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chr2:15,703-1,384,725

Best TWAS P=6.53e-12 · Best GWAS P=2.24e-62 conditioned to 2.9e-53

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Esophagus Muscularis	TMEM18	0.37	0.20	lasso	8	0.18	2.0e-11	6.0	6.9	6.5e-12	-0.28	1.00	0.00	TRUE
7	GTEx	Artery Tibial	AC092159.2	0.38	0.24	lasso	5	0.30	5.6e-24	6.0	6.8	7.4e-12	-0.19	1.00	0.00	FALSE
6	GTEx	Artery Tibial	TMEM18	0.35	0.08	enet	28	0.19	9.2e-15	4.7	6.8	7.6e-12	-0.19	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	AC092159.2	0.26	0.16	enet	7	0.20	5.3e-12	6.0	6.8	9.1e-12	-0.30	1.00	0.00	FALSE
12	GTEx	Heart Left Ventricle	TMEM18	0.22	0.19	lasso	7	0.16	8.3e-09	4.9	6.7	2.6e-11	-0.19	0.99	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	AC092159.2	0.29	0.11	enet	41	0.14	1.5e-07	4.9	6.4	1.8e-10	-0.12	0.92	0.00	FALSE
1	GTEx	Adipose Subcutaneous	TMEM18	0.32	0.21	lasso	9	0.25	4.7e-20	4.6	6.2	7.6e-10	-0.23	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	AC092159.2	0.29	0.14	lasso	14	0.19	4.2e-15	4.3	6.1	8.2e-10	-0.17	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	AC092159.2	0.18	0.09	lasso	5	0.10	1.5e-07	6.0	6.0	1.6e-09	-0.16	0.99	0.00	FALSE
13	GTEx	Heart Left Ventricle	AC092159.2	0.35	0.24	lasso	6	0.23	2.3e-12	4.9	6.0	1.7e-09	-0.20	1.00	0.00	FALSE
15	GTEx	Muscle Skeletal	TMEM18	0.40	0.30	lasso	7	0.33	2.0e-33	6.0	6.0	2.6e-09	-0.17	1.00	0.00	FALSE
16	GTEx	Muscle Skeletal	AC092159.2	0.46	0.34	enet	18	0.39	1.1e-40	6.0	5.9	3.1e-09	-0.17	1.00	0.00	FALSE
5	GTEx	Artery Aorta	AC092159.2	0.29	0.19	enet	9	0.23	9.7e-13	4.7	5.9	3.2e-09	-0.19	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM18	0.11	0.01	blup	74	0.04	1.3e-03	4.6	5.8	6.6e-09	-0.23	0.11	0.04	FALSE
19	METSIM	Adipose	TMEM18	0.20	0.12	lasso	6	0.12	9.2e-17	4.9	5.5	3.9e-08	-0.19	1.00	0.00	FALSE
4	GTEx	Artery Aorta	TMEM18	0.32	0.16	lasso	5	0.15	1.4e-08	4.6	5.5	4.2e-08	-0.19	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	AC092159.2	0.27	0.18	enet	5	0.20	2.5e-13	4.9	5.4	5.4e-08	-0.20	1.00	0.00	FALSE
14	GTEx	Lung	AC092159.2	0.22	0.17	lasso	3	0.18	1.1e-13	4.9	5.3	1.2e-07	-0.13	1.00	0.00	FALSE
11	GTEx	Heart Atrial Appendage	TMEM18	0.26	0.16	lasso	7	0.09	5.0e-05	4.6	5.2	2.2e-07	-0.24	0.84	0.06	FALSE
18	GTEx	Skin Sun Exposed Lower leg	AC092159.2	0.18	0.10	enet	15	0.13	1.4e-10	6.0	5.2	2.2e-07	-0.08	0.99	0.00	FALSE