TWAS hub - KLHL29

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.2010	0.0630	0.0012	-0.003	NA	0.006	NA	-0.002	0.60000	NA	0.1300	NA	0.4700
2	GTEx	Lung	0.0831	0.0324	0.0019	0.001	NA	-0.003	NA	0.000	0.25000	NA	0.6000	NA	0.3400
3	GTEx	Nerve Tibial	0.1573	0.0589	0.0013	-0.003	NA	-0.003	NA	-0.003	0.63000	NA	0.6000	NA	0.6600
4	ROSMAP	Brain Pre-frontal Cortex	0.0788	0.0312	0.0026	0.029	0.005	0.020	0.017	0.019	0.00011	0.0720	0.0011	0.0024	0.0013
5	TCGA	Thyroid Carcinoma	0.0760	0.0320	0.0023	0.004	0.021	0.016	NA	0.011	0.12000	0.0033	0.0088	NA	0.0250

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5
Guilty feelings	6.7	10.1	35.9	1.3	3.6	6.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.1	5.5	15.7	0.8	3.1	4.0	1.1
Sitting height	4.1	29.2	75.0	0.9	-8.7	-7.5	-3.6
Fed-up feelings	3.8	6.9	23.4	1.9	4.8	2.7	0.2
Heart attack/myocardial infarction (self-reported)	3.8	4.9	13.3	-0.3	-1.3	-3.1	-3.6
Frequency of depressed mood in last 2 weeks	3.6	5.0	18.8	0.9	2.0	4.3	1.2
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	18.0	1.5	2.8	4.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.6	16.2	-0.1	2.6	4.0	2.2
Depressed Affect (Nagel 2018)	3.4	7.1	17.7	2.8	4.2	3.2	0.2
Mood swings	3.4	6.2	14.9	2.0	3.2	3.9	-1.2
Ever had bowel cancer screening	3.3	3.8	7.1	1.0	-2.7	-2.4	2.3
Heart attack	3.2	4.0	11.0	-0.1	-0.9	-2.9	-3.3
Mouth/teeth dental problems: Dentures	3.2	5.4	17.2	2.4	4.1	2.0	-0.3
Neuroticism (2016)	3.1	4.4	9.1	3.0	1.8	2.3	2.0
Blood Red Count	3.0	28.6	126.0	-3.2	11.2	2.4	-0.9
Depression (Nagel 2018)	2.9	4.4	15.1	1.0	2.1	3.9	1.2
Reaction Time	2.8	5.3	14.4	0.4	-3.8	-1.9	-2.9
Qualifications: CSEs or equivalent	2.8	3.6	11.4	-1.7	1.9	3.4	0.8
Average weekly red wine intake	2.8	4.2	11.9	0.2	-2.8	-3.5	1.1
Neuroticism (Nagel 2018)	2.7	6.3	12.5	3.5	2.8	3.3	0.5
Neuroticism	2.7	6.5	14.1	2.9	3.8	2.8	1.4
Illnesses of siblings	2.7	3.7	12.2	-2.1	-3.5	-1.1	0.9
Mean time to correctly identify matches	2.7	5.2	14.5	1.6	-3.8	-2.3	-2.0
Blood White Count	2.6	19.4	67.1	-0.7	8.2	5.2	1.6
Sensitivity / hurt feelings	2.6	4.5	13.9	3.7	-0.9	2.5	1.1
Neuroticism score	2.6	5.5	12.2	2.6	2.8	3.5	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	10.4	3.2	0.2	2.6	0.1
Medication for cholesterol	2.6	3.9	9.1	-3.0	-3.0	-0.8	-0.9
HbA1C	2.5	2.8	13.4	0.0	3.7	0.2	0.7
Pulse wave Arterial Stiffness index	2.5	2.9	4.8	2.0	-2.2	-2.2	0.8
Miserableness	2.5	4.4	11.9	1.1	2.8	3.4	1.1
Hearing difficulty/problems with background noise	2.4	3.8	13.2	1.0	0.6	2.1	3.6
Mouth/teeth dental problems	2.4	3.6	10.6	-3.2	-2.8	0.1	-0.2
Happiness	2.2	2.6	7.0	2.6	1.4	1.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	18.8	-1.0	-3.0	-4.3	-2.5
Medication: Blood pressure	2.2	4.1	8.4	2.8	2.9	-2.0	0.8
Chronotype (morning person)	2.1	4.7	19.2	-0.9	4.4	-1.3	-1.4
Average weekly fortified wine intake	2.1	2.5	8.6	-0.9	-1.7	-2.9	0.4
Alcohol usually taken with meals	2.1	3.4	10.6	-0.5	-2.0	-3.3	1.6
Medication: Paracetamol	2.1	3.4	11.4	-0.1	2.4	3.4	-0.1
Medication: Seretide 50 evohaler	2.1	2.4	4.6	-0.3	-2.1	-1.9	-2.0
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	17.6	-0.6	-3.6	-4.2	-1.4
Long-standing illness, disability or infirmity	2.0	3.0	10.8	0.2	2.0	3.3	-0.3
Maternal smoking around birth	1.9	2.8	9.2	3.0	1.2	1.6	0.9
Leg fat percentage (right)	1.9	6.9	18.1	0.6	3.4	4.3	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	5.2	1.3	-2.0	0.4	2.3
Smoking status: Previous	1.9	2.8	12.4	3.5	0.5	0.6	0.9
Loneliness, isolation	1.9	2.6	6.6	2.6	1.6	1.9	-0.4
Heart disease (siblings)	1.9	2.4	5.9	0.6	2.1	2.4	1.1
Prostate Cancer	1.8	2.5	6.2	2.0	-2.5	-1.1	1.2
Height	1.8	34.3	114.5	3.6	-6.0	-10.7	-2.7
Ever had hysterectomy (womb removed)	1.8	2.0	6.9	0.8	1.5	0.1	-2.6
Pack years adult smoking proportion	1.8	2.7	9.7	-0.1	1.7	3.1	1.1
Past tobacco smoking	1.8	3.3	8.6	-2.9	-1.0	-2.2	-1.5
Smoking status: Current	1.8	2.8	9.6	-1.8	0.8	3.1	0.6
Leg fat percentage (left)	1.8	6.4	17.1	0.6	3.2	4.1	2.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	4.7	1.0	0.9	2.1	2.2
Pack years of smoking	1.8	2.6	9.1	0.4	1.9	3.0	0.6
Coronary Artery Disease (CAD)	1.7	2.0	7.8	-1.4	0.2	2.8	0.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	5.0	-2.2	1.8	1.3	0.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	6.1	-2.5	-1.8	-1.1	-1.8
Pulse wave peak to peak time	1.7	2.0	3.4	-1.8	1.8	1.6	-0.8
Health satisfaction	1.7	2.2	5.8	1.6	-2.4	-0.4	1.5
Commuting to job workplace: Walk	1.7	1.9	4.2	2.0	-2.0	-1.1	-0.2
Fasting Glucose	1.6	2.0	4.7	2.2	-0.2	0.6	2.2
Smoking Status	1.6	3.8	14.7	0.7	0.9	3.8	1.6
Supplements: Zinc	1.6	1.8	4.6	-0.9	-1.8	-0.7	-2.1
Current tobacco smoking	1.6	2.6	8.2	-1.8	1.2	2.9	0.2
Multivitamins +/- minerals	1.6	2.1	5.4	2.3	-0.2	1.0	-2.0
Stomach or abdominal pain in last month	1.6	2.0	4.2	1.2	-1.2	2.1	1.7
Depression (self-reported)	1.6	1.9	8.0	2.8	-0.4	0.8	0.9
Peak expiratory flow (PEF)	1.6	3.7	10.9	0.7	-3.3	-2.6	0.2
Worry too long after embarrassment	1.6	2.7	9.2	1.5	0.8	3.0	1.3
Family relationship satisfaction	1.6	2.0	9.5	3.1	0.6	0.1	0.5
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.7	1.4	0.6	1.7	2.2
Diabetes (father)	1.5	1.8	4.0	-0.2	1.2	2.0	2.0
Trunk fat-free mass	1.5	8.9	25.4	1.8	-5.0	-3.9	0.4
Trunk predicted mass	1.5	8.8	25.0	1.7	-5.0	-4.0	0.3
Friendships satisfaction	1.5	1.9	4.5	2.1	-1.5	-1.6	-0.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	6.7	2.6	1.1	0.6	-1.3
Medication: Lisinopril	1.5	1.9	4.7	-1.6	2.2	-1.4	-0.2
Vitamin and mineral supplements	1.4	1.9	5.9	-1.3	-0.1	-1.3	2.4
Medication: Atenolol	1.4	1.7	6.0	2.5	0.8	-0.3	1.4
Number of live births	1.4	1.9	5.7	2.4	-0.2	1.9	0.7
Standing height	1.4	14.3	44.9	2.4	-4.5	-6.7	-1.0
Glaucoma (self-reported)	1.4	1.7	4.1	1.4	0.9	1.2	-2.0
Birth weight	1.4	3.0	8.8	-0.4	-3.0	-1.9	1.6
High blood pressure (siblings)	1.4	2.0	4.5	1.2	1.9	-0.5	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.9	0.9	2.4	1.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	8.9	-0.8	-3.0	0.3	2.3
Whole body water mass	1.4	8.0	24.9	1.6	-5.0	-3.4	0.9
Average weekly champagne plus white wine intake	1.4	2.0	5.9	-0.5	-2.4	-0.4	-1.9
Diabetes (mother)	1.3	1.7	4.0	0.7	0.4	2.0	2.0
Supplements: Glucosamine	1.3	1.8	4.1	1.4	-1.3	-2.0	1.0
Qualifications: None of the above	1.3	2.8	11.3	1.2	3.4	0.8	-0.7
Medication: Simvastatin	1.3	1.9	4.9	-0.2	2.2	1.6	-1.4
Noisy workplace	1.3	1.6	4.7	1.4	-0.4	2.2	-1.0
Qualifications: A levels/AS levels or equivalent	1.3	2.9	9.0	-0.8	-3.0	-1.7	-1.3
Medication: Ventolin 100micrograms inhaler	1.3	1.6	6.3	0.3	-0.9	2.5	0.9
Comparative height size at age 10	1.3	7.3	21.7	0.5	-3.8	-4.7	0.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	3.9	-0.5	-1.7	-2.0	-0.9
Whole body fat-free mass	1.3	7.6	23.6	1.7	-4.9	-3.3	0.8
Medication: Paracetamol	1.3	2.1	6.6	-0.2	1.9	2.6	-0.4
Hearing difficulty/problems: Yes	1.2	1.9	7.1	-0.1	0.9	2.7	1.2
Hair/balding pattern: Pattern 2	1.2	1.5	3.7	1.9	-0.8	1.8	0.0
Tense / ‘highly strung’	1.2	2.0	8.9	3.0	0.6	0.6	0.6
Forced vital capacity (FVC), Best measure	1.2	4.4	14.2	0.1	-2.0	-3.8	-1.9
Medication for pain relief, constipation, heartburn	1.2	2.1	6.7	-0.8	-1.7	-2.6	-0.8
Medication: Allopurinol	1.2	1.5	6.0	-0.3	-1.2	-2.4	-0.3
Illnesses of siblings: Diabetes	1.2	1.5	4.9	2.2	-0.4	1.2	-1.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	6.6	0.7	0.4	2.6	0.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	6.8	0.9	-2.6	-1.4	0.3
Mineral and other dietary supplements	1.2	1.6	5.1	-2.3	0.3	1.1	1.3
Osteoporosis (self-reported)	1.2	1.4	3.1	-0.7	0.9	1.7	1.8
Mother’s age at death	1.2	1.5	3.7	1.7	1.0	-0.4	1.9
Commuting to job workplace: Cycle	1.2	1.5	3.8	1.2	-1.1	0.9	1.9
Average weekly spirits intake	1.1	1.3	6.0	2.4	-0.4	0.2	0.7
Age when periods started (menarche)	1.1	2.7	5.2	2.3	2.3	-1.3	-1.1
Forced vital capacity (FVC)	1.1	4.4	14.9	0.8	-2.4	-3.9	-0.6
Alcohol intake versus 10 years previously	1.1	1.7	4.0	-1.2	1.7	2.0	0.4
Hair/balding pattern: Pattern 3	1.1	1.6	6.2	0.7	2.5	0.8	-0.8
Lung cancer (father)	1.1	1.3	5.9	0.5	2.4	0.1	-0.3
Breastfed as a baby	1.1	1.4	3.2	-1.4	-1.2	-1.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.0	1.5	-0.2	1.4	2.0
Body fat percentage	1.1	4.4	11.0	0.3	2.6	3.3	2.0
Arm fat-free mass (right)	1.1	5.8	16.7	1.6	-4.1	-3.0	0.8
Number of children fathered	1.1	1.2	4.4	-1.0	-0.9	2.1	-0.1
Neck or shoulder pain in last month	1.1	1.6	3.6	1.1	1.7	1.9	-0.3
Medication: Omeprazole	1.1	1.4	4.4	1.0	1.0	2.1	0.6
Arm predicted mass (right)	1.1	5.4	16.2	1.6	-4.0	-2.8	0.7
Alcohol intake frequency.	1.1	2.5	9.3	0.3	3.0	1.3	-1.3
Qualifications: nursing, teaching	1.1	1.6	6.3	0.5	-2.5	-1.0	0.8
Ever smoked	1.1	1.9	3.8	1.5	1.1	1.9	1.4
Fractured/broken bones in last 5 years	1.1	1.4	3.5	0.5	0.5	1.9	1.8
Supplements: Calcium	1.1	1.2	5.2	2.3	-0.5	0.7	-0.1
Alzheimer’s Disease (in mother)	1.0	1.2	2.5	0.5	-1.6	-1.6	0.8
Bipolar Disorder (2011)	1.0	1.0	4.0	-0.0	0.9	0.4	-2.0
Nervous feelings	1.0	1.9	7.3	2.7	1.5	0.4	0.0
Pulse wave reflection index	1.0	1.3	3.4	1.6	-0.6	0.3	1.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.1	0.4	1.8	-0.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.6	1.4	-0.2	1.9	-0.7
Leg fat-free mass (right)	1.0	5.1	18.8	1.4	-4.3	-1.9	1.2
Arm fat percentage (left)	1.0	3.8	11.4	0.1	1.8	3.4	2.2
Leg predicted mass (right)	1.0	5.1	19.0	1.3	-4.4	-1.9	1.1
Eye problems/disorders: Glaucoma	1.0	1.1	2.8	0.7	0.8	1.4	-1.7
Basal metabolic rate	1.0	5.5	17.9	1.6	-4.2	-2.3	1.2
Arm fat-free mass (left)	1.0	5.0	16.2	1.3	-4.0	-2.6	0.9
Hand grip strength (left)	0.9	2.4	7.2	0.5	-1.9	-2.7	1.1
Leg fat-free mass (left)	0.9	4.6	16.3	1.5	-4.0	-1.8	1.2
Trunk fat percentage	0.9	3.5	7.8	0.4	2.4	2.8	1.9
Hand grip strength (right)	0.9	2.5	5.8	0.7	-2.4	-2.1	1.2
Leg predicted mass (left)	0.9	4.5	16.1	1.5	-4.0	-1.8	1.1
Angina (self-reported)	0.9	1.2	5.4	2.3	-0.1	0.7	-0.4
Suffer from ‘nerves’	0.9	1.5	3.5	1.6	0.9	1.9	0.7
Medication: Bendroflumethiazide	0.9	1.3	2.8	1.2	0.8	-1.4	1.7
Risk taking	0.9	1.3	4.8	-0.1	-1.1	2.2	-0.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	3.8	-0.0	-0.5	-1.9	1.0
Age started oral contraceptive pill	0.9	1.2	2.3	-1.0	-1.2	-1.5	-1.0
Unable to work because of sickness or disability	0.9	1.2	2.3	1.5	1.4	1.2	0.2
Arm predicted mass (left)	0.9	4.8	15.2	1.3	-3.9	-2.4	1.0
Bipolar Disorder (2018)	0.8	1.2	2.6	1.0	1.4	1.6	0.8
Bipolar Disorder or Schizophrenia	0.8	2.0	5.4	0.3	1.5	2.3	1.5
Worry (Nagel 2018)	0.8	1.7	7.9	2.8	0.1	-0.0	0.8
Lupus	0.8	1.3	3.2	-1.8	1.1	-0.8	-1.1
Lung FEV1/FVC ratio	0.8	4.3	8.2	-2.7	-2.9	-2.2	-1.1
Angina	0.8	1.1	4.7	2.2	-0.2	0.9	-0.1
Chronic bronchitis/emphysema (father)	0.8	1.0	1.8	1.0	-1.4	-0.9	-1.1
Body mass index (BMI)	0.8	3.3	10.6	0.5	0.3	3.3	2.4
Impedance of leg (left)	0.8	4.0	18.0	-0.7	4.2	-0.1	-1.1
Financial difficulties in last 2 years	0.8	1.1	4.9	0.3	-0.5	2.2	0.4
Arm fat percentage (right)	0.8	3.3	11.1	-0.2	1.5	3.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	-0.8	-1.1	-0.2	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.0	-1.4	1.4	1.1	0.3
Loud music exposure frequency	0.8	0.8	2.3	1.3	0.1	1.5	-0.1
Number of full brothers	0.8	1.0	3.1	1.8	-0.2	-0.0	-1.4
Medication: Ibuprofen	0.8	1.0	2.2	-1.4	1.5	0.9	0.3
Chest pain or discomfort	0.8	1.2	2.7	1.6	-0.6	-0.9	-1.5
Age at last live birth	0.8	1.1	1.9	1.3	-1.4	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.2	-0.7	-1.2	-1.4	-2.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.5	1.9	0.8	-0.6	0.1
High cholesterol (Self-reported)	0.8	1.4	4.7	-0.1	2.2	0.9	1.2
Medication: Atorvastatin	0.8	1.0	3.5	-0.3	-0.7	-1.9	-0.9
Crohns Disease (2017)	0.7	1.6	5.7	-0.6	2.4	1.3	-0.6
Rheumatoid Arthritis	0.7	0.9	2.5	-0.8	-1.3	-1.6	0.1
Schizophrenia (2014)	0.7	1.6	4.5	-0.4	1.6	2.1	0.9
BMI	0.7	4.1	13.0	-0.1	-0.5	3.6	2.7
Waist Hip Ratio (WHR)	0.7	3.1	11.0	0.3	3.3	1.8	1.2
Number of treatments/medications taken	0.7	1.3	3.8	2.0	1.4	0.8	-0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-0.3	-1.2	-1.0	-1.2
Medication: Co-codamol	0.7	0.9	2.3	0.2	1.4	1.5	0.1
Impedance of leg (right)	0.7	3.6	16.2	-0.7	4.0	-0.2	-1.1
High blood pressure (mother)	0.7	1.0	4.3	-0.9	-0.1	-0.0	-2.1
Waist circumference	0.7	2.5	7.0	0.8	0.9	2.1	2.6
Pain all over the body in last month	0.7	0.7	2.6	0.3	1.6	0.9	0.2
Father’s age at death	0.7	1.0	4.5	-0.6	-0.2	-2.1	0.1
Gout (self-reported)	0.7	1.0	3.2	-1.1	-0.7	-1.8	-0.3
Overall health rating	0.7	1.6	4.2	2.1	0.1	1.2	1.5
Hypertension (Self-reported)	0.7	1.8	5.6	0.9	1.1	-1.2	2.4
Number of self-reported non-cancer illnesses	0.7	1.3	3.1	1.8	0.1	1.6	0.7
Irritability	0.7	1.1	2.8	1.3	1.7	1.1	-0.1
Myopia	0.7	1.0	3.6	-1.9	-0.8	-0.8	-0.1
Impedance of whole body	0.7	3.8	16.5	-1.1	4.1	-0.3	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	8.9	0.6	-0.3	-3.0	0.1
Alzheimer’s Disease (in father)	0.6	0.6	2.2	-0.4	-1.5	0.7	-0.6
Breast Cancer	0.6	1.4	2.9	-1.4	1.7	1.5	-0.1
Allergy or Eczema	0.6	1.7	4.0	2.0	-1.2	-1.7	0.0
Respiratory disease	0.6	1.3	2.2	1.5	-1.4	1.1	1.1
Systolic blood pressure, automated reading	0.6	1.8	4.1	0.4	1.7	-1.3	2.0
Medication for hormone replacement therapy	0.6	0.7	1.6	1.1	0.8	1.3	0.1
Severe depression (siblings)	0.6	0.7	1.9	0.1	-1.4	-1.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.2	1.5	-0.0	0.8	0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	1.3	0.5	0.3	1.2
Had menopause	0.6	0.7	1.8	1.3	1.0	-0.9	-0.2
Had other major operations	0.6	0.7	1.8	-1.1	-1.3	0.5	-0.4
Medication: Lansoprazole	0.6	0.7	1.8	0.1	1.3	0.2	1.2
Length of working week for main job	0.6	0.7	1.7	-1.3	-0.1	-0.4	-1.2
Exposure to tobacco smoke at home	0.6	0.7	2.0	-1.4	0.2	1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-0.6	1.2	1.4	0.2
Qualifications: College or University degree	0.6	2.0	7.2	1.0	-2.7	-1.1	0.7
Leg fat mass (right)	0.6	2.4	6.8	1.1	1.1	2.6	1.7
Medication: Aspirin	0.6	0.7	3.5	0.3	0.3	-0.0	-1.9
Supplements: Vitamin C	0.6	0.7	2.6	-0.4	-0.7	-0.4	-1.6
Commuting to job workplace: Public transport	0.6	0.8	2.7	-1.6	0.4	-0.9	0.4
Diastolic blood pressure, automated reading	0.6	1.8	7.0	-0.7	0.8	-2.6	0.9
Alcohol drinker status: Previous	0.6	0.7	3.3	0.3	1.8	0.5	-0.0
Leg fat mass (left)	0.6	2.5	7.2	1.1	1.1	2.7	1.7
Schizophrenia (2018)	0.5	1.1	2.8	-0.4	0.8	1.7	1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	-0.4	-0.8	1.3	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	3.6	-0.1	-1.9	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	0.2	1.1	-1.0	-0.9
Systolic Blood Pressure	0.5	2.5	7.6	1.1	1.6	-1.1	2.8
Lung FVC	0.5	2.4	7.5	1.4	-1.1	-2.7	-1.2
Taking other prescription medications	0.5	0.8	3.0	0.2	0.9	1.7	-0.5
High blood pressure	0.5	1.5	4.6	0.5	0.8	-1.4	2.1
Diabetes (self-reported)	0.5	0.8	2.3	-0.5	0.8	0.8	-1.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.2	1.8	0.1	0.5	-0.1
Medication: Ramipril	0.5	0.6	1.5	1.1	0.5	-1.2	0.2
Falls in the last year	0.5	0.7	1.8	0.2	-0.2	1.4	1.3
Illnesses of mother	0.5	0.6	1.9	-0.8	0.7	-0.3	1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.8	1.7	0.4	-0.2	-0.2
Heart disease (mother)	0.5	0.6	2.4	0.1	-0.6	-0.6	-1.6
Knee pain experienced in last month	0.5	0.7	2.4	1.6	0.6	0.4	0.9
Diabetes diagnosed by doctor	0.5	0.9	1.6	0.1	1.2	1.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	-1.0	0.1	1.2	0.1
Back pain experienced in last month	0.5	0.8	1.7	-0.4	1.1	1.3	0.8
Breast cancer (self-reported)	0.5	0.6	2.2	-1.5	-0.8	0.2	0.3
Osteoarthritis (self-reported)	0.5	0.7	1.4	0.2	-0.9	1.0	1.2
Number of operations (self-reported)	0.5	0.7	1.5	1.2	-1.0	-0.5	1.0
Pain experienced in last month	0.5	0.8	2.5	-0.5	-0.6	-1.6	-0.8
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	1.0	1.4	0.2	-0.0
Irritable Bowel Disease (IBD)	0.4	1.0	2.7	-0.9	1.6	1.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.2	0.5	-0.1	-2.0	-0.5
Age at First Birth	0.4	0.7	1.9	-1.4	1.1	-0.2	0.2
Body Mass Index (BMI) (2010)	0.4	0.5	2.3	0.4	-0.1	1.5	0.5
Crohns Disease (2012)	0.4	0.6	1.9	-0.9	1.4	0.6	-0.4
Triglycerides	0.4	0.6	1.7	-0.6	1.3	0.8	-0.7
Blood Platelet Count	0.4	4.4	11.6	1.8	-3.4	0.3	2.7
Cardiovascular Disease	0.4	1.4	5.2	0.2	1.1	0.6	2.3
Hypothyroidism (self reported)	0.4	0.9	3.0	-1.7	0.9	-0.7	0.3
Relative age of first facial hair	0.4	0.9	2.4	-0.7	1.6	1.1	0.4
Townsend deprivation index at recruitment	0.4	0.5	1.9	0.6	-0.6	0.1	1.4
Relative age voice broke	0.4	0.6	1.3	-1.0	0.7	1.1	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	2.0	-1.4	-0.1	-0.6	-0.4
Medication: Levothyroxine sodium	0.4	0.7	3.0	-0.5	0.6	0.2	1.7
Trunk fat mass	0.4	1.7	3.5	1.1	0.9	1.7	1.9
Fluid intelligence score	0.4	0.7	2.2	1.5	-0.3	-1.1	0.4
Weight	0.4	1.9	3.8	1.6	-1.7	0.2	2.0
Prospective memory result	0.4	0.6	1.4	-0.0	1.1	0.3	1.2
Impedance of arm (left)	0.4	2.1	9.5	-0.6	3.1	-0.5	-0.5
Arm fat mass (right)	0.4	1.5	4.1	0.6	-0.2	2.0	1.8
Hair/balding pattern: Pattern 4	0.4	1.1	2.8	-1.4	1.7	-0.3	0.7
Exposure to tobacco smoke outside home	0.4	0.5	2.0	-0.7	0.4	0.0	-1.4
Age at first live birth	0.4	0.6	1.6	0.5	-1.3	-1.2	-0.0
Whole body fat mass	0.4	1.6	3.7	1.0	0.6	1.9	1.7
Had major operations	0.4	0.4	1.1	1.1	-0.7	-0.7	-0.1
Leg pain on walking	0.4	0.5	1.5	0.6	-0.6	-1.2	-0.3
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.1	1.0	0.6	1.0
Medication: Gliclazide	0.4	0.4	1.2	-0.1	0.1	1.1	-1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-0.6	0.5	-0.0	1.4
Arm fat mass (left)	0.4	1.7	4.2	0.5	-0.1	2.0	2.1
Ever taken oral contraceptive pill	0.4	0.5	1.3	-0.6	-0.8	-1.1	0.1
Hearing aid user	0.4	0.5	1.3	1.1	0.1	0.8	0.7
Financial situation satisfaction	0.4	0.5	1.5	0.7	-0.0	1.2	0.7
Alcohol drinker status: Never	0.4	0.5	2.1	0.5	0.3	-1.4	-0.5
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.2	0.0	1.2	1.2
Ever depressed for a whole week	0.4	0.4	1.8	-0.1	-0.3	-0.5	-1.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	-0.8	-0.9	1.6	-1.0
Major Depression (MDD)	0.3	0.4	2.0	-0.2	0.1	1.4	0.3
Ovarian Cancer	0.3	0.4	1.1	-0.3	-0.2	-1.1	-0.9
Heel T-Score	0.3	2.3	5.6	-1.8	-2.4	-1.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.0	-0.1	-0.8	-0.4
Medication: Metformin	0.3	0.5	1.0	-0.8	1.0	0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.7	-1.3	-1.1	-0.1	-0.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.7	-1.2	-0.9	-1.0
Number of incorrect matches in round	0.3	0.5	1.4	1.2	0.6	-0.1	0.9
Allergy	0.3	0.7	2.1	-1.1	1.4	-0.3	0.5
Impedance of arm (right)	0.3	1.4	4.5	-1.1	2.1	-0.6	-1.1
Hip circumference	0.3	1.5	3.2	1.0	-1.6	0.5	1.8
Time employed in main current job	0.3	0.3	0.8	0.3	-0.9	0.7	-0.3
Worrier / anxious feelings	0.3	0.6	1.7	1.3	0.4	0.8	0.8
Asthma	0.3	0.6	1.9	0.7	-1.4	0.7	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-0.9	1.1	-0.2	0.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.0	-0.4	0.9	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.7	0.1	0.6	1.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.7	-0.1	-0.0	-1.3	-0.4
Number of full sisters	0.3	0.4	2.1	0.1	0.1	1.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.1	-0.5	0.3	1.0	-0.2
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.2	0.7	0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.5	-0.4	0.4	1.1
Asthma (self-reported)	0.3	0.7	2.2	0.9	-1.5	0.5	-0.0
Medication: Aspirin	0.3	0.4	1.8	0.3	0.3	0.1	-1.3
Wears glasses or contact lenses	0.3	0.3	1.3	-0.3	0.4	0.2	1.1
Illnesses of father: High blood pressure	0.3	0.3	0.9	-0.1	0.7	0.9	0.4
Mean Putamen Volume	0.2	0.2	1.0	0.3	-0.4	1.0	0.1
Ulcerative Colitis	0.2	0.3	1.1	0.6	0.0	-1.1	-0.4
Blood Eosinophil Count	0.2	1.4	3.1	0.9	-0.8	1.5	1.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	-0.6	0.4	1.0	-0.5
Tanning	0.2	2.3	5.0	-0.6	2.2	2.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	0.2	0.2	1.0	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	-0.1	-0.2	1.3	-0.8
Pulse rate	0.2	0.3	0.7	-0.7	-0.8	-0.2	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.7	-0.8	-0.4	0.2	-0.7
Medication: Amlodipine	0.2	0.3	1.4	0.3	1.2	-0.0	0.4
Comparative body size at age 10	0.2	0.7	2.7	-0.6	0.3	1.6	0.4
Shortness of breath walking on level ground	0.2	0.2	0.5	0.4	0.7	-0.4	-0.5
Eye problems/disorders: None of the above	0.2	0.2	1.0	0.1	0.1	0.3	1.0
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.7	0.6	0.0
Medication: Blood pressure	0.2	0.3	0.8	-0.3	0.4	-0.7	0.9
Migraine (self-reported)	0.2	0.3	0.7	-0.8	-0.8	-0.0	-0.2
Pulse rate, automated reading	0.2	0.7	2.4	-0.8	-0.3	-0.5	-1.6
Cholesterol lowering medication	0.2	0.3	0.9	0.9	0.2	0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.8	-0.3	0.2	-0.6
HDL Cholesterol	0.1	0.2	0.6	-0.8	-0.5	0.4	-0.2
LDL Cholesterol	0.1	0.1	0.5	-0.3	0.1	0.7	0.2
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.4	0.3	0.5	0.2
Hair Pigment	0.1	4.2	12.3	-0.7	2.8	3.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.1	0.5	-0.1	0.2
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.6	0.2	-0.7	-0.2
Birth weight of first child	0.1	0.1	0.5	-0.1	0.1	0.7	-0.3
Headache pain in last month	0.1	0.2	0.6	-0.8	0.2	0.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.5	-0.3	-0.0	-0.5
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1

Hub : Genes

KLHL29

Models

Trait associations