TWAS
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Usage
Models
Genes
Traits
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Traits
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Body mass index (BMI)
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chr11:7,714,238-9,313,814
Best TWAS P=7.25e-08 · Best GWAS P=4.39e-12 conditioned to 0.00143
7.8M
8M
8.2M
8.4M
8.6M
8.8M
9M
9.2M
9.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
STK33
0.05
0.03
lasso
2
0.03
2.5e-04
-5.6
5.4
7.2e-08
-0.45
0.46
0.14
TRUE
1
CommonMind
Brain Pre-frontal Cortex
STK33
0.18
0.18
lasso
9
0.20
3.8e-24
-4.7
5.3
1.4e-07
-0.70
0.98
0.02
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
STK33
0.14
0.08
lasso
6
0.10
1.0e-09
-4.9
5.3
1.0e-07
-0.69
0.98
0.02
FALSE