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chr2:24,348,096-26,068,509

Best TWAS P=5.48e-18 · Best GWAS P=2.89e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	6.6	-8.6	5.5e-18	-0.51	0.96	0.04	TRUE
10	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	5.8	7.5	7.7e-14	0.45	1.00	0.00	TRUE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-4.5	-7.3	3.7e-13	-0.48	0.01	0.29	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	5.9	-6.3	3.1e-10	-0.28	1.00	0.00	TRUE
4	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	5.8	5.6	2.7e-08	0.32	0.91	0.02	TRUE
2	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	5.9	5.4	7.1e-08	0.27	0.82	0.02	TRUE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADCY3	0.09	0.02	enet	11	0.04	3.2e-05	-1.4	5.3	1.2e-07	0.20	0.12	0.03	TRUE
11	ROSMAP	Brain Pre-frontal Cortex	EFR3B	0.07	0.03	bslmm	348	0.03	3.5e-05	7.1	-5.2	2.0e-07	-0.63	0.01	0.96	TRUE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-3.2	-5.1	3.0e-07	-0.58	0.01	0.41	TRUE
7	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	5.8	-7.3	2.2e-13	-0.34	0.74	0.02	FALSE
6	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	5.8	-7.0	3.0e-12	-0.35	0.95	0.02	FALSE
9	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	5.9	6.9	7.1e-12	0.37	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-3.2	-6.7	1.5e-11	-0.58	0.38	0.62	FALSE
3	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	5.8	6.4	1.3e-10	0.34	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-3.2	-6.0	1.8e-09	-0.47	0.92	0.06	FALSE
8	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	5.8	5.8	8.5e-09	0.25	1.00	0.00	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	5.9	-5.7	1.0e-08	-0.28	0.36	0.04	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-5.5	-5.5	3.7e-08	-0.57	0.44	0.25	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-3.2	-5.4	5.6e-08	-0.46	0.97	0.03	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	2.7	-5.3	1.2e-07	-0.17	0.04	0.93	FALSE