Best TWAS P=3.42e-08 · Best GWAS P=5.12e-08 conditioned to 0.181
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POLR2A | 0.08 | 0.07 | lasso | 4 | 0.07 | 1.9e-08 | 5.1 | 5.2 | 1.7e-07 | 0.96 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | 4.8 | 5.4 | 6.8e-08 | 0.84 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Mucosa | CHRNB1 | 0.19 | 0.11 | lasso | 2 | 0.13 | 7.3e-09 | 4.8 | 5.5 | 3.4e-08 | 0.87 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Esophagus Mucosa | ZBTB4 | 0.12 | 0.10 | lasso | 2 | 0.08 | 8.0e-06 | 5.4 | 5.5 | 4.9e-08 | 1.00 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Esophagus Muscularis | ZBTB4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 6.3e-04 | 5.1 | 5.2 | 2.5e-07 | 0.96 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | CHRNB1 | 0.17 | 0.15 | lasso | 3 | 0.16 | 7.4e-09 | 4.8 | 5.3 | 8.8e-08 | 0.87 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CHRNB1 | 0.19 | 0.12 | enet | 13 | 0.12 | 3.0e-10 | 5.1 | 5.4 | 8.2e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Stomach | CHRNB1 | 0.28 | 0.19 | lasso | 4 | 0.23 | 2.0e-11 | 4.8 | 5.3 | 1.2e-07 | 0.70 | 0.03 | 0.96 | FALSE |
| 9 | YFS | Blood | CHRNB1 | 0.04 | 0.02 | lasso | 5 | 0.04 | 8.5e-12 | 4.8 | 5.4 | 6.1e-08 | 0.87 | 0.03 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNB1 | 0.18 | 0.09 | enet | 10 | 0.10 | 4.9e-11 | 4.8 | 5.3 | 1.1e-07 | 0.69 | 0.02 | 0.98 | FALSE |