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chr1:752,566-3,212,946

Best TWAS P=2.64e-14 · Best GWAS P=2.28e-10 conditioned to 0.0467

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Esophagus Muscularis	RP1-283E3.4	0.46	0.14	enet	23	0.24	1.6e-14	-3.3	-7.6	2.6e-14	0.01	0.95	0.00	TRUE
16	GTEx	Esophagus Muscularis	RP3-395M20.12	0.08	0.06	enet	6	0.06	2.3e-04	4.5	-6.4	2.0e-10	0.78	0.01	0.98	TRUE
10	GTEx	Brain Cerebellar Hemisphere	RP5-890O3.9	0.24	0.02	lasso	9	0.02	1.3e-01	-5.9	6.3	2.5e-10	-0.01	0.02	0.69	TRUE
14	GTEx	Esophagus Mucosa	RP1-283E3.4	0.53	0.12	enet	20	0.22	4.1e-15	-3.3	-7.3	2.4e-13	0.02	0.99	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	RP1-283E3.4	0.59	0.13	lasso	8	0.29	3.0e-22	4.0	-7.0	2.0e-12	0.01	0.99	0.01	FALSE
34	GTEx	Thyroid	RP1-283E3.4	0.59	0.04	lasso	10	0.22	3.8e-17	-3.3	-7.0	2.8e-12	0.00	0.73	0.03	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	RP1-283E3.4	0.48	0.12	lasso	5	0.31	1.1e-17	-3.3	-6.9	3.8e-12	0.01	0.43	0.15	FALSE
3	GTEx	Adipose Visceral Omentum	RP1-283E3.4	0.26	0.05	enet	25	0.16	1.5e-08	-3.3	-6.9	6.0e-12	-0.02	0.15	0.09	FALSE
1	GTEx	Adipose Subcutaneous	RP1-283E3.4	0.65	0.14	lasso	9	0.33	5.1e-28	-3.3	-6.7	1.9e-11	0.00	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	SLC35E2B	0.35	0.06	lasso	4	0.19	3.2e-18	-3.1	6.5	9.4e-11	0.01	0.98	0.00	FALSE
19	GTEx	Lung	RP1-283E3.4	0.58	0.07	lasso	7	0.34	8.8e-27	-3.3	-6.5	9.5e-11	0.02	0.99	0.00	FALSE
7	GTEx	Artery Tibial	RP1-283E3.4	0.66	0.09	lasso	6	0.38	4.9e-31	-3.3	-6.4	2.0e-10	0.01	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	RP11-345P4.10	0.54	0.06	lasso	7	0.29	4.7e-29	-3.1	6.3	2.6e-10	0.00	0.99	0.00	FALSE
21	GTEx	Muscle Skeletal	TMEM52	0.11	0.08	lasso	6	0.10	7.2e-10	-5.8	6.3	3.9e-10	-0.02	0.02	0.98	FALSE
5	GTEx	Artery Aorta	RP1-283E3.4	0.60	0.12	lasso	9	0.27	3.2e-15	-3.3	-6.2	4.5e-10	-0.01	0.55	0.03	FALSE
23	GTEx	Muscle Skeletal	RP1-283E3.4	0.51	0.12	lasso	6	0.29	2.4e-28	-3.3	-6.2	4.8e-10	0.01	1.00	0.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	TMEM52	0.17	0.14	lasso	7	0.15	2.0e-12	5.7	6.0	2.4e-09	-0.01	0.03	0.97	FALSE
8	GTEx	Artery Tibial	RP11-345P4.10	0.61	0.10	lasso	10	0.36	3.1e-29	-3.1	5.9	3.6e-09	0.01	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	TMEM52	0.17	0.18	lasso	2	0.20	2.9e-13	-5.9	5.8	5.1e-09	0.02	0.02	0.98	FALSE
18	GTEx	Lung	NADK	0.07	0.03	lasso	3	0.02	8.5e-03	5.5	-5.8	5.5e-09	0.01	0.03	0.90	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	MMP23B	0.05	0.04	lasso	2	0.03	1.9e-04	-5.8	-5.8	6.0e-09	0.02	0.02	0.98	FALSE
20	GTEx	Muscle Skeletal	NADK	0.06	0.00	enet	9	0.00	1.3e-01	-5.6	-5.8	6.2e-09	0.00	0.03	0.91	FALSE
17	GTEx	Heart Atrial Appendage	RP11-345P4.10	0.36	0.11	enet	15	0.16	1.1e-07	-3.1	5.8	6.9e-09	-0.01	0.10	0.05	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	TMEM52	0.19	0.18	lasso	4	0.14	2.6e-08	5.5	5.8	7.5e-09	-0.01	0.04	0.96	FALSE
9	GTEx	Brain Cerebellar Hemisphere	NADK	0.18	0.11	lasso	7	0.09	3.1e-03	-5.6	-5.8	8.4e-09	0.03	0.03	0.65	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM52	0.02	0.01	blup	37	0.02	6.6e-03	-5.8	5.7	9.6e-09	-0.02	0.01	0.79	FALSE
12	GTEx	Cells Transformed fibroblasts	RP11-345P4.10	0.66	0.17	lasso	13	0.32	7.5e-25	-3.1	5.6	1.7e-08	0.00	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	C1orf222	0.11	0.14	enet	18	0.14	1.8e-17	-5.0	5.6	1.7e-08	-0.02	0.46	0.55	FALSE
33	GTEx	Spleen	RP3-395M20.9	0.42	0.14	lasso	3	0.15	1.1e-04	-5.8	-5.6	2.0e-08	0.59	0.03	0.78	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TNFRSF14	0.18	0.02	blup	52	0.10	2.4e-04	2.7	5.5	3.7e-08	-0.68	0.01	0.42	FALSE
26	GTEx	Pancreas	TNFRSF14	0.13	0.04	enet	8	0.04	1.0e-02	4.5	5.5	4.0e-08	-0.63	0.17	0.73	FALSE
32	GTEx	Spleen	TMEM52	0.47	0.21	lasso	5	0.22	2.3e-06	-4.6	-5.4	6.2e-08	0.01	0.17	0.56	FALSE
25	GTEx	Nerve Tibial	CALML6	0.13	0.12	lasso	2	0.11	4.4e-08	-5.3	-5.4	6.4e-08	0.00	0.17	0.83	FALSE
27	GTEx	Pancreas	CALML6	0.21	0.08	lasso	4	0.06	2.2e-03	-5.4	-5.4	7.6e-08	0.00	0.14	0.71	FALSE
2	GTEx	Adipose Visceral Omentum	CALML6	0.13	0.03	lasso	5	0.03	1.6e-02	-5.4	-5.3	8.7e-08	0.00	0.12	0.46	FALSE
6	GTEx	Artery Coronary	AL645728.2	0.18	0.03	lasso	3	0.00	4.2e-01	-4.6	-5.3	9.4e-08	-0.01	0.04	0.21	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-345P4.10	0.28	0.12	enet	18	0.27	1.9e-14	-3.1	5.3	1.0e-07	0.02	0.49	0.02	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RP11-345P4.10	0.58	0.08	enet	26	0.35	6.6e-30	4.0	5.3	1.1e-07	0.02	0.99	0.01	FALSE
35	GTEx	Thyroid	RP11-345P4.10	0.66	0.21	lasso	17	0.39	1.5e-31	-3.1	5.1	2.8e-07	0.01	1.00	0.00	FALSE