[Hub]/) : Traits : Body mass index (BMI) :

chr1:752,566-3,212,946

Best TWAS P=2.64e-14 · Best GWAS P=2.28e-10 conditioned to 0.0467

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous RP1-283E3.4 0.65 0.14 lasso 9 0.33 5.1e-28 -3.3 -6.7 1.9e-11 0.00 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum CALML6 0.13 0.03 lasso 5 0.03 1.6e-02 -5.4 -5.3 8.7e-08 0.00 0.12 0.46 FALSE
3 GTEx Adipose Visceral Omentum RP1-283E3.4 0.26 0.05 enet 25 0.16 1.5e-08 -3.3 -6.9 6.0e-12 -0.02 0.15 0.09 FALSE
4 GTEx Adipose Visceral Omentum RP11-345P4.10 0.28 0.12 enet 18 0.27 1.9e-14 -3.1 5.3 1.0e-07 0.02 0.49 0.02 FALSE
5 GTEx Artery Aorta RP1-283E3.4 0.60 0.12 lasso 9 0.27 3.2e-15 -3.3 -6.2 4.5e-10 -0.01 0.55 0.03 FALSE
6 GTEx Artery Coronary AL645728.2 0.18 0.03 lasso 3 0.00 4.2e-01 -4.6 -5.3 9.4e-08 -0.01 0.04 0.21 FALSE
7 GTEx Artery Tibial RP1-283E3.4 0.66 0.09 lasso 6 0.38 4.9e-31 -3.3 -6.4 2.0e-10 0.01 1.00 0.00 FALSE
8 GTEx Artery Tibial RP11-345P4.10 0.61 0.10 lasso 10 0.36 3.1e-29 -3.1 5.9 3.6e-09 0.01 1.00 0.00 FALSE
9 GTEx Brain Cerebellar Hemisphere NADK 0.18 0.11 lasso 7 0.09 3.1e-03 -5.6 -5.8 8.4e-09 0.03 0.03 0.65 FALSE
10 GTEx Brain Cerebellar Hemisphere RP5-890O3.9 0.24 0.02 lasso 9 0.02 1.3e-01 -5.9 6.3 2.5e-10 -0.01 0.02 0.69 TRUE
11 GTEx Cells Transformed fibroblasts RP1-283E3.4 0.59 0.13 lasso 8 0.29 3.0e-22 4.0 -7.0 2.0e-12 0.01 0.99 0.01 FALSE
12 GTEx Cells Transformed fibroblasts RP11-345P4.10 0.66 0.17 lasso 13 0.32 7.5e-25 -3.1 5.6 1.7e-08 0.00 1.00 0.00 FALSE
13 GTEx Esophagus Mucosa TMEM52 0.17 0.18 lasso 2 0.20 2.9e-13 -5.9 5.8 5.1e-09 0.02 0.02 0.98 FALSE
14 GTEx Esophagus Mucosa RP1-283E3.4 0.53 0.12 enet 20 0.22 4.1e-15 -3.3 -7.3 2.4e-13 0.02 0.99 0.00 FALSE
15 GTEx Esophagus Muscularis RP1-283E3.4 0.46 0.14 enet 23 0.24 1.6e-14 -3.3 -7.6 2.6e-14 0.01 0.95 0.00 TRUE
16 GTEx Esophagus Muscularis RP3-395M20.12 0.08 0.06 enet 6 0.06 2.3e-04 4.5 -6.4 2.0e-10 0.78 0.01 0.98 TRUE
17 GTEx Heart Atrial Appendage RP11-345P4.10 0.36 0.11 enet 15 0.16 1.1e-07 -3.1 5.8 6.9e-09 -0.01 0.10 0.05 FALSE
18 GTEx Lung NADK 0.07 0.03 lasso 3 0.02 8.5e-03 5.5 -5.8 5.5e-09 0.01 0.03 0.90 FALSE
19 GTEx Lung RP1-283E3.4 0.58 0.07 lasso 7 0.34 8.8e-27 -3.3 -6.5 9.5e-11 0.02 0.99 0.00 FALSE
20 GTEx Muscle Skeletal NADK 0.06 0.00 enet 9 0.00 1.3e-01 -5.6 -5.8 6.2e-09 0.00 0.03 0.91 FALSE
21 GTEx Muscle Skeletal TMEM52 0.11 0.08 lasso 6 0.10 7.2e-10 -5.8 6.3 3.9e-10 -0.02 0.02 0.98 FALSE
22 GTEx Muscle Skeletal SLC35E2B 0.35 0.06 lasso 4 0.19 3.2e-18 -3.1 6.5 9.4e-11 0.01 0.98 0.00 FALSE
23 GTEx Muscle Skeletal RP1-283E3.4 0.51 0.12 lasso 6 0.29 2.4e-28 -3.3 -6.2 4.8e-10 0.01 1.00 0.00 FALSE
24 GTEx Muscle Skeletal RP11-345P4.10 0.54 0.06 lasso 7 0.29 4.7e-29 -3.1 6.3 2.6e-10 0.00 0.99 0.00 FALSE
25 GTEx Nerve Tibial CALML6 0.13 0.12 lasso 2 0.11 4.4e-08 -5.3 -5.4 6.4e-08 0.00 0.17 0.83 FALSE
26 GTEx Pancreas TNFRSF14 0.13 0.04 enet 8 0.04 1.0e-02 4.5 5.5 4.0e-08 -0.63 0.17 0.73 FALSE
27 GTEx Pancreas CALML6 0.21 0.08 lasso 4 0.06 2.2e-03 -5.4 -5.4 7.6e-08 0.00 0.14 0.71 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic TMEM52 0.19 0.18 lasso 4 0.14 2.6e-08 5.5 5.8 7.5e-09 -0.01 0.04 0.96 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic RP1-283E3.4 0.48 0.12 lasso 5 0.31 1.1e-17 -3.3 -6.9 3.8e-12 0.01 0.43 0.15 FALSE
30 GTEx Skin Sun Exposed Lower leg TMEM52 0.17 0.14 lasso 7 0.15 2.0e-12 5.7 6.0 2.4e-09 -0.01 0.03 0.97 FALSE
31 GTEx Skin Sun Exposed Lower leg RP11-345P4.10 0.58 0.08 enet 26 0.35 6.6e-30 4.0 5.3 1.1e-07 0.02 0.99 0.01 FALSE
32 GTEx Spleen TMEM52 0.47 0.21 lasso 5 0.22 2.3e-06 -4.6 -5.4 6.2e-08 0.01 0.17 0.56 FALSE
33 GTEx Spleen RP3-395M20.9 0.42 0.14 lasso 3 0.15 1.1e-04 -5.8 -5.6 2.0e-08 0.59 0.03 0.78 FALSE
34 GTEx Thyroid RP1-283E3.4 0.59 0.04 lasso 10 0.22 3.8e-17 -3.3 -7.0 2.8e-12 0.00 0.73 0.03 FALSE
35 GTEx Thyroid RP11-345P4.10 0.66 0.21 lasso 17 0.39 1.5e-31 -3.1 5.1 2.8e-07 0.01 1.00 0.00 FALSE
36 ROSMAP Brain Pre-frontal Cortex C1orf222 0.11 0.14 enet 18 0.14 1.8e-17 -5.0 5.6 1.7e-08 -0.02 0.46 0.55 FALSE
37 ROSMAP Brain Pre-frontal Cortex MMP23B 0.05 0.04 lasso 2 0.03 1.9e-04 -5.8 -5.8 6.0e-09 0.02 0.02 0.98 FALSE
38 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM52 0.02 0.01 blup 37 0.02 6.6e-03 -5.8 5.7 9.6e-09 -0.02 0.01 0.79 FALSE
39 The Cancer Genome Atlas Testicular Germ Cell Tumors TNFRSF14 0.18 0.02 blup 52 0.10 2.4e-04 2.7 5.5 3.7e-08 -0.68 0.01 0.42 FALSE