Hub : Genes

DDAH1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.2640 0.0725 2.2e-05 0.213 NA 0.186 NA 0.202 3.5e-08 NA 3.1e-07 NA 8.7e-08
2 GTEx Esophagus Mucosa 0.3130 0.0620 4.6e-08 0.144 NA 0.211 NA 0.208 7.5e-10 NA 3.7e-14 NA 6.1e-14
3 GTEx Liver 0.3630 0.0720 2.2e-07 0.421 NA 0.413 NA 0.429 5.1e-13 NA 1.0e-12 NA 2.8e-13
4 GTEx Skin Not Sun Exposed Suprapubic 0.1230 0.0430 1.6e-03 0.047 NA 0.051 NA 0.028 1.4e-03 NA 8.5e-04 NA 1.1e-02
5 ROSMAP Brain Pre-frontal Cortex 0.0297 0.0150 2.2e-02 0.035 0.009 0.010 0.012 0.019 2.3e-05 2.2e-02 1.4e-02 0.0096 1.5e-03
6 TCGA Liver Hepatocellular Carcinoma 0.1420 0.0520 1.0e-04 0.086 0.091 0.070 NA 0.083 7.2e-05 4.7e-05 3.3e-04 NA 9.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.6 4.1 10.6 -1.5 -1.0 2.6 -1.1 -1.8 3.3
Bipolar Disorder or Schizophrenia 0.3 0.6 1.8 1.1 -0.7 0.3 0.2 0.4 1.3
Depressed Affect (Nagel 2018) 0.1 0.3 0.9 0.3 0.6 0.5 0.4 -0.9 0.3
Depression (Nagel 2018) 0.2 0.3 0.9 -0.3 1.0 0.0 0.5 -0.3 -0.7
Intelligence (Savage-Jansen 2018) 0.5 1.6 4.0 -2.0 1.1 1.3 0.3 -1.1 1.1
Neuroticism (Nagel 2018) 0.6 1.4 3.3 1.1 1.8 -0.8 1.6 0.3 -0.8
Schizophrenia (2018) 1.3 2.7 6.8 2.6 -0.0 -1.7 1.1 2.0 -0.9
Schizophrenia vs Biploar Disorder 6.2 8.2 15.6 1.9 0.6 -3.9 1.3 3.5 -4.0
Worry (Nagel 2018) 1.0 2.1 3.7 1.6 1.9 -1.3 1.3 1.3 -1.2
Alzheimer’s Disease (in mother) 2.6 3.0 7.3 2.7 1.5 -1.4 1.6 1.4 -1.4
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.7 -0.7 0.1 -0.4 -0.3 0.1
Alzheimer’s Disease (including proxy) 0.9 1.4 3.8 2.0 1.2 -0.7 1.2 0.6 -0.6
Crohns Disease (2017) 0.2 0.5 1.0 1.0 -0.4 -0.7 -0.6 0.9 0.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.7 0.3 -0.1 -0.4 -0.0 0.8 -0.0
Ulcerative Colitis (UC) 0.2 0.4 0.7 -0.9 0.8 0.1 0.8 0.3 -0.4
Major Depression (MDD) 0.4 0.4 1.8 1.3 -0.3 -0.6 -0.4 -0.2 -0.4
Reaction Time 1.3 2.4 5.2 -0.4 -2.0 1.4 -2.3 -1.0 1.3
Verbal and Numeric Reasoning (VNR) 1.0 2.4 8.7 -3.0 0.8 1.3 -0.1 -1.6 0.8
Breast Cancer 0.1 0.2 0.3 -0.4 -0.5 -0.5 0.4 0.3 -0.6
Ovarian Cancer 0.6 0.8 1.5 0.6 0.5 -1.1 1.2 1.1 -0.3
Prostate Cancer 5.8 8.2 12.3 3.5 1.4 -3.5 2.1 2.6 -3.4
Age at First Birth 0.2 0.2 1.0 -0.1 0.1 -0.3 0.3 -0.5 -1.0
Bipolar Disorder (2011) 4.0 3.9 10.6 -0.9 -0.3 2.5 -0.9 -2.1 3.3
Body Mass Index (BMI) (2010) 0.7 1.0 2.2 0.1 -1.5 0.3 -1.1 0.6 1.4
Coronary Artery Disease (CAD) 0.6 0.7 1.7 -0.7 1.0 -0.4 0.2 0.8 -1.3
Crohns Disease (2012) 0.3 0.4 1.0 0.6 0.3 -1.0 0.2 0.9 -0.5
Mean Putamen Volume 0.5 0.6 1.4 -0.9 0.6 0.3 0.8 -1.2 -0.4
Fasting Glucose 2.4 2.8 5.2 -1.2 -1.9 1.2 -2.3 -0.8 2.2
HbA1C 0.4 0.5 0.8 -0.9 -0.8 -0.3 0.8 -0.1 -0.7
HDL Cholesterol 1.2 2.0 4.1 0.7 0.6 -1.9 1.8 0.4 -2.0
LDL Cholesterol 0.3 0.5 1.7 1.3 0.5 -0.5 -0.1 0.5 0.7
Lupus 1.5 2.3 5.9 -1.7 0.4 1.7 0.1 -2.4 1.3
Neuroticism (2016) 1.4 2.0 5.5 2.4 1.6 -1.1 0.3 1.4 -1.0
Primary Biliary Cirrhosis 1.1 1.6 2.8 -0.8 -0.9 1.7 -0.6 -1.6 1.6
Rheumatoid Arthritis 0.8 1.1 1.9 1.2 -0.6 -1.3 -0.2 1.2 -1.4
Schizophrenia (2014) 1.5 3.3 7.6 2.7 0.4 -1.9 1.3 2.4 -0.9
Triglycerides 0.7 1.2 3.2 1.3 -0.3 0.6 -1.4 0.3 1.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.9 -1.0 0.7 0.6 0.0 -0.3 0.3
Ulcerative Colitis 0.2 0.2 0.4 -0.6 0.1 0.6 0.4 -0.3 0.6
Blood Eosinophil Count 0.1 0.5 1.8 -0.4 0.7 0.0 1.4 0.4 0.3
Blood Platelet Count 0.2 2.9 5.5 2.3 -0.3 -2.0 0.8 1.5 -2.2
Blood Red Count 0.0 0.1 0.2 -0.0 -0.1 0.3 -0.5 0.2 0.2
Blood White Count 0.3 1.9 5.8 -2.0 -2.4 0.6 -1.1 -0.1 -0.3
Heel T-Score 0.3 2.3 7.8 2.2 2.8 -0.7 0.5 0.2 -0.4
BMI 1.3 7.4 17.9 -4.2 -0.5 3.4 -0.7 -2.3 3.0
Height 1.0 18.8 37.0 -4.6 1.2 6.1 -0.7 -5.6 4.6
Waist Hip Ratio (WHR) 0.9 4.1 8.8 0.7 2.5 -1.4 2.6 0.7 -3.0
Systolic Blood Pressure 0.2 0.8 1.9 -0.3 0.7 1.4 -0.3 -0.8 1.1
Smoking Status 1.5 3.7 6.2 -2.0 -1.9 1.6 -2.5 -1.4 2.0
Allergy or Eczema 0.9 2.4 4.1 -0.6 -0.9 1.8 -2.0 -1.9 1.5
Cardiovascular Disease 1.5 5.0 7.3 -2.7 -1.0 2.7 -2.3 -2.3 1.9
Hypothyroidism (self reported) 0.9 2.0 3.1 -1.4 -1.5 1.3 -1.8 -1.3 1.2
Respiratory disease 3.0 6.7 11.2 -3.1 -0.5 3.3 -1.2 -3.3 2.7
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.4 -1.5 0.0 1.3 -0.3 -1.6 0.7
Lung FEV1/FVC ratio 0.5 2.5 6.6 1.1 1.5 -0.7 2.6 0.5 -2.1
Lung FVC 0.6 2.9 12.6 3.5 1.8 -0.9 0.1 -0.0 0.7
Neuroticism 0.1 0.3 0.7 0.9 0.5 -0.6 0.1 0.2 -0.5
Chronotype (morning person) 1.0 2.4 4.0 2.0 0.3 -1.9 1.3 1.7 -1.5
Hair Pigment 0.0 0.5 0.9 1.0 0.2 -0.6 -0.8 0.4 -0.8
Tanning 0.7 8.5 13.6 -3.5 -0.3 3.6 -1.7 -3.0 3.7
Hand grip strength (left) 1.2 3.2 7.8 1.6 2.8 -1.5 1.6 1.6 -1.2
Number of treatments/medications taken 4.4 8.0 13.2 -3.6 -2.9 2.5 -3.3 -1.9 2.3
Average weekly spirits intake 1.9 2.3 4.2 1.1 -1.0 -2.0 0.7 1.9 -1.9
Sensitivity / hurt feelings 0.3 0.5 1.3 -0.9 0.2 0.5 -0.1 -1.1 -0.5
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.6 0.2 1.6 -0.2 1.1 -0.0 -0.9
Hearing difficulty/problems: Yes 0.5 0.7 1.5 0.2 -0.8 -1.0 0.1 0.9 -1.2
Relative age of first facial hair 0.7 1.5 4.1 -0.9 -2.0 0.9 -0.8 -0.8 1.4
Other serious medical condition/disability diagnosed by doctor 2.7 3.5 7.6 -2.8 -1.1 2.0 -1.6 -1.7 1.6
Ever used hormone-replacement therapy (HRT) 1.9 2.5 4.2 0.0 -1.9 -2.1 -0.9 1.8 -1.6
Ever had hysterectomy (womb removed) 2.8 3.1 6.1 1.8 1.3 -2.1 0.8 2.5 -1.7
Systolic blood pressure, automated reading 0.2 0.5 1.9 -0.1 1.4 0.3 1.0 -0.1 -0.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.5 -0.5 0.7 -0.2 0.4 0.3 -0.7
Angina 1.8 2.3 3.4 -1.5 -1.6 1.6 -1.8 -1.3 1.1
Medication for hormone replacement therapy 1.6 1.8 3.9 0.9 -0.0 -2.0 1.5 1.6 -1.2
Vitamin and mineral supplements 0.5 0.6 1.5 0.8 1.2 -0.6 0.3 1.1 -0.3
Supplements: Zinc 2.0 2.2 5.5 0.0 -0.8 -2.0 0.0 2.3 -1.7
Medication: Co-codamol 0.8 1.0 2.8 -0.8 -1.7 0.9 -0.8 -0.4 0.8
Medication: Metformin 0.7 0.9 3.3 -0.1 1.8 -0.3 1.2 -0.5 -0.9
Diabetes (father) 2.9 3.5 7.8 -1.6 -2.8 0.9 -2.7 -0.1 1.7
Diabetes (mother) 6.7 8.6 14.1 -3.0 -1.0 3.8 -3.0 -3.5 2.6
Severe depression (siblings) 1.9 2.2 5.3 -2.3 -0.1 1.9 -0.9 -0.6 1.8
Pack years adult smoking proportion 0.4 0.7 1.3 -1.1 0.6 -0.9 -0.1 0.7 -1.1
Impedance of leg (right) 2.8 13.3 18.8 4.3 4.0 -3.4 3.3 2.8 -3.9
Leg fat-free mass (left) 2.7 14.4 26.3 -5.1 -1.1 4.8 -1.6 -3.9 4.4
Trunk fat percentage 1.4 5.4 14.9 -3.9 0.5 2.8 -0.3 -2.2 2.1
Hand grip strength (right) 0.6 1.7 3.8 -1.2 0.1 1.5 -1.4 -0.8 2.0
Townsend deprivation index at recruitment 0.3 0.4 0.7 0.7 -0.7 -0.5 -0.8 0.6 -0.5
Current tobacco smoking 1.2 1.9 5.0 -0.8 -2.2 0.5 -2.2 -0.3 1.0
Average weekly fortified wine intake 4.1 4.8 6.5 -1.9 -2.2 2.5 -1.6 -2.2 2.5
Maternal smoking around birth 0.7 1.0 5.8 -2.4 0.1 0.4 0.2 0.2 0.1
Fed-up feelings 0.3 0.5 1.8 -0.2 1.3 0.5 0.7 -0.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 2.3 -0.6 1.5 0.3 1.1 -0.3 -1.3
Relative age voice broke 1.7 2.6 4.3 -2.1 -1.8 1.4 -1.6 -1.0 1.6
Taking other prescription medications 6.6 10.2 17.9 -4.2 -2.2 3.4 -3.3 -2.9 2.9
Age when periods started (menarche) 0.3 0.8 2.7 1.6 0.8 0.1 0.7 -0.9 0.6
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.2 0.8 -0.3 -1.3 -0.2 0.9 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 2.5 1.6 1.6 -1.4 0.0 1.4 -1.1
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 6.0 -0.5 -2.4 -0.1 -1.6 0.7 0.6
Qualifications: CSEs or equivalent 1.7 2.2 3.6 1.4 -0.4 -1.9 1.0 1.9 -1.6
Serious illness, injury or assault to yourself 1.4 1.7 4.4 -2.1 -0.8 0.8 -1.6 -1.1 0.9
High blood pressure 0.6 1.7 4.5 -2.1 -0.8 1.2 -1.4 -0.7 1.0
Hayfever, allergic rhinitis or eczema 1.1 2.4 4.7 -0.4 -1.5 1.6 -2.2 -1.5 1.6
Multivitamins +/- minerals 0.9 1.2 2.3 -1.0 -1.5 0.9 -0.4 -1.4 0.7
Stomach or abdominal pain in last month 1.1 1.4 2.5 -0.5 -0.2 1.5 -1.5 -1.1 1.6
Supplements: Glucosamine 0.9 1.2 2.3 -1.5 -1.0 0.7 -1.4 -1.0 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 0.3 -0.8 -0.1 -0.5 -0.3 -0.1
Medication: Atenolol 2.7 3.3 5.6 -2.0 -0.3 2.2 -0.9 -2.4 2.1
Medication: Levothyroxine sodium 0.8 1.3 3.2 -0.7 -1.6 0.5 -1.8 -0.4 1.2
Sitting height 0.8 5.8 9.2 -2.1 3.0 2.9 0.9 -2.4 2.4
Chronic bronchitis/emphysema (father) 0.8 1.0 2.6 -1.2 0.1 1.1 -0.3 -1.6 0.5
High blood pressure (mother) 0.6 0.8 2.3 -0.9 1.5 0.8 -0.5 -0.9 0.2
Body mass index (BMI) 1.9 8.0 22.3 -4.7 -1.1 3.1 -1.3 -2.6 2.5
Impedance of leg (left) 2.2 10.7 14.5 3.8 3.7 -3.0 3.0 2.3 -3.5
Leg predicted mass (left) 2.8 15.0 26.9 -5.2 -1.2 4.8 -1.7 -3.9 4.5
Trunk fat mass 2.0 8.7 22.9 -4.8 0.4 3.6 -0.4 -3.0 2.7
Waist circumference 2.1 7.7 22.2 -4.7 0.1 3.2 -0.1 -3.2 1.8
Number of incorrect matches in round 1.1 1.9 3.0 1.7 0.9 -1.4 1.2 1.7 -1.0
Past tobacco smoking 0.5 0.8 1.7 1.0 1.3 -0.5 0.9 0.6 -1.0
Alcohol usually taken with meals 0.4 0.7 2.2 -0.0 1.4 -0.1 1.5 -0.5 -0.3
Nervous feelings 1.6 2.9 5.0 1.2 1.2 -1.9 1.3 2.2 -2.0
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 3.2 1.5 1.8 -1.0 1.8 1.0 -1.5
Hearing difficulty/problems with background noise 0.4 0.7 1.5 -1.0 0.1 -0.8 0.8 0.5 -1.2
Hair/balding pattern: Pattern 2 2.9 3.7 9.6 3.1 0.4 -2.3 1.7 0.9 -1.8
Had menopause 0.2 0.2 0.3 -0.4 -0.5 0.0 0.5 -0.6 -0.4
Had other major operations 1.1 1.4 3.3 -1.8 -0.0 1.6 -0.2 -1.0 1.3
Forced vital capacity (FVC) 0.5 2.1 5.8 0.7 1.7 1.4 -0.1 -1.1 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.5 1.6 1.0 -1.1 -0.4 1.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.2 -1.1 -0.5 0.6 -0.5 0.1 0.2
Qualifications: None of the above 0.9 1.9 5.5 0.2 -2.4 0.8 -1.9 -1.1 0.6
Financial difficulties in last 2 years 3.2 4.3 9.8 -1.9 -0.6 3.1 -0.7 -2.6 2.1
Mouth/teeth dental problems 0.3 0.5 0.9 0.9 0.9 -0.2 -0.9 0.8 0.1
Heart attack 0.9 1.1 1.9 -1.3 -0.3 1.4 -0.2 -1.3 1.2
Allergy 1.2 2.9 4.9 0.9 0.7 -2.2 1.9 2.0 -1.8
Pain all over the body in last month 0.5 0.6 1.4 -0.5 -0.7 -0.6 0.5 1.2 -0.8
Diabetes (self-reported) 0.6 0.9 2.4 -1.0 -0.3 1.0 -0.6 -1.6 0.5
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 2.8 -1.4 -1.7 1.2 -1.6 -1.4 0.8
Medication: Ramipril 1.7 2.2 10.1 -3.2 -0.6 1.1 -1.1 -0.7 0.1
Medication: Simvastatin 1.4 2.1 3.3 -1.6 -0.0 1.6 -1.2 -1.8 1.7
Fluid intelligence score 1.1 2.3 6.0 -2.4 -0.4 1.3 -0.9 -1.5 1.6
Illnesses of siblings 0.6 0.8 1.7 0.5 0.1 -1.1 0.6 1.3 -1.1
Neuroticism score 0.2 0.4 1.4 0.3 1.2 -0.1 0.6 -0.2 -0.4
Weight 2.9 14.5 33.2 -5.8 -0.2 4.7 -1.0 -4.2 3.6
Impedance of arm (right) 1.0 4.5 10.0 3.2 1.7 -2.2 1.3 2.1 -1.9
Arm fat percentage (right) 1.1 4.2 13.7 -3.7 -0.0 2.2 -0.5 -1.9 1.8
Trunk fat-free mass 2.2 12.6 23.3 -4.8 -0.3 4.5 -0.8 -4.1 3.8
Hip circumference 3.1 13.3 26.6 -5.2 -0.5 4.5 -1.5 -4.1 3.7
Time employed in main current job 0.3 0.3 0.8 -0.6 0.9 0.1 0.7 -0.5 -0.4
Alcohol intake versus 10 years previously 0.9 1.3 3.4 -1.8 -0.7 1.0 -1.2 -1.1 0.7
Father’s age at death 0.1 0.1 0.3 0.3 -0.1 0.3 0.6 0.2 0.4
Worrier / anxious feelings 0.6 1.1 2.5 0.5 1.5 -1.1 0.6 0.5 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.7 0.1 -0.8 -0.0 0.5 -0.6
Falls in the last year 0.3 0.4 1.9 -1.4 -0.0 0.0 -0.1 0.5 0.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 -0.1 -0.0 0.4 -0.6 0.4 0.5
Number of live births 0.2 0.3 1.1 0.2 -1.1 -0.4 -0.5 -0.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 4.4 1.3 2.1 0.6 0.8 -0.5 1.1
Pulse rate 0.4 0.7 2.7 -0.1 0.3 0.7 -0.9 -0.3 1.6
Happiness 0.6 0.7 1.9 -0.5 -0.0 1.4 -0.4 -1.0 1.0
Noisy workplace 0.6 0.8 3.3 -0.2 -1.8 -0.0 -1.0 0.3 -0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.1 0.7 1.1 0.2 0.4 -0.6 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.6 -1.3 -0.3 1.8 -0.4 -1.9 1.3
Mouth/teeth dental problems: Dentures 1.2 2.0 3.9 -2.0 -1.1 1.4 -0.7 -1.6 1.4
Asthma 1.2 2.4 4.2 -2.0 -0.1 2.1 -0.7 -1.9 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.8 5.8 -0.6 -1.9 0.9 -2.4 -0.5 0.5
Medication: Cholesterol lowering 1.6 2.4 4.8 -1.8 -0.5 1.9 -1.0 -2.2 1.5
Depression (self-reported) 0.2 0.3 0.6 0.3 0.4 0.5 -0.8 -0.5 0.5
Medication: Lansoprazole 0.3 0.4 1.1 -0.7 0.2 0.7 -0.3 -1.1 0.1
Prospective memory result 0.3 0.4 1.3 -0.6 0.4 -0.0 0.2 -0.5 -1.1
Lung cancer (father) 1.1 1.3 2.7 -0.9 1.4 1.5 0.5 -1.6 0.3
Illnesses of mother 1.9 2.3 3.5 1.5 0.8 -1.6 1.9 1.7 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 6.2 1.6 2.5 0.6 1.4 -0.8 0.6
Pulse wave Arterial Stiffness index 0.6 0.7 1.9 -0.2 -1.4 -0.5 -0.8 1.0 -0.5
Impedance of arm (left) 0.7 3.1 7.2 2.7 1.2 -1.9 0.8 1.8 -1.6
Arm fat mass (right) 2.1 8.6 21.9 -4.7 -0.5 3.5 -1.0 -2.9 2.9
Trunk predicted mass 2.2 12.7 23.7 -4.9 -0.3 4.5 -0.9 -4.1 3.8
Standing height 1.0 9.8 18.7 -3.3 1.8 4.3 0.3 -4.1 3.0
Length of working week for main job 0.6 0.7 3.2 0.2 1.8 0.7 0.5 -0.1 0.5
Exposure to tobacco smoke at home 0.5 0.6 1.6 1.3 -0.7 -0.7 0.2 0.5 -0.7
Breastfed as a baby 0.3 0.4 1.2 -1.1 0.4 0.3 0.8 -0.7 -0.1
Tense / ‘highly strung’ 0.9 1.5 4.1 0.6 2.0 -0.7 1.6 0.6 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.8 0.7 1.3 -0.7 0.4 1.0 -0.8
Hair/balding pattern: Pattern 4 1.6 3.8 7.5 -2.7 -0.6 2.2 -1.1 -1.8 2.3
Birth weight of first child 0.8 1.4 5.3 -2.3 -1.4 0.5 -0.4 -0.6 0.3
Peak expiratory flow (PEF) 0.3 0.7 2.0 0.8 1.4 -0.2 1.1 0.4 -0.2
Pulse wave reflection index 1.7 2.1 4.2 0.4 -1.7 -1.6 -0.0 2.0 -1.6
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.3 -1.1 -0.7 -0.1 -0.1 0.3 -0.9
Loud music exposure frequency 0.3 0.4 1.3 -1.1 0.2 0.3 -0.5 0.4 0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.6 0.6 0.1 0.8 -0.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 0.4 -1.4 0.8 -0.6 -0.8 0.9
Blood clot in the leg (DVT) 1.1 1.4 2.3 0.8 1.2 -1.1 1.5 1.1 -1.2
Medication: Paracetamol 3.1 5.2 7.6 -2.4 -2.2 2.1 -2.5 -1.4 2.8
Headache pain in last month 0.5 0.9 4.0 -0.3 -2.0 -0.0 -0.8 0.7 0.5
Medication for cholesterol, blood pressure or diabetes 3.0 5.0 7.6 2.6 1.1 -2.6 1.8 2.1 -2.8
Glaucoma (self-reported) 3.3 3.8 7.6 2.7 1.1 -2.2 1.1 2.8 -0.9
Gout (self-reported) 0.5 0.7 2.1 -1.4 0.5 0.7 0.2 -0.5 0.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.1 -0.9 -1.2 0.7 -1.8 -0.6 0.9
Medication: Amlodipine 3.0 4.2 7.6 -2.4 -0.8 2.8 -1.1 -2.3 2.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.4 0.1 -1.2 0.1 -0.8 -0.2 0.6
Birth weight 1.4 3.0 6.6 0.8 1.2 -1.7 2.6 0.9 -2.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.8 -0.1 -0.2 -0.2 -1.3 -0.0 0.0
High blood pressure (siblings) 0.4 0.6 1.5 -0.4 1.0 0.8 0.3 -1.2 0.6
Forced vital capacity (FVC), Best measure 0.6 2.1 4.2 1.1 2.0 1.4 0.3 -1.4 1.8
Body fat percentage 1.1 4.2 13.0 -3.6 0.8 2.4 0.0 -1.9 1.4
Leg fat percentage (right) 0.5 1.8 5.5 -2.4 1.5 1.0 0.8 -1.1 0.1
Arm fat-free mass (right) 2.5 12.7 23.8 -4.9 -0.3 4.6 -1.1 -4.0 3.8
Exposure to tobacco smoke outside home 0.6 0.8 2.7 1.0 0.3 -1.0 0.2 1.7 -0.3
Comparative body size at age 10 0.3 0.7 2.3 -0.2 -0.4 0.9 -0.5 -0.8 1.5
Number of full brothers 2.6 3.3 5.1 -1.9 -1.7 2.2 -1.5 -1.9 1.6
Worry too long after embarrassment 3.8 6.4 9.4 2.7 3.1 -2.3 2.6 1.7 -2.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.7 1.1 1.3 0.5 0.6 0.5 0.9
Wheeze or whistling in the chest in last year 0.4 0.7 2.2 -1.5 -0.2 0.7 0.8 -0.3 0.8
Number of children fathered 0.5 0.6 2.3 0.5 0.6 0.7 0.3 -1.5 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 -0.2 0.7 -0.4 0.8 -0.3 -0.8
Age at first live birth 0.2 0.3 1.6 1.3 -0.1 -0.0 -0.0 -0.3 0.2
Pulse wave peak to peak time 0.8 1.0 2.2 -0.1 1.5 0.8 0.8 -1.4 0.7
Health satisfaction 3.8 5.0 7.0 -2.6 -2.3 2.3 -1.7 -2.4 1.9
Shortness of breath walking on level ground 1.5 1.7 3.5 -1.9 -0.9 1.4 -0.9 -1.0 1.5
Qualifications: College or University degree 0.3 0.9 2.5 -0.0 1.6 0.7 0.2 -1.2 1.1
Eye problems/disorders: None of the above 0.6 0.7 2.3 -1.5 -0.2 1.0 0.3 -0.8 0.6
Mouth/teeth dental problems: Loose teeth 2.0 2.4 5.0 -2.0 -2.2 0.9 -1.4 -1.1 1.2
Emphysema/chronic bronchitis 3.0 3.4 4.9 -2.2 -1.4 2.1 -1.9 -1.7 1.6
Medication for pain relief, constipation, heartburn 2.5 4.3 8.7 1.6 2.7 -1.5 3.0 0.8 -2.1
Neck or shoulder pain in last month 1.8 2.5 7.0 -1.9 -2.7 1.2 -1.5 -0.5 0.9
Medication: Blood pressure 4.0 7.1 10.2 -3.2 -2.1 2.6 -2.8 -1.9 3.1
Angina (self-reported) 1.6 2.1 2.7 -1.5 -1.5 1.6 -1.6 -1.3 1.3
Migraine (self-reported) 0.7 0.9 1.8 0.9 -0.1 -1.3 0.3 1.3 -0.9
Medication: Ibuprofen 1.2 1.4 4.4 -0.3 -1.8 0.7 -2.1 -0.4 0.3
Medication: Allopurinol 0.0 0.1 0.2 -0.1 0.4 -0.3 -0.1 0.4 0.1
Medication: Omeprazole 0.2 0.3 0.7 0.6 -0.8 -0.3 -0.8 0.0 -0.3
Medication: Seretide 50 evohaler 0.3 0.3 1.0 -0.6 -0.7 -0.4 -1.0 -0.0 0.3
Mean time to correctly identify matches 2.6 5.0 10.2 -0.7 -3.2 2.0 -3.1 -1.5 2.0
Heart disease (mother) 5.1 6.2 9.6 -2.7 -1.9 2.6 -3.1 -1.7 2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 5.7 0.7 1.1 -1.6 2.4 1.2 -1.3
Whole body fat mass 1.7 6.9 19.2 -4.4 0.6 3.1 -0.2 -2.6 2.3
Leg fat mass (right) 1.2 4.7 12.9 -3.6 1.0 2.5 0.4 -2.2 1.7
Arm predicted mass (right) 2.2 11.0 21.1 -4.6 -0.2 4.2 -0.8 -3.7 3.5
Pulse rate, automated reading 0.2 0.5 1.6 -0.6 1.3 0.7 0.7 -0.3 0.4
Alcohol intake frequency. 0.1 0.3 0.6 -0.6 -0.4 0.4 -0.8 0.3 0.4
Comparative height size at age 10 1.1 5.9 10.0 -3.2 2.2 3.1 0.6 -2.8 1.6
Number of full sisters 1.6 1.9 3.5 0.8 0.8 -1.8 0.8 1.7 -1.9
Suffer from ‘nerves’ 2.7 4.3 6.5 1.2 2.5 -1.8 2.2 1.8 -2.5
Overall health rating 0.8 1.6 3.3 -1.8 -1.7 0.7 -1.6 -0.3 0.6
Chest pain or discomfort 3.0 4.3 9.2 -3.0 -0.4 2.5 0.4 -2.2 2.2
Had major operations 0.2 0.2 0.3 -0.5 -0.4 -0.6 -0.4 0.5 -0.4
Age at last live birth 0.4 0.6 1.6 0.9 -0.7 0.5 -0.2 -0.8 1.3
Family relationship satisfaction 0.5 0.7 1.5 -0.8 0.4 1.2 -0.3 -1.2 -0.3
Leg pain on walking 0.9 1.1 4.9 -2.2 -1.0 0.6 -0.1 -0.8 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 -0.4 -0.8 0.5 -1.2 0.0 1.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.1 -0.8 1.2 0.4 1.8 -0.2 -0.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 2.8 1.7 0.9 -1.6 1.1 1.5 -1.3
Medication: Aspirin 0.9 1.2 2.2 -0.7 -1.0 1.1 -1.3 -1.0 1.5
Supplements: Vitamin C 0.5 0.5 1.7 0.1 -1.3 0.6 0.1 -0.4 1.0
Knee pain experienced in last month 3.7 5.7 9.7 -2.3 -2.1 2.2 -3.1 -2.3 2.2
Hypertension (Self-reported) 0.8 2.1 5.5 -2.3 -1.0 1.4 -1.7 -0.8 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 3.9 -2.0 -0.5 1.6 -0.9 -1.4 1.2
Illnesses of father: Heart disease 3.7 5.2 8.9 -2.3 -2.6 1.9 -3.0 -1.7 1.9
Illnesses of siblings: Diabetes 2.1 2.6 7.3 0.6 -2.0 1.2 -2.7 -0.6 1.5
Smoking status: Previous 0.1 0.2 0.4 -0.4 -0.4 0.5 -0.3 -0.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.2 -2.0 1.2 1.2 -0.3 -1.1 0.7
Whole body fat-free mass 2.7 15.2 28.3 -5.3 -0.7 4.9 -1.3 -4.2 4.3
Leg fat-free mass (right) 3.3 17.4 30.1 -5.5 -1.3 5.2 -2.0 -4.3 4.8
Arm fat percentage (left) 1.3 5.3 15.3 -3.9 -0.3 2.5 -0.8 -2.1 2.2
Average weekly red wine intake 0.2 0.4 1.4 -0.6 0.1 0.5 -0.1 -0.3 1.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 0.2 0.3 -0.1 0.4 0.6 -0.4
Mood swings 0.1 0.3 0.7 0.1 0.2 0.4 -0.5 -0.6 0.9
Loneliness, isolation 0.4 0.6 1.3 -0.5 0.4 -0.7 0.7 0.8 -1.1
Long-standing illness, disability or infirmity 4.3 6.5 17.2 -4.2 -1.7 2.4 -2.4 -2.1 1.8
Ever had bowel cancer screening 0.4 0.5 1.7 -0.0 -1.3 -0.5 0.1 -0.5 -0.9
Diabetes diagnosed by doctor 0.5 0.7 1.6 -1.1 -0.5 0.9 -0.8 -1.3 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.9 -0.7 0.1 1.0 0.2 -1.4 1.0
Friendships satisfaction 0.1 0.2 0.4 0.2 -0.7 -0.1 -0.4 -0.5 -0.4
Qualifications: nursing, teaching 1.1 1.7 3.9 -0.8 1.0 -1.1 2.0 1.3 -1.4
Commuting to job workplace: Walk 1.2 1.3 4.4 0.6 -2.1 -0.8 -1.4 0.7 0.4
Eye problems/disorders: Cataract 1.0 1.1 2.5 0.4 -1.4 0.3 -1.6 -0.5 1.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.7 0.3 1.2 -0.3 1.6 0.0 -0.8
Medication for cholesterol 0.3 0.5 1.4 -0.1 0.2 1.0 -0.2 -0.7 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.0 -0.7 0.4 -1.0 0.4 0.7 -1.0
Back pain experienced in last month 1.3 2.0 2.3 -1.3 -1.5 1.5 -1.3 -1.3 1.4
Mineral and other dietary supplements 1.1 1.5 4.0 1.4 2.0 -0.5 1.4 0.4 -0.6
Breast cancer (self-reported) 0.9 1.0 2.5 -0.3 0.2 1.6 -1.3 -1.0 0.9
Asthma (self-reported) 1.1 2.1 3.9 -1.9 0.1 2.0 -0.4 -1.9 1.3
Osteoporosis (self-reported) 0.4 0.4 1.2 -0.6 -1.0 0.3 -1.1 -0.3 -0.0
Osteoarthritis (self-reported) 2.0 2.7 6.2 -1.9 -0.4 2.5 -1.0 -1.8 1.4
Medication: Aspirin 0.9 1.2 1.8 -0.9 -1.1 0.9 -1.3 -0.9 1.3
Medication: Gliclazide 0.4 0.5 1.4 -1.2 0.5 0.4 0.2 -0.9 -0.6
Illnesses of father: None of the above (group 1) 5.1 6.3 8.9 3.0 1.5 -2.7 3.0 2.7 -1.8
Smoking status: Current 1.3 2.0 5.1 -0.9 -2.1 0.7 -2.3 -0.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 5.8 1.7 2.4 0.1 1.2 -0.2 0.0
Whole body water mass 2.6 15.1 28.5 -5.3 -0.8 4.8 -1.3 -4.2 4.3
Leg predicted mass (right) 3.2 17.2 29.7 -5.5 -1.3 5.2 -2.0 -4.3 4.8
Arm fat mass (left) 2.2 8.9 23.3 -4.8 -0.3 3.5 -0.9 -2.9 2.9
Number of self-reported non-cancer illnesses 4.0 6.9 10.9 -3.3 -2.3 2.9 -2.9 -2.3 1.7
Average weekly champagne plus white wine intake 0.5 0.7 1.3 -0.3 0.2 1.1 0.9 -1.1 1.1
Miserableness 1.2 2.0 4.7 -1.5 0.7 1.8 -0.3 -2.2 1.3
Guilty feelings 3.8 5.7 11.1 1.8 3.2 -1.7 3.3 1.1 -2.3
Wears glasses or contact lenses 0.5 0.6 1.3 -1.1 -0.8 0.4 -0.6 -0.8 0.8
Ever taken oral contraceptive pill 0.3 0.4 0.8 -0.4 0.8 0.4 0.9 -0.2 -0.6
Hearing aid user 0.6 0.6 1.8 -0.1 -1.0 -1.0 0.1 0.3 -1.4
Mother’s age at death 0.7 0.8 2.5 0.0 0.6 1.0 0.2 -1.6 1.1
Financial situation satisfaction 3.4 4.3 8.0 -1.0 -2.8 2.2 -1.9 -2.3 1.8
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.6 -1.6 -0.6 0.4 -0.5 0.0 -0.5
Commuting to job workplace: Public transport 2.1 2.5 4.1 -0.8 -2.0 1.7 -1.5 -1.6 1.7
Eye problems/disorders: Glaucoma 3.7 4.4 8.7 3.0 1.0 -2.5 1.2 2.8 -1.1
Medication: Blood pressure 0.2 0.3 0.9 -1.0 -0.5 0.2 -0.6 -0.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.7 -0.1 -0.5 0.8 -0.5 -0.9 0.5
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.7 -0.2 -0.8 -0.1 0.1 0.5 0.1
High cholesterol (Self-reported) 0.1 0.3 0.9 -0.1 0.7 0.2 -0.0 -0.9 -0.4
Medication: Bendroflumethiazide 1.9 2.8 5.1 -1.4 -1.2 2.0 -1.6 -1.5 2.3
Medication: Paracetamol 3.2 5.0 7.6 -1.9 -2.8 2.0 -2.2 -1.5 2.7
Medication: Lisinopril 4.7 6.1 12.0 -1.4 -1.7 2.7 -2.7 -2.3 3.5
Medication: Atorvastatin 1.2 1.4 1.8 1.2 1.4 -1.1 1.3 1.0 -1.2
Illnesses of father: High blood pressure 0.4 0.5 1.7 0.5 0.6 -0.5 -0.3 1.3 -0.6
Alcohol drinker status: Never 0.4 0.5 1.5 -0.5 -0.3 0.0 -1.2 0.7 0.8
Ever smoked 1.2 2.1 6.8 -1.5 -2.6 0.3 -1.4 -0.1 1.2
Basal metabolic rate 2.8 15.4 29.7 -5.5 -0.6 5.0 -1.3 -4.2 4.3
Leg fat percentage (left) 0.6 2.2 7.2 -2.7 1.2 1.4 0.4 -1.5 0.4
Arm fat-free mass (left) 2.4 12.3 25.8 -5.1 0.2 4.5 -0.6 -4.0 3.5
Number of operations (self-reported) 0.2 0.3 0.9 -1.0 -0.5 0.6 -0.1 -0.5 -0.1
Average weekly beer plus cider intake 0.2 0.3 0.6 0.2 0.7 0.8 -0.4 -0.8 0.2
Irritability 0.3 0.6 1.0 -0.8 -0.8 0.7 -0.1 -0.8 1.0
Risk taking 0.8 1.2 2.2 -1.2 -0.3 1.2 -1.0 -1.5 1.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.7 0.1 -1.3 -0.1 -0.1 0.2 -0.6
Fractured/broken bones in last 5 years 0.3 0.4 1.3 -0.4 1.1 0.5 -0.0 -0.7 0.0
Age started oral contraceptive pill 0.6 0.8 1.7 0.9 -0.3 -1.3 -0.2 1.2 -1.0
Diastolic blood pressure, automated reading 0.1 0.2 1.1 -1.0 -0.2 0.2 0.4 0.2 0.0
Ever depressed for a whole week 0.2 0.3 0.9 0.9 0.7 -0.2 0.5 0.3 0.1
Unable to work because of sickness or disability 0.6 0.8 1.7 -1.2 -0.9 0.8 -0.7 -1.3 -0.2
Commuting to job workplace: Cycle 0.7 0.8 2.7 1.6 0.3 -0.9 0.3 0.7 -0.9
Myopia 0.5 0.7 2.4 -0.5 -1.6 0.5 -0.8 -0.5 0.5
Vascular/heart problems diagnosed by doctor 1.2 3.3 7.0 2.6 0.7 -2.1 1.6 1.6 -1.7
Cholesterol lowering medication 0.1 0.1 0.3 -0.3 0.3 0.2 -0.5 -0.4 0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.5 0.3 0.0 -0.4 0.1 -0.2 -0.7
Pain experienced in last month 1.6 2.6 7.9 1.7 2.8 -0.7 1.7 0.2 -1.2
Supplements: Calcium 6.2 6.8 12.0 -2.6 -1.1 3.4 -2.3 -3.5 2.1
Basal cell carcinoma (self-reported) 1.1 1.3 3.6 -1.0 0.0 1.5 0.2 -0.8 1.9
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.5 -1.4 -0.2 1.6 -0.1 -1.5 1.3
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 3.0 1.2 1.6 -1.2 1.7 1.0 -1.3
Heart disease (siblings) 1.7 2.0 6.9 -1.5 -2.6 0.7 -1.1 -0.6 1.0
Alcohol drinker status: Previous 0.3 0.3 0.9 0.6 0.0 -0.7 0.3 0.9 -0.5
Pack years of smoking 0.4 0.6 1.4 -1.2 0.4 -0.7 -0.3 0.5 -1.0
Impedance of whole body 1.5 7.8 13.7 3.7 2.6 -2.8 2.1 2.4 -2.9
Leg fat mass (left) 1.4 5.7 14.7 -3.8 0.9 2.8 0.1 -2.6 1.9
Arm predicted mass (left) 2.5 12.9 25.5 -5.0 0.0 4.6 -0.8 -4.1 3.7