[Hub]/) : Traits : Weight :

chr2:24,348,096-26,068,509

Best TWAS P=5.48e-18 · Best GWAS P=2.89e-16 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 6.6 -8.6 5.5e-18 -0.51 0.96 0.04 TRUE
2 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 5.9 5.4 7.1e-08 0.27 0.82 0.02 TRUE
3 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 5.8 6.4 1.3e-10 0.34 1.00 0.00 FALSE
4 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 5.8 5.6 2.7e-08 0.32 0.91 0.02 TRUE
5 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 5.9 -5.7 1.0e-08 -0.28 0.36 0.04 FALSE
6 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 5.8 -7.0 3.0e-12 -0.35 0.95 0.02 FALSE
7 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 5.8 -7.3 2.2e-13 -0.34 0.74 0.02 FALSE
8 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 5.8 5.8 8.5e-09 0.25 1.00 0.00 FALSE
9 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 5.9 6.9 7.1e-12 0.37 1.00 0.00 FALSE
10 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 5.8 7.5 7.7e-14 0.45 1.00 0.00 TRUE
11 ROSMAP Brain Pre-frontal Cortex EFR3B 0.07 0.03 bslmm 348 0.03 3.5e-05 7.1 -5.2 2.0e-07 -0.63 0.01 0.96 TRUE
12 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 5.9 -6.3 3.1e-10 -0.28 1.00 0.00 TRUE
13 The Cancer Genome Atlas Breast Invasive Carcinoma POMC 0.08 0.05 lasso 3 0.06 2.6e-12 -3.2 -5.4 5.6e-08 -0.46 0.97 0.03 FALSE
14 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POMC 0.06 0.00 enet 12 0.03 9.3e-05 -3.2 -5.1 3.0e-07 -0.58 0.01 0.41 TRUE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFR3B 0.03 0.05 lasso 1 0.04 1.9e-05 -5.5 -5.5 3.7e-08 -0.57 0.44 0.25 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 2.7 -5.3 1.2e-07 -0.17 0.04 0.93 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma POMC 0.14 0.04 enet 7 0.08 5.3e-10 -3.2 -6.7 1.5e-11 -0.58 0.38 0.62 FALSE
18 The Cancer Genome Atlas Pancreatic Adenocarcinoma POMC 0.22 0.05 blup 37 0.03 2.1e-02 -4.5 -7.3 3.7e-13 -0.48 0.01 0.29 TRUE
19 The Cancer Genome Atlas Prostate Adenocarcinoma ADCY3 0.09 0.02 enet 11 0.04 3.2e-05 -1.4 5.3 1.2e-07 0.20 0.12 0.03 TRUE
20 The Cancer Genome Atlas Prostate Adenocarcinoma POMC 0.11 0.08 enet 7 0.09 1.6e-09 -3.2 -6.0 1.8e-09 -0.47 0.92 0.06 FALSE