Best TWAS P=8.19e-27 · Best GWAS P=6.64e-28 conditioned to 1.01e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DCAF16 | 0.21 | 0.15 | lasso | 3 | 0.17 | 5.1e-14 | 6.0 | 6.2 | 5.1e-10 | -0.23 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | DCAF16 | 0.19 | 0.06 | enet | 10 | 0.11 | 3.9e-06 | 6.0 | 7.4 | 1.1e-13 | -0.34 | 0.39 | 0.28 | FALSE |
| 3 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | -9.6 | 10.2 | 1.5e-24 | -0.79 | 0.10 | 0.58 | FALSE |
| 4 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | 6.5 | 7.3 | 2.0e-13 | -0.35 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | 6.0 | 7.8 | 7.9e-15 | -0.51 | 0.09 | 0.77 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | -9.3 | 10.7 | 8.2e-27 | -0.75 | 0.03 | 0.68 | TRUE |
| 7 | GTEx | Breast Mammary Tissue (Female) | DCAF16 | 0.16 | 0.13 | lasso | 2 | 0.06 | 7.8e-03 | 6.0 | 5.8 | 6.8e-09 | -0.26 | 0.06 | 0.10 | FALSE |
| 8 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | 6.0 | 6.3 | 2.5e-10 | -0.35 | 0.14 | 0.35 | FALSE |
| 9 | GTEx | Esophagus Muscularis | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 9.3e-09 | 6.0 | 5.8 | 6.0e-09 | -0.25 | 0.99 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 2.8e-10 | 6.0 | 6.7 | 1.5e-11 | -0.35 | 0.99 | 0.00 | FALSE |
| 11 | GTEx | Pituitary | DCAF16 | 0.27 | 0.20 | enet | 15 | 0.19 | 1.3e-05 | 6.0 | 5.9 | 2.9e-09 | -0.37 | 0.08 | 0.21 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | DCAF16 | 0.16 | 0.08 | lasso | 5 | 0.12 | 4.4e-07 | 5.8 | 6.4 | 2.0e-10 | -0.34 | 0.63 | 0.05 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | DCAF16 | 0.14 | 0.12 | enet | 14 | 0.12 | 5.4e-10 | 6.0 | 6.8 | 8.4e-12 | -0.27 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | 6.0 | 9.1 | 1.1e-19 | -0.65 | 0.04 | 0.65 | FALSE |
| 15 | GTEx | Stomach | DCAF16 | 0.21 | 0.04 | lasso | 6 | 0.02 | 5.6e-02 | 6.3 | 7.2 | 5.9e-13 | -0.25 | 0.19 | 0.05 | FALSE |
| 16 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | 6.0 | 9.0 | 2.1e-19 | -0.53 | 0.21 | 0.64 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | -9.3 | 8.8 | 1.4e-18 | -0.83 | 0.03 | 0.88 | FALSE |
| 18 | YFS | Blood | DCAF16 | 0.02 | 0.02 | lasso | 1 | 0.01 | 1.1e-04 | 6.5 | 6.5 | 1.1e-10 | -0.25 | 0.84 | 0.03 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | -9.5 | -8.5 | 2.4e-17 | 0.82 | 0.04 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | -9.3 | -9.2 | 5.3e-20 | 0.83 | 0.98 | 0.01 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | 6.5 | 9.7 | 3.4e-22 | -0.63 | 0.08 | 0.81 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | -9.5 | -9.5 | 1.4e-21 | 0.86 | 0.03 | 0.48 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | NCAPG | 0.06 | 0.02 | blup | 34 | 0.04 | 1.0e-05 | -9.5 | -5.7 | 1.4e-08 | 0.67 | 0.13 | 0.06 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | 6.0 | 9.3 | 1.6e-20 | -0.56 | 0.27 | 0.22 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | -9.1 | -8.5 | 2.2e-17 | 0.75 | 0.01 | 0.82 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | 6.3 | 9.4 | 8.1e-21 | -0.64 | 0.15 | 0.78 | FALSE |