Hub : Genes

CCDC171

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1700 0.0490 1.0e-05 0.045 NA 0.081 NA 0.051 1.3e-04 NA 3.4e-07 NA 5.3e-05
2 GTEx Artery Aorta 0.1750 0.0700 2.6e-03 0.050 NA 0.045 NA 0.084 9.6e-04 NA 1.6e-03 NA 2.2e-05
3 GTEx Artery Tibial 0.1047 0.0325 1.7e-05 0.089 NA 0.123 NA 0.095 1.8e-07 NA 7.2e-10 NA 7.4e-08
4 GTEx Brain Caudate basal ganglia 0.2960 0.0770 1.5e-05 0.184 NA 0.224 NA 0.234 5.7e-06 NA 4.6e-07 NA 2.4e-07
5 GTEx Brain Cerebellar Hemisphere 0.4560 0.0950 9.2e-07 0.187 NA 0.218 NA 0.231 1.6e-05 NA 2.6e-06 NA 1.3e-06
6 GTEx Brain Cerebellum 0.4630 0.1030 1.5e-06 0.215 NA 0.100 NA 0.150 5.7e-07 NA 7.1e-04 NA 3.5e-05
7 GTEx Brain Cortex 0.2640 0.0850 6.9e-04 0.153 NA 0.105 NA 0.164 5.2e-05 NA 7.8e-04 NA 2.8e-05
8 GTEx Brain Frontal Cortex BA9 0.2660 0.0890 9.0e-04 0.181 NA 0.192 NA 0.067 1.6e-05 NA 8.3e-06 NA 7.7e-03
9 GTEx Brain Hypothalamus 0.3210 0.1160 2.6e-03 0.172 NA 0.090 NA -0.012 7.6e-05 NA 4.0e-03 NA 7.5e-01
10 GTEx Breast Mammary Tissue 0.2110 0.0770 3.3e-04 0.010 NA 0.025 NA 0.027 9.4e-02 NA 1.8e-02 NA 1.5e-02
11 GTEx Breast Mammary Tissue (Male) 0.2451 0.1197 2.2e-02 -0.011 NA -0.011 NA -0.011 7.3e-01 NA 6.9e-01 NA 7.2e-01
12 GTEx Cells EBV-transformed lymphocytes 0.2540 0.0900 2.7e-03 0.079 NA 0.015 NA 0.065 1.5e-03 NA 1.0e-01 NA 3.7e-03
13 GTEx Lung 0.1314 0.0503 4.4e-04 0.030 NA 0.010 NA 0.010 2.3e-03 NA 5.0e-02 NA 5.6e-02
14 GTEx Nerve Tibial 0.2495 0.0608 1.6e-10 0.158 NA 0.118 NA 0.144 2.6e-11 NA 1.0e-08 NA 2.1e-10
15 GTEx Ovary 0.2080 0.0860 5.4e-03 0.189 NA 0.096 NA 0.164 2.2e-05 NA 2.5e-03 NA 7.7e-05
16 GTEx Pituitary 0.2760 0.0860 9.8e-05 0.161 NA 0.124 NA 0.045 7.6e-05 NA 5.2e-04 NA 2.8e-02
17 GTEx Skin Not Sun Exposed Suprapubic 0.1990 0.0600 1.1e-05 0.037 NA 0.056 NA 0.045 3.9e-03 NA 4.9e-04 NA 1.6e-03
18 GTEx Skin Sun Exposed Lower leg 0.1360 0.0370 1.1e-07 0.092 NA 0.124 NA -0.002 4.8e-08 NA 1.9e-10 NA 5.1e-01
19 GTEx Thyroid 0.0780 0.0320 2.6e-03 0.001 NA 0.017 NA 0.009 2.5e-01 NA 1.7e-02 NA 6.2e-02
20 GTEx Uterus 0.5120 0.1370 1.8e-03 -0.014 NA -0.010 NA -0.006 8.4e-01 NA 5.8e-01 NA 4.4e-01
21 METSIM Adipose 0.0332 0.0154 4.5e-03 -0.001 0.006 -0.002 -0.002 -0.001 6.4e-01 3.9e-02 6.9e-01 8.1e-01 5.2e-01
22 ROSMAP Brain Pre-frontal Cortex 0.1359 0.0295 1.0e-13 0.114 0.106 0.109 0.095 0.001 1.9e-14 1.6e-13 8.3e-14 3.3e-12 2.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bipolar Disorder (2018) 2.4 3.8 8.8 1.4 1.8 2.2 2.4 2.0 2.1 2.6 2.2 1.8 1.5 0.0 1.3 1.4 2.0 -3.0 2.0 1.7 2.3 1.7 0.1 2.2 2.6
Bipolar Disorder or Schizophrenia 1.7 4.1 12.4 2.2 3.5 2.1 2.3 1.8 1.8 2.0 1.8 1.1 1.6 0.0 2.3 0.5 1.5 -3.0 1.6 1.7 2.4 2.4 -0.9 2.5 2.2
Depressed Affect (Nagel 2018) 0.3 0.6 2.0 0.8 0.5 1.2 0.5 0.0 0.1 0.5 0.7 0.2 1.1 0.0 1.1 1.1 0.1 -1.2 0.6 0.1 1.4 1.4 0.1 0.4 0.3
Depression (Nagel 2018) 0.3 0.5 2.5 1.3 1.6 0.9 -0.1 -0.5 -0.4 -0.4 -0.7 -1.0 -0.5 0.0 1.0 0.5 -0.5 -0.8 -0.6 -0.1 0.2 0.3 -0.1 -0.4 0.3
Intelligence (Savage-Jansen 2018) 2.5 7.7 16.2 0.4 2.0 2.1 3.5 3.6 3.7 3.3 3.1 3.3 2.6 0.0 -1.0 1.9 4.0 -3.1 3.8 2.3 2.2 1.7 -0.9 4.0 3.1
Neuroticism (Nagel 2018) 1.4 3.3 7.5 2.0 2.4 2.7 1.9 1.5 1.4 1.3 1.9 1.0 2.1 0.0 1.2 2.6 1.4 -2.6 1.7 1.5 2.6 2.4 -0.0 1.3 1.2
Schizophrenia (2018) 0.7 1.4 9.3 1.8 3.0 1.0 1.0 0.7 0.6 0.5 0.6 -0.0 0.9 0.0 1.9 -0.4 0.3 -1.5 0.5 0.8 1.3 1.7 -1.3 1.4 0.7
Schizophrenia vs Biploar Disorder 0.1 0.1 1.7 -0.1 1.3 0.1 0.1 0.0 0.1 -0.1 -0.5 -0.2 0.1 0.0 -0.4 -0.3 -0.0 -0.1 -0.1 -0.5 -0.1 0.3 -0.3 -0.5 -0.4
Worry (Nagel 2018) 2.0 4.3 10.6 1.3 2.0 2.4 2.9 2.5 2.5 2.2 2.6 1.7 1.8 0.0 0.2 2.4 2.4 -3.3 2.1 1.8 2.3 1.7 0.2 1.7 1.8
Alzheimer’s Disease (in mother) 0.9 1.0 3.0 0.2 0.5 0.2 1.6 0.9 1.5 0.9 1.1 1.4 -0.0 0.0 -0.7 0.8 1.5 -1.3 1.0 -0.7 0.5 -0.5 -1.2 1.7 1.1
Alzheimer’s Disease (in father) 0.9 1.0 4.0 -2.0 -1.8 -1.4 -0.8 -0.6 -0.7 -0.7 -0.9 -0.6 -0.2 0.0 -0.7 -1.2 -0.4 1.1 -0.3 -0.5 -1.5 -0.9 -0.0 -0.4 -1.4
Alzheimer’s Disease (including proxy) 0.3 0.5 1.8 -1.2 -0.6 -1.0 0.0 -0.2 0.2 -0.2 -0.1 0.0 -0.1 0.0 -0.8 -0.8 0.3 -0.2 0.1 -1.3 -0.8 -1.4 -1.1 0.7 -0.4
Crohns Disease (2017) 0.2 0.3 2.1 -1.5 -0.4 -0.7 -0.1 -0.4 -0.3 -0.3 -0.3 -0.2 -0.7 0.0 -0.3 -1.2 -0.2 0.2 -0.3 -1.1 -0.3 -0.3 0.0 0.3 0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.9 -0.9 -0.1 -0.1 -0.1 -0.6 -0.3 -0.3 0.4 0.2 0.2 0.0 0.9 -0.7 -0.1 -0.3 0.3 -0.5 0.5 0.5 0.5 0.1 0.8
Ulcerative Colitis (UC) 0.2 0.3 2.5 0.0 0.3 0.5 -0.2 -0.5 -0.4 -0.3 0.6 0.2 1.0 0.0 1.6 0.0 -0.2 -0.2 0.4 0.2 0.9 1.1 0.3 -0.5 0.5
Major Depression (MDD) 2.3 2.8 6.5 -1.8 -0.7 -1.9 -1.5 -1.3 -1.4 -1.7 -1.6 -1.6 -2.6 0.0 -1.4 -1.2 -1.6 1.9 -1.9 -1.8 -2.3 -2.4 -0.4 -1.4 -2.1
Reaction Time 0.3 0.6 4.9 0.2 0.6 0.9 0.7 0.2 0.4 0.9 1.4 0.3 0.3 0.0 -0.2 0.9 0.6 -0.4 0.6 0.7 0.5 0.7 2.2 0.7 0.4
Verbal and Numeric Reasoning (VNR) 0.9 2.0 6.2 -0.9 0.9 0.4 1.8 2.0 2.0 1.8 1.1 1.6 0.7 0.0 -1.7 0.6 2.3 -1.4 1.9 0.7 0.2 -0.1 -1.1 2.5 1.6
Breast Cancer 0.2 0.5 1.3 -0.2 -0.6 0.0 1.1 0.4 1.1 0.9 0.4 0.7 -0.2 0.0 -0.8 -0.3 0.9 -0.6 0.8 0.1 -0.2 -0.9 -1.1 0.5 0.8
Ovarian Cancer 0.9 1.2 5.3 -0.9 -0.9 -0.2 1.3 1.4 1.6 1.1 0.9 0.6 -0.9 0.0 -1.9 0.9 1.2 -0.7 0.5 0.1 -0.4 -1.1 -2.3 1.1 0.7
Prostate Cancer 0.6 0.8 2.5 -1.0 -1.2 -1.4 -0.4 -0.2 -0.0 -0.0 -0.5 0.1 -1.6 0.0 -1.3 -0.8 -0.1 1.0 -0.7 -0.9 -1.4 -1.5 0.5 -0.7 -0.8
Age at First Birth 0.6 0.9 2.7 1.1 1.2 1.0 0.7 1.4 0.8 0.8 0.6 0.8 0.8 0.0 0.6 -0.0 0.6 -0.7 1.1 1.6 0.1 1.3 0.7 1.5 0.4
Bipolar Disorder (2011) 1.3 1.2 3.3 1.1 1.8 1.1 1.2 1.0 0.8 1.0 0.9 1.0 1.2 0.0 1.0 1.0 0.9 -1.5 0.9 0.4 1.3 1.1 0.9 1.6 1.2
Body Mass Index (BMI) (2010) 3.4 4.6 11.5 -0.6 0.0 -1.3 -3.2 -2.9 -3.4 -2.6 -2.9 -3.0 -1.2 0.0 2.1 -1.7 -3.3 2.4 -2.5 -0.6 -1.5 0.1 -0.1 -2.3 -2.5
Coronary Artery Disease (CAD) 1.6 1.9 4.3 -1.0 -0.7 -1.7 -1.3 -1.7 -1.5 -1.1 -1.5 -1.4 -1.2 0.0 -0.2 -2.1 -1.8 1.2 -1.7 -0.4 -1.3 -1.3 -1.6 -1.7 -1.9
Crohns Disease (2012) 0.4 0.7 2.2 -0.3 0.7 0.7 0.9 0.1 0.4 0.5 0.9 0.2 0.5 0.0 1.1 -0.1 0.2 -1.1 0.4 -0.4 1.1 1.3 -1.4 1.2 1.5
Mean Putamen Volume 0.1 0.2 0.8 0.0 0.4 0.0 0.6 0.5 0.4 0.3 0.4 0.1 0.9 0.0 -0.4 0.7 0.3 -0.2 0.4 0.0 0.3 0.4 -0.5 -0.2 0.3
Fasting Glucose 3.2 3.8 9.4 2.8 2.0 3.1 1.6 1.3 1.0 1.7 2.3 1.3 2.5 0.0 2.9 1.4 0.8 -2.7 1.8 1.2 3.0 2.6 0.1 1.4 1.0
HbA1C 1.8 2.0 6.1 -0.2 0.1 -1.0 -2.1 -1.7 -2.0 -1.7 -1.0 -1.8 -0.7 0.0 0.4 -2.5 -2.2 1.9 -1.4 -1.3 -1.2 -0.4 0.4 -1.3 -1.5
HDL Cholesterol 1.2 2.1 8.3 -0.5 -0.3 0.5 1.7 1.8 2.1 2.1 1.0 1.8 -0.4 0.0 -2.9 1.3 2.1 -1.2 1.5 0.7 0.1 -1.2 0.8 1.3 1.5
LDL Cholesterol 0.3 0.5 2.3 0.7 1.1 0.8 -0.4 -0.5 -0.5 -0.9 0.1 -0.6 0.7 0.0 1.5 0.4 -0.7 -0.2 -0.3 0.6 1.1 1.2 -0.4 -0.3 0.2
Lupus 0.7 1.1 3.4 0.8 -0.1 -0.1 -1.2 -1.3 -1.4 -1.3 -0.9 -1.1 -0.7 0.0 1.6 -0.1 -1.2 1.3 -1.3 -1.1 -0.5 -0.3 -0.2 -1.8 -1.2
Neuroticism (2016) 2.1 3.0 6.7 2.2 1.4 2.4 2.1 1.4 1.8 1.8 1.6 1.4 1.9 0.0 1.3 2.6 2.0 -2.0 1.8 0.8 2.0 1.8 -0.1 1.4 2.0
Primary Biliary Cirrhosis 0.1 0.2 0.7 -0.1 0.5 -0.5 -0.3 0.1 -0.3 -0.4 -0.6 -0.8 0.8 0.0 -0.2 -0.2 -0.4 0.6 -0.2 0.4 0.0 0.2 -0.3 0.4 -0.3
Rheumatoid Arthritis 2.9 4.0 10.3 -0.4 0.3 -1.2 -2.6 -2.9 -3.0 -2.6 -1.5 -3.2 -0.9 0.0 2.0 -2.1 -2.9 2.5 -2.4 -0.2 -1.3 -0.4 -0.6 -2.2 -2.3
Schizophrenia (2014) 1.5 3.3 15.7 2.2 4.0 1.8 1.8 1.6 1.4 1.4 1.3 0.9 1.4 0.0 2.0 0.5 1.2 -2.2 1.3 1.4 1.9 2.3 -1.5 2.2 1.7
Triglycerides 0.9 1.4 4.0 -1.1 -0.7 -1.6 -1.3 -1.3 -1.4 -1.9 -1.2 -1.8 0.3 0.0 1.3 -2.0 -1.4 1.2 -1.1 -0.5 -0.1 0.3 -0.6 -1.0 -0.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 5.7 -0.0 0.3 -0.8 -1.5 -1.7 -1.6 -1.1 -1.2 -1.0 -1.7 0.0 0.4 -1.1 -1.5 0.9 -1.7 -1.4 -1.3 -1.3 -0.1 -1.4 -2.4
Ulcerative Colitis 0.4 0.6 2.4 0.2 0.4 1.0 0.1 0.1 -0.2 0.3 0.9 0.5 1.3 0.0 1.6 0.9 -0.0 -0.6 0.5 1.0 1.2 1.3 -0.5 0.2 0.5
Blood Eosinophil Count 0.4 3.5 7.6 -1.4 -0.8 -1.2 -2.4 -2.6 -2.3 -2.0 -1.9 -2.0 -2.2 0.0 -0.6 -1.2 -1.7 2.4 -2.1 -1.1 -2.0 -1.4 2.5 -1.3 -2.8
Blood Platelet Count 0.1 0.7 3.9 0.4 0.1 0.2 -0.5 -0.9 -0.7 -0.8 -0.2 -0.6 -0.2 0.0 1.8 -0.6 -0.7 0.1 -0.9 1.4 -0.2 0.9 -2.0 -0.3 -0.7
Blood Red Count 0.1 1.1 7.2 -1.9 -1.6 -0.8 0.5 -0.2 0.6 0.4 0.2 0.6 -1.0 0.0 -2.7 0.2 0.8 0.1 0.2 -1.2 -1.3 -1.6 -0.6 0.3 0.4
Blood White Count 0.5 3.8 14.7 0.5 -0.7 -0.8 -2.6 -3.8 -3.0 -2.6 -1.8 -2.6 -1.3 0.0 1.9 -1.9 -2.9 1.7 -2.6 -0.6 -0.7 0.3 -0.9 -1.5 -1.9
Heel T-Score 0.4 2.8 13.6 -1.1 -0.9 -2.0 -1.6 -3.7 -1.6 -1.2 1.2 0.1 -1.6 0.0 0.2 -2.4 -1.4 1.8 -1.6 -0.2 -2.0 -1.5 -1.8 -1.0 -2.6
BMI 9.7 56.3 118.8 -4.3 -6.0 -7.0 -9.9 -10.9 -10.1 -9.1 -9.2 -8.4 -5.9 0.0 1.3 -7.4 -9.5 8.4 -9.3 -5.5 -6.8 -4.0 -1.4 -8.1 -8.7
Height 0.4 7.3 21.2 -0.1 -2.0 0.8 3.7 4.1 4.1 3.4 2.9 3.7 1.7 0.0 -1.5 1.0 4.1 -2.7 3.1 -1.2 1.2 0.1 -4.6 2.0 2.7
Waist Hip Ratio (WHR) 0.1 0.3 1.8 0.7 0.3 0.3 0.3 -0.0 0.1 0.5 0.8 0.6 0.4 0.0 0.5 -0.3 0.3 -0.5 0.2 1.1 0.5 0.3 1.3 0.0 -0.1
Systolic Blood Pressure 0.2 1.0 7.6 0.5 2.8 0.7 -1.0 0.2 -0.9 -1.1 -0.3 -1.0 -0.0 0.0 1.6 0.2 -1.2 0.1 -0.6 0.7 0.1 0.9 -1.7 -0.0 -0.3
Smoking Status 0.1 0.3 3.8 0.0 -0.0 -0.1 0.1 -0.1 0.5 -0.0 0.2 0.1 -0.5 0.0 -0.5 0.0 0.7 0.0 0.1 0.0 -0.2 -0.3 -2.0 1.1 0.2
Allergy or Eczema 0.0 0.1 0.4 -0.3 -0.6 -0.1 0.1 -0.6 0.2 -0.4 -0.0 0.1 -0.1 0.0 0.1 -0.6 0.3 -0.1 -0.3 -0.6 -0.4 0.1 0.6 -0.0 -0.0
Cardiovascular Disease 1.3 4.2 11.0 -1.3 -1.0 -1.5 -2.8 -2.3 -2.6 -2.1 -2.8 -2.0 -1.4 0.0 0.4 -1.2 -2.6 2.4 -2.5 -1.1 -1.7 -1.4 -3.3 -2.0 -2.6
Hypothyroidism (self reported) 0.2 0.4 2.7 1.6 0.1 -0.2 0.2 0.1 0.3 0.3 0.2 0.3 0.6 0.0 0.5 0.3 0.1 -0.4 0.3 1.2 0.7 0.4 -1.0 0.7 0.3
Respiratory disease 4.4 9.8 14.2 -2.5 -2.9 -3.5 -3.6 -3.6 -3.4 -3.5 -3.7 -3.5 -3.2 0.0 -1.2 -3.4 -3.3 3.8 -3.7 -2.7 -3.6 -2.6 1.4 -3.1 -3.5
Type 2 Diabetes (T2D) (2018) 0.7 1.2 2.6 -0.9 -1.1 -1.1 -1.5 -1.5 -1.3 -1.6 -1.5 -0.7 -0.7 0.0 0.6 -0.8 -1.4 0.9 -1.4 -0.7 -0.9 -1.0 -1.1 -1.3 -1.1
Lung FEV1/FVC ratio 4.8 24.4 45.6 -3.1 -3.2 -4.8 -6.4 -6.2 -6.5 -6.8 -5.5 -5.5 -4.1 0.0 0.4 -4.9 -6.6 6.1 -6.4 -1.9 -4.7 -2.9 -2.8 -5.5 -5.9
Lung FVC 4.2 21.5 50.1 3.1 3.1 5.1 6.0 7.1 6.2 5.8 5.0 5.0 3.2 0.0 -0.1 6.0 5.6 -5.8 5.7 1.5 4.3 2.4 0.2 4.8 5.2
Neuroticism 0.7 1.6 3.9 1.5 1.8 1.6 1.2 0.9 0.9 0.8 1.1 0.5 1.4 0.0 1.1 2.0 0.9 -1.9 1.1 1.3 1.6 1.8 -0.0 1.3 0.6
Chronotype (morning person) 3.2 7.5 12.5 -2.2 -1.7 -3.2 -3.2 -2.7 -3.1 -3.2 -3.0 -2.6 -3.0 0.0 -0.6 -3.1 -3.3 2.8 -3.5 -2.5 -2.8 -2.7 0.7 -3.2 -3.4
Hair Pigment 0.2 5.7 17.3 -1.8 -3.5 -3.5 -1.5 -0.1 -0.6 -1.3 -1.7 -2.2 -3.2 0.0 -2.4 -2.3 -1.4 2.8 -2.8 -2.4 -3.9 -4.2 1.1 -1.9 -1.7
Tanning 0.4 4.4 10.2 3.0 2.0 3.2 2.0 1.8 1.4 2.2 0.3 2.2 1.8 0.0 2.3 2.2 1.5 -2.5 2.0 2.9 2.4 2.5 -1.4 1.8 2.3
Hand grip strength (left) 0.1 0.4 1.5 0.9 -1.1 -0.7 -0.1 0.4 -0.0 -0.5 -0.7 -0.4 0.2 0.0 0.7 -0.5 -0.5 0.1 -0.6 -1.2 -0.1 0.0 1.0 -0.2 1.0
Number of treatments/medications taken 4.6 8.3 14.4 -1.4 -2.2 -2.6 -3.5 -3.0 -3.3 -3.1 -3.8 -3.0 -2.7 0.0 -0.5 -1.9 -3.4 3.1 -3.5 -3.6 -2.8 -3.1 -2.6 -3.2 -3.5
Average weekly spirits intake 0.6 0.7 6.4 1.3 -0.7 -0.2 -0.3 -0.4 -0.5 -0.5 -0.4 -0.5 0.5 0.0 1.8 -0.7 -0.6 -0.1 -0.7 -0.1 0.6 1.0 -2.5 -0.3 -0.5
Sensitivity / hurt feelings 0.8 1.4 5.6 1.8 1.4 1.6 0.2 0.1 -0.3 -0.5 0.4 -0.8 1.7 0.0 2.4 1.9 -0.6 -0.8 0.1 1.3 1.4 2.0 0.3 0.5 0.5
Frequency of depressed mood in last 2 weeks 0.3 0.5 2.0 1.2 0.9 0.2 -0.5 -0.9 -0.7 -0.4 -0.8 -1.1 -0.2 0.0 1.4 0.1 -0.7 -0.3 -0.7 -1.1 0.1 0.2 -0.2 -0.5 -0.3
Hearing difficulty/problems: Yes 0.7 1.0 2.9 -0.5 0.6 0.4 -0.7 -1.1 -0.7 -1.0 -0.8 -1.2 -1.4 0.0 -1.7 1.0 -0.8 0.7 -0.9 -1.6 -0.9 -1.0 -1.7 -0.6 -1.0
Relative age of first facial hair 0.3 0.6 2.6 0.6 -0.4 0.9 0.9 0.7 0.6 0.9 1.3 0.1 0.6 0.0 -0.1 1.0 0.5 -0.7 0.6 -0.6 0.4 0.5 1.6 0.8 0.5
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 7.5 -2.1 -2.4 -2.2 -1.5 -2.2 -1.5 -1.5 -1.4 -0.9 -1.5 0.0 -0.7 -2.7 -1.3 1.3 -1.5 -1.6 -1.6 -1.4 -1.6 -2.3 -1.9
Ever used hormone-replacement therapy (HRT) 3.1 3.9 5.5 -1.6 -2.3 -2.1 -2.2 -2.2 -1.9 -2.2 -2.3 -1.9 -2.3 0.0 -0.8 -2.2 -2.0 2.3 -1.9 -2.1 -2.1 -2.0 -0.9 -2.2 -2.0
Ever had hysterectomy (womb removed) 1.3 1.5 3.6 -1.9 -1.2 -0.6 -1.4 -1.1 -1.4 -1.7 -1.3 -1.4 -1.2 0.0 -0.1 0.2 -1.4 1.0 -1.3 -1.6 -1.0 -0.9 -0.5 -1.2 -1.9
Systolic blood pressure, automated reading 1.3 3.7 8.2 -1.1 0.9 -1.2 -2.7 -2.2 -2.7 -2.9 -2.0 -2.5 -1.9 0.0 0.6 -2.2 -2.8 1.8 -2.5 -0.7 -1.6 -0.3 -1.2 -1.9 -2.3
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 6.2 -1.1 -0.9 -0.4 -1.0 -0.8 -0.8 -0.9 -1.2 -0.2 -0.9 0.0 -0.4 -0.2 -0.8 0.4 -1.0 -1.1 -0.9 -0.9 -2.5 -0.8 -1.2
Angina 3.6 4.8 11.0 -1.9 -2.1 -2.3 -2.5 -2.6 -2.5 -2.1 -2.5 -2.1 -1.7 0.0 0.1 -2.1 -2.4 2.1 -2.6 -2.1 -1.8 -1.8 -1.9 -2.7 -3.3
Medication for hormone replacement therapy 0.4 0.5 2.5 -1.6 -1.1 0.0 0.7 0.6 0.7 0.1 0.2 0.8 0.2 0.0 -1.0 0.7 0.5 -0.8 0.7 -0.9 -0.0 -0.4 0.1 -0.7 0.4
Vitamin and mineral supplements 0.9 1.2 3.2 -0.1 0.2 -0.4 -1.8 -1.3 -1.8 -1.2 -1.3 -1.6 -0.7 0.0 0.6 -0.5 -1.6 1.5 -1.3 -0.6 -0.8 -0.2 0.7 -1.0 -1.3
Supplements: Zinc 1.3 1.4 4.2 0.4 0.6 1.4 1.0 0.6 0.9 1.3 1.3 1.5 1.8 0.0 -0.1 1.3 1.1 -0.9 1.5 2.0 1.1 1.4 0.3 1.5 1.3
Medication: Co-codamol 1.4 1.6 3.8 -0.2 -0.4 -0.9 -1.6 -1.8 -1.7 -1.3 -1.5 -0.9 -1.2 0.0 0.4 -1.6 -1.7 1.4 -1.7 0.0 -1.3 -0.4 -0.3 -1.8 -1.9
Medication: Metformin 0.8 1.2 4.5 -1.2 -2.1 -1.6 -0.7 -1.0 -0.5 -0.7 -0.8 0.2 -1.4 0.0 -0.6 -1.4 -0.7 0.5 -1.0 -0.7 -1.4 -1.6 -1.0 -0.4 -1.4
Diabetes (father) 1.1 1.3 5.6 -1.5 -2.2 -1.3 -0.5 -0.2 -0.0 -0.8 -1.0 0.0 -1.0 0.0 -0.8 -1.3 0.0 0.7 -0.9 -2.4 -1.0 -1.2 -1.8 -1.6 -0.5
Diabetes (mother) 0.5 0.6 1.9 1.0 1.0 0.7 0.0 -0.2 -0.1 -0.4 0.2 -0.2 1.2 0.0 1.4 0.9 0.3 -0.8 0.6 0.5 1.0 1.4 1.1 0.5 0.5
Severe depression (siblings) 0.6 0.6 2.5 -1.6 -1.2 -0.7 -0.1 -0.6 -0.2 -0.6 -0.8 -1.1 -0.1 0.0 -0.5 -0.7 -0.3 0.4 -0.4 -0.9 -0.8 -1.1 -1.3 -0.5 -0.5
Pack years adult smoking proportion 2.9 4.4 8.9 -1.2 -1.3 -1.7 -2.8 -3.0 -2.8 -2.8 -2.6 -2.4 -1.8 0.0 0.5 -2.3 -2.8 1.9 -2.8 -1.3 -1.9 -1.0 1.2 -2.3 -2.1
Impedance of leg (right) 0.1 0.5 2.5 1.2 0.4 0.8 0.5 0.4 0.3 -0.1 0.7 -0.0 1.0 0.0 0.5 -0.3 0.4 -0.2 0.4 1.3 1.0 1.6 0.6 0.2 0.5
Leg fat-free mass (left) 0.9 4.8 15.2 -2.9 -3.9 -2.6 -2.0 -2.4 -1.9 -1.5 -2.3 -1.1 -1.9 0.0 -0.7 -2.3 -1.7 1.9 -2.0 -3.6 -2.6 -2.3 -1.4 -1.6 -1.9
Trunk fat percentage 14.2 56.9 134.6 -3.6 -5.3 -5.9 -9.9 -11.6 -10.6 -9.3 -8.6 -8.8 -5.1 0.0 2.5 -7.9 -9.8 8.3 -9.3 -5.1 -6.5 -3.0 -2.5 -8.4 -9.4
Hand grip strength (right) 0.2 0.7 4.5 0.5 -2.1 -1.6 -0.3 -0.1 -0.2 -0.9 -0.6 -0.2 -0.2 0.0 0.7 -1.2 -0.5 0.5 -1.0 -1.4 -0.4 -0.2 -0.1 -0.5 0.7
Townsend deprivation index at recruitment 0.5 0.7 4.4 0.8 0.0 0.2 -0.8 -1.1 -1.0 -0.6 -0.4 -0.8 0.7 0.0 2.1 -0.6 -0.9 0.2 -0.7 0.7 0.4 1.3 0.8 -0.3 0.0
Current tobacco smoking 1.4 2.3 5.2 -0.8 -0.6 -1.4 -2.0 -1.3 -1.3 -1.8 -1.7 -1.8 -2.2 0.0 -1.1 -0.9 -1.3 2.3 -1.9 -0.5 -2.0 -1.4 -0.9 -1.4 -2.0
Average weekly fortified wine intake 0.5 0.6 2.6 0.2 1.4 1.2 0.4 -0.4 -0.0 0.4 0.3 0.1 0.9 0.0 -0.2 1.6 0.2 -0.4 0.6 0.3 0.8 1.2 -1.6 0.2 0.0
Maternal smoking around birth 6.5 9.5 15.2 -2.9 -2.8 -3.0 -3.6 -3.2 -3.5 -3.8 -3.7 -3.1 -3.3 0.0 -0.6 -2.8 -3.5 3.1 -3.9 -3.4 -2.9 -2.5 -1.0 -3.9 -3.5
Fed-up feelings 0.1 0.3 1.0 0.5 -0.2 0.8 -0.2 -0.0 -0.3 0.4 -0.4 -0.3 0.7 0.0 0.8 0.8 -0.4 -0.5 0.0 -0.2 0.7 1.0 -0.3 0.1 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.2 1.1 1.1 0.9 -0.8 -0.9 -0.8 -1.0 -1.2 -1.5 -0.8 0.0 1.3 0.6 -0.9 0.0 -0.9 -0.2 -0.2 -0.0 0.8 -1.2 -0.5
Relative age voice broke 0.2 0.4 2.9 0.7 -1.1 0.1 0.3 0.4 0.2 0.1 0.4 -0.8 0.6 0.0 -0.2 0.6 -0.1 -0.2 -0.2 -0.9 -0.3 0.3 1.7 0.3 0.1
Taking other prescription medications 5.0 7.8 11.9 -1.4 -1.8 -3.0 -3.3 -3.4 -3.3 -3.4 -3.3 -3.1 -2.8 0.0 -0.9 -3.0 -3.4 2.7 -3.5 -2.4 -2.9 -2.8 -1.3 -3.0 -3.4
Age when periods started (menarche) 0.6 1.4 3.7 0.2 -1.2 -1.0 -1.3 -1.5 -1.5 -1.9 -1.0 -1.2 -0.9 0.0 -0.5 -0.4 -1.7 1.2 -1.9 -1.3 -1.1 -0.9 0.1 -1.4 -0.9
Bilateral oophorectomy (both ovaries removed) 6.8 7.9 17.2 -1.1 -2.0 -2.2 -3.5 -4.2 -3.8 -3.9 -3.2 -3.7 -1.9 0.0 1.3 -2.4 -3.7 2.6 -3.7 -1.6 -1.8 -1.0 -0.7 -3.7 -3.8
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 6.5 -1.4 -0.5 -1.2 -1.6 -2.5 -1.7 -0.9 0.2 -0.9 -1.1 0.0 -0.3 -1.4 -1.5 1.7 -1.6 -0.7 -1.8 -0.5 -2.1 -1.9 -2.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.6 0.7 0.2 0.5 0.5 0.1 0.5 0.2 0.9 0.0 1.3 0.0 0.3 0.4 0.3 -0.4 0.7 0.6 0.6 0.7 -0.5 0.1 0.6
Qualifications: CSEs or equivalent 0.2 0.2 1.1 0.5 -0.6 -0.4 -0.0 0.2 -0.1 0.2 -0.5 -0.3 0.8 0.0 0.9 -0.7 -0.0 0.0 -0.2 -0.2 0.2 0.3 1.1 -0.0 0.3
Serious illness, injury or assault to yourself 0.7 0.9 3.0 -0.9 -1.0 -0.5 -1.2 -1.3 -1.3 -0.7 -1.1 -1.3 -0.2 0.0 0.2 -0.8 -1.1 0.6 -0.8 -1.7 -0.6 -0.5 -1.1 -0.4 -1.3
High blood pressure 0.8 2.3 12.4 0.2 0.5 -0.2 -2.0 -1.5 -2.1 -1.2 -1.6 -1.1 -1.0 0.0 1.2 -0.9 -2.1 1.7 -1.8 -0.6 -0.7 -0.3 -3.5 -1.5 -2.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 0.7 0.3 0.4 0.3 -0.3 0.3 -0.1 0.2 -0.1 0.7 0.0 0.8 -0.5 0.4 -0.4 0.0 0.5 0.4 0.9 0.1 0.2 0.5
Multivitamins +/- minerals 0.7 0.9 2.6 -0.4 -0.0 0.2 1.5 1.0 1.4 1.2 0.6 1.6 0.7 0.0 -1.0 0.6 1.3 -1.1 1.0 0.3 0.5 -0.4 -0.5 1.2 1.0
Stomach or abdominal pain in last month 0.6 0.7 2.0 -0.4 -0.4 0.2 1.1 1.0 1.2 1.4 0.9 0.7 0.1 0.0 -0.9 0.9 1.0 -1.3 0.8 -0.7 0.1 -0.6 1.2 0.2 0.8
Supplements: Glucosamine 1.7 2.2 6.1 -0.1 -0.6 0.4 2.4 2.0 2.4 2.4 1.2 2.5 0.7 0.0 -1.4 0.5 2.0 -1.9 1.5 0.2 1.1 -0.6 -0.2 1.5 1.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 4.9 -2.2 -1.3 -0.7 0.2 -0.5 0.1 -0.2 -0.0 -0.2 -1.8 0.0 -2.0 -0.4 -0.0 -0.0 -0.4 -1.6 -1.5 -1.4 0.5 -0.3 -0.4
Medication: Atenolol 0.4 0.5 1.2 -0.6 -0.1 -0.7 -1.1 -0.9 -1.0 -0.5 -0.9 -0.9 -0.4 0.0 0.2 -0.1 -0.8 0.8 -0.4 -0.7 -0.4 -0.8 -0.9 -0.4 -0.7
Medication: Levothyroxine sodium 0.3 0.5 3.8 1.9 0.7 0.4 0.3 0.1 0.2 0.1 -0.0 -0.1 0.7 0.0 0.6 0.5 -0.1 -0.1 0.2 0.9 0.5 0.3 -1.6 0.7 0.2
Sitting height 2.8 20.1 48.4 -1.1 -2.0 1.8 6.2 6.4 6.9 6.2 4.7 6.2 2.0 0.0 -3.7 3.5 7.0 -5.0 6.0 -1.1 2.2 -0.3 -3.4 4.6 5.4
Chronic bronchitis/emphysema (father) 3.8 4.5 11.6 -1.6 -1.5 -1.7 -2.2 -2.1 -2.1 -2.9 -3.2 -2.3 -2.4 0.0 -0.6 -0.9 -1.7 2.1 -2.6 -3.4 -2.5 -2.4 1.6 -2.0 -1.5
High blood pressure (mother) 1.5 2.1 7.4 2.5 0.9 1.7 1.1 1.1 1.1 1.8 1.1 1.1 1.6 0.0 2.7 1.7 1.2 -1.6 1.7 0.7 1.6 1.7 -0.2 1.2 1.2
Body mass index (BMI) 10.0 42.8 87.6 -4.1 -5.1 -6.0 -8.5 -9.4 -8.7 -7.6 -7.9 -7.2 -5.4 0.0 1.2 -6.5 -8.3 7.1 -8.1 -5.2 -6.2 -3.8 -1.8 -7.2 -7.9
Impedance of leg (left) 0.1 0.6 3.3 1.8 0.8 0.8 -0.0 -0.3 -0.3 -0.4 0.3 -0.4 1.0 0.0 1.1 -0.4 -0.0 0.1 -0.0 1.4 0.9 1.7 0.2 -0.3 0.1
Leg predicted mass (left) 1.0 5.1 14.0 -2.9 -3.7 -2.6 -2.2 -2.6 -2.0 -1.6 -2.4 -1.2 -2.0 0.0 -0.6 -2.3 -1.8 2.0 -2.1 -3.6 -2.7 -2.4 -1.5 -1.8 -2.1
Trunk fat mass 11.0 47.2 106.1 -3.8 -5.7 -5.7 -8.9 -10.3 -9.4 -8.2 -7.9 -7.6 -4.9 0.0 1.8 -7.3 -8.7 7.5 -8.4 -5.4 -6.2 -3.2 -2.7 -7.5 -8.5
Waist circumference 6.8 24.7 53.4 -3.6 -4.2 -4.4 -6.3 -7.3 -6.5 -5.4 -5.7 -5.0 -4.5 0.0 0.2 -5.1 -6.1 5.2 -6.0 -4.2 -4.8 -3.2 -1.7 -5.5 -6.3
Number of incorrect matches in round 0.6 1.0 2.5 -1.0 -0.4 -0.9 -1.4 -0.7 -1.1 -1.3 -0.8 -1.1 -0.9 0.0 -0.9 -0.7 -1.3 1.6 -1.0 -0.1 -1.4 -0.6 0.6 -0.8 -1.1
Past tobacco smoking 2.6 4.8 8.9 -2.1 -1.7 -2.1 -2.7 -2.5 -2.7 -2.2 -2.2 -2.7 -1.8 0.0 -0.7 -1.5 -2.5 3.0 -2.5 -1.2 -2.6 -1.4 1.9 -2.9 -2.8
Alcohol usually taken with meals 2.4 3.8 6.4 0.9 0.6 1.7 2.3 2.4 2.2 1.9 2.2 2.5 1.7 0.0 0.2 2.2 2.4 -2.2 2.4 2.5 2.1 1.5 2.2 1.3 2.3
Nervous feelings 2.4 4.5 7.7 1.0 1.9 2.5 2.8 2.7 2.5 2.3 2.3 1.8 1.9 0.0 -0.0 2.6 2.6 -2.6 2.4 2.3 2.3 1.9 1.6 1.7 2.0
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 5.8 -0.5 -0.2 -1.3 -2.0 -2.3 -2.0 -1.9 -2.2 -2.3 -1.8 0.0 0.3 -1.6 -1.9 1.3 -2.3 -1.1 -1.9 -0.9 -0.6 -2.1 -2.4
Hearing difficulty/problems with background noise 0.2 0.4 2.3 0.3 1.5 0.8 0.2 -0.7 -0.0 0.1 0.4 -0.1 -0.2 0.0 -0.5 1.3 0.1 -0.2 0.2 0.3 0.1 0.8 -1.5 0.1 -0.1
Hair/balding pattern: Pattern 2 0.3 0.4 2.2 -0.2 0.9 0.5 0.2 0.1 0.2 -0.4 1.0 -0.5 0.2 0.0 -0.2 1.2 0.3 -0.7 0.4 0.3 0.1 0.5 -1.5 0.6 1.1
Had menopause 0.3 0.3 2.9 0.1 1.7 0.6 -0.1 -0.0 -0.2 -0.4 -0.2 -0.2 -1.1 0.0 -0.8 0.7 -0.1 0.2 -0.0 0.7 -0.3 -0.6 -0.3 -0.2 -0.5
Had other major operations 0.6 0.7 2.0 -0.2 -0.5 0.1 0.9 1.3 1.1 1.1 0.4 1.4 0.8 0.0 -0.8 1.0 1.2 -0.6 1.1 0.3 0.3 0.1 0.4 0.8 1.2
Forced vital capacity (FVC) 6.6 25.4 54.1 2.8 1.1 4.4 6.8 7.4 7.2 6.7 5.8 5.7 3.9 0.0 -0.5 5.2 7.0 -6.2 6.3 0.7 4.1 2.0 -1.4 6.0 6.1
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 8.0 -2.1 -0.6 -1.5 -1.7 -2.4 -1.8 -0.9 0.0 -0.9 -1.3 0.0 -0.6 -1.9 -1.8 1.9 -1.9 -0.9 -1.9 -0.8 -2.1 -1.9 -2.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.3 0.8 0.6 0.3 -0.3 -1.0 -0.8 -0.6 0.2 -0.7 0.8 0.0 1.5 -0.2 -0.7 -0.1 -0.4 1.3 0.3 0.7 1.2 -0.3 -0.2
Qualifications: None of the above 1.9 4.0 10.9 0.6 1.1 -0.1 -2.9 -2.6 -3.0 -2.9 -2.2 -3.3 -1.8 0.0 1.5 -0.1 -3.1 2.2 -2.5 -0.6 -1.3 -0.3 -0.0 -1.8 -2.6
Financial difficulties in last 2 years 2.8 3.7 7.5 -1.2 -2.1 -2.3 -2.1 -1.9 -1.6 -1.8 -2.5 -2.2 -2.2 0.0 -0.4 -1.7 -1.7 2.0 -2.3 -2.7 -2.4 -2.1 -0.3 -1.9 -2.2
Mouth/teeth dental problems 0.2 0.3 1.2 -0.4 -0.7 -0.6 0.2 0.4 0.2 0.6 -0.1 0.5 -0.5 0.0 -0.9 -0.5 -0.0 0.3 -0.2 -1.1 -0.9 -0.7 -0.4 0.1 -1.0
Heart attack 0.9 1.2 2.6 -0.6 0.1 -0.7 -1.3 -1.5 -1.3 -1.0 -1.5 -1.0 -1.3 0.0 -0.5 -0.6 -1.3 1.0 -1.4 -1.2 -1.0 -1.5 0.3 -1.3 -1.6
Allergy 0.3 0.6 2.0 0.6 1.0 0.8 0.8 1.4 0.6 1.0 0.7 1.0 0.8 0.0 0.1 1.2 0.4 -0.7 1.1 0.6 1.0 0.2 -0.0 0.9 0.8
Pain all over the body in last month 3.5 3.8 8.6 -1.3 -1.6 -1.7 -2.3 -2.7 -2.5 -2.2 -1.9 -1.9 -1.2 0.0 0.1 -2.9 -2.2 2.1 -2.4 -1.6 -1.7 -1.0 -1.8 -2.2 -2.3
Diabetes (self-reported) 0.2 0.3 2.5 -1.0 -0.3 -0.3 -0.5 -0.5 -0.4 -0.6 -0.6 -0.1 -0.2 0.0 0.0 0.1 -0.6 -0.2 -0.5 -0.1 0.0 -0.7 -1.6 -0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.8 -0.2 -0.2 -1.5 -1.6 -1.4 -1.2 -1.6 -1.3 -1.2 -0.1 0.0 0.5 -2.0 -0.8 1.6 -1.1 -1.1 -0.8 -0.2 -0.7 -1.3 -1.7
Medication: Ramipril 1.1 1.4 3.7 -1.6 -1.2 -1.0 -1.1 -0.4 -0.9 -0.8 -1.2 -0.8 -1.3 0.0 -1.6 -0.5 -1.1 1.1 -1.2 -1.7 -1.2 -1.4 -0.5 -1.0 -1.9
Medication: Simvastatin 1.3 1.9 4.2 -1.6 -1.2 -1.5 -1.4 -1.7 -1.4 -0.8 -1.1 -1.0 -1.7 0.0 -1.0 -0.9 -1.5 1.2 -1.6 -1.6 -1.7 -2.0 -1.0 -0.9 -1.8
Fluid intelligence score 0.3 0.6 2.7 -1.2 0.2 -0.5 0.4 0.7 0.8 0.6 0.5 0.5 -0.3 0.0 -1.6 -0.2 1.2 0.2 1.0 0.2 -1.0 -0.7 -0.7 1.3 -0.3
Illnesses of siblings 1.5 2.2 4.9 0.8 -0.2 0.9 1.9 2.1 2.1 1.8 1.5 2.1 0.9 0.0 -0.7 1.1 2.2 -1.6 1.8 0.7 1.0 0.6 1.2 1.8 1.9
Neuroticism score 0.6 1.2 4.3 1.3 1.6 1.4 1.0 0.8 0.9 0.6 0.7 0.4 1.0 0.0 0.9 2.1 0.8 -1.7 0.9 1.0 1.3 1.1 -0.8 0.8 0.5
Weight 5.2 25.5 48.0 -3.9 -5.5 -5.0 -6.1 -6.9 -6.2 -5.4 -5.9 -4.9 -4.2 0.0 0.4 -5.4 -5.8 5.3 -5.9 -5.2 -5.1 -3.3 -2.5 -5.3 -5.9
Impedance of arm (right) 0.2 1.0 4.7 1.2 1.4 1.5 0.5 -0.4 -0.0 -0.0 1.2 -0.4 1.4 0.0 0.7 0.1 0.3 -0.1 0.8 2.2 1.3 1.6 1.2 0.5 0.1
Arm fat percentage (right) 14.0 55.3 125.4 -3.8 -5.0 -6.1 -9.8 -11.2 -10.4 -9.1 -8.7 -8.7 -5.5 0.0 2.1 -7.5 -9.7 8.3 -9.2 -4.8 -6.6 -3.4 -1.2 -8.3 -9.4
Trunk fat-free mass 0.3 1.9 9.6 -2.2 -3.1 -1.6 0.3 0.8 0.8 0.7 -0.4 0.9 -1.3 0.0 -1.8 -0.5 0.8 0.0 0.1 -2.9 -1.4 -2.0 -1.6 0.4 0.3
Hip circumference 5.9 25.3 51.8 -3.8 -4.5 -4.3 -6.4 -7.2 -6.6 -5.7 -6.1 -5.5 -4.3 0.0 0.5 -4.8 -6.1 5.4 -6.0 -4.6 -4.7 -3.0 -2.5 -5.4 -5.9
Time employed in main current job 0.8 0.9 3.8 0.0 -0.1 1.1 1.1 1.4 1.1 1.3 1.2 2.0 0.7 0.0 -0.3 0.9 1.1 -0.8 1.2 0.6 0.7 0.3 0.4 0.9 1.0
Alcohol intake versus 10 years previously 0.4 0.5 2.4 -0.7 -0.9 0.4 0.8 0.4 0.7 0.6 0.4 0.4 -0.0 0.0 -1.0 0.2 0.8 -0.9 0.9 -0.2 -0.3 -0.6 1.6 0.6 1.5
Father’s age at death 2.3 3.1 7.9 -0.0 1.1 0.8 2.5 2.0 2.3 2.3 2.4 1.8 0.8 0.0 -1.2 1.3 2.1 -2.0 2.3 1.6 1.6 0.5 0.9 2.8 2.2
Worrier / anxious feelings 3.2 6.1 12.4 3.5 3.5 3.1 2.6 2.0 2.3 2.1 2.6 1.8 2.4 0.0 2.0 3.4 2.2 -3.4 2.3 1.8 3.0 2.5 -0.6 1.8 2.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.6 -1.6 -1.4 -0.6 -1.4 -1.1 -1.2 -0.6 -1.1 -1.2 -0.4 0.0 -0.2 -0.6 -1.2 1.0 -0.6 -0.3 -0.8 -0.6 1.5 -0.7 -1.0
Falls in the last year 1.8 2.4 5.7 -0.9 -1.6 -1.2 -2.0 -2.4 -2.2 -1.8 -1.9 -1.8 -1.2 0.0 0.7 -1.4 -1.6 1.4 -1.7 -1.2 -1.0 -0.4 -0.6 -2.2 -2.0
Hair/balding pattern: Pattern 3 0.1 0.1 1.0 -0.7 0.3 -0.3 0.4 0.1 0.3 0.2 0.2 0.2 -0.1 0.0 -1.0 -0.2 0.2 -0.2 0.2 0.3 0.3 -0.7 -0.3 0.1 -0.5
Number of live births 5.5 7.7 15.0 -2.0 -2.2 -3.7 -2.9 -2.8 -2.6 -2.9 -2.4 -2.2 -3.4 0.0 -2.0 -2.5 -2.5 3.3 -3.2 -1.6 -3.8 -3.9 -0.8 -2.9 -3.8
Forced expiratory volume in 1-second (FEV1) 3.9 13.2 28.4 2.0 0.6 3.3 4.8 5.3 5.0 4.7 4.2 4.0 3.1 0.0 0.0 4.0 5.0 -4.3 4.6 0.2 3.0 1.6 -1.7 4.4 4.4
Pulse rate 1.1 1.8 7.8 -2.8 -1.3 -1.7 -1.5 -1.2 -1.0 -0.9 -1.1 -0.7 -1.0 0.0 -0.6 -2.1 -0.7 1.4 -1.0 -1.2 -1.6 -0.7 -1.9 -0.8 -0.9
Happiness 0.4 0.5 1.6 0.5 1.3 0.0 -0.9 -0.9 -1.0 -0.7 -0.6 -0.6 -0.4 0.0 0.9 -0.2 -1.2 0.5 -0.7 0.1 -0.6 0.2 -0.7 -0.6 -0.9
Noisy workplace 0.7 0.8 2.2 0.9 0.9 0.3 -0.9 -1.2 -1.1 -1.1 -0.6 -1.1 -0.2 0.0 1.5 0.0 -1.5 0.7 -1.3 0.5 0.3 0.5 -1.2 -0.5 -1.0
Qualifications: A levels/AS levels or equivalent 3.1 6.8 12.8 1.4 1.5 2.6 3.3 3.3 3.5 3.4 3.6 2.5 2.1 0.0 -0.5 3.3 3.3 -2.7 3.1 1.6 2.0 1.6 -0.5 3.4 3.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 2.8 1.0 -0.8 -0.7 0.1 -0.1 -0.1 0.2 -0.1 0.6 0.3 0.0 0.5 -1.7 -0.3 -0.6 -0.3 0.7 0.6 0.2 0.9 -0.5 -0.4
Mouth/teeth dental problems: Dentures 0.4 0.7 2.3 0.4 1.3 0.3 -1.4 -1.0 -1.1 -1.5 -0.8 -0.9 -0.5 0.0 0.2 0.4 -1.1 1.0 -1.1 0.5 -0.4 -0.2 -0.2 -0.9 -1.0
Asthma 1.1 2.2 6.1 -1.5 -1.0 -1.3 -1.6 -1.6 -1.5 -1.5 -1.5 -1.8 -1.7 0.0 -1.0 -1.1 -1.3 1.6 -1.6 -0.9 -1.8 -1.2 2.5 -1.2 -1.9
Medication: Ibuprofen (e.g. Nurofen) 2.9 3.7 6.8 -1.3 -2.0 -1.7 -2.3 -2.1 -2.3 -1.9 -1.5 -2.3 -1.5 0.0 0.7 -2.5 -2.6 1.9 -2.4 -2.3 -1.6 -1.3 -1.5 -2.0 -2.6
Medication: Cholesterol lowering 1.0 1.5 3.9 -0.8 -0.8 -0.9 -1.6 -1.3 -1.8 -1.2 -1.3 -1.2 -0.6 0.0 0.5 -0.9 -2.0 1.2 -1.5 -1.0 -0.6 -0.8 -1.8 -1.5 -1.8
Depression (self-reported) 2.9 3.5 9.2 -1.5 -1.0 -1.7 -1.9 -2.2 -1.7 -1.9 -2.3 -2.1 -3.0 0.0 -1.1 -1.9 -1.7 1.5 -2.1 -1.4 -2.2 -2.8 0.1 -1.8 -2.1
Medication: Lansoprazole 0.7 0.8 2.0 -0.8 -0.5 -1.1 -1.0 -0.6 -0.7 -0.6 -1.4 -1.1 -1.2 0.0 -0.5 -1.2 -0.7 0.9 -0.8 -1.2 -1.0 -0.9 0.0 -1.1 -0.9
Prospective memory result 3.9 4.8 10.2 -0.9 -0.6 -1.6 -2.9 -2.8 -3.0 -2.6 -2.2 -2.4 -2.2 0.0 0.4 -2.0 -3.2 2.4 -3.0 -2.0 -1.6 -1.0 1.3 -3.1 -2.5
Lung cancer (father) 1.9 2.3 4.9 -1.2 -1.5 -1.2 -1.8 -2.0 -1.7 -2.2 -2.0 -1.8 -1.1 0.0 -0.3 -0.8 -1.8 1.6 -2.0 -1.5 -1.2 -1.2 -0.4 -1.8 -1.6
Illnesses of mother 0.6 0.7 5.5 -1.6 -0.7 -0.6 0.4 0.7 0.7 0.5 0.4 0.8 0.5 0.0 -2.3 -0.2 0.8 0.3 0.5 -0.1 -0.1 -0.8 1.2 0.3 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.5 18.3 0.7 -0.2 2.2 3.8 4.3 4.0 3.9 2.9 2.8 2.1 0.0 -0.2 2.9 3.9 -3.2 3.6 -0.6 2.2 0.7 -0.9 3.4 3.4
Pulse wave Arterial Stiffness index 3.5 4.1 9.0 -2.1 -0.4 -1.9 -2.3 -2.1 -2.2 -1.4 -2.1 -1.7 -1.8 0.0 -0.6 -2.6 -2.2 2.6 -2.3 -1.9 -2.3 -1.4 -2.9 -1.5 -3.0
Impedance of arm (left) 0.2 0.9 3.4 1.4 1.2 1.4 0.2 -0.7 -0.4 -0.4 0.8 -0.5 1.5 0.0 1.2 -0.0 -0.0 0.0 0.4 1.9 1.1 1.6 0.8 0.1 -0.2
Arm fat mass (right) 10.9 44.8 95.3 -4.0 -5.5 -5.9 -8.6 -9.8 -9.0 -7.9 -8.0 -7.4 -5.2 0.0 1.5 -6.9 -8.4 7.4 -8.3 -5.2 -6.2 -3.6 -2.1 -7.4 -8.2
Trunk predicted mass 0.3 1.9 9.7 -2.2 -3.1 -1.6 0.3 0.8 0.8 0.7 -0.4 0.9 -1.3 0.0 -1.8 -0.5 0.7 0.0 0.0 -2.9 -1.3 -2.0 -1.7 0.4 0.3
Standing height 0.8 7.8 18.3 -0.0 -1.5 1.4 3.9 4.1 4.2 3.9 3.3 4.0 1.8 0.0 -1.6 1.7 4.3 -3.0 3.6 -0.8 1.5 0.3 -2.1 3.0 3.3
Length of working week for main job 0.4 0.4 2.8 -0.7 -1.7 -0.6 -0.4 -0.5 -0.5 -0.0 -1.0 -0.4 0.3 0.0 1.3 -1.1 -0.2 0.3 -0.3 0.5 -0.4 0.2 -0.1 -0.2 0.4
Exposure to tobacco smoke at home 0.2 0.3 1.3 0.1 -0.9 -0.6 0.4 -0.4 0.2 -0.1 0.8 0.7 0.4 0.0 1.1 -0.8 0.1 -0.4 0.2 -0.6 0.5 0.4 0.2 0.6 0.5
Breastfed as a baby 2.9 3.6 6.4 -2.5 -1.0 -1.9 -2.1 -2.2 -2.2 -2.1 -1.9 -1.9 -2.4 0.0 -1.0 -1.6 -2.2 2.0 -2.2 -1.1 -2.2 -1.5 -0.7 -2.1 -2.3
Tense / ‘highly strung’ 0.7 1.1 3.8 0.7 1.0 0.9 1.2 1.2 0.9 0.6 0.7 0.3 1.5 0.0 0.9 0.6 0.7 -2.0 0.8 1.5 1.7 1.4 -1.0 1.0 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.2 -0.7 -0.5 -1.4 -1.4 -1.7 -1.3 -2.1 -1.6 -1.9 -1.5 0.0 -0.2 -1.8 -1.5 1.2 -1.7 -1.1 -1.3 -1.7 0.9 -1.0 -1.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.3 0.9 -0.0 0.7 0.5 0.5 0.6 0.9 -0.1 1.1 0.7 0.0 0.9 0.3 0.7 -0.1 0.3 -0.6 0.2 0.6 -1.1 0.4 0.8
Birth weight of first child 0.6 1.0 4.2 -0.6 -1.4 -1.6 -0.6 -2.0 -0.7 -0.2 -0.2 -1.2 -1.0 0.0 0.2 -1.6 -0.5 0.3 -0.6 -1.3 -1.0 -0.8 -2.0 -0.5 -0.3
Peak expiratory flow (PEF) 0.4 1.0 2.5 0.7 -0.6 0.7 1.2 1.6 1.2 1.1 1.0 1.5 0.9 0.0 0.3 1.4 1.1 -1.1 1.2 -0.9 0.9 0.4 0.3 1.1 1.3
Pulse wave reflection index 0.7 0.8 2.9 0.4 -0.2 -0.9 -0.8 -1.1 -1.0 -0.6 -1.1 -0.3 -0.1 0.0 0.1 -1.2 -1.1 1.1 -1.2 -1.1 -0.9 -0.6 -1.7 -1.0 -1.3
Ever highly irritable/argumentative for 2 days 2.1 2.5 5.2 0.9 -1.4 -0.9 -2.0 -2.1 -2.1 -1.8 -1.8 -1.7 -0.7 0.0 1.7 -1.1 -2.0 1.7 -1.9 -1.2 -1.4 -0.6 -0.9 -2.2 -2.3
Loud music exposure frequency 0.1 0.2 0.7 -0.6 -0.5 0.2 -0.0 -0.2 -0.0 0.1 -0.0 -0.2 -0.5 0.0 -0.8 0.7 -0.0 0.0 -0.2 0.1 -0.5 -0.1 -0.8 -0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 7.4 0.9 -0.0 0.9 2.6 2.2 2.5 2.2 2.3 2.7 2.3 0.0 0.3 0.6 2.4 -1.9 2.4 0.7 1.7 1.0 0.3 1.6 2.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.4 -0.6 -1.1 -0.7 -0.2 -0.8 -0.4 -0.5 -0.4 -0.7 -0.2 0.0 0.7 -0.2 -0.3 0.4 -0.2 -1.2 -0.3 -0.5 0.7 -0.3 0.8
Blood clot in the leg (DVT) 1.0 1.3 7.2 -1.5 -2.7 -1.4 0.6 0.8 1.0 0.8 0.5 0.5 -1.3 0.0 -2.5 -0.9 0.7 -0.0 0.3 -0.4 -1.3 -1.6 -0.9 -0.0 -0.3
Medication: Paracetamol 2.6 4.3 8.8 -2.0 -2.4 -1.7 -2.1 -3.0 -2.4 -2.4 -1.8 -1.8 -2.5 0.0 -0.4 -1.3 -2.3 1.8 -2.4 -2.9 -1.8 -2.2 -0.6 -2.1 -2.5
Headache pain in last month 3.5 6.0 17.8 -2.1 -4.2 -3.3 -2.0 -2.2 -1.9 -2.3 -2.3 -2.4 -2.4 0.0 -1.2 -3.1 -2.2 2.2 -2.7 -3.1 -3.3 -2.7 -0.7 -1.9 -2.5
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 9.1 0.6 0.4 0.2 0.8 0.5 1.1 0.7 0.7 0.7 -0.5 0.0 -1.0 0.5 1.4 -0.3 0.7 1.0 -0.0 -0.1 3.0 0.6 1.0
Glaucoma (self-reported) 0.3 0.3 1.5 -0.5 0.6 0.1 -0.5 -0.4 -0.7 -0.7 -0.6 -0.3 0.9 0.0 0.7 0.4 -0.8 0.4 -0.3 0.7 0.3 0.4 1.2 -0.6 0.3
Gout (self-reported) 0.9 1.3 4.5 -1.5 -1.4 -1.3 -0.8 -0.8 -0.5 -0.7 -0.8 -0.4 -1.3 0.0 -1.8 -1.0 -0.4 0.7 -0.8 -1.0 -1.8 -2.1 -0.9 -0.8 -1.3
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 7.2 2.7 1.3 1.3 1.2 1.1 1.1 1.1 1.1 1.1 1.7 0.0 1.0 1.5 0.7 -1.3 1.1 2.5 1.6 1.4 -2.1 1.6 1.1
Medication: Amlodipine 0.6 0.9 8.7 0.4 0.7 -0.3 -0.8 -0.9 -1.0 -0.7 -0.3 -1.2 -0.0 0.0 1.1 -0.9 -1.1 0.8 -0.7 -0.7 -0.4 -0.0 -3.0 0.3 -0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 4.0 0.7 -0.1 0.5 0.7 1.0 0.8 0.4 0.3 0.9 0.3 0.0 -0.5 0.7 0.7 -0.2 0.8 0.5 0.2 0.6 2.0 0.2 0.7
Birth weight 0.5 1.1 4.1 -0.5 -1.6 -1.5 -0.8 -1.0 -0.9 -0.0 -1.4 -0.8 -1.0 0.0 -0.3 -1.2 -1.0 1.2 -1.0 -2.0 -1.1 -1.0 0.0 -0.9 -0.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 5.1 1.2 1.4 0.5 -1.0 -0.7 -1.0 -0.8 -1.0 -0.9 -0.1 0.0 2.3 -0.4 -0.9 1.1 -0.5 0.4 -0.1 0.9 -0.7 -0.6 -0.1
High blood pressure (siblings) 0.5 0.7 3.0 -1.2 -0.7 -1.1 -0.3 -0.5 -0.3 0.1 -0.5 -0.8 -1.0 0.0 -0.5 -0.3 -0.5 0.5 -0.5 -1.7 -1.0 -1.4 -1.3 -0.6 -0.6
Forced vital capacity (FVC), Best measure 4.8 17.5 40.9 1.2 -0.2 3.1 5.8 6.4 6.2 5.9 4.5 4.8 2.9 0.0 -1.1 4.3 6.1 -5.0 5.4 -0.5 3.2 0.7 -0.5 4.8 5.3
Body fat percentage 15.8 62.5 144.0 -3.8 -5.6 -6.4 -10.4 -12.0 -11.0 -9.8 -9.2 -9.1 -5.6 0.0 2.5 -8.2 -10.3 8.8 -9.8 -5.3 -6.9 -3.2 -2.1 -8.9 -9.8
Leg fat percentage (right) 16.6 60.2 129.1 -3.8 -5.5 -6.5 -10.2 -11.4 -10.8 -9.7 -9.1 -9.0 -5.7 0.0 2.4 -8.2 -10.3 8.6 -9.8 -5.3 -6.8 -3.0 -1.8 -8.5 -9.4
Arm fat-free mass (right) 0.8 4.2 14.1 -2.5 -3.8 -2.7 -1.7 -1.6 -1.3 -1.2 -2.3 -0.7 -2.1 0.0 -0.9 -1.9 -1.2 1.6 -1.8 -3.6 -2.6 -2.4 -2.1 -1.6 -1.5
Exposure to tobacco smoke outside home 1.4 1.8 4.5 -0.2 -0.9 -1.3 -1.5 -2.1 -1.9 -1.6 -1.4 -1.7 -0.4 0.0 1.8 -1.7 -2.0 0.7 -1.6 -0.4 -0.7 0.2 -1.5 -1.0 -1.5
Comparative body size at age 10 1.0 2.8 6.6 2.1 1.1 2.3 1.5 1.0 1.2 2.2 1.7 1.3 2.1 0.0 1.7 1.6 1.3 -2.0 1.9 0.4 1.7 2.3 0.0 2.6 1.6
Number of full brothers 0.8 1.0 3.1 1.6 1.7 1.3 -0.2 0.2 -0.4 0.3 -0.1 -0.2 1.5 0.0 1.5 1.1 -0.4 0.1 0.4 1.5 1.2 1.5 -1.0 0.4 0.5
Worry too long after embarrassment 2.0 3.3 8.1 1.4 1.9 2.5 1.9 2.0 1.9 1.8 1.9 2.0 1.5 0.0 0.5 2.8 2.2 -2.1 2.3 1.5 1.9 1.4 -1.1 1.1 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.3 0.1 -1.0 -1.3 -1.6 -1.7 -1.6 -1.8 -1.8 -1.2 -1.0 0.0 0.8 -1.8 -1.7 1.2 -1.7 -0.7 -1.1 -0.7 -1.6 -1.6 -1.3
Wheeze or whistling in the chest in last year 6.1 10.9 22.5 -1.0 -1.7 -2.3 -4.3 -4.7 -4.3 -4.3 -4.3 -4.0 -2.8 0.0 0.9 -2.8 -4.0 3.9 -4.2 -1.4 -3.1 -1.7 0.3 -4.7 -4.2
Number of children fathered 0.4 0.5 3.3 -0.4 0.7 1.4 0.4 0.9 0.4 0.7 0.4 0.9 -0.1 0.0 -0.5 1.8 0.1 -0.7 0.4 0.1 0.4 -0.1 0.1 0.8 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 2.3 0.0 1.5 0.4 0.6 0.2 0.5 0.5 0.9 0.3 0.7 0.0 0.3 -0.2 0.5 -0.4 0.4 1.3 0.6 0.4 -0.8 1.3 0.5
Age at first live birth 2.9 5.2 11.8 0.5 -0.3 1.2 3.2 3.3 3.4 3.2 2.7 3.1 1.3 0.0 -0.9 1.9 3.4 -2.7 3.3 0.5 1.6 0.8 -0.1 2.3 2.9
Pulse wave peak to peak time 4.1 4.8 10.0 2.1 0.4 2.1 2.5 2.4 2.4 1.7 2.4 1.9 2.0 0.0 0.6 2.8 2.4 -2.8 2.5 2.1 2.4 1.4 2.9 1.8 3.2
Health satisfaction 2.3 3.0 8.0 -2.4 -1.9 -1.4 -1.6 -1.9 -1.6 -1.2 -2.0 -1.2 -1.2 0.0 -0.9 -1.7 -1.3 1.7 -1.6 -2.8 -2.0 -1.4 -2.4 -1.4 -2.4
Shortness of breath walking on level ground 0.8 0.9 2.9 -0.4 0.2 -0.3 -1.1 -1.2 -1.2 -0.3 -0.9 -0.9 -0.4 0.0 1.2 -1.1 -1.4 0.6 -1.1 -1.7 -0.5 -0.1 -1.4 -1.2 -1.1
Qualifications: College or University degree 1.3 4.0 12.3 -0.7 -0.1 0.0 2.9 2.4 3.2 2.5 2.3 2.9 0.1 0.0 -2.8 0.6 3.5 -2.0 2.4 -0.0 0.4 -0.8 1.4 2.2 2.2
Eye problems/disorders: None of the above 0.7 0.8 4.0 -1.6 -2.0 -1.1 0.6 0.7 0.8 0.8 0.7 0.3 0.1 0.0 -2.0 -1.1 0.7 0.0 0.5 -0.8 -0.7 -0.9 0.5 0.1 -0.4
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.6 -1.2 -1.1 -0.9 -0.4 -0.6 -0.4 -0.8 -0.5 -0.7 -0.2 0.0 -0.0 -0.6 -0.4 0.2 -0.4 -0.8 -0.2 -0.8 -0.6 -0.6 -1.0
Emphysema/chronic bronchitis 2.1 2.3 6.2 0.4 -0.5 -1.2 -1.8 -1.7 -1.8 -1.7 -2.5 -1.5 -1.2 0.0 1.0 -2.1 -1.8 1.7 -2.0 -1.9 -1.1 -0.5 0.6 -2.2 -1.2
Medication for pain relief, constipation, heartburn 3.6 6.1 11.8 1.7 1.5 2.0 2.8 3.4 3.0 2.6 2.6 2.6 2.8 0.0 -0.3 1.8 2.8 -2.3 3.0 3.1 2.2 2.6 2.2 2.6 3.4
Neck or shoulder pain in last month 1.4 2.0 4.1 -1.2 -1.5 -1.0 -1.5 -1.6 -1.7 -1.4 -1.5 -1.7 -1.3 0.0 0.4 -1.4 -1.8 1.2 -1.8 -2.0 -1.3 -1.1 0.1 -1.6 -1.5
Medication: Blood pressure 0.4 0.7 4.8 0.3 0.0 0.4 -0.4 -0.1 -0.8 -0.2 -0.6 -0.5 0.9 0.0 1.7 -0.5 -1.1 0.2 -0.3 -1.3 0.3 0.7 -2.2 0.0 -0.3
Angina (self-reported) 3.1 4.1 9.6 -1.9 -2.1 -2.2 -2.3 -2.4 -2.2 -1.9 -2.1 -1.9 -1.6 0.0 -0.1 -2.1 -2.1 1.8 -2.4 -2.0 -1.7 -1.7 -1.7 -2.4 -3.1
Migraine (self-reported) 3.1 3.8 9.0 -0.4 -3.0 -2.3 -2.3 -2.4 -2.0 -2.2 -1.9 -1.5 -1.6 0.0 -0.3 -2.9 -2.2 2.0 -2.2 -1.8 -2.0 -1.4 0.6 -2.1 -2.4
Medication: Ibuprofen 4.8 5.8 11.4 -1.4 -1.9 -1.9 -2.8 -2.7 -2.8 -2.6 -2.5 -2.8 -2.2 0.0 0.6 -2.9 -3.1 2.4 -3.0 -2.6 -2.2 -1.8 -1.9 -2.6 -3.4
Medication: Allopurinol 1.1 1.5 3.9 -1.6 -1.1 -1.1 -1.0 -1.0 -0.9 -1.0 -1.7 -1.0 -1.3 0.0 -1.2 -1.1 -1.0 0.9 -1.3 -1.5 -1.8 -2.0 -1.1 -1.1 -1.1
Medication: Omeprazole 4.4 5.2 9.2 -0.8 -1.5 -2.1 -3.0 -2.9 -2.9 -2.3 -2.5 -2.6 -2.1 0.0 0.1 -2.5 -2.6 3.0 -2.7 -2.1 -2.4 -1.6 0.1 -2.6 -3.0
Medication: Seretide 50 evohaler 0.8 0.9 2.6 -0.8 -0.9 -0.4 -0.8 -0.8 -1.0 -0.7 -1.5 -1.0 -0.9 0.0 -0.5 -1.4 -1.3 1.0 -1.0 -1.6 -1.2 -0.5 -0.3 0.1 -0.4
Mean time to correctly identify matches 0.3 0.5 2.9 0.1 1.1 1.2 0.7 0.4 0.4 0.7 1.7 0.1 0.3 0.0 -0.3 1.3 0.4 -0.5 0.6 0.8 0.7 0.5 0.4 0.6 0.3
Heart disease (mother) 0.8 1.0 3.6 -1.1 -1.5 -0.3 -0.6 -1.1 -0.8 -0.7 -1.4 -0.5 -1.6 0.0 -0.2 -0.3 -0.9 0.4 -1.0 -0.7 -0.9 -1.0 -1.9 -1.8 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.1 1.8 1.5 1.1 0.6 -0.3 0.2 0.3 1.0 0.9 1.4 0.0 1.5 0.0 0.4 -0.7 0.6 0.2 1.1 1.6 0.5 0.2 0.6
Whole body fat mass 11.6 48.4 106.1 -4.0 -5.9 -6.0 -8.9 -10.3 -9.4 -8.3 -8.2 -7.6 -5.1 0.0 1.8 -7.2 -8.7 7.6 -8.5 -5.5 -6.4 -3.4 -2.4 -7.7 -8.6
Leg fat mass (right) 12.0 46.4 97.8 -4.0 -5.7 -6.1 -8.7 -9.9 -9.1 -8.1 -8.2 -7.4 -5.3 0.0 1.4 -7.2 -8.6 7.4 -8.4 -5.6 -6.4 -3.5 -2.1 -7.4 -8.2
Arm predicted mass (right) 0.9 4.4 15.5 -2.6 -3.9 -2.8 -1.7 -1.6 -1.3 -1.2 -2.1 -0.8 -2.1 0.0 -1.1 -2.0 -1.1 1.6 -1.8 -3.7 -2.7 -2.5 -2.3 -1.5 -1.5
Pulse rate, automated reading 2.1 6.9 20.9 -3.2 -3.0 -3.5 -2.5 -3.5 -2.5 -2.6 -2.6 -1.9 -2.2 0.0 -0.5 -4.6 -2.1 2.3 -2.8 -2.2 -2.9 -1.4 -3.0 -2.1 -2.6
Alcohol intake frequency. 0.7 1.7 6.7 0.2 -0.0 1.2 1.4 0.9 1.5 1.9 1.4 1.6 0.8 0.0 -1.1 1.6 1.6 -1.5 1.8 0.5 0.4 0.2 2.6 1.4 1.4
Comparative height size at age 10 0.9 4.7 10.6 0.2 -0.5 1.6 3.0 2.6 2.9 3.3 2.8 2.8 1.5 0.0 -0.3 1.2 2.7 -2.4 2.7 0.3 1.7 0.7 -3.2 3.0 1.9
Number of full sisters 2.9 3.6 8.6 0.1 0.2 -0.4 -2.4 -2.5 -2.7 -2.9 -2.6 -2.9 -1.4 0.0 1.1 -1.1 -2.7 2.0 -2.9 -0.2 -1.0 -0.3 -0.3 -2.4 -2.1
Suffer from ‘nerves’ 1.8 2.8 6.1 1.5 2.1 2.1 2.1 2.2 2.0 1.9 1.5 1.3 1.4 0.0 0.2 2.0 1.8 -2.2 1.8 2.5 1.7 1.3 0.3 1.5 1.1
Overall health rating 2.0 4.3 8.7 -2.6 -2.4 -1.8 -2.2 -2.7 -2.3 -1.5 -2.9 -2.0 -1.7 0.0 -1.0 -1.8 -2.4 1.7 -2.3 -1.9 -2.3 -2.2 -1.1 -2.3 -2.2
Chest pain or discomfort 0.7 1.1 3.5 -1.1 -1.4 -0.6 -0.7 -1.4 -0.6 -0.6 -0.4 -0.6 -1.6 0.0 -1.3 -0.3 -0.4 0.5 -0.7 -1.5 -1.3 -1.1 -0.2 -1.4 -1.9
Had major operations 4.1 4.8 9.7 -1.8 -1.6 -2.3 -2.9 -2.7 -3.1 -2.5 -2.3 -2.5 -1.0 0.0 0.7 -2.7 -3.0 2.6 -2.9 -0.9 -1.8 -1.0 1.9 -1.7 -2.4
Age at last live birth 0.7 1.0 3.2 -0.9 -1.8 -1.2 0.9 1.4 1.2 1.1 0.4 1.2 -0.2 0.0 -1.7 -0.3 1.3 -0.3 1.0 -0.5 -0.6 -1.2 -0.1 0.3 0.8
Family relationship satisfaction 0.2 0.2 1.3 -0.7 0.4 -0.0 0.2 0.1 0.3 0.2 -0.2 0.2 -0.8 0.0 -0.5 0.8 0.4 -0.5 0.2 0.0 0.0 -0.6 1.2 -0.3 0.6
Leg pain on walking 1.0 1.2 3.4 -1.3 -1.6 -0.5 -1.0 -0.6 -1.0 -0.2 -0.8 -1.2 -0.7 0.0 0.3 -1.3 -1.2 0.7 -1.1 -1.8 -0.9 -0.8 -1.8 -1.7 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.5 -1.6 -1.4 -1.3 -0.3 -0.4 -0.2 -0.4 -0.8 0.1 -0.5 0.0 -1.2 -1.1 -0.2 0.8 -0.4 -0.1 -1.1 -1.0 0.9 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.9 -2.0 -0.7 -1.0 -1.4 -1.2 -1.3 -0.9 -1.0 -1.5 -1.9 0.0 -0.2 -1.1 -1.2 0.9 -1.2 -1.5 -1.4 -1.7 -0.8 -1.0 -2.0
Illness, injury, bereavement, stress in last 2 years 2.8 3.5 7.0 0.0 1.0 1.9 2.2 2.6 2.4 2.0 2.4 2.2 1.1 0.0 -0.8 2.6 2.4 -1.6 2.4 0.7 1.2 1.3 0.8 2.4 2.6
Medication: Aspirin 2.1 2.7 7.1 -0.6 0.7 -1.0 -2.0 -1.5 -1.8 -1.8 -2.7 -1.5 -1.9 0.0 0.2 -0.7 -1.8 1.6 -1.9 -1.8 -1.4 -1.8 -2.2 -2.1 -2.1
Supplements: Vitamin C 1.5 1.8 3.2 1.4 0.9 1.2 1.3 1.2 1.3 1.4 1.8 1.7 1.6 0.0 0.8 0.3 1.2 -0.9 1.7 1.4 1.5 1.7 1.4 1.3 1.4
Knee pain experienced in last month 0.6 1.0 3.6 -1.1 -1.0 -0.4 -1.1 -0.7 -1.1 -0.5 -1.3 -0.9 -0.8 0.0 0.4 0.2 -1.0 0.8 -0.9 -1.2 -0.7 -0.4 -1.9 -0.8 -1.8
Hypertension (Self-reported) 1.0 2.7 7.5 -0.4 -0.1 -0.8 -2.2 -1.6 -2.1 -1.4 -2.0 -1.5 -1.6 0.0 0.3 -1.2 -2.2 2.1 -2.1 -1.4 -1.4 -1.0 -2.7 -1.5 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 0.2 -0.5 -0.2 -0.5 -0.0 -0.3 -0.2 -0.1 -0.3 0.2 0.0 0.4 -0.1 -0.5 0.5 -0.2 -0.6 0.3 0.5 -0.1 -0.5 -0.5
Illnesses of father: Heart disease 0.4 0.5 2.7 1.6 1.2 0.6 -0.6 -0.9 -0.8 0.1 -0.8 -0.5 0.3 0.0 1.0 0.2 -0.5 0.2 -0.3 0.6 0.4 0.4 -1.5 -0.2 -0.1
Illnesses of siblings: Diabetes 0.7 0.9 3.9 0.1 0.0 0.4 -1.2 -2.0 -1.6 -1.6 -0.8 -0.8 -0.2 0.0 0.5 0.3 -1.4 0.5 -1.0 -0.5 -0.1 0.1 0.3 -1.3 -1.5
Smoking status: Previous 2.2 3.2 6.5 1.6 0.8 1.7 2.1 2.0 2.1 1.7 1.7 2.4 1.8 0.0 0.8 1.2 1.9 -2.5 2.0 0.3 1.9 1.2 -2.2 2.5 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 0.4 -1.3 -0.3 1.0 1.1 1.1 1.2 1.2 1.0 1.1 0.0 -0.0 0.0 1.2 -0.9 0.8 0.0 0.6 0.2 -0.4 1.2 1.2
Whole body fat-free mass 0.5 2.8 12.9 -2.5 -3.6 -2.2 -0.9 -0.7 -0.5 -0.3 -1.4 -0.1 -1.7 0.0 -1.3 -1.5 -0.4 1.0 -1.0 -3.4 -2.1 -2.3 -1.8 -0.7 -0.8
Leg fat-free mass (right) 0.7 3.5 11.0 -2.4 -3.3 -2.1 -1.7 -2.1 -1.5 -1.0 -2.0 -0.8 -1.7 0.0 -0.5 -1.9 -1.3 1.6 -1.6 -3.2 -2.3 -2.1 -1.6 -1.4 -1.6
Arm fat percentage (left) 14.6 58.2 132.2 -3.7 -5.2 -6.2 -10.0 -11.5 -10.7 -9.4 -9.0 -8.9 -5.5 0.0 2.4 -7.7 -10.0 8.5 -9.5 -5.1 -6.7 -3.3 -1.3 -8.6 -9.6
Average weekly red wine intake 1.0 1.5 4.8 1.6 2.2 1.4 0.9 1.0 0.8 0.8 0.7 1.2 0.9 0.0 0.7 0.8 1.0 -0.5 1.2 2.2 1.3 1.6 1.6 1.3 1.0
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.0 1.7 1.9 2.0 1.5 0.8 1.1 1.5 1.3 1.0 1.3 0.0 0.4 1.6 1.1 -1.5 1.1 0.9 1.8 1.6 0.5 1.1 1.4
Mood swings 0.3 0.6 2.8 1.4 0.3 0.8 0.1 0.0 -0.3 0.3 0.3 -0.4 1.3 0.0 1.7 0.4 -0.4 -1.0 0.2 -0.2 1.4 1.4 0.1 0.5 -0.2
Loneliness, isolation 0.2 0.3 0.9 -0.2 0.6 0.5 -0.2 -0.9 -0.5 -0.7 -0.1 -0.7 -0.3 0.0 0.9 0.6 -0.4 -0.5 -0.3 0.2 0.2 0.4 -0.1 -0.7 -0.4
Long-standing illness, disability or infirmity 10.2 15.6 26.4 -2.0 -3.3 -3.2 -5.0 -5.1 -5.1 -4.7 -4.6 -4.6 -3.2 0.0 0.6 -4.0 -5.0 4.3 -4.8 -3.5 -3.9 -2.4 -2.8 -4.7 -4.6
Ever had bowel cancer screening 1.7 2.0 5.2 1.1 1.6 1.6 1.6 2.3 1.6 1.4 1.2 0.9 1.3 0.0 -0.1 1.3 1.3 -1.2 2.0 0.8 1.4 1.1 -1.6 2.1 1.6
Diabetes diagnosed by doctor 1.2 2.0 4.0 -2.0 -1.8 -1.6 -1.6 -1.6 -1.4 -1.5 -1.8 -0.8 -1.4 0.0 -0.7 -0.7 -1.5 1.0 -1.6 -1.3 -1.4 -1.9 -1.4 -0.9 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 9.2 -1.0 -0.5 -1.0 1.0 0.6 1.3 0.9 -0.2 0.5 -0.8 0.0 -3.0 -0.2 1.1 -0.4 0.5 -1.3 -0.8 -2.2 0.1 0.4 1.2
Friendships satisfaction 1.2 1.4 3.1 0.3 1.0 0.8 1.6 1.3 1.7 1.4 1.3 1.7 0.6 0.0 -0.4 1.8 1.6 -1.6 1.5 1.2 0.7 0.1 -0.5 1.1 1.4
Qualifications: nursing, teaching 0.4 0.6 1.6 -1.1 -0.6 0.0 0.9 1.1 1.0 1.1 0.9 0.9 0.3 0.0 -0.5 0.2 1.3 -0.7 1.0 -1.1 0.4 -0.2 -0.5 -0.3 0.7
Commuting to job workplace: Walk 0.2 0.2 1.1 0.1 -0.3 -0.3 -0.5 -0.7 -0.6 -0.7 0.1 -0.3 0.5 0.0 -0.3 -0.6 -0.4 0.7 -0.3 0.6 -0.4 0.3 1.0 -0.2 0.1
Eye problems/disorders: Cataract 1.4 1.6 5.3 1.9 2.3 1.9 0.6 0.8 0.5 0.5 0.4 1.0 1.2 0.0 1.5 2.1 0.6 -1.2 0.8 0.9 1.7 1.4 -1.2 1.2 1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.6 0.5 -0.1 0.1 0.1 -0.4 -0.0 -0.3 0.4 -0.0 0.2 0.0 0.7 -0.3 0.3 -0.4 0.2 0.6 1.0 0.5 -1.3 -0.6 0.6
Medication for cholesterol 0.4 0.5 2.2 1.2 0.5 0.5 0.5 0.2 0.3 0.2 0.9 0.3 0.8 0.0 1.1 -0.5 0.3 -0.5 0.6 1.1 0.7 1.5 1.2 0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.1 -1.0 0.0 -0.0 -0.5 -1.0 -0.7 -0.1 -0.5 -0.6 -0.8 0.0 -1.1 0.2 -0.9 -0.2 -0.3 0.1 -0.4 -0.9 -0.6 0.2 -0.5
Back pain experienced in last month 0.3 0.5 2.7 -0.1 -0.9 0.3 0.6 0.5 0.4 1.2 0.3 0.8 -0.4 0.0 -0.2 0.7 0.3 -0.9 0.0 -1.1 -0.1 -0.7 -1.7 0.4 -0.2
Mineral and other dietary supplements 5.0 6.8 13.7 -0.8 -1.7 -2.5 -3.7 -3.3 -3.7 -3.4 -2.7 -3.1 -1.6 0.0 2.0 -2.4 -3.4 3.0 -3.1 -1.2 -2.4 -0.6 -0.9 -3.3 -3.2
Breast cancer (self-reported) 0.3 0.3 2.1 0.5 -0.0 0.1 -0.1 -0.3 -0.2 -0.6 0.6 -0.2 0.9 0.0 1.5 0.3 0.2 -0.2 0.3 0.6 0.8 1.3 0.4 0.5 0.3
Asthma (self-reported) 1.6 3.3 5.4 -1.8 -1.2 -1.9 -2.0 -2.1 -1.9 -2.0 -1.8 -2.0 -1.9 0.0 -1.0 -1.8 -1.7 2.0 -2.1 -1.1 -2.1 -1.3 2.3 -1.7 -2.3
Osteoporosis (self-reported) 0.5 0.6 3.6 1.9 0.6 0.6 -0.5 -0.7 -0.7 -0.3 -0.0 -1.0 0.1 0.0 1.4 -0.9 -0.5 0.2 -0.4 0.3 0.9 1.0 -0.6 -0.1 -0.7
Osteoarthritis (self-reported) 4.0 5.2 10.5 -1.1 -0.7 -1.6 -2.9 -3.2 -3.2 -2.6 -2.8 -2.7 -2.1 0.0 1.1 -2.9 -3.1 2.5 -3.1 -0.5 -1.6 -1.3 -0.7 -2.5 -2.9
Medication: Aspirin 2.5 3.3 9.0 -0.4 0.8 -1.1 -2.3 -1.9 -2.1 -1.9 -3.0 -1.7 -2.1 0.0 0.4 -1.1 -2.2 1.8 -2.3 -1.7 -1.6 -1.7 -2.1 -2.2 -2.2
Medication: Gliclazide 0.1 0.1 1.0 -0.2 -1.0 -0.1 -0.1 -0.1 0.1 0.2 0.4 0.6 -0.1 0.0 0.4 0.1 -0.1 -0.4 -0.0 0.3 0.4 -0.2 0.0 -0.0 -0.2
Illnesses of father: None of the above (group 1) 0.8 1.0 2.7 0.7 0.3 0.6 1.3 1.3 1.4 1.0 1.6 1.4 0.5 0.0 -0.1 0.2 1.0 -1.4 0.9 0.9 1.4 1.2 1.0 0.6 1.1
Smoking status: Current 0.7 1.2 2.8 -0.4 -0.2 -1.0 -1.3 -0.7 -0.8 -1.3 -1.3 -1.4 -1.7 0.0 -1.1 -0.4 -0.8 1.7 -1.4 0.1 -1.3 -1.1 -0.8 -1.0 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.4 0.7 0.4 0.4 1.4 2.1 1.5 1.2 1.1 0.7 1.0 0.0 1.0 0.9 1.3 -1.2 1.1 -0.5 1.2 0.5 -0.0 1.2 1.2
Whole body water mass 0.5 3.0 13.1 -2.6 -3.6 -2.2 -1.0 -0.8 -0.6 -0.4 -1.5 -0.2 -1.9 0.0 -1.4 -1.4 -0.5 1.1 -1.1 -3.4 -2.2 -2.4 -1.8 -0.8 -0.9
Leg predicted mass (right) 0.6 3.2 10.5 -2.3 -3.2 -2.1 -1.6 -2.0 -1.4 -1.0 -1.9 -0.8 -1.6 0.0 -0.5 -1.8 -1.2 1.5 -1.5 -3.2 -2.2 -2.1 -1.6 -1.3 -1.5
Arm fat mass (left) 11.4 47.0 99.5 -4.0 -5.7 -6.1 -8.8 -10.0 -9.2 -8.1 -8.1 -7.6 -5.3 0.0 1.4 -7.1 -8.6 7.5 -8.4 -5.3 -6.4 -3.7 -2.1 -7.6 -8.4
Number of self-reported non-cancer illnesses 1.1 1.9 5.8 0.3 -0.5 -0.7 -1.8 -1.9 -1.8 -1.8 -1.7 -0.6 -0.8 0.0 0.7 -0.8 -1.7 1.5 -1.7 -0.5 -0.9 -0.9 -2.0 -1.9 -2.4
Average weekly champagne plus white wine intake 0.4 0.6 1.8 0.2 -0.8 0.3 0.5 0.8 0.5 0.3 0.9 1.1 1.4 0.0 1.1 0.3 0.6 -0.2 0.9 0.8 1.2 0.9 -0.8 -0.2 0.7
Miserableness 0.2 0.4 1.9 1.0 -0.5 -0.3 -0.3 -0.9 -0.7 -0.5 -0.3 0.1 0.4 0.0 1.4 0.1 -0.7 -0.1 -0.4 -0.7 0.3 0.4 1.3 -0.5 -0.8
Guilty feelings 0.4 0.6 3.8 0.1 2.0 0.9 -0.4 -0.3 -0.4 -0.5 -0.8 -0.8 -0.8 0.0 -0.8 1.7 -0.2 -0.0 -0.2 0.2 0.2 -0.7 0.9 -0.2 -0.7
Wears glasses or contact lenses 0.3 0.3 2.1 -1.1 -0.2 -0.1 0.6 0.5 0.5 0.2 0.4 0.6 -0.2 0.0 -1.4 0.2 0.3 -0.3 0.0 -0.8 -0.2 -0.7 -0.7 0.4 0.2
Ever taken oral contraceptive pill 1.1 1.2 3.5 -0.9 -0.6 -0.1 1.4 1.3 1.8 1.4 0.7 1.6 -0.3 0.0 -1.5 0.4 1.9 -1.4 1.2 0.5 0.5 -1.0 -0.5 0.8 1.0
Hearing aid user 0.4 0.4 3.2 0.9 1.1 1.1 -0.3 0.4 -0.1 -0.0 -0.6 0.3 0.1 0.0 0.4 1.8 -0.5 0.0 0.3 0.3 0.4 0.3 0.6 -0.4 -0.5
Mother’s age at death 3.2 4.0 7.9 2.4 1.9 2.3 2.5 1.9 2.4 2.0 2.8 2.2 1.3 0.0 -0.7 1.9 2.2 -2.5 2.1 2.3 1.8 1.5 0.9 2.2 2.0
Financial situation satisfaction 5.9 7.3 12.8 -1.6 -1.6 -3.1 -3.2 -3.1 -3.0 -3.6 -3.3 -2.8 -2.8 0.0 0.7 -2.4 -3.1 3.0 -3.5 -2.3 -3.0 -2.3 -0.4 -3.4 -3.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.5 1.9 0.3 1.7 0.6 0.1 0.4 0.7 1.1 0.8 0.7 0.0 0.4 0.9 0.4 -1.0 0.6 0.4 1.4 1.4 -1.2 1.2 0.1
Commuting to job workplace: Public transport 2.9 3.4 6.2 2.2 1.4 1.8 2.2 2.0 2.1 2.2 1.8 2.3 1.9 0.0 0.2 1.4 2.0 -1.6 2.2 1.5 2.3 1.8 1.3 2.0 2.5
Eye problems/disorders: Glaucoma 0.4 0.5 2.2 0.3 1.4 0.8 -0.2 -0.2 -0.4 -0.1 -0.2 -0.0 0.4 0.0 0.8 1.2 -0.5 0.0 -0.0 1.5 0.8 0.6 1.2 -0.5 0.6
Medication: Blood pressure 0.7 1.3 3.1 -0.1 0.5 -0.1 -1.6 -1.0 -1.4 -1.1 -1.6 -1.1 -1.4 0.0 -0.0 0.4 -1.3 1.7 -1.5 -0.9 -1.1 -1.4 -1.0 -0.7 -1.8
Pain type(s) experienced in last month: Hip pain 4.2 5.3 11.7 -1.6 -1.5 -1.7 -2.9 -3.4 -3.1 -2.9 -3.0 -2.9 -2.3 0.0 0.5 -2.3 -3.1 2.4 -2.9 -1.9 -1.7 -1.5 0.5 -2.1 -2.4
Supplements: Fish oil (including cod liver oil) 3.7 4.8 9.5 1.5 1.1 2.2 3.1 2.7 3.0 2.7 2.4 2.6 1.8 0.0 -0.6 2.2 2.8 -2.4 2.8 0.7 2.0 1.2 0.7 2.6 2.8
High cholesterol (Self-reported) 3.7 6.5 10.2 -2.7 -3.0 -2.8 -2.7 -2.8 -2.5 -2.3 -2.8 -2.1 -2.6 0.0 -1.9 -2.3 -2.5 2.6 -2.8 -3.0 -2.9 -2.9 -2.1 -2.3 -3.2
Medication: Bendroflumethiazide 0.4 0.6 2.1 -1.3 -1.3 0.1 0.0 0.7 0.5 0.4 -0.2 0.4 -0.7 0.0 -1.5 0.8 0.5 0.5 0.3 -1.0 -0.8 -1.3 -1.0 0.7 -0.1
Medication: Paracetamol 4.0 6.2 12.1 -2.0 -2.4 -2.1 -2.8 -3.5 -3.0 -2.7 -2.7 -2.4 -3.2 0.0 -0.5 -1.9 -2.9 2.3 -3.1 -2.8 -2.4 -2.5 -1.1 -2.5 -3.1
Medication: Lisinopril 0.2 0.3 1.1 0.5 -0.8 0.1 0.6 1.0 0.6 0.4 0.0 0.9 0.6 0.0 0.6 0.1 0.4 -0.6 0.4 -0.5 0.4 0.3 -0.7 0.8 0.3
Medication: Atorvastatin 0.7 0.8 8.6 -0.9 -0.0 0.2 -0.8 -0.6 -0.8 -0.4 -0.9 -0.7 -0.5 0.0 -0.3 0.3 -0.9 1.1 -0.7 -0.5 -0.3 -1.0 -2.9 -0.9 -0.8
Illnesses of father: High blood pressure 0.9 1.1 5.1 -1.4 0.0 0.6 1.2 1.6 1.2 2.3 0.6 1.0 0.6 0.0 -1.4 0.3 1.3 -0.8 1.4 0.1 0.1 -0.3 0.8 1.1 0.8
Alcohol drinker status: Never 0.5 0.5 3.5 -0.8 -0.5 -0.4 0.7 1.0 1.0 0.7 0.2 0.6 0.0 0.0 -1.9 0.6 1.0 -0.4 0.9 -0.4 -0.2 -0.5 0.5 0.8 0.6
Ever smoked 4.9 8.7 14.9 2.7 3.4 3.1 3.4 3.5 3.5 3.1 2.8 3.0 2.3 0.0 1.0 2.3 3.3 -3.6 3.3 2.4 3.5 2.1 -1.0 3.8 3.9
Basal metabolic rate 1.2 6.7 18.7 -3.0 -4.3 -3.1 -2.5 -2.6 -2.2 -1.9 -2.8 -1.6 -2.5 0.0 -0.9 -2.7 -2.0 2.3 -2.5 -4.1 -3.1 -2.7 -2.1 -2.1 -2.3
Leg fat percentage (left) 17.0 61.4 136.9 -3.4 -5.2 -6.4 -10.4 -11.7 -11.0 -9.8 -9.2 -9.2 -5.6 0.0 2.9 -8.2 -10.4 8.7 -9.9 -5.2 -6.8 -2.8 -1.9 -8.8 -9.5
Arm fat-free mass (left) 1.1 5.7 17.1 -2.9 -4.1 -3.1 -2.2 -2.0 -1.7 -1.6 -2.7 -1.2 -2.6 0.0 -1.0 -2.4 -1.6 2.0 -2.2 -3.9 -2.9 -2.6 -2.2 -2.0 -1.9
Number of operations (self-reported) 1.6 2.4 4.9 -1.2 -0.9 -1.4 -2.0 -1.7 -2.1 -1.5 -2.2 -1.7 -1.0 0.0 -0.4 -1.4 -2.2 1.9 -1.8 -0.5 -1.4 -1.1 1.9 -1.4 -1.9
Average weekly beer plus cider intake 1.9 2.7 5.2 -1.2 -0.3 -1.6 -1.9 -1.7 -1.8 -2.0 -2.1 -1.5 -2.1 0.0 -0.4 -1.4 -2.0 1.9 -2.0 -2.3 -2.1 -1.4 -0.4 -1.3 -2.0
Irritability 2.1 3.6 7.6 2.5 1.9 2.4 1.7 1.9 1.7 1.1 1.5 1.1 2.4 0.0 1.7 2.6 1.5 -2.2 1.8 1.4 2.8 2.5 0.4 2.2 1.8
Risk taking 7.5 10.9 19.5 -2.2 -2.5 -3.9 -4.2 -4.1 -4.1 -4.1 -4.1 -4.0 -2.4 0.0 -0.1 -4.4 -3.8 4.0 -4.2 -1.6 -3.7 -2.2 0.5 -2.6 -3.3
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.5 1.3 1.7 1.5 1.2 1.9 1.1 1.3 1.3 0.5 0.8 0.0 0.7 0.6 0.4 -0.7 1.2 1.1 1.5 1.5 0.6 0.7 1.3
Fractured/broken bones in last 5 years 0.3 0.4 1.4 0.1 0.6 -0.1 -0.8 -1.2 -1.1 -0.6 -0.9 -0.6 -0.2 0.0 0.3 -0.7 -1.0 0.8 -0.7 0.5 -0.1 0.1 0.6 -0.2 -0.9
Age started oral contraceptive pill 0.1 0.2 2.2 0.1 0.8 0.4 -0.1 0.2 0.0 -0.0 0.3 0.3 -0.1 0.0 0.2 0.3 -0.2 0.4 0.3 0.4 -0.2 0.3 1.5 0.2 -0.1
Diastolic blood pressure, automated reading 1.4 4.2 9.7 -0.2 0.8 -1.5 -2.9 -3.1 -3.1 -2.8 -2.2 -2.1 -1.1 0.0 1.8 -3.1 -2.8 2.0 -2.4 0.6 -1.4 0.2 -0.4 -2.1 -2.4
Ever depressed for a whole week 0.2 0.3 1.7 0.5 -0.3 -0.2 -0.1 -0.4 -0.1 0.2 0.4 -0.1 0.9 0.0 1.1 -0.6 0.2 -0.1 0.3 1.3 0.1 0.6 0.5 0.3 0.1
Unable to work because of sickness or disability 3.2 4.2 8.9 -0.7 -1.0 -1.1 -2.4 -2.5 -2.3 -1.7 -2.9 -2.7 -2.2 0.0 0.2 -1.5 -2.2 1.8 -2.6 -3.0 -1.9 -1.6 -1.9 -2.6 -2.3
Commuting to job workplace: Cycle 1.7 2.0 4.2 0.8 0.1 1.2 1.8 1.7 1.7 1.4 1.6 1.6 1.7 0.0 0.6 2.1 1.7 -1.7 1.7 0.0 1.6 1.5 0.8 1.2 1.9
Myopia 4.8 7.0 16.3 1.0 -0.1 2.4 3.5 3.0 3.2 2.9 4.0 3.4 3.1 0.0 0.1 0.9 2.9 -3.3 3.4 2.3 2.8 2.4 1.0 3.5 2.5
Vascular/heart problems diagnosed by doctor 1.4 3.9 15.8 0.4 -0.6 0.7 2.5 2.1 2.7 1.7 2.0 1.7 1.5 0.0 -1.1 1.2 2.8 -2.3 2.5 0.8 1.3 0.9 4.0 2.0 3.0
Cholesterol lowering medication 3.6 5.2 9.3 -2.1 -1.1 -2.2 -2.5 -2.9 -2.3 -2.0 -2.3 -2.2 -2.8 0.0 -1.4 -1.8 -2.3 2.6 -2.9 -1.8 -2.7 -2.8 -2.6 -1.7 -3.1
Medication: Omeprazole (e.g. Zanprol) 2.3 2.7 5.1 -0.8 -0.9 -1.4 -2.2 -2.2 -2.2 -1.5 -1.8 -1.9 -1.7 0.0 0.3 -2.1 -1.9 2.0 -2.0 -1.4 -1.5 -1.0 0.3 -2.0 -2.3
Pain experienced in last month 2.7 4.5 9.1 2.1 2.4 2.4 2.1 1.8 2.1 1.5 2.3 2.1 2.0 0.0 0.4 2.6 2.4 -1.9 2.5 3.0 2.5 2.0 1.5 1.7 3.0
Supplements: Calcium 0.2 0.2 0.9 1.0 0.9 0.5 0.2 0.4 0.3 0.1 0.5 0.0 -0.2 0.0 -0.2 -0.5 -0.1 -0.0 0.2 0.9 0.4 0.1 0.5 0.5 0.0
Basal cell carcinoma (self-reported) 1.9 2.3 6.2 -0.6 -0.8 -1.1 -1.7 -2.0 -2.0 -1.8 -1.5 -2.5 -1.4 0.0 1.0 -1.3 -2.0 1.4 -1.9 -1.4 -0.9 -0.6 1.3 -1.9 -1.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.8 -0.7 0.1 -0.8 -1.3 -1.5 -1.3 -1.1 -1.5 -0.9 -1.2 0.0 -0.5 -0.6 -1.3 1.1 -1.4 -1.4 -1.1 -1.5 0.2 -1.3 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 6.7 -1.3 -2.6 -1.4 0.2 0.5 0.5 0.6 -0.1 0.2 -1.4 0.0 -2.1 -1.0 0.4 0.3 -0.1 -0.4 -1.3 -1.5 -0.9 -0.3 -0.7
Heart disease (siblings) 2.9 3.5 7.5 -1.9 -0.4 -1.2 -2.7 -2.5 -2.6 -2.3 -1.9 -2.4 -1.6 0.0 -0.3 -1.3 -2.7 2.2 -2.2 -0.2 -1.5 -1.3 -0.5 -2.4 -2.4
Alcohol drinker status: Previous 0.2 0.2 0.8 0.8 0.5 0.6 -0.1 -0.7 -0.2 0.2 -0.2 0.4 0.1 0.0 0.6 0.2 -0.1 0.0 0.1 -0.4 0.1 0.5 -0.9 0.3 -0.5
Pack years of smoking 2.6 3.8 8.4 -1.0 -0.9 -1.4 -2.7 -2.7 -2.8 -2.6 -2.3 -2.1 -1.7 0.0 0.8 -2.0 -2.9 1.8 -2.6 -0.9 -1.6 -0.8 1.4 -2.1 -2.2
Impedance of whole body 0.2 1.0 3.8 1.9 1.2 1.4 0.3 -0.3 -0.1 -0.2 0.8 -0.4 1.6 0.0 1.3 -0.2 0.2 -0.2 0.5 1.8 1.3 1.9 0.6 0.1 0.2
Leg fat mass (left) 11.9 46.6 100.0 -3.9 -5.7 -6.0 -8.8 -10.0 -9.2 -8.1 -8.1 -7.4 -5.3 0.0 1.6 -7.1 -8.6 7.4 -8.5 -5.5 -6.3 -3.4 -2.0 -7.6 -8.3
Arm predicted mass (left) 1.3 6.4 18.1 -2.9 -4.3 -3.2 -2.3 -2.2 -1.9 -1.8 -2.8 -1.5 -2.7 0.0 -1.1 -2.5 -1.8 2.2 -2.4 -3.9 -3.1 -2.8 -2.5 -2.1 -2.1