[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted :

chr4:17,104,059-18,507,692

Best TWAS P=8.19e-27 · Best GWAS P=6.64e-28 conditioned to 1.01e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous DCAF16 0.21 0.15 lasso 3 0.17 5.1e-14 6.0 6.2 5.1e-10 -0.23 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum DCAF16 0.19 0.06 enet 10 0.11 3.9e-06 6.0 7.4 1.1e-13 -0.34 0.39 0.28 FALSE
3 GTEx Artery Aorta DCAF16 0.10 0.01 enet 6 0.02 4.7e-02 -9.6 10.2 1.5e-24 -0.79 0.10 0.58 FALSE
4 GTEx Artery Tibial DCAF16 0.16 0.16 lasso 5 0.13 1.5e-10 6.5 7.3 2.0e-13 -0.35 1.00 0.00 FALSE
5 GTEx Breast Mammary Tissue DCAF16 0.12 0.08 lasso 4 0.10 6.4e-06 6.0 7.8 7.9e-15 -0.51 0.09 0.77 FALSE
6 GTEx Breast Mammary Tissue (Male) DCAF16 0.24 0.03 enet 18 -0.01 4.4e-01 -9.3 10.7 8.2e-27 -0.75 0.03 0.68 TRUE
7 GTEx Breast Mammary Tissue (Female) DCAF16 0.16 0.13 lasso 2 0.06 7.8e-03 6.0 5.8 6.8e-09 -0.26 0.06 0.10 FALSE
8 GTEx Esophagus Mucosa DCAF16 0.10 0.02 lasso 4 0.02 8.3e-03 6.0 6.3 2.5e-10 -0.35 0.14 0.35 FALSE
9 GTEx Esophagus Muscularis DCAF16 0.16 0.14 lasso 3 0.14 9.3e-09 6.0 5.8 6.0e-09 -0.25 0.99 0.00 FALSE
10 GTEx Nerve Tibial DCAF16 0.16 0.14 lasso 3 0.14 2.8e-10 6.0 6.7 1.5e-11 -0.35 0.99 0.00 FALSE
11 GTEx Pituitary DCAF16 0.27 0.20 enet 15 0.19 1.3e-05 6.0 5.9 2.9e-09 -0.37 0.08 0.21 FALSE
12 GTEx Skin Not Sun Exposed Suprapubic DCAF16 0.16 0.08 lasso 5 0.12 4.4e-07 5.8 6.4 2.0e-10 -0.34 0.63 0.05 FALSE
13 GTEx Skin Sun Exposed Lower leg DCAF16 0.14 0.12 enet 14 0.12 5.4e-10 6.0 6.8 8.4e-12 -0.27 1.00 0.00 FALSE
14 GTEx Spleen DCAF16 0.35 0.02 lasso 5 0.11 8.5e-04 6.0 9.1 1.1e-19 -0.65 0.04 0.65 FALSE
15 GTEx Stomach DCAF16 0.21 0.04 lasso 6 0.02 5.6e-02 6.3 7.2 5.9e-13 -0.25 0.19 0.05 FALSE
16 GTEx Thyroid DCAF16 0.11 0.02 lasso 5 0.03 2.3e-03 6.0 9.0 2.1e-19 -0.53 0.21 0.64 FALSE
17 ROSMAP Brain Pre-frontal Cortex DCAF16 0.04 0.02 bslmm 379 0.01 3.9e-02 -9.3 8.8 1.4e-18 -0.83 0.03 0.88 FALSE
18 YFS Blood DCAF16 0.02 0.02 lasso 1 0.01 1.1e-04 6.5 6.5 1.1e-10 -0.25 0.84 0.03 FALSE
19 The Cancer Genome Atlas Colon Adenocarcinoma NCAPG 0.08 0.04 blup 34 0.09 1.1e-05 -9.5 -8.5 2.4e-17 0.82 0.04 0.93 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NCAPG 0.14 0.07 lasso 3 0.07 5.2e-08 -9.3 -9.2 5.3e-20 0.83 0.98 0.01 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma DCAF16 0.09 0.02 lasso 3 0.04 5.2e-05 6.5 9.7 3.4e-22 -0.63 0.08 0.81 FALSE
22 The Cancer Genome Atlas Brain Lower Grade Glioma NCAPG 0.02 0.03 lasso 1 0.02 9.0e-04 -9.5 -9.5 1.4e-21 0.86 0.03 0.48 FALSE
23 The Cancer Genome Atlas Lung Adenocarcinoma NCAPG 0.06 0.02 blup 34 0.04 1.0e-05 -9.5 -5.7 1.4e-08 0.67 0.13 0.06 FALSE
24 The Cancer Genome Atlas Prostate Adenocarcinoma DCAF16 0.04 0.04 blup 31 0.04 2.2e-05 6.0 9.3 1.6e-20 -0.56 0.27 0.22 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma NCAPG 0.02 0.02 blup 34 0.02 3.4e-03 -9.1 -8.5 2.2e-17 0.75 0.01 0.82 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma DCAF16 0.07 0.04 blup 31 0.07 4.9e-07 6.3 9.4 8.1e-21 -0.64 0.15 0.78 FALSE