Best TWAS P=6.07e-18 · Best GWAS P=6.6e-17 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EBPL | 0.34 | 0.16 | bslmm | 399 | 0.33 | 2.5e-41 | 0.17 | -5.7 | 1.5e-08 | -0.17 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TRIM13 | 0.15 | 0.04 | lasso | 5 | 0.12 | 1.1e-14 | 8.21 | -7.5 | 4.6e-14 | -0.80 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | EBPL | 0.27 | 0.03 | enet | 17 | 0.20 | 1.4e-10 | 8.27 | -5.6 | 2.7e-08 | -0.20 | 0.03 | 0.97 | FALSE |
4 | GTEx | Artery Aorta | EBPL | 0.43 | 0.20 | enet | 78 | 0.28 | 8.1e-16 | 7.11 | -6.2 | 6.1e-10 | -0.35 | 0.18 | 0.82 | FALSE |
5 | GTEx | Artery Coronary | EBPL | 0.48 | 0.03 | enet | 99 | 0.12 | 9.7e-05 | 8.27 | -5.1 | 2.9e-07 | -0.31 | 0.04 | 0.86 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | EBPL | 0.54 | 0.32 | enet | 17 | 0.34 | 1.2e-09 | 0.17 | -5.2 | 2.2e-07 | -0.16 | 0.08 | 0.87 | FALSE |
7 | GTEx | Brain Cerebellum | EBPL | 0.50 | 0.30 | enet | 23 | 0.36 | 1.8e-11 | 8.27 | -6.8 | 9.1e-12 | -0.24 | 0.02 | 0.97 | FALSE |
8 | GTEx | Brain Frontal Cortex BA9 | EBPL | 0.50 | 0.20 | enet | 18 | 0.34 | 7.0e-10 | 0.17 | -5.2 | 1.7e-07 | -0.18 | 0.16 | 0.66 | FALSE |
9 | GTEx | Brain Nucleus accumbens basal ganglia | EBPL | 0.25 | 0.11 | enet | 21 | 0.11 | 7.9e-04 | 7.07 | -5.5 | 4.8e-08 | -0.26 | 0.09 | 0.32 | FALSE |
10 | GTEx | Brain Putamen basal ganglia | EBPL | 0.31 | -0.01 | enet | 18 | 0.05 | 2.9e-02 | 7.07 | -6.6 | 5.3e-11 | -0.37 | 0.04 | 0.40 | FALSE |
11 | GTEx | Breast Mammary Tissue (Male) | EBPL | 0.20 | 0.05 | enet | 6 | 0.03 | 7.9e-02 | 1.87 | -5.3 | 1.1e-07 | -0.16 | 0.04 | 0.24 | FALSE |
12 | GTEx | Esophagus Gastroesophageal Junction | EBPL | 0.27 | 0.24 | enet | 14 | 0.26 | 4.6e-10 | 7.03 | -7.3 | 2.2e-13 | -0.30 | 0.42 | 0.58 | FALSE |
13 | GTEx | Esophagus Muscularis | EBPL | 0.39 | 0.16 | enet | 36 | 0.29 | 9.2e-18 | 7.11 | -6.0 | 1.7e-09 | -0.26 | 0.99 | 0.01 | FALSE |
14 | GTEx | Heart Atrial Appendage | EBPL | 0.17 | 0.04 | lasso | 5 | 0.05 | 2.2e-03 | 8.27 | -6.0 | 2.2e-09 | -0.17 | 0.04 | 0.85 | FALSE |
15 | GTEx | Nerve Tibial | EBPL | 0.33 | 0.09 | enet | 25 | 0.27 | 4.6e-19 | 7.03 | -5.8 | 7.3e-09 | -0.24 | 0.55 | 0.45 | FALSE |
16 | GTEx | Nerve Tibial | DLEU2 | 0.11 | 0.05 | lasso | 3 | 0.02 | 7.8e-03 | 8.34 | 8.2 | 1.8e-16 | 0.99 | 0.01 | 0.98 | TRUE |
17 | GTEx | Pancreas | EBPL | 0.18 | 0.10 | enet | 5 | 0.09 | 1.6e-04 | 8.27 | -6.9 | 4.1e-12 | -0.23 | 0.02 | 0.96 | FALSE |
18 | GTEx | Pituitary | EBPL | 0.44 | 0.32 | enet | 29 | 0.37 | 3.1e-10 | 7.11 | -7.6 | 3.6e-14 | -0.37 | 0.17 | 0.82 | FALSE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | EBPL | 0.34 | 0.26 | enet | 12 | 0.30 | 4.0e-17 | 7.11 | -7.4 | 1.8e-13 | -0.26 | 0.36 | 0.64 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | EBPL | 0.28 | 0.21 | lasso | 5 | 0.20 | 2.5e-16 | 6.95 | -7.4 | 1.3e-13 | -0.32 | 0.99 | 0.01 | FALSE |
21 | GTEx | Testis | EBPL | 0.33 | 0.17 | lasso | 6 | 0.24 | 8.4e-11 | 7.03 | -8.6 | 6.1e-18 | -0.32 | 0.08 | 0.92 | TRUE |
22 | GTEx | Thyroid | EBPL | 0.36 | 0.14 | enet | 33 | 0.30 | 5.1e-23 | 7.03 | -7.0 | 3.4e-12 | -0.31 | 0.09 | 0.91 | FALSE |
23 | ROSMAP | Brain Pre-frontal Cortex | EBPL | 0.43 | 0.28 | lasso | 8 | 0.43 | 7.3e-60 | 7.03 | -5.3 | 1.4e-07 | -0.21 | 0.99 | 0.01 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EBPL | 0.27 | 0.16 | blup | 59 | 0.22 | 1.0e-12 | -0.66 | -6.1 | 8.6e-10 | -0.24 | 0.36 | 0.63 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DLEU2 | 0.03 | 0.01 | blup | 61 | 0.02 | 2.4e-03 | 8.26 | 8.0 | 1.4e-15 | 0.90 | 0.01 | 0.96 | FALSE |
26 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EBPL | 0.21 | 0.09 | enet | 10 | 0.13 | 4.9e-06 | 8.27 | -5.6 | 1.7e-08 | -0.23 | 0.00 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | EBPL | 0.28 | 0.18 | blup | 59 | 0.19 | 4.3e-08 | 7.07 | -6.3 | 3.3e-10 | -0.23 | 0.02 | 0.97 | FALSE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EBPL | 0.08 | 0.01 | blup | 59 | 0.04 | 6.4e-05 | 7.07 | -6.9 | 6.4e-12 | -0.27 | 0.01 | 0.87 | FALSE |
29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EBPL | 0.10 | 0.07 | enet | 7 | 0.08 | 2.8e-06 | 8.27 | -5.4 | 6.2e-08 | -0.23 | 0.00 | 0.99 | FALSE |