Best TWAS P=7.09e-14 · Best GWAS P=3.52e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | UBXN2A | 0.22 | 0.18 | enet | 28 | 0.24 | 3.0e-28 | 5.90 | -6.4 | 1.6e-10 | -0.91 | 0.28 | 0.72 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | UBXN2A | 0.10 | 0.08 | enet | 29 | 0.03 | 9.8e-03 | 5.03 | 7.3 | 2.9e-13 | 0.45 | 0.45 | 0.43 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | UBXN2A | 0.08 | 0.02 | lasso | 3 | 0.02 | 5.2e-02 | 7.01 | 7.5 | 7.1e-14 | 0.96 | 0.02 | 0.94 | TRUE |
| 4 | METSIM | Adipose | UBXN2A | 0.07 | 0.03 | bslmm | 403 | 0.06 | 5.3e-10 | 5.66 | 6.7 | 2.6e-11 | 0.78 | 0.18 | 0.82 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | KLHL29 | 0.08 | 0.03 | enet | 27 | 0.02 | 1.1e-03 | 6.29 | 6.0 | 2.1e-09 | 0.17 | 0.78 | 0.16 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | UBXN2A | 0.03 | 0.01 | lasso | 4 | 0.02 | 2.2e-03 | 7.07 | -6.1 | 1.2e-09 | -0.82 | 0.02 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBXN2A | 0.04 | 0.04 | lasso | 1 | 0.03 | 1.4e-04 | 6.98 | -7.0 | 2.9e-12 | -0.97 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | UBXN2A | 0.05 | 0.00 | blup | 46 | 0.01 | 1.3e-02 | -0.88 | 6.6 | 4.1e-11 | 0.66 | 0.01 | 0.44 | FALSE |