TWAS hub - POLR2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.026	0.0001	0.068	0.027	0.049	0.046	0.066	1.1e-08	0.00024	1.1e-06	2.8e-06	1.9e-08
2	ROSMAP	Brain Pre-frontal Cortex	0.0503	0.021	0.0052	0.013	0.016	0.007	0.019	0.017	6.3e-03	0.00330	3.8e-02	1.6e-03	2.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	14.8	286.2	416.2	20.4	12.5
Standing height	11.6	114.9	176.9	13.3	7.3
Forced expiratory volume in 1-second (FEV1), predicted	10.0	20.9	27.4	5.2	3.8
Medication: Amlodipine	9.9	13.9	19.1	-4.4	-3.0
Deep venous thrombosis (DVT) (self-reported)	9.9	12.7	16.5	-4.1	-3.0
Blood clot in the leg (DVT)	8.9	11.5	15.8	-4.0	-2.7
Alcohol usually taken with meals	8.7	14.1	18.6	4.3	3.1
Sitting height	8.6	61.0	98.6	9.9	4.8
Wears glasses or contact lenses	7.9	9.1	10.2	3.2	2.8
Lung FVC	7.7	39.4	55.8	-7.5	-4.8
Mother’s age at death	7.6	9.5	11.4	2.8	3.4
Headache pain in last month	7.2	12.4	13.4	-3.4	-3.7
Prospective memory result	7.0	8.6	9.0	-3.0	-2.9
Qualifications: CSEs or equivalent	6.8	9.0	11.7	-3.4	-2.5
Average weekly red wine intake	6.7	9.8	10.4	3.2	3.0
Alcohol drinker status: Never	6.1	7.3	7.7	-2.6	-2.8
Trunk fat-free mass	6.0	34.6	59.6	7.7	3.1
Trunk predicted mass	6.0	34.1	58.7	7.7	3.1
High blood pressure (mother)	5.8	8.1	10.4	-2.4	-3.2
Length of working week for main job	5.7	6.3	7.0	2.7	2.4
Heel T-Score	5.6	44.3	55.5	-7.5	-5.8
Frequency of depressed mood in last 2 weeks	5.5	7.8	8.0	-2.7	-2.8
Fed-up feelings	5.5	10.1	12.4	-3.5	-2.8
Heart disease (siblings)	5.5	6.8	8.4	2.3	2.9
Ever used hormone-replacement therapy (HRT)	5.0	6.4	7.1	2.7	2.4
Medication: Bendroflumethiazide	5.0	7.7	8.7	-3.0	-2.6
Depression (Nagel 2018)	4.9	7.3	7.9	-2.8	-2.6
Neuroticism	4.7	11.3	11.3	-3.4	-3.4
Major Depression (MDD)	4.6	5.6	9.6	-3.1	-1.2
Qualifications: A levels/AS levels or equivalent	4.3	9.6	15.9	4.0	1.8
Respiratory disease	4.0	8.8	10.4	3.2	2.7
Whole body fat-free mass	4.0	23.0	40.2	6.3	2.4
Basal cell carcinoma (self-reported)	4.0	4.7	7.5	-2.7	-1.4
Breast Cancer	3.9	9.4	15.8	1.7	4.0
Alcohol intake frequency.	3.9	9.0	10.3	-3.2	-2.8
Whole body water mass	3.9	22.4	39.2	6.3	2.4
Arm predicted mass (left)	3.9	19.6	35.6	6.0	1.9
Diverticular disease/diverticulitis (self-reported)	3.8	4.5	5.8	-2.4	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	3.8	8.8	10.5	-3.2	-2.7
Chest pain or discomfort	3.8	5.5	6.7	2.0	2.6
Mood swings	3.8	6.8	7.1	-2.7	-2.6
Ever had bowel cancer screening	3.8	4.4	4.8	2.0	2.2
Arm fat-free mass (left)	3.8	19.4	35.6	6.0	1.8
Waist Hip Ratio (WHR)	3.7	16.7	22.8	4.8	3.3
Frequency of tiredness / lethargy in last 2 weeks	3.7	6.0	8.4	-2.9	-1.9
Qualifications: nursing, teaching	3.7	5.7	8.6	2.9	1.7
Neuroticism score	3.6	7.5	8.0	-2.8	-2.6
Qualifications: College or University degree	3.6	11.5	17.0	4.1	2.4
Miserableness	3.5	6.1	8.0	-2.8	-2.0
Depressed Affect (Nagel 2018)	3.4	7.1	9.2	-3.0	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	4.8	-2.2	-1.9
Medication: Lansoprazole	3.2	3.6	4.9	-2.2	-1.5
Arm fat-free mass (right)	3.2	16.6	30.2	5.5	1.7
Arm predicted mass (right)	3.2	16.3	29.7	5.5	1.7
Hand grip strength (left)	3.1	8.2	12.4	3.5	2.0
Basal metabolic rate	3.1	17.0	30.5	5.5	1.9
Hand grip strength (right)	3.0	8.2	12.8	3.6	1.9
Bilateral oophorectomy (both ovaries removed)	3.0	3.4	3.5	1.9	1.8
Tense / ‘highly strung’	3.0	5.0	5.7	-2.4	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	10.2	-3.2	-1.6
Primary Biliary Cirrhosis	2.9	4.1	5.3	1.7	2.3
Exposure to tobacco smoke at home	2.9	3.2	3.4	-1.7	-1.8
Leg fat percentage (right)	2.9	10.4	10.9	-3.1	-3.3
Fractured/broken bones in last 5 years	2.8	3.6	4.2	2.1	1.7
Leg fat percentage (left)	2.7	9.9	10.0	-3.1	-3.2
Worry (Nagel 2018)	2.6	5.4	6.1	-2.2	-2.5
Number of children fathered	2.5	2.8	3.1	1.6	1.8
Medication: Blood pressure	2.5	4.4	4.9	-2.2	-2.0
Arm fat percentage (left)	2.5	10.1	14.7	-3.8	-2.3
Commuting to job workplace: Walk	2.5	2.6	4.4	0.9	2.1
Neuroticism (Nagel 2018)	2.4	5.7	6.5	-2.5	-2.2
BMI	2.4	13.7	16.8	-4.1	-3.3
Systolic Blood Pressure	2.4	11.8	14.4	-3.8	-3.0
Relative age of first facial hair	2.4	4.9	5.9	-2.4	-2.0
Severe depression (siblings)	2.4	2.7	3.0	-1.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	4.6	-2.1	-1.7
Medication: Paracetamol	2.4	3.9	4.6	-1.8	-2.1
Medication for pain relief, constipation, heartburn	2.4	4.1	4.7	1.9	2.2
Blood Red Count	2.3	22.6	23.7	-4.9	-4.6
Chronic bronchitis/emphysema (father)	2.3	2.7	3.5	1.9	1.4
Body mass index (BMI)	2.3	9.9	10.4	-3.2	-3.1
Gout (self-reported)	2.3	3.2	4.7	-2.2	-1.3
Body Mass Index (BMI) (2010)	2.2	3.0	4.2	-2.0	-1.4
Arm fat percentage (right)	2.2	8.8	11.5	-3.4	-2.4
Medication: Omeprazole	2.2	2.6	3.6	1.3	1.9
Leg predicted mass (right)	2.2	11.6	19.7	4.4	1.9
Irritability	2.2	3.7	4.5	-2.1	-1.7
Stomach or abdominal pain in last month	2.1	2.6	3.5	-1.9	-1.3
Leg fat-free mass (right)	2.1	11.4	19.4	4.4	1.8
Loneliness, isolation	2.1	3.0	4.0	-2.0	-1.4
Asthma (self-reported)	2.1	4.1	4.6	2.1	1.9
Ulcerative Colitis (UC)	2.0	3.8	4.5	-2.1	-1.7
Body fat percentage	2.0	7.9	9.2	-3.0	-2.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.2	-1.8	-1.3
Illnesses of siblings: Diabetes	2.0	2.4	4.0	-2.0	-0.9
Back pain experienced in last month	2.0	2.9	4.3	1.2	2.1
Medication: Blood pressure	2.0	3.8	6.4	-2.5	-1.1
Sensitivity / hurt feelings	1.9	3.3	4.4	-1.5	-2.1
Wheeze or whistling in the chest in last year	1.9	3.4	4.4	1.6	2.1
Medication: Allopurinol	1.9	2.5	4.3	-2.1	-0.8
Leg fat-free mass (left)	1.8	9.8	17.5	4.2	1.4
Leg predicted mass (left)	1.8	9.4	16.9	4.1	1.4
Angina (self-reported)	1.8	2.4	3.8	0.9	2.0
Heart attack	1.7	2.1	2.8	1.2	1.7
Asthma	1.7	3.4	4.3	2.1	1.6
Birth weight of first child	1.7	3.2	6.0	2.5	0.6
Comparative height size at age 10	1.7	9.6	18.1	4.2	1.1
Triglycerides	1.6	2.7	3.4	-1.4	-1.8
Ulcerative Colitis	1.6	2.3	2.3	-1.5	-1.5
Blood Platelet Count	1.6	18.1	26.7	-5.2	-3.1
Systolic blood pressure, automated reading	1.6	4.7	5.7	-2.4	-1.9
Medication for hormone replacement therapy	1.6	1.8	3.2	1.8	0.6
Mean time to correctly identify matches	1.6	3.0	5.2	2.3	1.0
Family relationship satisfaction	1.6	2.0	3.0	0.9	1.7
Hypertension (Self-reported)	1.6	4.5	6.2	-2.5	-1.7
Handedness (chirality/laterality): Left-handed	1.6	1.9	2.0	-1.4	-1.4
Number of self-reported non-cancer illnesses	1.6	2.7	5.3	-2.3	-0.4
Guilty feelings	1.6	2.4	4.2	-2.0	-0.8
Blood Eosinophil Count	1.5	11.8	13.9	-3.7	-3.1
Lung FEV1/FVC ratio	1.5	7.7	10.6	-2.2	-3.3
High blood pressure	1.5	4.1	5.5	-2.3	-1.6
Hearing difficulty/problems with background noise	1.5	2.4	4.6	0.5	2.1
Had menopause	1.5	1.9	2.0	1.3	1.4
Medication: Simvastatin	1.5	2.2	2.4	-1.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.8	3.5	-0.5	-1.9
Depression (self-reported)	1.5	1.8	2.4	-1.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	2.6	-1.6	-1.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	1.5	1.2	1.2
High blood pressure (siblings)	1.4	2.0	3.7	-1.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	1.9	1.4	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	1.7	-1.3	-1.1
Illnesses of father: High blood pressure	1.4	1.8	2.7	-1.6	-0.9
Unable to work because of sickness or disability	1.4	1.8	2.0	-1.4	-1.3
Myopia	1.4	2.1	2.7	1.2	1.6
Medication: Metformin	1.3	1.8	2.8	0.8	1.7
Number of live births	1.3	1.8	3.5	-1.9	-0.5
Peak expiratory flow (PEF)	1.3	3.0	3.8	2.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.4	1.8	0.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.5	-1.6	-0.9
Migraine (self-reported)	1.3	1.7	1.7	-1.3	-1.3
Pulse rate, automated reading	1.3	4.2	5.5	2.4	1.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	2.2	0.9	1.5
Angina	1.2	1.6	2.7	0.7	1.6
Trunk fat percentage	1.2	4.8	5.8	-2.4	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	3.1	-1.8	-1.6
Medication: Atenolol	1.2	1.5	2.1	-1.4	-1.0
Fluid intelligence score	1.2	2.4	4.5	-0.5	-2.1
Glaucoma (self-reported)	1.2	1.4	1.9	1.0	1.4
Forced vital capacity (FVC), Best measure	1.2	4.4	5.9	2.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	1.6	-1.2	-1.3
Suffer from ‘nerves’	1.2	1.8	2.8	-0.9	-1.7
Osteoarthritis (self-reported)	1.2	1.5	2.9	0.4	1.7
Financial situation satisfaction	1.2	1.5	2.2	-0.9	1.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.0	1.1	1.4
Schizophrenia vs Biploar Disorder	1.1	1.5	1.6	1.3	1.1
Hair/balding pattern: Pattern 2	1.1	1.5	2.2	-1.5	-0.9
Forced vital capacity (FVC)	1.1	4.3	6.0	2.4	1.6
Hypothyroidism (self reported)	1.0	2.3	2.3	1.5	1.5
Hearing difficulty/problems: Yes	1.0	1.5	2.9	0.2	1.7
Average weekly fortified wine intake	1.0	1.2	1.6	0.9	1.3
Age when periods started (menarche)	1.0	2.3	3.4	-1.1	-1.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	0.5	1.5
Supplements: Vitamin C	1.0	1.2	1.5	1.0	1.2
Ever depressed for a whole week	1.0	1.2	2.4	-1.5	-0.2
Alcohol drinker status: Previous	1.0	1.1	1.3	-1.1	-1.0
HDL Cholesterol	0.9	1.5	2.2	0.9	1.5
Cardiovascular Disease	0.9	2.9	4.4	-2.1	-1.2
Weight	0.9	4.3	8.4	2.9	0.5
Comparative body size at age 10	0.9	2.6	3.8	-1.2	-1.9
Medication: Ibuprofen	0.9	1.0	2.0	-0.3	-1.4
Smoking status: Previous	0.9	1.3	1.5	1.1	1.2
Ever taken oral contraceptive pill	0.9	1.0	1.0	1.0	1.0
Schizophrenia (2014)	0.8	1.8	2.8	0.8	1.7
Smoking Status	0.8	1.8	3.0	-1.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	1.9	1.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.2	1.1	0.7
Number of incorrect matches in round	0.8	1.3	1.5	-1.2	-1.1
Qualifications: None of the above	0.8	1.7	2.8	-1.7	-0.7
Father’s age at death	0.8	1.1	1.7	0.7	1.3
Hair/balding pattern: Pattern 4	0.8	1.9	3.3	1.8	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.1	-1.1	-0.9
Birth weight	0.8	1.6	2.6	1.6	-0.8
Heart disease (mother)	0.8	0.9	1.2	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.5	-0.6	1.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.5	-0.7	-1.2
Medication: Aspirin	0.8	1.0	2.0	-1.4	-0.2
Age started oral contraceptive pill	0.8	1.1	1.7	0.6	1.3
Schizophrenia (2018)	0.7	1.4	2.6	0.4	1.6
Alzheimer’s Disease (in father)	0.7	0.8	1.3	1.2	-0.4
Irritable Bowel Disease (IBD)	0.7	1.7	2.4	-1.5	-1.0
Neuroticism (2016)	0.7	1.0	1.8	-1.3	0.4
Chronotype (morning person)	0.7	1.6	2.7	-1.7	-0.7
Number of treatments/medications taken	0.7	1.2	2.3	-1.5	-0.4
Diabetes (father)	0.7	0.9	1.6	1.3	0.3
Current tobacco smoking	0.7	1.2	1.2	-1.1	-1.1
Worrier / anxious feelings	0.7	1.4	1.6	-1.1	-1.3
Happiness	0.7	0.8	1.6	-1.3	-0.1
Leg pain on walking	0.7	0.9	1.0	0.9	1.0
Long-standing illness, disability or infirmity	0.7	1.1	1.5	-0.8	1.2
Friendships satisfaction	0.7	0.8	1.6	-0.1	1.3
Osteoporosis (self-reported)	0.7	0.9	1.7	-0.2	1.3
Commuting to job workplace: Public transport	0.7	0.8	1.5	1.2	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.1	0.9	1.1
Ever smoked	0.7	1.2	1.4	1.2	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.1	1.8	0.9
Pain experienced in last month	0.7	1.2	2.4	-0.2	-1.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	0.3	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.8	-0.4	-1.7
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	-1.1	-0.4
Past tobacco smoking	0.6	1.1	1.3	-0.9	-1.1
Illnesses of siblings	0.6	0.9	1.6	1.3	-0.4
Falls in the last year	0.6	0.9	1.0	-1.0	-0.9
Neck or shoulder pain in last month	0.6	0.8	1.3	-1.1	0.5
Leg fat mass (right)	0.6	2.4	3.9	-1.0	-2.0
Smoking status: Current	0.6	1.0	1.1	-0.9	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.5	0.3	1.6
Allergy or Eczema	0.5	1.2	1.7	1.3	0.9
Medication: Co-codamol	0.5	0.6	1.1	-0.4	-1.0
Taking other prescription medications	0.5	0.8	1.5	-1.2	0.5
Had other major operations	0.5	0.6	1.0	-0.4	1.0
Pain all over the body in last month	0.5	0.6	1.0	0.4	1.0
Diabetes (self-reported)	0.5	0.8	1.6	-0.0	1.3
Noisy workplace	0.5	0.7	0.7	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.4	1.6	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	0.8	0.9	0.5
Number of full brothers	0.5	0.6	0.9	-0.6	0.9
Eye problems/disorders: None of the above	0.5	0.5	1.1	-0.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.8	-0.9	-0.7
Medication: Aspirin	0.5	0.6	1.2	-1.1	-0.0
Average weekly champagne plus white wine intake	0.5	0.7	1.3	1.2	0.1
Leg fat mass (left)	0.5	1.9	3.1	-0.8	-1.8
Fasting Glucose	0.4	0.5	0.8	0.3	-0.9
HbA1C	0.4	0.4	0.6	0.5	-0.8
LDL Cholesterol	0.4	0.7	0.9	-0.7	0.9
Lupus	0.4	0.6	1.1	1.1	0.4
Average weekly spirits intake	0.4	0.5	0.5	-0.7	-0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.1	-1.1	-0.2
Pack years adult smoking proportion	0.4	0.7	1.0	-1.0	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-0.9	-0.3
Impedance of arm (left)	0.4	1.7	3.2	-0.5	1.8
Breastfed as a baby	0.4	0.5	1.0	-1.0	0.1
Pulse wave reflection index	0.4	0.5	1.0	-1.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	0.9	0.6
Health satisfaction	0.4	0.6	0.9	0.5	0.9
Number of full sisters	0.4	0.5	1.0	1.0	0.1
Overall health rating	0.4	0.9	1.7	-0.2	1.3
Age at last live birth	0.4	0.5	1.0	1.0	0.2
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.9	-0.3
Eye problems/disorders: Cataract	0.4	0.5	0.9	0.2	1.0
Mineral and other dietary supplements	0.4	0.5	0.9	-0.2	-1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.0	1.0
High cholesterol (Self-reported)	0.4	0.7	0.9	-1.0	-0.6
Number of operations (self-reported)	0.4	0.6	1.1	-1.0	-0.3
Cholesterol lowering medication	0.4	0.6	1.1	-1.1	0.0
Pack years of smoking	0.4	0.6	0.9	-0.9	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	0.6	0.6	0.8
Reaction Time	0.3	0.7	0.8	0.9	-0.7
Prostate Cancer	0.3	0.4	0.7	0.3	-0.8
Mean Putamen Volume	0.3	0.4	0.5	0.7	-0.5
Vitamin and mineral supplements	0.3	0.4	0.9	-0.1	-0.9
Multivitamins +/- minerals	0.3	0.3	0.4	-0.5	0.7
Supplements: Glucosamine	0.3	0.3	0.4	0.6	0.6
Allergy	0.3	0.6	0.9	-0.5	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.3	1.0
Illnesses of mother	0.3	0.3	0.4	0.5	0.6
Arm fat mass (right)	0.3	1.4	2.1	-0.9	-1.4
Whole body fat mass	0.3	1.2	2.1	-0.6	-1.4
Medication for cholesterol	0.3	0.5	0.5	0.7	0.7
Breast cancer (self-reported)	0.3	0.4	0.4	-0.6	-0.7
Arm fat mass (left)	0.3	1.2	1.4	-1.0	-1.2
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.1	0.7	-1.0
Age at First Birth	0.2	0.3	0.5	0.7	0.3
Blood White Count	0.2	1.3	2.0	0.8	1.4
Supplements: Zinc	0.2	0.2	0.3	-0.4	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.4	-0.4	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.6	0.6	0.8
Mouth/teeth dental problems	0.2	0.4	0.7	0.8	-0.1
Impedance of arm (right)	0.2	0.9	1.8	-0.2	1.4
Time employed in main current job	0.2	0.2	0.4	0.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.4	1.2	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.2	-0.6
Worry too long after embarrassment	0.2	0.4	0.7	0.8	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.2	-0.4	-0.5
Knee pain experienced in last month	0.2	0.3	0.6	-0.7	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.0	-0.6
Medication: Gliclazide	0.2	0.3	0.5	-0.7	0.0
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.0	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.2	0.6
Bipolar Disorder (2018)	0.1	0.1	0.2	0.1	0.4
Rheumatoid Arthritis	0.1	0.2	0.2	-0.5	0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.6	-0.2
Relative age voice broke	0.1	0.1	0.2	-0.5	-0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.0	0.5
Trunk fat mass	0.1	0.4	0.7	-0.1	-0.9
Waist circumference	0.1	0.4	0.6	0.8	-0.4
Nervous feelings	0.1	0.1	0.3	-0.5	0.0
Financial difficulties in last 2 years	0.1	0.1	0.2	0.1	0.4
Medication: Ramipril	0.1	0.1	0.2	-0.4	0.3
Hip circumference	0.1	0.5	0.8	0.4	-0.9
Pulse rate	0.1	0.1	0.1	0.4	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.1	0.7
Lung cancer (father)	0.1	0.1	0.2	-0.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.2	-0.4	0.5
Loud music exposure frequency	0.1	0.1	0.1	-0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	0.4	0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.5	-0.2
Age at first live birth	0.1	0.3	0.3	0.5	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.0	-0.5
Had major operations	0.1	0.1	0.1	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.0	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.3	0.5
Hearing aid user	0.1	0.1	0.2	-0.4	0.3
Medication: Paracetamol	0.1	0.2	0.4	-0.1	-0.7
Medication: Atorvastatin	0.1	0.1	0.1	-0.2	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.4	0.1
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.2	-0.9
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.3	0.5
Supplements: Calcium	0.1	0.2	0.3	-0.0	0.6
Impedance of whole body	0.1	0.4	0.7	-0.2	0.8
Crohns Disease (2017)	0.0	0.1	0.1	-0.3	-0.2
Ovarian Cancer	0.0	0.0	0.0	0.2	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.0	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.1	0.3	-0.2
Tanning	0.0	0.2	0.3	-0.4	-0.5
Diabetes (mother)	0.0	0.0	0.0	-0.0	-0.1
Impedance of leg (right)	0.0	0.1	0.1	0.4	-0.1
Maternal smoking around birth	0.0	0.1	0.1	-0.3	-0.2
Impedance of leg (left)	0.0	0.2	0.3	0.5	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	0.1	-0.2
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	0.0
Pulse wave peak to peak time	0.0	0.0	0.0	-0.1	-0.1
Medication: Lisinopril	0.0	0.1	0.1	-0.3	-0.0
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	0.1
Risk taking	0.0	0.1	0.1	-0.4	0.0

Hub : Genes

POLR2A

Models

Trait associations