery Aorta
DRAM1
0.20
0.03
lasso
9
0.03
6.3e-03
-4.1
5.5
3.0e-08
0.20
0.69
0.08
FALSE
6
The Cancer Genome Atlas
Liver Hepatocellular Carcinoma
C12orf48
0.09
0.08
lasso
4
0.07
3.5e-04
5.2
5.4
6.4e-08
0.84
0.06
0.74
FALSE