Best TWAS P=7.06e-13 · Best GWAS P=3.95e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC91 | 0.08 | 0.06 | lasso | 6 | 0.07 | 9.4e-09 | 5.5 | -5.8 | 5.6e-09 | 0.61 | 0.96 | 0.04 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-967K21.1 | 0.08 | 0.02 | lasso | 8 | 0.01 | 2.1e-02 | -6.4 | -6.0 | 2.1e-09 | 0.85 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Artery Aorta | CCDC91 | 0.16 | 0.00 | enet | 37 | 0.02 | 4.1e-02 | 5.7 | 6.4 | 2.0e-10 | -0.47 | 0.26 | 0.32 | TRUE |
| 4 | GTEx | Artery Aorta | RP11-967K21.1 | 0.07 | 0.02 | lasso | 7 | 0.01 | 7.9e-02 | -5.8 | -7.0 | 3.3e-12 | 0.74 | 0.08 | 0.75 | FALSE |
| 5 | GTEx | Artery Coronary | RP11-967K21.1 | 0.18 | 0.12 | lasso | 7 | 0.07 | 1.8e-03 | -6.4 | -6.8 | 1.2e-11 | 0.93 | 0.03 | 0.94 | FALSE |
| 6 | GTEx | Artery Tibial | RP11-967K21.1 | 0.09 | 0.10 | lasso | 11 | 0.07 | 2.4e-06 | -6.9 | -7.2 | 7.1e-13 | 0.96 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | CCDC91 | 0.10 | 0.10 | lasso | 5 | 0.09 | 5.5e-07 | 5.8 | 5.9 | 2.9e-09 | -0.50 | 0.88 | 0.11 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-967K21.1 | 0.07 | 0.07 | lasso | 2 | 0.07 | 3.7e-06 | 5.3 | -5.6 | 1.6e-08 | 0.50 | 0.72 | 0.27 | FALSE |
| 9 | GTEx | Colon Transverse | CCDC91 | 0.11 | 0.01 | lasso | 6 | 0.00 | 4.6e-01 | 5.7 | 6.7 | 1.6e-11 | -0.69 | 0.19 | 0.47 | FALSE |
| 10 | GTEx | Colon Transverse | RP11-967K21.1 | 0.12 | 0.07 | lasso | 8 | 0.05 | 1.6e-03 | -6.8 | -6.9 | 5.2e-12 | 0.93 | 0.02 | 0.97 | FALSE |
| 11 | GTEx | Esophagus Muscularis | RP11-967K21.1 | 0.07 | 0.06 | lasso | 5 | 0.04 | 2.2e-03 | -6.9 | -6.6 | 3.8e-11 | 0.94 | 0.01 | 0.96 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | RP11-967K21.1 | 0.08 | 0.09 | lasso | 1 | 0.08 | 2.3e-04 | 5.3 | -5.3 | 9.7e-08 | 0.46 | 0.44 | 0.11 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | CCDC91 | 0.09 | 0.01 | enet | 8 | 0.01 | 2.6e-02 | 5.3 | 5.2 | 1.8e-07 | -0.48 | 0.27 | 0.54 | FALSE |
| 14 | GTEx | Thyroid | CCDC91 | 0.15 | 0.12 | enet | 42 | 0.12 | 2.9e-09 | 5.7 | 5.8 | 8.0e-09 | -0.56 | 0.94 | 0.06 | FALSE |
| 15 | NTR | Blood | CCDC91 | 0.01 | 0.01 | blup | 648 | 0.00 | 9.0e-03 | -6.7 | 6.6 | 3.9e-11 | -0.73 | 0.02 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC91 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-06 | 5.5 | 5.6 | 2.4e-08 | -0.53 | 0.96 | 0.04 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC91 | 0.06 | 0.02 | blup | 174 | 0.04 | 2.9e-05 | -5.7 | 6.8 | 1.2e-11 | -0.81 | 0.04 | 0.96 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC91 | 0.09 | 0.01 | blup | 170 | 0.02 | 1.0e-03 | 5.7 | 6.3 | 2.3e-10 | -0.66 | 0.08 | 0.85 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC91 | 0.09 | 0.11 | lasso | 2 | 0.12 | 2.3e-05 | 5.5 | 5.5 | 4.5e-08 | -0.53 | 0.74 | 0.04 | FALSE |