Best TWAS P=2.41e-18 · Best GWAS P=1.9e-18 conditioned to 0.0681
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | 7.0 | 7.2 | 5.8e-13 | 0.66 | 0.96 | 0.04 | FALSE |
2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | -3.6 | -6.0 | 1.5e-09 | -0.48 | 0.06 | 0.09 | FALSE |
3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | 8.3 | 8.6 | 5.9e-18 | 0.90 | 0.07 | 0.93 | FALSE |
4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | 8.2 | 8.7 | 2.4e-18 | 0.92 | 0.09 | 0.91 | TRUE |
5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | 8.7 | 6.9 | 4.6e-12 | 0.85 | 0.03 | 0.88 | FALSE |
6 | The Cancer Genome Atlas | Thyroid Carcinoma | CADM2 | 0.05 | 0.00 | blup | 339 | 0.02 | 3.2e-03 | 3.2 | 6.9 | 4.4e-12 | 0.68 | 0.04 | 0.52 | FALSE |