Best TWAS P=2.64e-14 · Best GWAS P=2.28e-10 conditioned to 0.0467
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP1-283E3.4 | 0.65 | 0.14 | lasso | 9 | 0.33 | 5.1e-28 | -3.3 | -6.7 | 1.9e-11 | 0.00 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CALML6 | 0.13 | 0.03 | lasso | 5 | 0.03 | 1.6e-02 | -5.4 | -5.3 | 8.7e-08 | 0.00 | 0.12 | 0.46 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | -3.3 | -6.9 | 6.0e-12 | -0.02 | 0.15 | 0.09 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | RP11-345P4.10 | 0.28 | 0.12 | enet | 18 | 0.27 | 1.9e-14 | -3.1 | 5.3 | 1.0e-07 | 0.02 | 0.49 | 0.02 | FALSE |
| 5 | GTEx | Artery Aorta | RP1-283E3.4 | 0.60 | 0.12 | lasso | 9 | 0.27 | 3.2e-15 | -3.3 | -6.2 | 4.5e-10 | -0.01 | 0.55 | 0.03 | FALSE |
| 6 | GTEx | Artery Coronary | AL645728.2 | 0.18 | 0.03 | lasso | 3 | 0.00 | 4.2e-01 | -4.6 | -5.3 | 9.4e-08 | -0.01 | 0.04 | 0.21 | FALSE |
| 7 | GTEx | Artery Tibial | RP1-283E3.4 | 0.66 | 0.09 | lasso | 6 | 0.38 | 4.9e-31 | -3.3 | -6.4 | 2.0e-10 | 0.01 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Artery Tibial | RP11-345P4.10 | 0.61 | 0.10 | lasso | 10 | 0.36 | 3.1e-29 | -3.1 | 5.9 | 3.6e-09 | 0.01 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | -5.6 | -5.8 | 8.4e-09 | 0.03 | 0.03 | 0.65 | FALSE |
| 10 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | -5.9 | 6.3 | 2.5e-10 | -0.01 | 0.02 | 0.69 | TRUE |
| 11 | GTEx | Cells Transformed fibroblasts | RP1-283E3.4 | 0.59 | 0.13 | lasso | 8 | 0.29 | 3.0e-22 | 4.0 | -7.0 | 2.0e-12 | 0.01 | 0.99 | 0.01 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | RP11-345P4.10 | 0.66 | 0.17 | lasso | 13 | 0.32 | 7.5e-25 | -3.1 | 5.6 | 1.7e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | -5.9 | 5.8 | 5.1e-09 | 0.02 | 0.02 | 0.98 | FALSE |
| 14 | GTEx | Esophagus Mucosa | RP1-283E3.4 | 0.53 | 0.12 | enet | 20 | 0.22 | 4.1e-15 | -3.3 | -7.3 | 2.4e-13 | 0.02 | 0.99 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Muscularis | RP1-283E3.4 | 0.46 | 0.14 | enet | 23 | 0.24 | 1.6e-14 | -3.3 | -7.6 | 2.6e-14 | 0.01 | 0.95 | 0.00 | TRUE |
| 16 | GTEx | Esophagus Muscularis | RP3-395M20.12 | 0.08 | 0.06 | enet | 6 | 0.06 | 2.3e-04 | 4.5 | -6.4 | 2.0e-10 | 0.78 | 0.01 | 0.98 | TRUE |
| 17 | GTEx | Heart Atrial Appendage | RP11-345P4.10 | 0.36 | 0.11 | enet | 15 | 0.16 | 1.1e-07 | -3.1 | 5.8 | 6.9e-09 | -0.01 | 0.10 | 0.05 | FALSE |
| 18 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | 5.5 | -5.8 | 5.5e-09 | 0.01 | 0.03 | 0.90 | FALSE |
| 19 | GTEx | Lung | RP1-283E3.4 | 0.58 | 0.07 | lasso | 7 | 0.34 | 8.8e-27 | -3.3 | -6.5 | 9.5e-11 | 0.02 | 0.99 | 0.00 | FALSE |
| 20 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | -5.6 | -5.8 | 6.2e-09 | 0.00 | 0.03 | 0.91 | FALSE |
| 21 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | -5.8 | 6.3 | 3.9e-10 | -0.02 | 0.02 | 0.98 | FALSE |
| 22 | GTEx | Muscle Skeletal | SLC35E2B | 0.35 | 0.06 | lasso | 4 | 0.19 | 3.2e-18 | -3.1 | 6.5 | 9.4e-11 | 0.01 | 0.98 | 0.00 | FALSE |
| 23 | GTEx | Muscle Skeletal | RP1-283E3.4 | 0.51 | 0.12 | lasso | 6 | 0.29 | 2.4e-28 | -3.3 | -6.2 | 4.8e-10 | 0.01 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Muscle Skeletal | RP11-345P4.10 | 0.54 | 0.06 | lasso | 7 | 0.29 | 4.7e-29 | -3.1 | 6.3 | 2.6e-10 | 0.00 | 0.99 | 0.00 | FALSE |
| 25 | GTEx | Nerve Tibial | CALML6 | 0.13 | 0.12 | lasso | 2 | 0.11 | 4.4e-08 | -5.3 | -5.4 | 6.4e-08 | 0.00 | 0.17 | 0.83 | FALSE |
| 26 | GTEx | Pancreas | TNFRSF14 | 0.13 | 0.04 | enet | 8 | 0.04 | 1.0e-02 | 4.5 | 5.5 | 4.0e-08 | -0.63 | 0.17 | 0.73 | FALSE |
| 27 | GTEx | Pancreas | CALML6 | 0.21 | 0.08 | lasso | 4 | 0.06 | 2.2e-03 | -5.4 | -5.4 | 7.6e-08 | 0.00 | 0.14 | 0.71 | FALSE |
| 28 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | 5.5 | 5.8 | 7.5e-09 | -0.01 | 0.04 | 0.96 | FALSE |
| 29 | GTEx | Skin Not Sun Exposed Suprapubic | RP1-283E3.4 | 0.48 | 0.12 | lasso | 5 | 0.31 | 1.1e-17 | -3.3 | -6.9 | 3.8e-12 | 0.01 | 0.43 | 0.15 | FALSE |
| 30 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | 5.7 | 6.0 | 2.4e-09 | -0.01 | 0.03 | 0.97 | FALSE |
| 31 | GTEx | Skin Sun Exposed Lower leg | RP11-345P4.10 | 0.58 | 0.08 | enet | 26 | 0.35 | 6.6e-30 | 4.0 | 5.3 | 1.1e-07 | 0.02 | 0.99 | 0.01 | FALSE |
| 32 | GTEx | Spleen | TMEM52 | 0.47 | 0.21 | lasso | 5 | 0.22 | 2.3e-06 | -4.6 | -5.4 | 6.2e-08 | 0.01 | 0.17 | 0.56 | FALSE |
| 33 | GTEx | Spleen | RP3-395M20.9 | 0.42 | 0.14 | lasso | 3 | 0.15 | 1.1e-04 | -5.8 | -5.6 | 2.0e-08 | 0.59 | 0.03 | 0.78 | FALSE |
| 34 | GTEx | Thyroid | RP1-283E3.4 | 0.59 | 0.04 | lasso | 10 | 0.22 | 3.8e-17 | -3.3 | -7.0 | 2.8e-12 | 0.00 | 0.73 | 0.03 | FALSE |
| 35 | GTEx | Thyroid | RP11-345P4.10 | 0.66 | 0.21 | lasso | 17 | 0.39 | 1.5e-31 | -3.1 | 5.1 | 2.8e-07 | 0.01 | 1.00 | 0.00 | FALSE |
| 36 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | -5.0 | 5.6 | 1.7e-08 | -0.02 | 0.46 | 0.55 | FALSE |
| 37 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | -5.8 | -5.8 | 6.0e-09 | 0.02 | 0.02 | 0.98 | FALSE |
| 38 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | -5.8 | 5.7 | 9.6e-09 | -0.02 | 0.01 | 0.79 | FALSE |
| 39 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TNFRSF14 | 0.18 | 0.02 | blup | 52 | 0.10 | 2.4e-04 | 2.7 | 5.5 | 3.7e-08 | -0.68 | 0.01 | 0.42 | FALSE |