Best TWAS P=6.53e-12 · Best GWAS P=2.24e-62 conditioned to 2.9e-53
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM18 | 0.32 | 0.21 | lasso | 9 | 0.25 | 4.7e-20 | 4.6 | 6.2 | 7.6e-10 | -0.23 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC092159.2 | 0.29 | 0.14 | lasso | 14 | 0.19 | 4.2e-15 | 4.3 | 6.1 | 8.2e-10 | -0.17 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | AC092159.2 | 0.29 | 0.11 | enet | 41 | 0.14 | 1.5e-07 | 4.9 | 6.4 | 1.8e-10 | -0.12 | 0.92 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | TMEM18 | 0.32 | 0.16 | lasso | 5 | 0.15 | 1.4e-08 | 4.6 | 5.5 | 4.2e-08 | -0.19 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | AC092159.2 | 0.29 | 0.19 | enet | 9 | 0.23 | 9.7e-13 | 4.7 | 5.9 | 3.2e-09 | -0.19 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Tibial | TMEM18 | 0.35 | 0.08 | enet | 28 | 0.19 | 9.2e-15 | 4.7 | 6.8 | 7.6e-12 | -0.19 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | AC092159.2 | 0.38 | 0.24 | lasso | 5 | 0.30 | 5.6e-24 | 6.0 | 6.8 | 7.4e-12 | -0.19 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Mucosa | AC092159.2 | 0.27 | 0.18 | enet | 5 | 0.20 | 2.5e-13 | 4.9 | 5.4 | 5.4e-08 | -0.20 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Muscularis | TMEM18 | 0.37 | 0.20 | lasso | 8 | 0.18 | 2.0e-11 | 6.0 | 6.9 | 6.5e-12 | -0.28 | 1.00 | 0.00 | TRUE |
| 10 | GTEx | Esophagus Muscularis | AC092159.2 | 0.26 | 0.16 | enet | 7 | 0.20 | 5.3e-12 | 6.0 | 6.8 | 9.1e-12 | -0.30 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Heart Atrial Appendage | TMEM18 | 0.26 | 0.16 | lasso | 7 | 0.09 | 5.0e-05 | 4.6 | 5.2 | 2.2e-07 | -0.24 | 0.84 | 0.06 | FALSE |
| 12 | GTEx | Heart Left Ventricle | TMEM18 | 0.22 | 0.19 | lasso | 7 | 0.16 | 8.3e-09 | 4.9 | 6.7 | 2.6e-11 | -0.19 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Heart Left Ventricle | AC092159.2 | 0.35 | 0.24 | lasso | 6 | 0.23 | 2.3e-12 | 4.9 | 6.0 | 1.7e-09 | -0.20 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Lung | AC092159.2 | 0.22 | 0.17 | lasso | 3 | 0.18 | 1.1e-13 | 4.9 | 5.3 | 1.2e-07 | -0.13 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Muscle Skeletal | TMEM18 | 0.40 | 0.30 | lasso | 7 | 0.33 | 2.0e-33 | 6.0 | 6.0 | 2.6e-09 | -0.17 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Muscle Skeletal | AC092159.2 | 0.46 | 0.34 | enet | 18 | 0.39 | 1.1e-40 | 6.0 | 5.9 | 3.1e-09 | -0.17 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Nerve Tibial | AC092159.2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 1.5e-07 | 6.0 | 6.0 | 1.6e-09 | -0.16 | 0.99 | 0.00 | FALSE |
| 18 | GTEx | Skin Sun Exposed Lower leg | AC092159.2 | 0.18 | 0.10 | enet | 15 | 0.13 | 1.4e-10 | 6.0 | 5.2 | 2.2e-07 | -0.08 | 0.99 | 0.00 | FALSE |
| 19 | METSIM | Adipose | TMEM18 | 0.20 | 0.12 | lasso | 6 | 0.12 | 9.2e-17 | 4.9 | 5.5 | 3.9e-08 | -0.19 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMEM18 | 0.11 | 0.01 | blup | 74 | 0.04 | 1.3e-03 | 4.6 | 5.8 | 6.6e-09 | -0.23 | 0.11 | 0.04 | FALSE |