Best TWAS P=5.48e-18 · Best GWAS P=2.89e-16 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | 6.6 | -8.6 | 5.5e-18 | -0.51 | 0.96 | 0.04 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | ADCY3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 3.2e-02 | 5.9 | 5.4 | 7.1e-08 | 0.27 | 0.82 | 0.02 | TRUE |
| 3 | GTEx | Artery Tibial | ADCY3 | 0.21 | 0.14 | lasso | 6 | 0.15 | 4.3e-12 | 5.8 | 6.4 | 1.3e-10 | 0.34 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-443B20.1 | 0.17 | 0.08 | enet | 40 | 0.09 | 8.2e-08 | 5.8 | 5.6 | 2.7e-08 | 0.32 | 0.91 | 0.02 | TRUE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | 5.9 | -5.7 | 1.0e-08 | -0.28 | 0.36 | 0.04 | FALSE |
| 6 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | 5.8 | -7.0 | 3.0e-12 | -0.35 | 0.95 | 0.02 | FALSE |
| 7 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | 5.8 | -7.3 | 2.2e-13 | -0.34 | 0.74 | 0.02 | FALSE |
| 8 | GTEx | Whole Blood | DNAJC27 | 0.08 | 0.10 | lasso | 1 | 0.10 | 2.2e-09 | 5.8 | 5.8 | 8.5e-09 | 0.25 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | 5.9 | 6.9 | 7.1e-12 | 0.37 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | 5.8 | 7.5 | 7.7e-14 | 0.45 | 1.00 | 0.00 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | EFR3B | 0.07 | 0.03 | bslmm | 348 | 0.03 | 3.5e-05 | 7.1 | -5.2 | 2.0e-07 | -0.63 | 0.01 | 0.96 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | 5.9 | -6.3 | 3.1e-10 | -0.28 | 1.00 | 0.00 | TRUE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POMC | 0.08 | 0.05 | lasso | 3 | 0.06 | 2.6e-12 | -3.2 | -5.4 | 5.6e-08 | -0.46 | 0.97 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POMC | 0.06 | 0.00 | enet | 12 | 0.03 | 9.3e-05 | -3.2 | -5.1 | 3.0e-07 | -0.58 | 0.01 | 0.41 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EFR3B | 0.03 | 0.05 | lasso | 1 | 0.04 | 1.9e-05 | -5.5 | -5.5 | 3.7e-08 | -0.57 | 0.44 | 0.25 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY3 | 0.03 | 0.02 | blup | 81 | 0.02 | 7.1e-04 | 2.7 | -5.3 | 1.2e-07 | -0.17 | 0.04 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | POMC | 0.14 | 0.04 | enet | 7 | 0.08 | 5.3e-10 | -3.2 | -6.7 | 1.5e-11 | -0.58 | 0.38 | 0.62 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POMC | 0.22 | 0.05 | blup | 37 | 0.03 | 2.1e-02 | -4.5 | -7.3 | 3.7e-13 | -0.48 | 0.01 | 0.29 | TRUE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADCY3 | 0.09 | 0.02 | enet | 11 | 0.04 | 3.2e-05 | -1.4 | 5.3 | 1.2e-07 | 0.20 | 0.12 | 0.03 | TRUE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POMC | 0.11 | 0.08 | enet | 7 | 0.09 | 1.6e-09 | -3.2 | -6.0 | 1.8e-09 | -0.47 | 0.92 | 0.06 | FALSE |