Best TWAS P=1.15e-11 · Best GWAS P=1.28e-11 conditioned to 0.18
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DPYSL4 | 0.09 | 0.03 | enet | 16 | 0.05 | 9.9e-07 | 6.8 | 5.1 | 3.1e-07 | 0.81 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adrenal Gland | DPYSL4 | 0.38 | 0.21 | lasso | 5 | 0.39 | 3.4e-15 | 3.0 | 5.6 | 2.2e-08 | 0.74 | 0.05 | 0.95 | FALSE |
3 | GTEx | Muscle Skeletal | DPYSL4 | 0.27 | 0.06 | enet | 9 | 0.10 | 2.0e-10 | 2.9 | 5.1 | 2.9e-07 | 0.68 | 0.86 | 0.14 | FALSE |
4 | GTEx | Pituitary | DPYSL4 | 0.24 | 0.11 | lasso | 4 | 0.26 | 3.0e-07 | 3.1 | 5.9 | 4.1e-09 | 0.63 | 0.02 | 0.81 | FALSE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DPYSL4 | 0.28 | 0.22 | enet | 19 | 0.25 | 3.0e-21 | -5.6 | 5.1 | 2.7e-07 | 0.85 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DPYSL4 | 0.19 | 0.30 | enet | 19 | 0.37 | 3.1e-79 | 6.8 | 5.7 | 1.6e-08 | 0.90 | 0.00 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DPYSL4 | 0.31 | 0.19 | lasso | 10 | 0.18 | 3.4e-09 | 6.8 | 6.8 | 1.2e-11 | 0.91 | 0.00 | 1.00 | TRUE |
8 | The Cancer Genome Atlas | Glioblastoma Multiforme | STK32C | 0.13 | -0.01 | blup | 107 | 0.08 | 1.6e-03 | 2.6 | -5.5 | 3.5e-08 | -0.36 | 0.04 | 0.07 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DPYSL4 | 0.16 | 0.24 | blup | 60 | 0.27 | 7.6e-31 | -5.8 | 5.3 | 1.1e-07 | 0.92 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPYSL4 | 0.16 | 0.21 | enet | 16 | 0.24 | 7.1e-27 | 6.8 | 5.8 | 6.3e-09 | 0.91 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DPYSL4 | 0.17 | 0.24 | lasso | 3 | 0.23 | 2.4e-13 | 6.8 | 6.7 | 3.0e-11 | 0.99 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPYSL4 | 0.13 | 0.12 | lasso | 7 | 0.16 | 3.1e-17 | 6.8 | 5.9 | 4.3e-09 | 0.95 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DPYSL4 | 0.13 | 0.11 | enet | 7 | 0.08 | 2.0e-04 | 6.8 | 6.7 | 2.2e-11 | 0.95 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | DPYSL4 | 0.17 | 0.16 | enet | 18 | 0.23 | 1.5e-26 | 6.7 | 5.9 | 3.4e-09 | 0.87 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | GPR123 | 0.05 | 0.00 | blup | 56 | 0.02 | 8.0e-04 | 4.1 | 6.1 | 9.9e-10 | 0.00 | 0.00 | 0.27 | TRUE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DPYSL4 | 0.11 | 0.07 | blup | 60 | 0.13 | 1.0e-14 | 6.8 | 5.2 | 2.3e-07 | 0.83 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DPYSL4 | 0.24 | 0.21 | lasso | 7 | 0.28 | 2.5e-19 | 6.8 | 5.8 | 6.6e-09 | 0.84 | 0.00 | 1.00 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DPYSL4 | 0.34 | 0.37 | enet | 15 | 0.46 | 2.2e-53 | -5.9 | 5.7 | 1.0e-08 | 0.93 | 0.00 | 1.00 | FALSE |
19 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | DPYSL4 | 0.27 | 0.07 | blup | 64 | 0.07 | 7.1e-03 | 6.8 | 5.4 | 8.4e-08 | 0.88 | 0.01 | 0.78 | FALSE |
20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DPYSL4 | 0.17 | 0.12 | blup | 64 | 0.11 | 1.3e-04 | -5.8 | 6.1 | 1.4e-09 | 0.85 | 0.01 | 0.97 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | DPYSL4 | 0.30 | 0.24 | enet | 15 | 0.38 | 1.7e-38 | 3.0 | 5.8 | 5.0e-09 | 0.78 | 0.01 | 0.99 | FALSE |