Best TWAS P=4.31e-12 · Best GWAS P=5.34e-11 conditioned to 0.0128
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CCDC171 | 0.18 | 0.05 | lasso | 5 | 0.08 | 2.2e-05 | -4.6 | -5.5 | 4.6e-08 | 0.17 | 0.31 | 0.13 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | 5.9 | -6.1 | 8.9e-10 | 0.71 | 0.12 | 0.87 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | -5.8 | -6.9 | 4.3e-12 | 0.69 | 0.13 | 0.84 | TRUE |
4 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | -6.0 | -6.2 | 5.1e-10 | 0.73 | 0.07 | 0.92 | FALSE |
5 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | -4.4 | -5.4 | 7.5e-08 | 0.66 | 0.14 | 0.78 | FALSE |
6 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | 5.8 | -5.9 | 4.9e-09 | 0.62 | 0.09 | 0.84 | FALSE |
7 | GTEx | Lung | CCDC171 | 0.13 | 0.03 | enet | 9 | 0.01 | 5.0e-02 | 3.9 | -5.4 | 6.8e-08 | 0.49 | 0.25 | 0.60 | FALSE |
8 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | -5.8 | -5.8 | 6.9e-09 | 0.73 | 0.22 | 0.78 | FALSE |
9 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | 5.5 | 5.3 | 1.2e-07 | -0.62 | 0.11 | 0.67 | FALSE |
10 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | 5.7 | -5.9 | 3.4e-09 | 0.68 | 0.15 | 0.80 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC171 | 0.20 | 0.04 | enet | 45 | 0.06 | 4.9e-04 | 5.8 | -5.2 | 1.9e-07 | 0.23 | 0.20 | 0.77 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | CCDC171 | 0.14 | 0.09 | enet | 13 | 0.12 | 1.9e-10 | 5.5 | -5.1 | 2.6e-07 | 0.43 | 0.24 | 0.76 | FALSE |
13 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | 5.7 | -5.3 | 1.1e-07 | 0.59 | 0.15 | 0.68 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | 6.1 | -5.9 | 3.2e-09 | 0.64 | 0.10 | 0.90 | FALSE |