Hub : Traits :

Guilty feelings

101 significantly associated models · 32 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	22911727	24924438	2	2	7.1e-14	3.5e-13	1.0000	100	KLHL29 UBXN2A
2	6	104706579	106230491	1	1	1.2e-07	1.8e-07	0.2070	94	LIN28B
3	8	8092025	8794801	1	1	5.2e-08	3.3e-07	0.1180	91	FAM86B3P
4	8	10265712	11891593	3	1	8.9e-09	1.4e-07	0.1930	94	AF131215.2
5	11	46917983	48303325	2	1	1.6e-07	1.1e-07	0.1890	94	C1QTNF4
6	11	56742853	58178587	3	1	5.3e-09	1.3e-07	0.1910	94	MED19
7	11	112135760	113969669	5	3	3.0e-09	2.4e-09	0.1110	93	ANKK1 DRD2 TTC12
8	14	74424938	76089054	4	1	1.8e-09	2.9e-09	0.0036	76	AREL1
9	15	77207277	78806023	1	1	1.6e-07	2.0e-07	1.0000	100	LINGO1
10	17	42774693	43913030	7	1	9.3e-09	1.8e-07	0.0838	89	PLEKHM1
11	22	39229593	40615276	1	1	1.0e-07	2.8e-07	0.3330	96	ATF4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Neuroticism score	21.65	13	11	24.4	0.96	3.6e-07	AF131215.2 ANKK1 AREL1 ATF4 C1QTNF4 DRD2 FAM86B3P KLHL29 LINGO1 MED19 PLEKHM1 TTC12 UBXN2A
Neuroticism	15.56	11	9	20.0	0.95	5.0e-06	ANKK1 AREL1 ATF4 C1QTNF4 DRD2 LIN28B LINGO1 MED19 PLEKHM1 TTC12 UBXN2A
Neuroticism (Nagel 2018)	14.86	10	8	17.8	0.95	3.2e-05	ANKK1 AREL1 C1QTNF4 DRD2 LIN28B LINGO1 MED19 PLEKHM1 TTC12 UBXN2A
Miserableness	14.43	9	6	13.3	0.98	2.2e-06	AF131215.2 ANKK1 C1QTNF4 DRD2 FAM86B3P LINGO1 PLEKHM1 TTC12 UBXN2A
Neuroticism (2016)	13.51	8	3	6.7	0.97	6.7e-05	AF131215.2 ANKK1 AREL1 C1QTNF4 DRD2 FAM86B3P LINGO1 PLEKHM1
Worrier / anxious feelings	13.21	7	4	8.9	0.94	1.8e-03	AF131215.2 AREL1 DRD2 FAM86B3P LINGO1 MED19 PLEKHM1
Mood swings	12.78	9	5	11.1	0.98	1.5e-06	AF131215.2 ANKK1 AREL1 C1QTNF4 DRD2 FAM86B3P KLHL29 PLEKHM1 TTC12
Depressed Affect (Nagel 2018)	12.57	10	6	13.3	0.96	1.6e-05	ANKK1 AREL1 C1QTNF4 DRD2 LIN28B LINGO1 MED19 PLEKHM1 TTC12 UBXN2A
Age when periods started (menarche)	12.37	3	1	2.2	0.00	1.0e+00	C1QTNF4 LIN28B PLEKHM1
Fed-up feelings	12.36	10	6	13.3	0.97	2.1e-06	AF131215.2 ANKK1 AREL1 C1QTNF4 DRD2 FAM86B3P LINGO1 MED19 PLEKHM1 UBXN2A
Sensitivity / hurt feelings	11.97	7	3	6.7	0.95	1.0e-03	AF131215.2 ANKK1 DRD2 FAM86B3P MED19 PLEKHM1 TTC12
Worry too long after embarrassment	11.70	9	5	11.1	0.98	1.5e-06	AF131215.2 ANKK1 ATF4 DRD2 FAM86B3P LINGO1 MED19 PLEKHM1 TTC12
Suffer from 'nerves'	11.04	9	3	6.7	0.97	9.4e-06	AF131215.2 ANKK1 AREL1 C1QTNF4 DRD2 FAM86B3P LINGO1 PLEKHM1 TTC12
Nervous feelings	11.01	8	4	8.9	0.97	8.2e-05	AF131215.2 ANKK1 AREL1 C1QTNF4 DRD2 FAM86B3P LINGO1 PLEKHM1
Irritability	9.44	6	3	6.7	0.97	1.3e-03	AF131215.2 ANKK1 AREL1 DRD2 FAM86B3P PLEKHM1
Frequency of depressed mood in last 2 weeks	9.34	9	0	0.0	1.00	1.1e-08	AF131215.2 ANKK1 C1QTNF4 DRD2 FAM86B3P KLHL29 MED19 PLEKHM1 UBXN2A
Tense / 'highly strung'	8.68	7	2	4.4	0.98	9.1e-05	AF131215.2 ANKK1 AREL1 DRD2 FAM86B3P PLEKHM1 TTC12
Worry (Nagel 2018)	8.64	7	4	8.9	0.98	1.2e-04	ANKK1 AREL1 C1QTNF4 DRD2 LINGO1 PLEKHM1 TTC12
Frequency of tenseness / restlessness in last 2 weeks	8.13	5	1	2.2	0.98	4.4e-03	ANKK1 C1QTNF4 DRD2 KLHL29 PLEKHM1
Frequency of unenthusiasm / disinterest in last 2 weeks	7.80	6	0	0.0	0.99	4.4e-05	ANKK1 DRD2 KLHL29 MED19 TTC12 UBXN2A
Loneliness, isolation	7.09	2	1	2.2	0.00	1.0e+00	C1QTNF4 PLEKHM1
Relative age of first facial hair	6.96	2	2	4.4	0.00	1.0e+00	LIN28B PLEKHM1
Seen doctor (GP) for nerves, anxiety, tension or depression	6.96	4	1	2.2	0.99	1.3e-02	ANKK1 AREL1 DRD2 TTC12
Depression (Nagel 2018)	6.94	6	0	0.0	1.00	8.4e-06	ANKK1 DRD2 KLHL29 MED19 PLEKHM1 UBXN2A
Hair/balding pattern: Pattern 4	6.73	1	1	2.2	0.00	1.0e+00	PLEKHM1
Relative age voice broke	6.72	2	2	4.4	0.00	1.0e+00	LIN28B PLEKHM1
Heel bone mineral density (BMD) T-score, automated (right)	6.63	4	2	4.4	-0.78	2.2e-01	AF131215.2 FAM86B3P LIN28B PLEKHM1
Frequency of tiredness / lethargy in last 2 weeks	6.48	6	0	0.0	1.00	1.8e-05	ANKK1 DRD2 KLHL29 LINGO1 MED19 UBXN2A
Heel bone mineral density (BMD) T-score, automated (left)	6.23	4	2	4.4	-0.74	2.6e-01	AF131215.2 FAM86B3P LIN28B PLEKHM1
Hand grip strength (left)	5.46	6	3	6.7	-0.51	3.1e-01	AREL1 C1QTNF4 LIN28B LINGO1 PLEKHM1 UBXN2A
Arm fat percentage (left)	5.32	7	3	6.7	-0.08	8.6e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P MED19 TTC12
Hearing difficulty/problems with background noise	5.25	3	0	0.0	0.00	1.0e+00	LIN28B PLEKHM1 TTC12
Impedance of arm (right)	5.20	6	4	8.9	0.40	4.4e-01	AF131215.2 FAM86B3P LIN28B MED19 PLEKHM1 UBXN2A
Alcohol intake frequency.	5.18	6	2	4.4	0.37	4.7e-01	ATF4 C1QTNF4 DRD2 MED19 PLEKHM1 UBXN2A
Arm fat percentage (right)	5.17	7	2	4.4	-0.04	9.3e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P MED19 TTC12
Systolic blood pressure, automated reading	5.11	6	4	8.9	-0.56	2.5e-01	AF131215.2 AREL1 C1QTNF4 FAM86B3P MED19 PLEKHM1
Medication: Paracetamol	5.07	3	1	2.2	0.00	1.0e+00	MED19 PLEKHM1 UBXN2A
Impedance of arm (left)	5.03	6	4	8.9	0.38	4.6e-01	AF131215.2 FAM86B3P LIN28B MED19 PLEKHM1 UBXN2A
Impedance of whole body	5.00	6	5	11.1	0.39	4.5e-01	AF131215.2 AREL1 FAM86B3P LIN28B PLEKHM1 UBXN2A
Trunk fat percentage	4.99	7	3	6.7	-0.05	9.2e-01	ANKK1 AREL1 C1QTNF4 LIN28B MED19 PLEKHM1 TTC12
Body fat percentage	4.88	6	2	4.4	-0.03	9.5e-01	ANKK1 AREL1 C1QTNF4 FAM86B3P PLEKHM1 TTC12
Systolic Blood Pressure	4.83	4	4	8.9	0.32	6.8e-01	AREL1 C1QTNF4 MED19 PLEKHM1
Headache pain in last month	4.81	2	1	2.2	0.00	1.0e+00	MED19 PLEKHM1
Comparative body size at age 10	4.67	4	4	8.9	-0.61	3.9e-01	AF131215.2 C1QTNF4 FAM86B3P LIN28B
Forced expiratory volume in 1-second (FEV1)	4.65	6	1	2.2	-0.35	5.0e-01	AF131215.2 C1QTNF4 FAM86B3P KLHL29 PLEKHM1 UBXN2A
Blood Red Count	4.63	6	2	4.4	0.64	1.7e-01	ATF4 C1QTNF4 DRD2 MED19 PLEKHM1 UBXN2A
Leg fat percentage (left)	4.61	7	2	4.4	0.06	9.0e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P KLHL29 TTC12
Hair/balding pattern: Pattern 3	4.57	1	1	2.2	0.00	1.0e+00	PLEKHM1
Schizophrenia (2014)	4.56	5	0	0.0	-0.25	6.8e-01	AREL1 DRD2 FAM86B3P LIN28B TTC12
Medication: Paracetamol	4.56	3	1	2.2	0.00	1.0e+00	MED19 PLEKHM1 UBXN2A
Lung FVC	4.51	3	2	4.4	0.00	1.0e+00	LIN28B PLEKHM1 UBXN2A
Leg fat percentage (right)	4.47	8	2	4.4	0.14	7.4e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P KLHL29 TTC12 UBXN2A
Body mass index (BMI)	4.45	4	3	6.7	-0.77	2.3e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P
Impedance of leg (left)	4.38	8	4	8.9	0.55	1.6e-01	AF131215.2 AREL1 C1QTNF4 FAM86B3P LIN28B LINGO1 PLEKHM1 UBXN2A
Forced expiratory volume in 1-second (FEV1), Best measure	4.35	6	1	2.2	-0.34	5.1e-01	AF131215.2 C1QTNF4 FAM86B3P KLHL29 PLEKHM1 UBXN2A
Peak expiratory flow (PEF)	4.31	4	1	2.2	-0.15	8.5e-01	AF131215.2 FAM86B3P PLEKHM1 UBXN2A
Impedance of leg (right)	4.26	7	4	8.9	0.58	1.7e-01	AF131215.2 AREL1 C1QTNF4 FAM86B3P LIN28B PLEKHM1 UBXN2A
Medication for pain relief, constipation, heartburn	4.16	4	1	2.2	-0.98	1.9e-02	AREL1 LIN28B PLEKHM1 UBXN2A
Seen a psychiatrist for nerves, anxiety, tension or depression	4.15	1	0	0.0	0.00	1.0e+00	DRD2
Number of treatments/medications taken	4.14	2	1	2.2	0.00	1.0e+00	AREL1 LIN28B
Sitting height	4.11	5	4	8.9	-0.72	1.7e-01	C1QTNF4 FAM86B3P KLHL29 PLEKHM1 UBXN2A
Arm fat mass (right)	4.03	5	3	6.7	-0.34	5.8e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P TTC12
Arm fat mass (left)	4.03	5	3	6.7	-0.35	5.7e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P TTC12
Taking other prescription medications	3.96	1	1	2.2	0.00	1.0e+00	AREL1
Hand grip strength (right)	3.82	5	2	4.4	-0.45	4.4e-01	AREL1 C1QTNF4 LIN28B LINGO1 PLEKHM1
Forced vital capacity (FVC), Best measure	3.82	4	2	4.4	-0.86	1.4e-01	C1QTNF4 KLHL29 PLEKHM1 UBXN2A
Trunk fat mass	3.81	8	1	2.2	-0.30	4.7e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P LIN28B PLEKHM1 TTC12
Medication: Blood pressure	3.79	3	2	4.4	0.00	1.0e+00	AF131215.2 FAM86B3P PLEKHM1
Major Depression (MDD)	3.78	1	0	0.0	0.00	1.0e+00	AREL1
Current tobacco smoking	3.77	2	0	0.0	0.00	1.0e+00	C1QTNF4 UBXN2A
Diastolic blood pressure, automated reading	3.77	3	2	4.4	0.00	1.0e+00	AF131215.2 C1QTNF4 FAM86B3P
Medication: Ibuprofen (e.g. Nurofen)	3.76	2	0	0.0	0.00	1.0e+00	PLEKHM1 UBXN2A
Schizophrenia (2018)	3.75	5	0	0.0	0.14	8.2e-01	ANKK1 DRD2 FAM86B3P LIN28B TTC12
Forced vital capacity (FVC)	3.72	4	1	2.2	-0.89	1.1e-01	C1QTNF4 KLHL29 PLEKHM1 UBXN2A
Whole body fat mass	3.72	6	1	2.2	-0.09	8.6e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P TTC12
Leg fat mass (right)	3.71	6	3	6.7	-0.14	7.9e-01	AF131215.2 ANKK1 AREL1 C1QTNF4 FAM86B3P TTC12
Leg fat mass (left)	3.70	5	3	6.7	-0.32	6.1e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P TTC12
High blood pressure	3.69	4	2	4.4	-0.66	3.4e-01	AF131215.2 C1QTNF4 FAM86B3P PLEKHM1
Body Mass Index (BMI) (2010)	3.65	1	1	2.2	0.00	1.0e+00	C1QTNF4
Hypertension (Self-reported)	3.60	4	2	4.4	-0.66	3.4e-01	AF131215.2 C1QTNF4 FAM86B3P PLEKHM1
Smoking status: Current	3.57	2	0	0.0	0.00	1.0e+00	AF131215.2 UBXN2A
Average weekly red wine intake	3.54	1	0	0.0	0.00	1.0e+00	MED19
Hypothyroidism/myxoedema (self-reported)	3.53	2	1	2.2	0.00	1.0e+00	AF131215.2 FAM86B3P
Overall health rating	3.53	4	0	0.0	0.60	4.0e-01	AF131215.2 ANKK1 DRD2 TTC12
Standing height	3.51	8	4	8.9	-0.47	2.4e-01	AF131215.2 AREL1 C1QTNF4 FAM86B3P KLHL29 LIN28B PLEKHM1 UBXN2A
Medication: Bendroflumethiazide	3.51	3	0	0.0	0.00	1.0e+00	AF131215.2 C1QTNF4 FAM86B3P
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.42	2	1	2.2	0.00	1.0e+00	AF131215.2 PLEKHM1
Depression (self-reported)	3.34	1	0	0.0	0.00	1.0e+00	LIN28B
Vascular/heart problems diagnosed by doctor	3.31	4	1	2.2	0.68	3.2e-01	AF131215.2 C1QTNF4 FAM86B3P PLEKHM1
Height	3.30	6	6	13.3	-0.81	5.0e-02	AREL1 C1QTNF4 KLHL29 LIN28B PLEKHM1 UBXN2A
Health satisfaction	3.29	1	0	0.0	0.00	1.0e+00	DRD2
Average weekly beer plus cider intake	3.27	2	0	0.0	0.00	1.0e+00	AF131215.2 FAM86B3P
Financial difficulties in last 2 years	3.24	1	0	0.0	0.00	1.0e+00	DRD2
Lupus	3.19	2	0	0.0	0.00	1.0e+00	AF131215.2 FAM86B3P
Ovarian Cancer	3.16	1	1	2.2	0.00	1.0e+00	PLEKHM1
Ever unenthusiastic/disinterested for a whole week	3.16	1	0	0.0	0.00	1.0e+00	PLEKHM1
Long-standing illness, disability or infirmity	3.16	1	0	0.0	0.00	1.0e+00	LIN28B
Bipolar Disorder or Schizophrenia	3.08	4	0	0.0	-0.33	6.7e-01	DRD2 FAM86B3P LIN28B TTC12
Medication: Ibuprofen	3.07	2	0	0.0	0.00	1.0e+00	PLEKHM1 UBXN2A
Alcohol usually taken with meals	3.05	1	0	0.0	0.00	1.0e+00	MED19
Waist circumference	3.04	3	1	2.2	0.00	1.0e+00	ANKK1 C1QTNF4 TTC12
Number of operations (self-reported)	3.00	1	0	0.0	0.00	1.0e+00	LIN28B
Risk taking	2.99	1	0	0.0	0.00	1.0e+00	AF131215.2
Other serious medical condition/disability diagnosed by doctor	2.89	1	0	0.0	0.00	1.0e+00	TTC12
Medication: Levothyroxine sodium	2.89	1	1	2.2	0.00	1.0e+00	FAM86B3P
Age at first live birth	2.89	2	0	0.0	0.00	1.0e+00	AF131215.2 PLEKHM1
Father's age at death	2.86	1	0	0.0	0.00	1.0e+00	AF131215.2
Mouth/teeth dental problems: Mouth ulcers	2.84	1	1	2.2	0.00	1.0e+00	PLEKHM1
Ever depressed for a whole week	2.82	1	0	0.0	0.00	1.0e+00	PLEKHM1
Verbal and Numeric Reasoning (VNR)	2.80	3	0	0.0	0.00	1.0e+00	ATF4 C1QTNF4 PLEKHM1
Age at last live birth	2.80	1	0	0.0	0.00	1.0e+00	AF131215.2
Wheeze or whistling in the chest in last year	2.76	1	0	0.0	0.00	1.0e+00	TTC12
Handedness (chirality/laterality): Left-handed	2.69	1	1	2.2	0.00	1.0e+00	PLEKHM1
BMI	2.65	4	1	2.2	0.27	7.3e-01	ANKK1 C1QTNF4 KLHL29 TTC12
Alcohol drinker status: Previous	2.58	1	0	0.0	0.00	1.0e+00	ATF4
Emphysema/chronic bronchitis	2.56	1	0	0.0	0.00	1.0e+00	FAM86B3P
Hair/balding pattern: Pattern 2	2.52	1	1	2.2	0.00	1.0e+00	PLEKHM1
Blood White Count	2.49	5	3	6.7	0.36	5.5e-01	C1QTNF4 KLHL29 LIN28B PLEKHM1 UBXN2A
Time employed in main current job	2.47	1	0	0.0	0.00	1.0e+00	PLEKHM1
Trunk predicted mass	2.47	6	1	2.2	-0.97	1.6e-03	AF131215.2 AREL1 FAM86B3P KLHL29 LIN28B UBXN2A
Number of self-reported non-cancer illnesses	2.46	1	0	0.0	0.00	1.0e+00	AREL1
Trunk fat-free mass	2.45	6	1	2.2	-0.97	1.8e-03	AF131215.2 AREL1 FAM86B3P KLHL29 LIN28B UBXN2A
Hip circumference	2.45	4	1	2.2	-0.69	3.1e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P
Waist Hip Ratio (WHR)	2.42	4	1	2.2	0.95	5.4e-02	ANKK1 AREL1 PLEKHM1 UBXN2A
Medication for cholesterol	2.42	1	0	0.0	0.00	1.0e+00	PLEKHM1
Medication: Metformin	2.38	1	1	2.2	0.00	1.0e+00	C1QTNF4
Medication: Blood pressure	2.38	2	0	0.0	0.00	1.0e+00	AF131215.2 C1QTNF4
Hearing difficulty/problems: Yes	2.33	1	0	0.0	0.00	1.0e+00	LIN28B
Qualifications: A levels/AS levels or equivalent	2.32	2	0	0.0	0.00	1.0e+00	AREL1 PLEKHM1
Alcohol intake versus 10 years previously	2.30	1	0	0.0	0.00	1.0e+00	UBXN2A
Weight	2.23	6	2	4.4	-0.70	1.2e-01	AF131215.2 ANKK1 C1QTNF4 FAM86B3P LIN28B UBXN2A
Forced expiratory volume in 1-second (FEV1), predicted	2.23	1	1	2.2	0.00	1.0e+00	LIN28B
Whole body water mass	2.22	4	2	4.4	-0.99	5.2e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Leg pain on walking	2.21	1	0	0.0	0.00	1.0e+00	PLEKHM1
Whole body fat-free mass	2.21	4	2	4.4	-1.00	4.3e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Alcohol drinker status: Never	2.21	1	0	0.0	0.00	1.0e+00	C1QTNF4
Intelligence (Savage-Jansen 2018)	2.17	2	0	0.0	0.00	1.0e+00	ATF4 PLEKHM1
Leg predicted mass (left)	2.17	4	3	6.7	-0.99	5.7e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Leg fat-free mass (right)	2.17	4	3	6.7	-1.00	4.4e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Leg fat-free mass (left)	2.16	4	3	6.7	-0.99	5.3e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Pain experienced in last month	2.16	2	0	0.0	0.00	1.0e+00	MED19 PLEKHM1
Leg predicted mass (right)	2.15	4	3	6.7	-1.00	4.6e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Hypothyroidism (self reported)	2.08	2	0	0.0	0.00	1.0e+00	AREL1 C1QTNF4
Arm predicted mass (right)	2.05	3	3	6.7	0.00	1.0e+00	AF131215.2 FAM86B3P UBXN2A
Birth weight	2.03	1	0	0.0	0.00	1.0e+00	UBXN2A
Arm fat-free mass (right)	2.03	3	2	4.4	0.00	1.0e+00	AF131215.2 FAM86B3P UBXN2A
Basal metabolic rate	2.03	4	2	4.4	-1.00	2.3e-03	AF131215.2 FAM86B3P LIN28B UBXN2A
Mouth/teeth dental problems	2.02	1	0	0.0	0.00	1.0e+00	PLEKHM1
Arm fat-free mass (left)	2.02	3	2	4.4	0.00	1.0e+00	AF131215.2 FAM86B3P UBXN2A
Arm predicted mass (left)	2.02	3	2	4.4	0.00	1.0e+00	AF131215.2 FAM86B3P UBXN2A
Chronotype (morning person)	2.00	1	0	0.0	0.00	1.0e+00	UBXN2A
Fluid intelligence score	2.00	1	0	0.0	0.00	1.0e+00	PLEKHM1
Past tobacco smoking	1.96	1	0	0.0	0.00	1.0e+00	PLEKHM1
Heel T-Score	1.94	4	2	4.4	-0.13	8.7e-01	AREL1 C1QTNF4 LIN28B PLEKHM1
Serious illness, injury or assault of a close relative in last 2 years	1.93	1	0	0.0	0.00	1.0e+00	AF131215.2
Number of full brothers	1.91	1	0	0.0	0.00	1.0e+00	PLEKHM1
Qualifications: College or University degree	1.90	1	1	2.2	0.00	1.0e+00	PLEKHM1
Smoking Status	1.89	2	0	0.0	0.00	1.0e+00	KLHL29 PLEKHM1
Primary Biliary Cirrhosis	1.86	1	0	0.0	0.00	1.0e+00	PLEKHM1
Fractured/broken bones in last 5 years	1.86	1	0	0.0	0.00	1.0e+00	PLEKHM1
Vitamin and mineral supplements	1.80	1	0	0.0	0.00	1.0e+00	PLEKHM1
Mouth/teeth dental problems: Dentures	1.79	2	0	0.0	0.00	1.0e+00	AF131215.2 FAM86B3P
Blood Eosinophil Count	1.76	1	1	2.2	0.00	1.0e+00	PLEKHM1
Cardiovascular Disease	1.75	3	0	0.0	0.00	1.0e+00	ANKK1 DRD2 TTC12
Supplements: Fish oil (including cod liver oil)	1.74	1	0	0.0	0.00	1.0e+00	FAM86B3P
Average weekly champagne plus white wine intake	1.65	1	0	0.0	0.00	1.0e+00	PLEKHM1
Fasting Glucose	1.60	1	0	0.0	0.00	1.0e+00	C1QTNF4
HbA1C	1.60	1	0	0.0	0.00	1.0e+00	UBXN2A
Alzheimer’s Disease (including proxy)	1.50	1	0	0.0	0.00	1.0e+00	C1QTNF4
Breast Cancer	1.47	1	1	2.2	0.00	1.0e+00	PLEKHM1
Blood Platelet Count	1.47	5	4	8.9	0.21	7.4e-01	AREL1 C1QTNF4 MED19 PLEKHM1 UBXN2A
Number of live births	1.46	1	0	0.0	0.00	1.0e+00	PLEKHM1
Triglycerides	1.41	1	0	0.0	0.00	1.0e+00	AF131215.2
Comparative height size at age 10	1.37	3	0	0.0	0.00	1.0e+00	KLHL29 PLEKHM1 UBXN2A
Lung FEV1/FVC ratio	1.30	2	1	2.2	0.00	1.0e+00	AREL1 PLEKHM1
Respiratory disease	1.28	1	0	0.0	0.00	1.0e+00	MED19
Diabetes diagnosed by doctor	1.22	1	0	0.0	0.00	1.0e+00	C1QTNF4
Reaction Time	1.20	1	0	0.0	0.00	1.0e+00	UBXN2A
Type 2 Diabetes (T2D) (2018)	1.10	1	0	0.0	0.00	1.0e+00	C1QTNF4
Tanning	0.40	2	0	0.0	0.00	1.0e+00	AREL1 C1QTNF4
Hair Pigment	0.11	2	0	0.0	0.00	1.0e+00	KLHL29 PLEKHM1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	2	0.434	1.9
GTEx	Uterus	4	0.705	1.9
GTEx	Artery Coronary	2	0.169	1.7
GTEx	Brain Caudate basal ganglia	0	0.000	1.7
GTEx	Brain Cortex	2	0.193	1.7
GTEx	Brain Hippocampus	1	0.191	1.7
GTEx	Cells EBV-transformed lymphocytes	4	0.281	1.7
GTEx	Heart Atrial Appendage	1	0.063	1.7
GTEx	Adipose Visceral Omentum	2	0.098	1.6
GTEx	Adrenal Gland	1	0.069	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.6
GTEx	Brain Frontal Cortex BA9	2	0.216	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.6
GTEx	Brain Putamen basal ganglia	1	0.160	1.6
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.6
GTEx	Colon Sigmoid	2	0.137	1.6
GTEx	Colon Transverse	1	0.048	1.6
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.6
GTEx	Esophagus Muscularis	1	0.031	1.6
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Liver	1	0.139	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Pancreas	2	0.123	1.6
GTEx	Pituitary	1	0.090	1.6
GTEx	Prostate	2	0.240	1.6
GTEx	Skin Not Sun Exposed Suprapubic	2	0.081	1.6
GTEx	Spleen	2	0.142	1.6
GTEx	Stomach	1	0.069	1.6
GTEx	Testis	6	0.190	1.6
GTEx	Vagina	0	0.000	1.6
ROSMAP	Brain Pre-frontal Cortex	3	0.068	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.6
GTEx	Adipose Subcutaneous	3	0.086	1.5
GTEx	Artery Aorta	2	0.067	1.5
GTEx	Artery Tibial	2	0.053	1.5
GTEx	Brain Cerebellum	2	0.101	1.5
GTEx	Brain Hypothalamus	2	0.339	1.5
GTEx	Breast Mammary Tissue	1	0.051	1.5
GTEx	Cells Transformed fibroblasts	3	0.071	1.5
GTEx	Esophagus Mucosa	1	0.030	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Muscle Skeletal	5	0.173	1.5
GTEx	Nerve Tibial	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.5
GTEx	Thyroid	2	0.050	1.5
GTEx	Whole Blood	1	0.050	1.5
NTR	Blood	0	0.000	1.5
CommonMind	Brain Pre-frontal Cortex	3	0.056	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	2	0.168	1.4
METSIM	Adipose	2	0.043	1.4
YFS	Blood	3	0.065	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3