Best TWAS P=1.4e-09 · Best GWAS P=2.23e-09 conditioned to 0.00961
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | ROSMAP | Brain Pre-frontal Cortex | C1orf52 | 0.05 | 0.02 | blup | 564 | 0.03 | 9.5e-05 | 4.1 | 6.1 | 1.4e-09 | 0.56 | 0.35 | 0.46 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | ZNHIT6 | 0.05 | 0.01 | bslmm | 552 | 0.01 | 1.9e-02 | 4.4 | -5.5 | 3.7e-08 | -0.26 | 0.22 | 0.05 | TRUE |
| 6 | YFS | Blood | ODF2L | 0.04 | 0.04 | enet | 18 | 0.04 | 1.8e-12 | 5.5 | -5.4 | 8.0e-08 | -0.01 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adrenal Gland | DDAH1 | 0.26 | 0.21 | lasso | 6 | 0.20 | 8.7e-08 | 4.9 | -5.8 | 8.1e-09 | -0.71 | 0.09 | 0.91 | FALSE |
| 5 | YFS | Blood | BCL10 | 0.24 | 0.12 | enet | 48 | 0.19 | 1.1e-59 | 4.6 | 5.8 | 8.3e-09 | 0.47 | 0.67 | 0.32 | FALSE |
| 3 | GTEx | Lung | C1orf52 | 0.17 | 0.08 | lasso | 6 | 0.04 | 4.9e-04 | 4.8 | 5.1 | 3.1e-07 | 0.44 | 0.58 | 0.35 | FALSE |