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chr2:26,505,858-28,038,799

Best TWAS P=2.71e-08 · Best GWAS P=2.71e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	KHK	0.18	0.23	lasso	7	0.26	2.4e-21	-5.3	-5.2	2.0e-07	0.98	0.02	0.98	FALSE
2	GTEx	Artery Aorta	KHK	0.08	0.06	enet	8	0.06	5.4e-04	-5.3	-5.3	1.4e-07	0.96	0.02	0.97	FALSE
3	GTEx	Artery Tibial	KHK	0.07	0.10	lasso	4	0.09	1.7e-07	-5.4	-5.2	1.7e-07	0.96	0.03	0.97	FALSE
4	GTEx	Breast Mammary Tissue	KHK	0.22	0.20	lasso	8	0.24	8.4e-13	-5.4	-5.2	2.4e-07	0.97	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue (Female)	KHK	0.17	0.17	lasso	4	0.16	1.5e-05	-5.4	-5.2	2.0e-07	0.96	0.04	0.95	FALSE
6	GTEx	Cells Transformed fibroblasts	MAPRE3	0.07	0.05	lasso	5	0.05	1.7e-04	-5.2	-5.2	2.2e-07	0.96	0.04	0.96	FALSE
7	GTEx	Cells Transformed fibroblasts	CGREF1	0.10	0.11	lasso	8	0.12	6.4e-09	-5.0	-5.3	1.4e-07	0.97	0.04	0.96	FALSE
8	GTEx	Esophagus Muscularis	KHK	0.10	0.08	lasso	3	0.08	1.8e-05	-5.2	-5.3	1.4e-07	0.98	0.02	0.98	FALSE
9	GTEx	Lung	KHK	0.09	0.11	lasso	4	0.12	3.0e-09	-5.4	-5.3	1.2e-07	0.98	0.01	0.99	FALSE
10	GTEx	Muscle Skeletal	KHK	0.16	0.19	lasso	4	0.24	5.0e-23	-5.0	-5.3	1.5e-07	0.98	0.01	0.99	FALSE
11	GTEx	Nerve Tibial	KHK	0.24	0.19	lasso	7	0.20	2.2e-14	-5.4	-5.4	8.5e-08	0.94	0.01	0.99	FALSE
12	GTEx	Ovary	KHK	0.29	-0.01	lasso	3	0.01	1.6e-01	-5.3	-5.3	1.1e-07	0.96	0.03	0.55	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	KHK	0.19	0.28	lasso	5	0.26	2.9e-14	-5.4	-5.4	7.7e-08	0.98	0.01	0.99	FALSE
14	GTEx	Skin Sun Exposed Lower leg	CGREF1	0.07	0.00	lasso	7	0.01	7.1e-02	-5.3	-5.2	2.0e-07	0.82	0.03	0.85	FALSE
15	GTEx	Skin Sun Exposed Lower leg	KHK	0.21	0.30	lasso	6	0.34	3.2e-29	-5.4	-5.2	1.6e-07	0.98	0.01	0.99	FALSE
16	GTEx	Testis	KHK	0.20	0.15	lasso	4	0.17	8.0e-08	-5.2	-5.4	7.8e-08	0.97	0.02	0.98	FALSE
17	GTEx	Thyroid	KHK	0.15	0.19	lasso	4	0.22	1.1e-16	-5.3	-5.3	9.0e-08	0.97	0.01	0.99	FALSE
18	YFS	Blood	KHK	0.06	0.07	lasso	5	0.06	2.2e-20	-5.4	-5.4	6.8e-08	0.98	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	KHK	0.04	0.07	lasso	2	0.07	1.2e-13	-5.6	-5.5	3.1e-08	1.00	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	MAPRE3	0.18	0.05	blup	53	0.09	1.4e-03	-5.3	-5.4	6.5e-08	0.94	0.02	0.81	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CGREF1	0.05	0.03	blup	37	0.03	4.3e-04	-5.2	-5.4	8.4e-08	0.91	0.02	0.96	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CGREF1	0.03	0.02	blup	37	0.03	2.3e-04	-4.8	-5.4	7.5e-08	0.92	0.02	0.93	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KHK	0.02	0.02	blup	36	0.02	2.2e-03	-5.3	-5.3	1.3e-07	0.97	0.01	0.93	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	KHK	0.13	0.14	lasso	2	0.13	5.1e-06	-5.6	-5.6	2.7e-08	1.00	0.01	0.98	TRUE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	KHK	0.13	0.21	blup	37	0.23	1.4e-23	-5.3	-5.4	5.5e-08	0.96	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	OST4	0.02	0.02	lasso	1	0.02	8.9e-03	-5.3	5.3	1.0e-07	-0.93	0.01	0.74	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	KHK	0.09	0.19	lasso	5	0.19	2.2e-18	-5.3	-5.3	1.5e-07	0.98	0.02	0.98	FALSE