Best TWAS P=1.07e-09 · Best GWAS P=7.72e-19 conditioned to 9.07e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PTGFR | 0.12 | 0.04 | enet | 17 | 0.04 | 4.7e-04 | 5.1 | -5.4 | 5.4e-08 | -0.26 | 0.97 | 0.00 | TRUE |
| 2 | GTEx | Nerve Tibial | DNAJB4 | 0.08 | 0.07 | lasso | 3 | 0.07 | 1.3e-05 | -5.1 | -5.2 | 2.1e-07 | -0.14 | 0.82 | 0.01 | FALSE |
| 3 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -5.6 | 5.8 | 5.8e-09 | 0.22 | 0.83 | 0.02 | FALSE |
| 4 | METSIM | Adipose | DNAJB4 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.1e-05 | -4.9 | -5.4 | 7.5e-08 | -0.26 | 0.70 | 0.01 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DNAJB4 | 0.08 | 0.09 | lasso | 2 | 0.09 | 1.3e-11 | -5.2 | -5.2 | 2.0e-07 | -0.18 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -4.8 | 6.1 | 1.1e-09 | 0.28 | 0.07 | 0.06 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIPC2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | -5.6 | 5.7 | 1.5e-08 | 0.22 | 0.37 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJB4 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.2e-05 | 5.7 | -5.7 | 1.1e-08 | -0.45 | 0.00 | 1.00 | FALSE |