Best TWAS P=2.09e-08 · Best GWAS P=1.34e-07 conditioned to 0.481
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | EVI5 | 0.08 | 0.08 | lasso | 10 | 0.12 | 9.5e-10 | 4.8 | 5.2 | 1.8e-07 | 0.88 | 0.10 | 0.89 | FALSE |
2 | GTEx | Brain Cortex | EVI5 | 0.25 | 0.33 | lasso | 13 | 0.30 | 4.1e-09 | 5.2 | 5.2 | 1.9e-07 | 0.99 | 0.02 | 0.98 | FALSE |
3 | GTEx | Breast Mammary Tissue | EVI5 | 0.07 | 0.06 | lasso | 4 | 0.07 | 2.3e-04 | 5.3 | 5.3 | 1.4e-07 | 0.99 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | EVI5 | 0.18 | 0.11 | enet | 28 | 0.20 | 5.9e-15 | 4.5 | 5.3 | 8.8e-08 | 0.83 | 0.10 | 0.89 | FALSE |
5 | GTEx | Colon Sigmoid | EVI5 | 0.13 | 0.16 | lasso | 3 | 0.12 | 7.0e-05 | 5.2 | 5.2 | 1.7e-07 | 1.00 | 0.02 | 0.98 | FALSE |
6 | GTEx | Heart Atrial Appendage | EVI5 | 0.09 | 0.06 | lasso | 7 | 0.05 | 4.2e-03 | 5.2 | 5.4 | 7.8e-08 | 1.00 | 0.02 | 0.95 | FALSE |
7 | GTEx | Heart Left Ventricle | EVI5 | 0.07 | 0.11 | lasso | 5 | 0.08 | 7.7e-05 | 5.2 | 5.3 | 1.3e-07 | 0.99 | 0.02 | 0.98 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | EVI5 | 0.07 | 0.05 | lasso | 6 | 0.08 | 2.2e-05 | 4.3 | 5.1 | 3.0e-07 | 0.72 | 0.06 | 0.92 | FALSE |
9 | GTEx | Uterus | EVI5 | 0.23 | 0.12 | enet | 27 | 0.16 | 4.3e-04 | 5.2 | 5.4 | 6.5e-08 | 0.90 | 0.04 | 0.86 | FALSE |
10 | GTEx | Whole Blood | EVI5 | 0.03 | 0.01 | lasso | 2 | 0.01 | 6.8e-02 | 5.3 | 5.4 | 6.5e-08 | 0.96 | 0.02 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | EVI5 | 0.14 | 0.04 | blup | 93 | 0.06 | 8.9e-03 | 4.3 | 5.2 | 2.5e-07 | 0.88 | 0.03 | 0.73 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EVI5 | 0.08 | 0.04 | blup | 96 | 0.06 | 8.6e-08 | 4.3 | 5.6 | 2.1e-08 | 0.88 | 0.03 | 0.96 | TRUE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EVI5 | 0.04 | 0.02 | blup | 96 | 0.04 | 1.4e-03 | 4.4 | 5.4 | 5.2e-08 | 0.85 | 0.03 | 0.65 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EVI5 | 0.18 | 0.16 | lasso | 7 | 0.15 | 2.0e-16 | 5.2 | 5.4 | 6.5e-08 | 0.98 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EVI5 | 0.04 | 0.04 | blup | 93 | 0.03 | 4.8e-04 | 4.2 | 5.2 | 1.5e-07 | 0.85 | 0.09 | 0.87 | FALSE |
16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | EVI5 | 0.05 | 0.02 | blup | 96 | 0.03 | 2.3e-03 | 3.6 | 5.2 | 1.8e-07 | 0.83 | 0.09 | 0.70 | FALSE |
17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EVI5 | 0.10 | 0.06 | blup | 94 | 0.08 | 2.9e-04 | 5.2 | 5.2 | 1.7e-07 | 0.92 | 0.02 | 0.96 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EVI5 | 0.06 | 0.10 | blup | 94 | 0.10 | 1.7e-10 | 5.2 | 5.5 | 3.5e-08 | 0.92 | 0.01 | 0.99 | FALSE |